Chemical Formula: C16H14Br2N6O4S
Chemical Formula C16H14Br2N6O4S
Found 2 metabolite its formula value is C16H14Br2N6O4S
Aprocitentan
Aprocitentan
C28313 - Endothelin Receptor Antagonist Aprocitentan (ACT-132577) is the major and pharmacologically active metabolite of Macitentan. Aprocitentan is dual ETA/ETB antagonist with IC50s of 3.4 nM and 987 nM, and pA2 valus of 6.7 and 5.5, respectively[1].
ACT-132577
ACT-132577
A member of the class of sulfamides in which one of the amino groups of sulfonamide is substituted by a 5-(4-bromophenyl)-6-{2-[(5-bromopyrimidin-2-yl)oxy]ethoxy}pyrimidin-4-yl group. An active metabolite of macitentan (obtained by oxidative depropylation), an orphan drug used for the treatment of pulmonary arterial hypertension.
