Exact Mass: 443.1704

Exact Mass Matches: 443.1704

Found 68 metabolites which its exact mass value is equals to given mass value 443.1704, within given mass tolerance error 0.01 dalton. Try search metabolite list with more accurate mass tolerance error 0.001 dalton.

Thiothixene

(9Z)-N,N-dimethyl-9-[3-(4-methylpiperazin-1-yl)propylidene]-9H-thioxanthene-2-sulfonamide

C23H29N3O2S2 (443.1701)


Thiothixene is only found in individuals that have used or taken this drug. It is a thioxanthine used as an antipsychotic agent. Its effects are similar to the phenothiazine antipsychotics. [PubChem]Thiothixene acts as an antagonist (blocking agent) on different postsysnaptic receptors -on dopaminergic-receptors (subtypes D1, D2, D3 and D4 - different antipsychotic properties on productive and unproductive symptoms), on serotonergic-receptors (5-HT1 and 5-HT2, with anxiolytic, antidepressive and antiaggressive properties as well as an attenuation of extrapypramidal side-effects, but also leading to weight gain, fall in blood pressure, sedation and ejaculation difficulties), on histaminergic-receptors (H1-receptors, sedation, antiemesis, vertigo, fall in blood pressure and weight gain), alpha1/alpha2-receptors (antisympathomimetic properties, lowering of blood pressure, reflex tachycardia, vertigo, sedation, hypersalivation and incontinence as well as sexual dysfunction, but may also attenuate pseudoparkinsonism - controversial) and finally on muscarinic (cholinergic) M1/M2-receptors (causing anticholinergic symptoms like dry mouth, blurred vision, obstipation, difficulty/inability to urinate, sinus tachycardia, ECG-changes and loss of memory, but the anticholinergic action may attenuate extrapyramidal side-effects). D002492 - Central Nervous System Depressants > D014149 - Tranquilizing Agents > D014150 - Antipsychotic Agents D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D014149 - Tranquilizing Agents N - Nervous system > N05 - Psycholeptics > N05A - Antipsychotics > N05AF - Thioxanthene derivatives D018377 - Neurotransmitter Agents > D015259 - Dopamine Agents > D018492 - Dopamine Antagonists D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants C78272 - Agent Affecting Nervous System > C29710 - Antipsychotic Agent (Z)-Thiothixene is an antagonist of serotonergic receptor extracted from patent US 20150141345 A1.

   

8-AHA-cAMP

6-{6-amino-8-[(6-aminohexyl)amino]purin-9-yl}-2,7-dihydroxy-tetrahydro-4H-2lambda5-furo[3,2-d][1,3,2]dioxaphosphinin-2-one

C16H26N7O6P (443.1682)


   

8-Aminohexylamino cAMP

6-{6-amino-8-[(1-pentylhydrazin-1-yl)methyl]-9H-purin-9-yl}-2,7-dihydroxy-hexahydro-2lambda5-furo[3,2-d][1,3,2]dioxaphosphinin-2-one

C16H26N7O6P (443.1682)


   

Pevonedistat

((1S,2S,4R)-4-(4-((1S)-2,3-Dihydro-1H-inden-1-ylamino)-7H-pyrrolo(2,3-D)pyrimidin-7-yl)-2-hydroxycyclopentyl)methyl sulphamate

C21H25N5O4S (443.1627)


   
   

2-O-(2S-Amino-3R-hydroxybutanoyl)sucrose

2-O-(2S-Amino-3R-hydroxybutanoyl)sucrose

C16H29NO13 (443.1639)


   

oxalatrunculin B

oxalatrunculin B

C20H29NO8S (443.1614)


   

beta-D-fructofuranosyl-(2->1)-alpha-D-[2-O-L-threonyl]glucopyranoside

beta-D-fructofuranosyl-(2->1)-alpha-D-[2-O-L-threonyl]glucopyranoside

C16H29NO13 (443.1639)


   

