Exact Mass: 537.301
Exact Mass Matches: 537.301
Found 500 metabolites which its exact mass value is equals to given mass value 537.301
,
within given mass tolerance error 0.05 dalton. Try search metabolite list with more accurate mass tolerance error
0.01 dalton.
Cholylglutamic acid
Cholylglutamic acid belongs to a class of molecules known as bile acid-amino acid conjugates. These are bile acid conjugates that consist of a primary bile acid such as cholic acid, doxycholic acid and chenodeoxycholic acid, conjugated to an amino acid. Cholylglutamic acid consists of the bile acid cholic acid conjugated to the amino acid Glutamic acid conjugated at the C24 acyl site.Bile acids play an important role in regulating various physiological systems, such as fat digestion, cholesterol metabolism, vitamin absorption, liver function, and enterohepatic circulation through their combined signaling, detergent, and antimicrobial mechanisms (PMID: 34127070). Bile acids also act as detergents in the gut and support the absorption of fats through the intestinal membrane. These same properties allow for the disruption of bacterial membranes, thereby allowing them to serve a bacteriocidal or bacteriostatic function. In humans (and other mammals) bile acids are normally conjugated with the amino acids glycine and taurine by the liver. This conjugation catalyzed by two liver enzymes, bile acid CoA ligase (BAL) and bile acid CoA: amino acid N-acyltransferase (BAT). Glycine and taurine bound BAs are also referred to as bile salts due to their decreased pKa and complete ionization resulting in these compounds being present as anions in vivo. Unlike glycine and taurine-conjugated bile acids, these recently discovered bile acids, such as Cholylglutamic acid, are produced by the gut microbiota, making them secondary bile acids (PMID: 32103176) or microbially conjugated bile acids (MCBAs) (PMID: 34127070). Evidence suggests that these bile acid-amino acid conjugates are produced by microbes belonging to Clostridia species (PMID: 32103176). These unusual bile acid-amino acid conjugates are found in higher frequency in patients with inflammatory bowel disease (IBD), cystic fibrosis (CF) and in infants (PMID: 32103176). Cholylglutamic acid appears to act as an agonist for the farnesoid X receptor (FXR) and it can also lead to reduced expression of bile acid synthesis genes (PMID: 32103176). It currently appears that microbially conjugated bile acids (MCBAs) or amino acid-bile acid conjugates are only conjugated to cholic acid, deoxycholic