Chemical Formula: C25H40N2O3

Chemical Formula C25H40N2O3

Found 2 metabolite its formula value is C25H40N2O3

Pactimibe

2-{7-[(1-hydroxy-2,2-dimethylpropylidene)amino]-4,6-dimethyl-1-octyl-2,3-dihydro-1H-indol-5-yl}acetate

C25H40N2O3 (416.30387700000006)


D006133 - Growth Substances > D010937 - Plant Growth Regulators > D007210 - Indoleacetic Acids C471 - Enzyme Inhibitor Pactimibe (CS-505 free base) is a dual ACAT1/2 inhibitor with IC50s of 4.9 μM and 3.0 μM, respectively. Pactimibe (CS-505 free base) inhibits ACAT with IC50s of 2.0 μM, 2.7 μM, 4.7 μM in the liver, macrophages and THP-1 cells, respectively[1]. Pactimibe (CS-505 free base) noncompetitively inhibits oleoyl-CoA with a Ki value of 5.6 μM. Moreover, Pactimibe (CS-505 free base) obviously inhibits cholesteryl ester formation with an IC50 of 6.7 μM. Pactimibe (CS-505 free base) possesses anti-atherosclerotic potential with lowering plasma cholesterol activity[2].

   

NA-Orn 20:5(5Z,8Z,11Z,14Z,17Z)

NA-Orn 20:5(5Z,8Z,11Z,14Z,17Z)

C25H40N2O3 (416.30387700000006)