Chemical Formula: C17H12F3NO4S

Chemical Formula C17H12F3NO4S

Found 5 metabolite its formula value is C17H12F3NO4S

3-{[(1s)-2,2-Difluoro-1-Hydroxy-7-(Methylsulfonyl)-2,3-Dihydro-1h-Inden-4-Yl]oxy}-5-Fluorobenzonitrile

3-{[(1S)-2,2-difluoro-1-hydroxy-7-(methylsulphonyl)-2,3-dihydro-1H-inden-4-yl]oxy}-5-fluorobenzonitrile

Belzutifan

3-{[(1S,2S,3R)-2,3-difluoro-1-hydroxy-7-methanesulphonyl-2,3-dihydro-1H-inden-4-yl]oxy}-5-fluorobenzonitrile

C274 - Antineoplastic Agent > C2189 - Signal Transduction Inhibitor > C129824 - Antineoplastic Protein Inhibitor L - Antineoplastic and immunomodulating agents > L01 - Antineoplastic agents D000970 - Antineoplastic Agents Belzutifan (PT2977) is an orally active and selective HIF-2α inhibitor with an IC50 of 9 nM. Belzutifan, as a second-generation HIF-2α inhibitor, increases potency and improves pharmacokinetic profile. Belzutifan is a potential treatment for clear cell renal cell carcinoma (ccRCC)[1].

3-{[(1s)-2,2-Difluoro-1-Hydroxy-7-(Methylsulfonyl)-2,3-Dihydro-1h-Inden-4-Yl]oxy}-5-Fluorobenzonitrile

3-{[(1S)-2,2-difluoro-1-hydroxy-7-(methylsulphonyl)-2,3-dihydro-1H-inden-4-yl]oxy}-5-fluorobenzonitrile

C17H12F3NO4S (383.04391080000005)

PT-2385

C17H12F3NO4S (383.04391080000005)

PT-2385 is a selective HIF-2α inhibitor with a Ki of less than 50 nM[1][2].