Chemical Formula: C10H7Cl2N3O

Chemical Formula C10H7Cl2N3O

Found 5 metabolite its formula value is C10H7Cl2N3O

Anagrelide

Imidazo(2,1-b)quinazolin-2(3H)-one, 6,7-dichloro-1,5-dihydro-, monohydrochloride

C10H7Cl2N3O (254.99661519999998)

Anagrelide is only found in individuals that have used or taken this drug. It is a drug used for the treatment of essential thrombocytosis (ET; essential thrombocythemia). It also has been used in the treatment of chronic myeloid leukemia. [Wikipedia]The mechanism by which anagrelide reduces blood platelet count is still under investigation. Studies in patients support a hypothesis of dose-related reduction in platelet production resulting from a decrease in megakaryocyte hypermaturation. In blood withdrawn from normal volunteers treated with anagrelide, a disruption was found in the postmitotic phase of megakaryocyte development and a reduction in megakaryocyte size and ploidy. At therapeutic doses, anagrelide does not produce significant changes in white cell counts or coagulation parameters, and may have a small, but clinically insignificant effect on red cell parameters. Anagrelide inhibits cyclic AMP phosphodiesterase III (PDEIII). PDEIII inhibitors can also inhibit platelet aggregation. However, significant inhibition of platelet aggregation is observed only at doses of anagrelide higher than those required to reduce platelet count. L - Antineoplastic and immunomodulating agents > L01 - Antineoplastic agents C78275 - Agent Affecting Blood or Body Fluid > C1327 - Antiplatelet Agent D006401 - Hematologic Agents > D010975 - Platelet Aggregation Inhibitors D006401 - Hematologic Agents > D005343 - Fibrinolytic Agents D050299 - Fibrin Modulating Agents D002317 - Cardiovascular Agents

1-(2,4-dichlorophenyl)-2-(1h-1,2,4-triazol-1-yl)ethanone

ETHANONE, 1-(2,4-DICHLOROPHENYL)-2-(1H-1,2,4-TRIAZOL-1-YL)-

C10H7Cl2N3O (254.99661519999998)

PRP_M256

ETHANONE, 1-(2,4-DICHLOROPHENYL)-2-(1H-1,2,4-TRIAZOL-1-YL)-

C10H7Cl2N3O (254.99661519999998)

CONFIDENCE Transformation product, tentative ID (Level 2b); INTERNAL_ID 2404

anagrelide

6,7-dichloro-1H,2H,3H,5H-imidazolidino[2,1-b]quinazolin-2-one

C10H7Cl2N3O (254.99661519999998)

L - Antineoplastic and immunomodulating agents > L01 - Antineoplastic agents C78275 - Agent Affecting Blood or Body Fluid > C1327 - Antiplatelet Agent D006401 - Hematologic Agents > D010975 - Platelet Aggregation Inhibitors D006401 - Hematologic Agents > D005343 - Fibrinolytic Agents D050299 - Fibrin Modulating Agents D002317 - Cardiovascular Agents

2,4-dichloro-6-(4-methoxyphenyl)-1,3,5-triazine

C10H7Cl2N3O (254.99661519999998)