1-{4-[(N-methyl-glycyl)-amino]-2-oxo-2H-pyrimidin-1-yl}-3-(seryl-amino)-beta-D-1,3-dideoxy-allopyranuronic acid amide|Gougerotin

1-{4-[(N-methyl-glycyl)-amino]-2-oxo-2H-pyrimidin-1-yl}-3-(seryl-amino)-beta-D-1,3-dideoxy-allopyranuronic acid amide|Gougerotin

C16H25N7O8 (443.1765)


   
   
   
   
   
   
   

Thiothixene

(e)-Thiothixene

C23H29N3O2S2 (443.1701)


D002492 - Central Nervous System Depressants > D014149 - Tranquilizing Agents > D014150 - Antipsychotic Agents D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D014149 - Tranquilizing Agents D018377 - Neurotransmitter Agents > D015259 - Dopamine Agents > D018492 - Dopamine Antagonists D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants N - Nervous system > N05 - Psycholeptics > N05A - Antipsychotics > N05AF - Thioxanthene derivatives C78272 - Agent Affecting Nervous System > C29710 - Antipsychotic Agent (Z)-Thiothixene is an antagonist of serotonergic receptor extracted from patent US 20150141345 A1.

   

His Asn Ser Ser

(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-amino-3-(1H-imidazol-4-yl)propanamido]-3-carbamoylpropanamido]-3-hydroxypropanamido]-3-hydroxypropanoic acid

C16H25N7O8 (443.1765)


   

His Ser Asn Ser

(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-amino-3-(1H-imidazol-4-yl)propanamido]-3-hydroxypropanamido]-3-carbamoylpropanamido]-3-hydroxypropanoic acid

C16H25N7O8 (443.1765)


   

His Ser Ser Asn

(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-amino-3-(1H-imidazol-4-yl)propanamido]-3-hydroxypropanamido]-3-hydroxypropanamido]-3-carbamoylpropanoic acid

C16H25N7O8 (443.1765)


   

Asn His Ser Ser

(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-amino-3-carbamoylpropanamido]-3-(1H-imidazol-4-yl)propanamido]-3-hydroxypropanamido]-3-hydroxypropanoic acid

C16H25N7O8 (443.1765)


   

Asn Ser His Ser

(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-amino-3-carbamoylpropanamido]-3-hydroxypropanamido]-3-(1H-imidazol-4-yl)propanamido]-3-hydroxypropanoic acid

C16H25N7O8 (443.1765)


   

Asn Ser Ser His

(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-amino-3-carbamoylpropanamido]-3-hydroxypropanamido]-3-hydroxypropanamido]-3-(1H-imidazol-4-yl)propanoic acid

C16H25N7O8 (443.1765)


   

Ser His Asn Ser

(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-amino-3-hydroxypropanamido]-3-(1H-imidazol-4-yl)propanamido]-3-carbamoylpropanamido]-3-hydroxypropanoic acid

C16H25N7O8 (443.1765)


   

Ser His Ser Asn

(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-amino-3-hydroxypropanamido]-3-(1H-imidazol-4-yl)propanamido]-3-hydroxypropanamido]-3-carbamoylpropanoic acid

C16H25N7O8 (443.1765)


   

Ser Asn His Ser

(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-amino-3-hydroxypropanamido]-3-carbamoylpropanamido]-3-(1H-imidazol-4-yl)propanamido]-3-hydroxypropanoic acid

C16H25N7O8 (443.1765)


   

Ser Asn Ser His

(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-amino-3-hydroxypropanamido]-3-carbamoylpropanamido]-3-hydroxypropanamido]-3-(1H-imidazol-4-yl)propanoic acid

C16H25N7O8 (443.1765)


   

Ser Ser His Asn

(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-amino-3-hydroxypropanamido]-3-hydroxypropanamido]-3-(1H-imidazol-4-yl)propanamido]-3-carbamoylpropanoic acid

C16H25N7O8 (443.1765)


   