acid and chenodeoxycholic acid (PMID: 34127070). It has been estimated that if microbial conjugation of bile acids is very promiscuous and occurs for all potential oxidized, epimerized, and dehydroxylated states of each hydroxyl group present on cholic acid (C3, C7, C12) in addition to ring orientation, the total number of potential human bile acid conjugates could be over 2800 (PMID: 34127070).
Ile Cys Phe Arg
Tyr Asp Ile Lys
Val Tyr Glu Lys
Ile Asp Tyr Lys
Tyr Glu Val Lys
Cys Phe Ile Arg
Cys Phe Leu Arg
Cys Phe Arg Ile
Cys Phe Arg Leu
Cys Ile Phe Arg
Cys Ile Arg Phe
Cys Leu Phe Arg
Cys Leu Arg Phe
Cys Arg Phe Ile
Cys Arg Phe Leu
Cys Arg Ile Phe
Cys Arg Leu Phe
Asp Ile Lys Tyr
Asp Ile Tyr Lys
Asp Lys Ile Tyr
Asp Lys Leu Tyr
Asp Lys Tyr Ile
Asp Lys Tyr Leu
Asp Leu Lys Tyr
Asp Leu Tyr Lys
Asp Tyr Ile Lys
Asp Tyr Lys Ile
Asp Tyr Lys Leu
Asp Tyr Leu Lys
Glu His Pro Arg
Glu His Arg Pro
Glu Lys Val Tyr
Glu Lys Tyr Val
Glu Pro His Arg
Glu Pro Arg His
Glu Arg His Pro
Glu Arg Pro His
Glu Val Lys Tyr
Glu Val Tyr Lys
Glu Tyr Lys Val
Glu Tyr Val Lys
Phe Cys Ile Arg
Phe Cys Leu Arg
Phe Cys Arg Ile
Phe Cys Arg Leu
Phe Phe Lys Pro
Phe Phe Pro Lys
Phe Ile Cys Arg
Phe Ile Lys Met
Phe Ile Met Lys
Phe Ile Met Gln
Phe Ile Gln Met
Phe Ile Arg Cys
Phe Lys Phe Pro
Phe Lys Ile Met
Phe Lys Leu Met
Phe Lys Met Ile
Phe Lys Met Leu
Phe Lys Pro Phe
Phe Leu Cys Arg
Phe Leu Lys Met
Phe Leu Met Lys
Phe Leu Met Gln
Phe Leu Gln Met
Phe Leu Arg Cys
Phe Met Ile Lys
Phe Met Ile Gln
Phe Met Lys Ile
Phe Met Lys Leu
Phe Met Leu Lys
Phe Met Leu Gln
Phe Met Gln Ile
Phe Met Gln Leu
Phe Pro Phe Lys
Phe Pro Lys Phe
Phe Gln Ile Met
Phe Gln Leu Met
Phe Gln Met Ile
Phe Gln Met Leu
Phe Arg Cys Ile
Phe Arg Cys Leu
Phe Arg Ile Cys
Phe Arg Leu Cys
His Glu Pro Arg
His Glu Arg Pro
His Ile Ile Arg
His Ile Leu Arg
His Ile Arg Ile
His Ile Arg Leu
His Leu Ile Arg
His Leu Leu Arg
His Leu Arg Ile
His Leu Arg Leu
His Pro Glu Arg
His Pro Arg Glu
His Pro Val Trp
His Pro Trp Val
His Arg Glu Pro
His Arg Ile Ile
His Arg Ile Leu
His Arg Leu Ile
His Arg Leu Leu
His Arg Pro Glu
His Val Pro Trp
His Val Trp Pro
His Trp Pro Val
His Trp Val Pro
Ile Cys Arg Phe
Ile Asp Lys Tyr
Ile Phe Cys Arg
Ile Phe Lys Met
Ile Phe Met Lys
Ile Phe Met Gln
Ile Phe Gln Met
Ile Phe Arg Cys
Ile His Ile Arg
Ile His Leu Arg
Ile His Arg Ile
Ile His Arg Leu
Ile Ile His Arg
Ile Ile Arg His
Ile Lys Asp Tyr
Ile Lys Phe Met
Ile Lys Met Phe
Ile Lys Tyr Asp
Ile Leu His Arg
Ile Leu Arg His
Ile Met Phe Lys
Ile Met Phe Gln
Ile Met Lys Phe
Ile Met Gln Phe
Ile Gln Phe Met
Ile Gln Met Phe
Ile Arg Cys Phe
