Chemical Formula: C22H20F3N3O4
Chemical Formula C22H20F3N3O4
Found 1 metabolite its formula value is C22H20F3N3O4
Glucosylceramide synthase-IN-2
Glucosylceramide synthase-IN-2
C22H20F3N3O4 (447.14058360000007)
Glucosylceramide synthase-IN-2 (compound T-690) is a potent, brain-penetrant and orally active glucosylceramide synthase (GCS) inhibitor with IC50s of 15 nM and 190 nM for human GCS and mouse GCS, respectively.Glucosylceramide synthase-IN-2 exhibits noncompetitive type inhibition with C8-ceramide and UDP-glucose.Glucosylceramide synthase-IN-2 can be used for Gaucher's disease research[1].