Ser Ser Asn His

(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-amino-3-hydroxypropanamido]-3-hydroxypropanamido]-3-carbamoylpropanamido]-3-(1H-imidazol-4-yl)propanoic acid

C16H25N7O8 (443.1765)


   

Fmoc-Hyp(Bzl)-OH

Fmoc-Hyp(Bzl)-OH

C27H25NO5 (443.1733)


   
   

5-Deoxy-5-fluoro-N-[(pentyloxy)carbonyl]cytidine 2,3-diacetate

5-Deoxy-5-fluoro-N-[(pentyloxy)carbonyl]cytidine 2,3-diacetate

C19H26FN3O8 (443.1704)


   

Pevonedistat

Pevonedistat

C21H25N5O4S (443.1627)


C274 - Antineoplastic Agent > C2189 - Signal Transduction Inhibitor > C129824 - Antineoplastic Protein Inhibitor C471 - Enzyme Inhibitor > C129825 - Antineoplastic Enzyme Inhibitor D004791 - Enzyme Inhibitors

   

S 14506

S 14506 hydrochloride

C24H27ClFN3O2 (443.1776)


S-14506 hydrochloride is a potent 5-HT1A agonist, as well as 5-HT2A/2C antagonist. S-14506 hydrochloride displays dopamine antagonist properties by blocking dopamine D2 receptors. S-14506 hydrochloride inhibits the in vivo binding of [3H]raclopride in striatum and olfactory bulbs. S-14506 hydrochloride has the potential for the research of anxiolytic agent[1][2][3].

   

7-Monodemethyl Minocycline

7-Monodemethyl Minocycline

C22H25N3O7 (443.1692)


   
   

1,5-dimethyl-3-[(2-methyl-1H-indol-3-yl)azo]-2-phenyl-1H-pyrazolium methyl sulphate

1,5-dimethyl-3-[(2-methyl-1H-indol-3-yl)azo]-2-phenyl-1H-pyrazolium methyl sulphate

C21H25N5O4S (443.1627)


   

Fmoc-Tyr(All)-OH

Fmoc-Tyr(All)-OH

C27H25NO5 (443.1733)


   
   

[3-Carboxy-2-[3-[(2-hydroxy-3,3-dimethyl-4-phosphonooxybutanoyl)amino]propanoyloxy]propyl]-trimethylazanium

[3-Carboxy-2-[3-[(2-hydroxy-3,3-dimethyl-4-phosphonooxybutanoyl)amino]propanoyloxy]propyl]-trimethylazanium

C16H32N2O10P+ (443.1794)


   

8-(6-aminohexylamino) 3,5-cyclic AMP

8-(6-aminohexylamino) 3,5-cyclic AMP

C16H26N7O6P (443.1682)


   

8-chloro-3-methyl-11-[1-(4-pyridylacetyl)piperidin-4-ylidene]-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine

8-chloro-3-methyl-11-[1-(4-pyridylacetyl)piperidin-4-ylidene]-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine

C27H26ClN3O (443.1764)


   

N-(2,5-dimethylphenyl)-2-[[3-(4-ethylphenoxy)-4-oxo-1-benzopyran-7-yl]oxy]acetamide

N-(2,5-dimethylphenyl)-2-[[3-(4-ethylphenoxy)-4-oxo-1-benzopyran-7-yl]oxy]acetamide

C27H25NO5 (443.1733)


   

N-[2-[5-[(4-tert-butylphenyl)methylthio]-1,3,4-oxadiazol-2-yl]phenyl]benzamide

N-[2-[5-[(4-tert-butylphenyl)methylthio]-1,3,4-oxadiazol-2-yl]phenyl]benzamide

C26H25N3O2S (443.1667)


   

2-Phenyl-N-(18-phenyl-11-oxa-13,15-diazatetracyclo[8.8.0.02,7.012,17]octadeca-1(10),2,4,6,8,12,14,16-octaen-16-yl)acetamide

2-Phenyl-N-(18-phenyl-11-oxa-13,15-diazatetracyclo[8.8.0.02,7.012,17]octadeca-1(10),2,4,6,8,12,14,16-octaen-16-yl)acetamide

C29H21N3O2 (443.1634)


   
   

Phe-Tyr-Asp

Phe-Tyr-Asp

C22H25N3O7 (443.1692)


A tripeptide composed of L-phenylalanine, L-tyrosine and L-aspartic acid joined by peptide linkages.

