Chemical Formula: C27H37Cl2N3O3

Chemical Formula C27H37Cl2N3O3

Found 1 metabolite its formula value is C27H37Cl2N3O3

E6446 (dihydrochloride)

E6446 (dihydrochloride)

C27H37Cl2N3O3 (521.2211832)


E6446 dihydrochloride is a potent and orally acitve TLR7 and TLR9 antagonist, used in the research of deleterious inflammatory responses. E6446 dihydrochloride is also a potent SCD1 inhibitor (KD: 4.61 μM), significantly inhibiting adipogenic differentiation and hepatic lipogenesis through SCD1-ATF3 signaling. E6446 dihydrochloride also improves liver pathology in high-fat diet (HFD)-fed mice and may be useful in the study of non-alcoholic fatty liver disease (NAFLD)[1][2][3].