Chemical Formula: C18H17N3O3S

VU0152099 is a potent, selective and brain-penetrant mAChR M4 positive allosteric modulator with an EC50 of 0.4 μM for rat M4 receptor. VU0152099 is inactive for other mAChR subtypes or other GPCRs. VU0152099 has no agonist activity but potentiated responses of M4 to acetylcholine[1]. VU0152099 is a potent, selective and brain-penetrant mAChR M4 positive allosteric modulator with an EC50 of 0.4 μM for rat M4 receptor. VU0152099 is inactive for other mAChR subtypes or other GPCRs. VU0152099 has no agonist activity but potentiated responses of M4 to acetylcholine[1].

(3s,6r,8s,10s)-9-thia-11,15,20-triazaheptacyclo[12.6.1.1³,¹⁰.0²,¹².0³,⁸.0⁵,²⁰.0¹⁷,²¹]docosa-1,11,13,15,17(21)-pentaene-6,8,13-triol

C18H17N3O3S (355.0991)

Chemical Formula: C18H17N3O3S

Chemical Formula C18H17N3O3S

5-[4-[2-[N-Methyl-N-(2-pyridinyl)amino]ethoxy]benzylidene]-2,4-thiazolidinedione

{(2z)-4-Amino-2-[(4-Methoxyphenyl)imino]-2,3-Dihydro-1,3-Thiazol-5-Yl}(4-Methoxyphenyl)methanone

N-[5-(2,4-dimethoxyphenyl)-1,3,4-thiadiazol-2-yl]-2-phenylacetamide

2-[(4-Oxo-2-pyrido[1,2-a]pyrimidinyl)methylthio]-3-pyridinecarboxylic acid propan-2-yl ester

2-[(1-acetyl-2-benzimidazolyl)thio]-N-(2-methoxyphenyl)acetamide

N-(4-methylphenyl)-2-[(4E)-4-[(5-methylthiophen-2-yl)methylidene]-2,5-dioxoimidazolidin-1-yl]acetamide

4-[[3-Cyano-4-methyl-6-(3-pyridinyl)-2-pyridinyl]thio]-3-oxobutanoic acid ethyl ester

N-(3-methylphenyl)-2-{(4E)-4-[(5-methylthien-2-yl)methylene]-2,5-dioxoimidazolidin-1-yl}acetamide

VU0152099

(3s,6r,8s,10s)-9-thia-11,15,20-triazaheptacyclo[12.6.1.1³,¹⁰.0²,¹².0³,⁸.0⁵,²⁰.0¹⁷,²¹]docosa-1,11,13,15,17(21)-pentaene-6,8,13-triol

N-(2-Ethoxyphenyl)-2-[(4-hydroxyquinazolin-2-YL)sulfanyl]acetamide

2-[(4-Hydroxyquinazolin-2-YL)sulfanyl]-N-[(4-methoxyphenyl)methyl]acetamide

2-[(4-Hydroxyquinazolin-2-YL)sulfanyl]-N-[(3-methoxyphenyl)methyl]acetamide

2-[(4-Hydroxyquinazolin-2-YL)sulfanyl]-N-(2-methoxy-5-methylphenyl)acetamide