Chemical Formula: C19H20BrF2N3O

Chemical Formula C19H20BrF2N3O

Found 1 metabolite its formula value is C19H20BrF2N3O

ZK53

ZK53

C19H20BrF2N3O (423.0757714)


ZK53 is a selective activator of mitochondrial caseinolytic protease P (HsClpP) (EC50: 1.37?μM for α-casein hydrolysis by HsClpP). ZK53 is is inactive toward bacterial ClpP proteins. ZK53 induces apoptosis in H1703, H520 and SK-MES-1 cells. ZK53 induces dysregulation of mitochondrial functions in lung squamous cell carcinoma (LUSC) cells. ZK53 inhibits tumor growth in H1703 xenograft mouse model[1].