Chemical Formula: C24H26F2N4O3

Chemical Formula C24H26F2N4O3

Found 1 metabolite its formula value is C24H26F2N4O3

P2X3 antagonist 34

C24H26F2N4O3 (456.19728699999996)

P2X3 antagonist 34 is a potent, selective and orally active P2X3 homotrimeric receptor antagonist with IC50s of 25?nM, 92?nM and 126?nM for human P2X3, rat P2X3 and guinea pig P2X3 receptors, respectively. P2X3 antagonist 34 is less active against human, rat and guinea pig P2X2/3 heterotrimeric receptors. P2X3 antagonist 34 has strong anti-tussive effect[1].