Chemical Formula: C10H14O4
Chemical Formula C10H14O4
Found 153 metabolite its formula value is C10H14O4
Guaifenesin
Guaifenesin is a member of methoxybenzenes. Guaifenesin possesses a storied history, having been originally formally approved by the US FDA in 1952 and continues to be one of very few - if not perhaps the only drug that is readily available and used as an expectorant. Since that time the agent has been a combination component of various prescription and non-prescription over-the-counter cough and cold products and is currently a widely available over-the-counter generic medication. Although it is principally believed that guaifenesin elicits an action to facilitate productive cough to manage chest congestion, it is not known whether the agent can reliably mitigate coughing. Regardless, on March 1, 2007, the FDA received a petition asking the FDA to notify the public that some antitussives, expectorants, decongestants, antihistamines, and cough/cold combinations are not known to be safe and effective in children under the age of 6 years. After the negotiation between FDA and major manufacturers, a voluntary transition of labels for not using guaifenesin in children under the age of 4 years was endorsed by FDA in 2008. Furthermore, there has also been contemporary research to suggest that guaifenesin possesses and is capable of demonstrating anticonvulsant and muscle relaxant effects to some degree possibly by acting as an NMDA receptor antagonist. Guaifenesin is an Expectorant. The physiologic effect of guaifenesin is by means of Decreased Respiratory Secretion Viscosity, and Increased Respiratory Secretions. Guaifenesin is a natural product found in Plectranthus with data available. Guaifenesin is a glyceryl guaiacolate with expectorant effects. Guaifenesin increases respiratory tract mucus secretions, acts as an irritant to gastric vagal receptors and recruits efferent parasympathetic reflexes that cause glandular exocytosis. This agent reduces the viscosity of mucus secretion by reducing adhesiveness and surface tension as well as increasing hydration of mucus. Guaifenesin promotes the efficiency of the mucociliary mechanism important in removing accumulated secretions from the upper and lower airway. An expectorant that also has some muscle relaxing action. It is used in many cough preparations. [PubChem] An expectorant that also has some muscle relaxing action. It is used in many cough preparations. See also: Dextromethorphan Hydrobromide; Guaifenesin (component of); Guaifenesin; Phenylephrine Hydrochloride (component of); Guaifenesin; Pseudoephedrine Hydrochloride (component of) ... View More ... Guaifenesin (International Noproprietary Name) or guaiphenesin (former British Approved Name) is an expectorant drug usually taken orally to assist the expectoration (bringing up) of phlegm from the airways in acute respiratory tract infections. It is a common ingredient in many over-the-counter cough/cold medications. Guaifenesin is also used in the experimental guaifenesin protocol in the treatment of fibromyalgia. It was first approved by the Food and Drug Administration (FDA) in 1952. Guaifenesin works by drawing water into the bronchi. The water both thins mucus and lubricates the airway, facilitating the removal of mucus by coughing. Guaifenesin (INN) or guaiphenesin (former BAN) is an expectorant drug usually taken orally to assist the expectoration (bringing up) of phlegm from the airways in acute respiratory tract infections. It is a common ingredient in many over-the-counter cough/cold medications. Guaifenesin is also used in the experimental guaifenesin protocol in the treatment of fibromyalgia. It was first approved by the Food and Drug Administration (FDA) in 1952. Guaifenesin works by drawing water into the bronchi. The water both thins mucus and lubricates the airway, facilitating the removal of mucus by coughing. [HMDB] R - Respiratory system > R05 - Cough and cold preparations > R05C - Expectorants, excl. combinations with cough suppressants > R05CA - Expectorants C78273 - Agent Affecting Respiratory System > C29767 - Expectorant D019141 - Respiratory System Agents > D005100 - Expectorants Guaifenesin (Guaiacol glyceryl ether), a constituent of guaiac resin from the wood of Guajacum officinale Linné, is an expectorant. Guaifenesin can alleviate cough discomfortby increasing sputum volume and decreasing its viscosity, thereby promoting effective cough[1][2]. Guaifenesin (Guaiacol glyceryl ether), a constituent of guaiac resin from the wood of Guajacum officinale Linné, is an expectorant. Guaifenesin can alleviate cough discomfortby increasing sputum volume and decreasing its viscosity, thereby promoting effective cough[1][2].
3-(4-Hydroxy-3-methoxyphenyl)-1,2-propanediol
3-(4-Hydroxy-3-methoxyphenyl)-1,2-propanediol is found in herbs and spices. 3-(4-Hydroxy-3-methoxyphenyl)-1,2-propanediol is a constituent of allspice (Pimenta dioica). Constituent of allspice (Pimenta dioica). 3-(4-Hydroxy-3-methoxyphenyl)-1,2-propanediol is found in herbs and spices.
(2E,4E)-2,7-Dimethyl-2,4-octadienedioic acid
(2E,4E)-2,7-Dimethyl-2,4-octadienedioic acid is found in garden tomato. (2E,4E)-2,7-Dimethyl-2,4-octadienedioic acid is produced by a mutant tomato variety flacca deficient in abscisic acid. Production by a mutant tomato variety flacca deficient in abscisic acid. (2E,4E)-2,7-Dimethyl-2,4-octadienedioic acid is found in garden tomato.
5-(3E-Pentenyl)tetrahydro-2-oxo-3-furancarboxylic acid
5-(3E-Pentenyl)tetrahydro-2-oxo-3-furancarboxylic acid is found in milk and milk products. 5-(3E-Pentenyl)tetrahydro-2-oxo-3-furancarboxylic acid is a possible latent butter aroma compoun
3,4-Methylene suberic acid
3,4-Methylene suberic acid belongs to the family of Branched Fatty Acids. These are fatty acids containing a branched chain.
