Chemical Formula: C24H29N7O5

Chemical Formula C24H29N7O5

Found 25 metabolite its formula value is C24H29N7O5

WYE-354

Methyl 4-[6-[4-(methoxycarbonylamino)phenyl]-4-morpholin-4-ylpyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carboxylate

C24H29N7O5 (495.22300640000003)


WYE-354 is an ATP-competitive mTOR inhibitor with an IC50 of 5 nM. WYE-354 also inhibits PI3Kα and PI3Kγ with IC50s of 1.89 μM and 7.37 μM, respectively. WYE-354 inhibits both mTORC1 and mTORC2. WYE-354 induces autophagy activation in vitro[3]. WYE-354 is an ATP-competitive mTOR inhibitor with an IC50 of 5 nM. WYE-354 also inhibits PI3Kα and PI3Kγ with IC50s of 1.89 μM and 7.37 μM, respectively. WYE-354 inhibits both mTORC1 and mTORC2. WYE-354 induces autophagy activation in vitro[3].

   

Gly His Pro Trp

(2S)-2-{[(2S)-1-[(2S)-2-(2-aminoacetamido)-3-(1H-imidazol-4-yl)propanoyl]pyrrolidin-2-yl]formamido}-3-(1H-indol-3-yl)propanoic acid

C24H29N7O5 (495.22300640000003)


   

Gly His Trp Pro

(2S)-1-[(2S)-2-[(2S)-2-(2-aminoacetamido)-3-(1H-imidazol-4-yl)propanamido]-3-(1H-indol-3-yl)propanoyl]pyrrolidine-2-carboxylic acid

C24H29N7O5 (495.22300640000003)


   

Gly Pro His Trp

(2S)-2-[(2S)-2-{[(2S)-1-(2-aminoacetyl)pyrrolidin-2-yl]formamido}-3-(1H-imidazol-4-yl)propanamido]-3-(1H-indol-3-yl)propanoic acid

C24H29N7O5 (495.22300640000003)


   

Gly Pro Trp His

(2S)-2-[(2S)-2-{[(2S)-1-(2-aminoacetyl)pyrrolidin-2-yl]formamido}-3-(1H-indol-3-yl)propanamido]-3-(1H-imidazol-4-yl)propanoic acid

C24H29N7O5 (495.22300640000003)


   

Gly Trp His Pro

(2S)-1-[(2S)-2-[(2S)-2-(2-aminoacetamido)-3-(1H-indol-3-yl)propanamido]-3-(1H-imidazol-4-yl)propanoyl]pyrrolidine-2-carboxylic acid

C24H29N7O5 (495.22300640000003)


   

Gly Trp Pro His

(2S)-2-{[(2S)-1-[(2S)-2-(2-aminoacetamido)-3-(1H-indol-3-yl)propanoyl]pyrrolidin-2-yl]formamido}-3-(1H-imidazol-4-yl)propanoic acid

C24H29N7O5 (495.22300640000003)


   

His Gly Pro Trp

(2S)-2-{[(2S)-1-{2-[(2S)-2-amino-3-(1H-imidazol-4-yl)propanamido]acetyl}pyrrolidin-2-yl]formamido}-3-(1H-indol-3-yl)propanoic acid

C24H29N7O5 (495.22300640000003)


   

His Gly Trp Pro

(2S)-1-[(2S)-2-{2-[(2S)-2-amino-3-(1H-imidazol-4-yl)propanamido]acetamido}-3-(1H-indol-3-yl)propanoyl]pyrrolidine-2-carboxylic acid

C24H29N7O5 (495.22300640000003)


   

His Pro Gly Trp

(2S)-2-(2-{[(2S)-1-[(2S)-2-amino-3-(1H-imidazol-4-yl)propanoyl]pyrrolidin-2-yl]formamido}acetamido)-3-(1H-indol-3-yl)propanoic acid

C24H29N7O5 (495.22300640000003)


   

His Pro Trp Gly

2-[(2S)-2-{[(2S)-1-[(2S)-2-amino-3-(1H-imidazol-4-yl)propanoyl]pyrrolidin-2-yl]formamido}-3-(1H-indol-3-yl)propanamido]acetic acid

C24H29N7O5 (495.22300640000003)


   