Ile Arg Phe Cys
Ile Arg His Ile
Ile Arg His Leu
Ile Arg Ile His
Ile Arg Leu His
Ile Arg Ser Tyr
Ile Arg Tyr Ser
Ile Ser Arg Tyr
Ile Ser Tyr Arg
Ile Tyr Asp Lys
Ile Tyr Lys Asp
Ile Tyr Arg Ser
Ile Tyr Ser Arg
Lys Asp Ile Tyr
Lys Asp Leu Tyr
Lys Asp Tyr Ile
Lys Asp Tyr Leu
Lys Glu Val Tyr
Lys Glu Tyr Val
Lys Phe Phe Pro
Lys Phe Ile Met
Lys Phe Leu Met
Lys Phe Met Ile
Lys Phe Met Leu
Lys Phe Pro Phe
Lys Ile Asp Tyr
Lys Ile Phe Met
Lys Ile Met Phe
Lys Ile Tyr Asp
Lys Leu Asp Tyr
Lys Leu Phe Met
Lys Leu Met Phe
Lys Leu Tyr Asp
Lys Met Phe Ile
Lys Met Phe Leu
Lys Met Ile Phe
Lys Met Leu Phe
Lys Met Pro Tyr
Lys Met Tyr Pro
Lys Pro Phe Phe
Lys Pro Met Tyr
Lys Pro Tyr Met
Lys Val Glu Tyr
Lys Val Tyr Glu
Lys Tyr Asp Ile
Lys Tyr Asp Leu
Lys Tyr Glu Val
Lys Tyr Ile Asp
Lys Tyr Leu Asp
Lys Tyr Met Pro
Lys Tyr Pro Met
Lys Tyr Val Glu
Leu Cys Phe Arg
Leu Cys Arg Phe
Leu Asp Lys Tyr
Leu Asp Tyr Lys
Leu Phe Cys Arg
Leu Phe Lys Met
Leu Phe Met Lys
Leu Phe Met Gln
Leu Phe Gln Met
Leu Phe Arg Cys
Leu His Ile Arg
Leu His Leu Arg
Leu His Arg Ile
Leu His Arg Leu
Leu Ile His Arg
Leu Ile Arg His
Leu Lys Asp Tyr
Leu Lys Phe Met
Leu Lys Met Phe
Leu Lys Tyr Asp
Leu Leu His Arg
Leu Leu Arg His
Leu Met Phe Lys
Leu Met Lys Phe
Leu Arg Cys Phe
Leu Arg Phe Cys
Leu Arg His Ile
Leu Arg His Leu
Leu Arg Ile His
Leu Arg Leu His
Leu Arg Ser Tyr
Leu Arg Tyr Ser
Leu Ser Arg Tyr
Leu Ser Tyr Arg
Leu Tyr Asp Lys
Leu Tyr Lys Asp
Leu Tyr Arg Ser
Leu Tyr Ser Arg
Met Phe Ile Lys
Met Phe Lys Ile
Met Phe Lys Leu
Met Phe Leu Lys
Met Ile Phe Lys
Met Ile Lys Phe
Met Lys Phe Ile
Met Lys Phe Leu
Met Lys Ile Phe
Met Lys Leu Phe
Met Leu Phe Lys
Met Leu Lys Phe
Pro Glu His Arg
Pro Glu Arg His
Pro Phe Phe Lys
Pro Phe Lys Phe
Pro His Glu Arg
Pro His Arg Glu
Pro His Val Trp
Pro His Trp Val
Pro Lys Phe Phe
Pro Arg Glu His
Pro Arg His Glu
Pro Val His Trp
Pro Val Trp His
Pro Trp His Val
Pro Trp Val His
Arg Cys Phe Ile
Arg Cys Phe Leu
Arg Cys Ile Phe
Arg Cys Leu Phe
Arg Glu His Pro
Arg Glu Pro His
Arg Phe Cys Ile
Arg Phe Cys Leu
Arg Phe Ile Cys
Arg Phe Leu Cys
Arg His Glu Pro
Arg His Ile Ile
Arg His Ile Leu
Arg His Leu Ile
Arg His Leu Leu
Arg His Pro Glu
Arg Ile Cys Phe
Arg Ile Phe Cys
Arg Ile His Ile
Arg Ile His Leu
Arg Ile Ile His
Arg Ile Leu His
Arg Ile Ser Tyr
Arg Ile Tyr Ser
Arg Leu Cys Phe
Arg Leu Phe Cys
Arg Leu His Ile
Arg Leu His Leu
Arg Leu Ile His
Arg Leu Leu His
Arg Leu Ser Tyr
Arg Leu Tyr Ser
Arg Pro Glu His
Arg Pro His Glu
Arg Ser Ile Tyr
Arg Ser Leu Tyr
Arg Ser Tyr Ile
Arg Ser Tyr Leu
Arg Thr Val Tyr
Arg Thr Tyr Val
Arg Val Thr Tyr
Arg Val Tyr Thr
Arg Tyr Ile Ser
