Chemical Formula: C10H12N2O2
Chemical Formula C10H12N2O2
Found 111 metabolite its formula value is C10H12N2O2
Oxoamide
Oxoamide is a metabolite of Cotinine, which is a major metabolite of Nicotine. A metabolite of Cotinine, which is a major metabolite of Nicotine. [HMDB]
Hydroxycotinine
Quantitatively, the most important metabolite of nicotine in most mammalian species is cotinine. In humans, about 70 to 80\\\% of nicotine is converted to cotinine. 3-Hydroxycotinine (3HC) is the main nicotine metabolite detected in smokers urine. It is also excreted as a glucuronide conjugate (3HC-Gluc). 3HC and 3HC-Gluc account for 40-60\\\% of the nicotine dose in urine. [HMDB] Quantitatively, the most important metabolite of nicotine in most mammalian species is cotinine. In humans, about 70 to 80\\\% of nicotine is converted to cotinine. 3-Hydroxycotinine (3HC) is the main nicotine metabolite detected in smokers urine. It is also excreted as a glucuronide conjugate (3HC-Gluc). 3HC and 3HC-Gluc account for 40-60\\\% of the nicotine dose in urine. Hydroxycotinine is the main nicotine metabolite detected in smokers urine.
Cotinine N-oxide
Cotinine N-oxide is a minor metabolite of nicotine, cotinine formation being the major pathway of nicotine metabolism in smokers. Cotinine N-oxide accounts for less than 5\\% of the nicotine dose. Cotinine N-oxide can be reduced back to the parent amine in vivo. Nicotine is a naturally occurring alkaloid found in many plants. The principal sources of nicotine exposure are through the use of tobacco, nicotine containing gum and nicotine replacement therapies. Nicotine is an amine composed of pyridine and pyrrolidine rings. It has been shown that nicotine crosses biological membranes and the blood brain barrier easily. The absorbed nicotine is extensively metabolized in the liver to form a wide variety of metabolites including and cotinine N-oxide. Nicotine has been shown to affect a wide variety of biological functions ranging from gene expression, regulation of hormone secretion and enzyme activities. (PMID: 16359169, 15109883) [HMDB] Cotinine N-oxide is a minor metabolite of nicotine, cotinine formation being the major pathway of nicotine metabolism in smokers. Cotinine N-oxide accounts for less than 5\\% of the nicotine dose. Cotinine N-oxide can be reduced back to the parent amine in vivo. Nicotine is a naturally occurring alkaloid found in many plants. The principal sources of nicotine exposure are through the use of tobacco, nicotine containing gum and nicotine replacement therapies. Nicotine is an amine composed of pyridine and pyrrolidine rings. It has been shown that nicotine crosses biological membranes and the blood brain barrier easily. The absorbed nicotine is extensively metabolized in the liver to form a wide variety of metabolites including and cotinine N-oxide. Nicotine has been shown to affect a wide variety of biological functions ranging from gene expression, regulation of hormone secretion and enzyme activities. (PMID: 16359169, 15109883).
N'-Hydroxymethylnorcotinine
N-Hydroxymethylnorcotinine is a cotinine metabolite derived from liver. Formation of norcotinine via N-demethylation of cotinine is expected to proceed via the N-hydroxymethyl intermediate, which is predicted to be relatively stable, due to the low pKa of the pyrrolidone-N moiety.
5'-Hydroxycotinine
A hydroxylated derivative of cotinine. Cotinine is dervied from nicotine. [HMDB]. 5-Hydroxycotinine is found in many foods, some of which are shiitake, sweet cherry, moth bean, and blackcurrant. 5-Hydroxycotinine is a hydroxylated derivative of cotinine. Cotinine is dervied from nicotine.
2,3,5,6-Tetramethyl-1H,7H-pyrazolo[1,2-a]pyrazole-1,7-dione
trans-3'-hydroxycotinine
Trans-3-hydroxycotinine, also known as 1-methyl-3-hydroxy-5-(3-pyridyl)-2-pyrrolidinone, is a member of the class of compounds known as pyrrolidinylpyridines. Pyrrolidinylpyridines are compounds containing a pyrrolidinylpyridine ring system, which consists of a pyrrolidine ring linked to a pyridine ring. Trans-3-hydroxycotinine is soluble (in water) and a very weakly acidic compound (based on its pKa). Trans-3-hydroxycotinine can be found in a number of food items such as annual wild rice, macadamia nut, corn salad, and radish, which makes trans-3-hydroxycotinine a potential biomarker for the consumption of these food products.
3-hydroxy-1-methyl-5-pyridin-3-yl-pyrrolidin-2-one|Hydroxy-cotinin
2-Acetyl-3-hydroxy-5-methyl-6,7-dihydro-5H-cyclopentapyrazin
4-Oxo-N-methyl-4--butyramid|gamma-<3-Pyridyl>-beta-oxo-N-methylbutyramid|N-methyl-3-oxo-4-pyridin-3-yl-butyramide
Hydroxycotinine
CONFIDENCE standard compound; INTERNAL_ID 2275 Hydroxycotinine is the main nicotine metabolite detected in smokers urine.
Cotinine N-oxide
An N-alkylpyrrolidine that is nicotine in which the methylene hydrogens at position 2 on the pyrrolidine ring have been replaced by an oxo group and the pyridine nitrogen converted into the corresponding N-oxide. A minor metabolite of nicotine.
3-Nitro-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridine
6-AMINO-2,2-DIMETHYL-2H-BENZO[B][1,4]OXAZIN-3(4H)-ONE
Methyl 5,6,7,8-tetrahydro-1,7-naphthyridine-3-carboxylate
(2e)-3-[6-(trifluoromethyl)pyridin-3-yl]propenoicacid
Acetamide,N-(3,4-dimethylphenyl)-2-(hydroxyimino)-
6-Hydroxy-4-methyl-2-oxo-1-propyl-1,2-dihydro-3-pyridinecarbonitr ile
1H-Benzimidazole,2-ethoxy-1-hydroxy-5-methyl-(9CI)
1-(6-amino-2,3-dihydro-1,4-benzoxazin-4-yl)ethanone
8-METHOXY-1,3,4,5-TETRAHYDRO-2H-1,5-BENZODIAZEPIN-2-ONE
6-amino-2,4-dimethyl-2H-1,4-benzoxazin-3(4H)-one(SALTDATA: FREE)
2,3,6,7-Tetramethyl-1,5-diazabicyclo[3.3.0]octa-2,6-diene-4,8-dione
DL-2-amino-2-[2,3-dihydro-5-benzo(b)furanyl]-acetamide
1H-Benzimidazole-2-methanol,6-methoxy-1-methyl-(9CI)
1H-Benzimidazole-2-methanol,4-methoxy-alpha-methyl-(9CI)
1H-Benzimidazole-2-ethanol,1-(hydroxymethyl)-(9CI)
1H-Benzimidazole-2-methanol,5-methoxy-alpha-methyl-(9CI)
1H-Benzimidazole-2-methanol,1-(methoxymethyl)-(9CI)
2-Pyrrolidinone, 3-hydroxy-1-methyl-5-(3-pyridinyl)-
trans-3-Hydroxycotinine
An N-alkylpyrrolidine that is cotinine substituted at position C-3 by a hydroxy group (the 3R,5S-diastereomer).