Chemical Formula: C23H22F4N6O2

Chemical Formula C23H22F4N6O2

Found 1 metabolite its formula value is C23H22F4N6O2

IDH-305

IDH-305 is an orally available, mutant-selective and brain-penetrant IDH1 inhibitor that targets IDH1 (R132) mutation. IDH-305 exhibits greater than 200 fold selectivity for mutant IDH1 isoforms vs. WT (IC50= 27 nM (IDH1R132H), 28 nM (IDH1R132C), 6.14 μM (IDH1WT))[1][2].