2,3-Methylene suberic acid
2,3-Methylene suberic acid belongs to the family of Branched Fatty Acids. These are fatty acids containing a branched chain.
4,5-Dihydro-2,5-dimethyl-4-oxo-3-furanyl butyrate
It is used as a food additive .
(Z)-2-[[(Z)-2-methylbut-2-enoyl]oxymethyl]but-2-enoic acid
1-hydroxy-9-(hydroxymethyl)-6-methyl-7-oxatricyclo[4.3.0.0?,?]nonan-4-one
(4R,5S,6S,7R)-5-acetyl-6,7-dihydroxy-4-methylcycloheptenone|keisslone
(1R,3R,5S,7S,8S,9S)-3,8-epoxy-1,7dihydroxy-Delta4,11-dihyronepetane|jatamanin D
2,3-Dimethoxy-5,6-dimethyl-2-cyclohexene-1,4-dione
(+)-cephalosporolide E|(+)-cephalosporolide F|(-)-cephalosporolide F|cephalosporolide E|cephalosporolide F|Cepharosporolide F
delta-Lactone-(2R,3R,5Z)-5-Ethylidene-2-hydroxy-2,3-dimethylhexanedioic acid
(3-ethylidene-2-oxotetrahydropyran-4-yl)-acetic acid methyl ester
4-(erythro-6,7-dihydroxy-9-methylpent-8-enyl)furan-2(5H)-one|aruncin A
(1R,4aS,6S,7R,7aS)-1,6-dihydroxy-7-methyl-1,4a,5,6,7,7a-hexahydrocyclopenta[c]pyran-4-carbaldehyde|cachinol
threo-1-(4-Hydroxy-3-methoxyphenyl)propane-1,2-diol
Ac-(+)- Dihydro-5-(1-hydroxy-2-butenyl)-2(3H)-furanone
(5S,7S,8S,9S)-7,8-dihydroxy-Delta4,11-dihyronepetalactone|jatamanin A
(+)-6-hydroxyramulosin|6,8-dihydroxy-3-methyl-3,4,4a,5,6,7-hexahydro-1H-isochromen-1-one|6-Hydroxyramulosin
(Z)-2-Angeloyloxymethyl-2-butenoic
2-Butenoic acid, 2-methyl-, 2-carboxy-2-butenyl ester, (Z,Z)- is a fatty acid ester. 2-Butenoic acid, 2-methyl-, 2-carboxy-2-butenyl ester, (Z,Z)- is a natural product found in Anthriscus sylvestris with data available.
JunipediolA
Junipediol A is a natural product found in Saussurea medusa, Peucedanum japonicum, and Juniperus phoenicea with data available.
Guaifenesin
R - Respiratory system > R05 - Cough and cold preparations > R05C - Expectorants, excl. combinations with cough suppressants > R05CA - Expectorants C78273 - Agent Affecting Respiratory System > C29767 - Expectorant D019141 - Respiratory System Agents > D005100 - Expectorants Guaifenesin (Guaiacol glyceryl ether), a constituent of guaiac resin from the wood of Guajacum officinale Linné, is an expectorant. Guaifenesin can alleviate cough discomfortby increasing sputum volume and decreasing its viscosity, thereby promoting effective cough[1][2]. Guaifenesin (Guaiacol glyceryl ether), a constituent of guaiac resin from the wood of Guajacum officinale Linné, is an expectorant. Guaifenesin can alleviate cough discomfortby increasing sputum volume and decreasing its viscosity, thereby promoting effective cough[1][2].
1,7,7-trimethyl-2-oxo-3-oxabicyclo[2.2.1]heptane-4-carboxylic acid
5-(4-methyl-5-oxo-2H-furan-3-yl)pentanoic acid
(Z)-2-[[(Z)-2-methylbut-2-enoyl]oxymethyl]but-2-enoic acid
C10H14O4_2H-Oxecin-2-one, 5,8,9,10-tetrahydro-5,8-dihydroxy-10-methyl-, (3Z,6E)
(5E,8Z)-4,7-dihydroxy-2-methyl-2,3,4,7-tetrahydrooxecin-10-one
(Z)-2-[[(Z)-2-methylbut-2-enoyl]oxymethyl]but-2-enoic acid_major
5-(4-methyl-5-oxo-2H-furan-3-yl)pentanoic acid_major
5-tert-Butyl-4-hydroxymethylfuran-2-carboxylic acid
2-(2-hydroxy-3-oxobutan-2-yl)-2,5-dimethylfuran-3-one
METHYL 2,2-DIMETHYL-4,6-DIOXOCYCLOHEXANECARBOXYLATE
ethyl 4-hydroxy-2-oxo-6-methylcyclohex-3-ene-1-carboxylate
Ethylene methacrylate
D019995 - Laboratory Chemicals > D007202 - Indicators and Reagents > D003432 - Cross-Linking Reagents
Spiro[3.3]heptane-2,6-dicarboxylic acid monomethyl ester
2,5-Dimethyl-2,4-hexadienedioic acid dimethyl ester
7-Deoxyloganetic acid
An iridoid monoterpenoid that is 1,4a,5,6,7,7a-hexahydrocyclopenta[c]pyran-4-carboxylic acid substituted at positions 1 and 7 by hydroxy and methyl groups respectively; the aglycone of 7-deoxyloganic acid.