Chemical Formula: C26H25ClN4O2

Chemical Formula C26H25ClN4O2

Found 1 metabolite its formula value is C26H25ClN4O2

Pifusertib (hydrochloride)

Pifusertib (hydrochloride)

C26H25ClN4O2 (460.166594)


Pifusertib (TAS-117) hydrochloride is a potent, selective, orally active allosteric Akt inhibitor (with IC50s of 4.8, 1.6, and 44 nM for Akt1, 2, and 3, respectively). Pifusertib hydrochloride triggers anti-myeloma activities and enhances fatal endoplasmic reticulum (ER) stress induced by proteasome inhibition. Pifusertib hydrochloride induces apoptosis and autophagy[1].