Exact Mass: 471.3043
Exact Mass Matches: 471.3043
Found 114 metabolites which its exact mass value is equals to given mass value 471.3043
,
within given mass tolerance error 0.01 dalton. Try search metabolite list with more accurate mass tolerance error
0.001 dalton.
Terfenadine
Terfenadine is only found in individuals that have used or taken this drug. In the U.S., Terfenadine was superseded by fexofenadine in the 1990s due to the risk of cardiac arrhythmia caused by QT interval prolongation.Terfenadine competes with histamine for binding at H1-receptor sites in the GI tract, uterus, large blood vessels, and bronchial muscle. This reversible binding of terfenadine to H1-receptors suppresses the formation of edema, flare, and pruritus resulting from histaminic activity. As the drug does not readily cross the blood-brain barrier, CNS depression is minimal. R - Respiratory system > R06 - Antihistamines for systemic use > R06A - Antihistamines for systemic use D018377 - Neurotransmitter Agents > D018494 - Histamine Agents > D006633 - Histamine Antagonists C308 - Immunotherapeutic Agent > C29578 - Histamine-1 Receptor Antagonist Terfenadine ((±)-Terfenadine) is a potent open-channel blocker of hERG with an IC50 of 204 nM[1]. Terfenadine, an H1 histamine receptor antagonist, acts as a potent apoptosis inducer in melanoma cells through modulation of Ca2+ homeostasis. Terfenadine induces ROS-dependent apoptosis, simultaneously activates Caspase-4, -2, -9[2].
N-(1,4-Dihydroxy-1,2,3,4-tetrahydronaphthyl)-propyl-N-diphenylmethyl-N-3,3-dimethylbutylamine
terfenadine
R - Respiratory system > R06 - Antihistamines for systemic use > R06A - Antihistamines for systemic use D018377 - Neurotransmitter Agents > D018494 - Histamine Agents > D006633 - Histamine Antagonists C308 - Immunotherapeutic Agent > C29578 - Histamine-1 Receptor Antagonist Terfenadine ((±)-Terfenadine) is a potent open-channel blocker of hERG with an IC50 of 204 nM[1]. Terfenadine, an H1 histamine receptor antagonist, acts as a potent apoptosis inducer in melanoma cells through modulation of Ca2+ homeostasis. Terfenadine induces ROS-dependent apoptosis, simultaneously activates Caspase-4, -2, -9[2].
Ile Ile Ile Asn
Ile Ile Leu Asn
Ile Ile Asn Ile
Ile Ile Asn Leu
Ile Ile Gln Val
Ile Ile Val Gln
Ile Leu Ile Asn
Ile Leu Leu Asn
Ile Leu Asn Ile
Ile Leu Asn Leu
Ile Leu Gln Val
Ile Leu Val Gln
Ile Asn Ile Ile
Ile Asn Ile Leu
Ile Asn Leu Ile
Ile Asn Leu Leu
Ile Gln Ile Val
Ile Gln Leu Val
Ile Gln Val Ile
Ile Gln Val Leu
Ile Val Ile Gln
Ile Val Leu Gln
Ile Val Gln Ile
Ile Val Gln Leu
Leu Ile Ile Asn
Leu Ile Leu Asn
Leu Ile Asn Ile
Leu Ile Asn Leu
Leu Ile Gln Val
Leu Ile Val Gln
Leu Leu Ile Asn
Leu Leu Leu Asn
Leu Leu Asn Ile
Leu Leu Asn Leu
Leu Leu Gln Val
Leu Leu Val Gln
Leu Asn Ile Ile
Leu Asn Ile Leu
Leu Asn Leu Ile
Leu Asn Leu Leu
Leu Gln Ile Val
Leu Gln Leu Val
Leu Gln Val Ile
Leu Gln Val Leu
Leu Val Ile Gln
Leu Val Leu Gln
Leu Val Gln Ile
Leu Val Gln Leu
Asn Ile Ile Ile
Asn Ile Ile Leu
Asn Ile Leu Ile
Asn Ile Leu Leu
Asn Leu Ile Ile
Asn Leu Ile Leu
Asn Leu Leu Ile
Asn Leu Leu Leu
Gln Ile Ile Val
Gln Ile Leu Val
Gln Ile Val Ile
Gln Ile Val Leu
Gln Leu Ile Val
Gln Leu Leu Val
Gln Leu Val Ile
Gln Leu Val Leu
Gln Val Ile Ile
Gln Val Ile Leu
Gln Val Leu Ile
Gln Val Leu Leu
Val Ile Ile Gln
Val Ile Leu Gln
Val Ile Gln Ile
Val Ile Gln Leu
Val Leu Ile Gln
Val Leu Leu Gln
Val Leu Gln Ile
Val Leu Gln Leu
Val Gln Ile Ile
Val Gln Ile Leu
Val Gln Leu Ile
Val Gln Leu Leu
Sodium glycochenodeoxycholate
A bile acid salt that is the sodium salt of glycochenodeoxycholic acid. Glycochenodeoxycholic acid sodium salt (Chenodeoxycholylglycine sodium salt) is a bile acid formed in the liver from chenodeoxycholate and glycine. It acts as a detergent to solubilize fats for absorption and is itself absorbed. Glycochenodeoxycholic acid sodium salt (Chenodeoxycholylglycine sodium salt) induces hepatocyte apoptosis[1][2].
Sodium glycodeoxycholate
A bile acid salt that is the sodium salt of glycodeoxycholic acid.