Exact Mass: 521.2211832
Exact Mass Matches: 521.2211832
Found 1 metabolites which its exact mass value is equals to given mass value 521.2211832,
within given mass tolerance error 1.024E-10 dalton. Try search metabolite list with more accurate mass tolerance error
2.048E-11 dalton.
E6446 (dihydrochloride)
E6446 (dihydrochloride)
E6446 dihydrochloride is a potent and orally acitve TLR7 and TLR9 antagonist, used in the research of deleterious inflammatory responses. E6446 dihydrochloride is also a potent SCD1 inhibitor (KD: 4.61 μM), significantly inhibiting adipogenic differentiation and hepatic lipogenesis through SCD1-ATF3 signaling. E6446 dihydrochloride also improves liver pathology in high-fat diet (HFD)-fed mice and may be useful in the study of non-alcoholic fatty liver disease (NAFLD)[1][2][3].