Arg Tyr Leu Ser
Arg Tyr Ser Ile
Arg Tyr Ser Leu
Arg Tyr Thr Val
Arg Tyr Val Thr
Ser Ile Arg Tyr
Ser Ile Tyr Arg
Ser Leu Arg Tyr
Ser Leu Tyr Arg
Ser Arg Ile Tyr
Ser Arg Leu Tyr
Ser Arg Tyr Ile
Ser Arg Tyr Leu
Ser Tyr Ile Arg
Ser Tyr Leu Arg
Ser Tyr Arg Ile
Ser Tyr Arg Leu
Thr Arg Val Tyr
Thr Arg Tyr Val
Thr Val Arg Tyr
Thr Val Tyr Arg
Thr Tyr Arg Val
Thr Tyr Val Arg
Val Glu Lys Tyr
Val Glu Tyr Lys
Val His Pro Trp
Val His Trp Pro
Val Lys Glu Tyr
Val Lys Tyr Glu
Val Pro His Trp
Val Pro Trp His
Val Arg Thr Tyr
Val Arg Tyr Thr
Val Thr Arg Tyr
Val Thr Tyr Arg
Val Trp His Pro
Val Trp Pro His
Val Tyr Lys Glu
Val Tyr Arg Thr
Val Tyr Thr Arg
Trp His Pro Val
Trp His Val Pro
Trp Pro His Val
Trp Pro Val His
Trp Val His Pro
Trp Val Pro His
Tyr Asp Lys Ile
Tyr Asp Lys Leu
Tyr Asp Leu Lys
Tyr Glu Lys Val
Tyr Ile Asp Lys
Tyr Ile Lys Asp
Tyr Ile Arg Ser
Tyr Ile Ser Arg
Tyr Lys Asp Ile
Tyr Lys Asp Leu
Tyr Lys Glu Val
Tyr Lys Ile Asp
Tyr Lys Leu Asp
Tyr Lys Val Glu
Tyr Leu Asp Lys
Tyr Leu Lys Asp
Tyr Leu Arg Ser
Tyr Leu Ser Arg
Tyr Arg Ile Ser
Tyr Arg Leu Ser
Tyr Arg Ser Ile
Tyr Arg Ser Leu
Tyr Arg Thr Val
Tyr Arg Val Thr
Tyr Ser Ile Arg
Tyr Ser Leu Arg
Tyr Ser Arg Ile
Tyr Ser Arg Leu
Tyr Thr Arg Val
Tyr Thr Val Arg
Tyr Val Glu Lys
Tyr Val Lys Glu
Tyr Val Arg Thr
Tyr Val Thr Arg
N-dodecanoyl-L-HSL-3-hydrazone-biotin
Sodium taurocholate
D005765 - Gastrointestinal Agents > D002756 - Cholagogues and Choleretics D005765 - Gastrointestinal Agents > D001647 - Bile Acids and Salts D005765 - Gastrointestinal Agents > D002793 - Cholic Acids D013501 - Surface-Active Agents > D003902 - Detergents Emulsifier in foods Taurocholic acid sodium (Sodium taurocholate; N-Choloyltaurine sodium) has marked bioactive effects such as an inhibitory potential against hepatic artery ligation induced biliary damage by upregulation of VEGF-A expression. Immunoregulation effect[1]. Taurocholic acid sodium (Sodium taurocholate; N-Choloyltaurine sodium) has marked bioactive effects such as an inhibitory potential against hepatic artery ligation induced biliary damage by upregulation of VEGF-A expression. Immunoregulation effect[1].
fexofenadine
D018377 - Neurotransmitter Agents > D018494 - Histamine Agents > D006633 - Histamine Antagonists C308 - Immunotherapeutic Agent > C29578 - Histamine-1 Receptor Antagonist D018926 - Anti-Allergic Agents Fexofenadine (MDL-16455) hydrochloride is an orally active and nonsedative H1 receptor antagonist. Fexofenadine hydrochloride can be used in allergic rhinitis and chronic idiopathic urticarial research[1][2][3].