Exact Mass: 447.14058360000007

Exact Mass Matches: 447.14058360000007

Found 1 metabolites which its exact mass value is equals to given mass value 447.14058360000007, within given mass tolerance error 2.56E-9 dalton. Try search metabolite list with more accurate mass tolerance error 5.12E-10 dalton.

Glucosylceramide synthase-IN-2

Glucosylceramide synthase-IN-2

C22H20F3N3O4 (447.14058360000007)


Glucosylceramide synthase-IN-2 (compound T-690) is a potent, brain-penetrant and orally active glucosylceramide synthase (GCS) inhibitor with IC50s of 15 nM and 190 nM for human GCS and mouse GCS, respectively.Glucosylceramide synthase-IN-2 exhibits noncompetitive type inhibition with C8-ceramide and UDP-glucose.Glucosylceramide synthase-IN-2 can be used for Gaucher's disease research[1].