His Trp Gly Pro

(2S)-1-{2-[(2S)-2-[(2S)-2-amino-3-(1H-imidazol-4-yl)propanamido]-3-(1H-indol-3-yl)propanamido]acetyl}pyrrolidine-2-carboxylic acid

C24H29N7O5 (495.22300640000003)


   

His Trp Pro Gly

2-{[(2S)-1-[(2S)-2-[(2S)-2-amino-3-(1H-imidazol-4-yl)propanamido]-3-(1H-indol-3-yl)propanoyl]pyrrolidin-2-yl]formamido}acetic acid

C24H29N7O5 (495.22300640000003)


   

Pro Gly His Trp

(2S)-2-[(2S)-3-(1H-imidazol-4-yl)-2-{2-[(2S)-pyrrolidin-2-ylformamido]acetamido}propanamido]-3-(1H-indol-3-yl)propanoic acid

C24H29N7O5 (495.22300640000003)


   

Pro Gly Trp His

(2S)-3-(1H-imidazol-4-yl)-2-[(2S)-3-(1H-indol-3-yl)-2-{2-[(2S)-pyrrolidin-2-ylformamido]acetamido}propanamido]propanoic acid

C24H29N7O5 (495.22300640000003)


   

Pro His Gly Trp

(2S)-2-{2-[(2S)-3-(1H-imidazol-4-yl)-2-[(2S)-pyrrolidin-2-ylformamido]propanamido]acetamido}-3-(1H-indol-3-yl)propanoic acid

C24H29N7O5 (495.22300640000003)


   

Pro His Trp Gly

2-[(2S)-2-[(2S)-3-(1H-imidazol-4-yl)-2-[(2S)-pyrrolidin-2-ylformamido]propanamido]-3-(1H-indol-3-yl)propanamido]acetic acid

C24H29N7O5 (495.22300640000003)


   

Pro Trp Gly His

(2S)-3-(1H-imidazol-4-yl)-2-{2-[(2S)-3-(1H-indol-3-yl)-2-[(2S)-pyrrolidin-2-ylformamido]propanamido]acetamido}propanoic acid

C24H29N7O5 (495.22300640000003)


   

Pro Trp His Gly

2-[(2S)-3-(1H-imidazol-4-yl)-2-[(2S)-3-(1H-indol-3-yl)-2-[(2S)-pyrrolidin-2-ylformamido]propanamido]propanamido]acetic acid

C24H29N7O5 (495.22300640000003)


   

Trp Gly His Pro

(2S)-1-[(2S)-2-{2-[(2S)-2-amino-3-(1H-indol-3-yl)propanamido]acetamido}-3-(1H-imidazol-4-yl)propanoyl]pyrrolidine-2-carboxylic acid

C24H29N7O5 (495.22300640000003)


   

Trp Gly Pro His

(2S)-2-{[(2S)-1-{2-[(2S)-2-amino-3-(1H-indol-3-yl)propanamido]acetyl}pyrrolidin-2-yl]formamido}-3-(1H-imidazol-4-yl)propanoic acid

C24H29N7O5 (495.22300640000003)


   

Trp His Gly Pro

(2S)-1-{2-[(2S)-2-[(2S)-2-amino-3-(1H-indol-3-yl)propanamido]-3-(1H-imidazol-4-yl)propanamido]acetyl}pyrrolidine-2-carboxylic acid

C24H29N7O5 (495.22300640000003)


   

Trp His Pro Gly

2-{[(2S)-1-[(2S)-2-[(2S)-2-amino-3-(1H-indol-3-yl)propanamido]-3-(1H-imidazol-4-yl)propanoyl]pyrrolidin-2-yl]formamido}acetic acid

C24H29N7O5 (495.22300640000003)


   

Trp Pro Gly His

(2S)-2-(2-{[(2S)-1-[(2S)-2-amino-3-(1H-indol-3-yl)propanoyl]pyrrolidin-2-yl]formamido}acetamido)-3-(1H-imidazol-4-yl)propanoic acid

C24H29N7O5 (495.22300640000003)


   

Trp Pro His Gly

2-[(2S)-2-{[(2S)-1-[(2S)-2-amino-3-(1H-indol-3-yl)propanoyl]pyrrolidin-2-yl]formamido}-3-(1H-imidazol-4-yl)propanamido]acetic acid

C24H29N7O5 (495.22300640000003)