   
   

(1S,9R,10R,11R)-12-[(3-chlorophenyl)methyl]-10-(hydroxymethyl)-11-(morpholine-4-carbonyl)-7,12-diazatricyclo[7.2.1.02,7]dodeca-2,4-dien-6-one

(1S,9R,10R,11R)-12-[(3-chlorophenyl)methyl]-10-(hydroxymethyl)-11-(morpholine-4-carbonyl)-7,12-diazatricyclo[7.2.1.02,7]dodeca-2,4-dien-6-one

C23H26ClN3O4 (443.1612)


   

(1R,9S,10S,11S)-12-[(3-chlorophenyl)methyl]-10-(hydroxymethyl)-11-(morpholine-4-carbonyl)-7,12-diazatricyclo[7.2.1.02,7]dodeca-2,4-dien-6-one

(1R,9S,10S,11S)-12-[(3-chlorophenyl)methyl]-10-(hydroxymethyl)-11-(morpholine-4-carbonyl)-7,12-diazatricyclo[7.2.1.02,7]dodeca-2,4-dien-6-one

C23H26ClN3O4 (443.1612)


   
   
   
   
   

5-[[4-[4-(3-Hydroxy-2,4,5-trimethyl-6-oxocyclohexa-1,4-dien-1-yl)-2-methylbutoxy]phenyl]methyl]-1,3-thiazolidine-2,4-dione

5-[[4-[4-(3-Hydroxy-2,4,5-trimethyl-6-oxocyclohexa-1,4-dien-1-yl)-2-methylbutoxy]phenyl]methyl]-1,3-thiazolidine-2,4-dione

C24H29NO5S (443.1766)


   

sulfamic acid [4-[4-(2,3-dihydro-1H-inden-1-ylamino)-7-pyrrolo[2,3-d]pyrimidinyl]-2-hydroxycyclopentyl]methyl ester

sulfamic acid [4-[4-(2,3-dihydro-1H-inden-1-ylamino)-7-pyrrolo[2,3-d]pyrimidinyl]-2-hydroxycyclopentyl]methyl ester

C21H25N5O4S (443.1627)


   
   

JNJ-61432059

JNJ-61432059

C25H22FN5O2 (443.1757)


JNJ-61432059 is an oral active and selective negative modulator of AMPAR associated with trans-membrane AMPAR regulatory protein (TARP) γ-8, with a pIC50 of 9.7 for GluA1/γ-8. Exhibits time- and dose-dependent AMPAR/γ-8 receptor occupancy in mouse hippocampus, resulting in robust seizure protection in corneal kindling and pentylenetetrazole (PTZ) anticonvulsant models[1].

   

n-[4-({[2-(2,3-dihydroxyphenyl)-5-methyl-4,5-dihydro-1,3-oxazol-4-yl](hydroxy)methylidene}amino)butyl]-2,3-dihydroxybenzenecarboximidic acid

n-[4-({[2-(2,3-dihydroxyphenyl)-5-methyl-4,5-dihydro-1,3-oxazol-4-yl](hydroxy)methylidene}amino)butyl]-2,3-dihydroxybenzenecarboximidic acid

C22H25N3O7 (443.1692)


   

3-[(1,3-dihydroxy-2-{[1-hydroxy-2-(methylamino)ethylidene]amino}propylidene)amino]-4,5-dihydroxy-6-(2-hydroxy-4-iminopyrimidin-1-yl)oxane-2-carboximidic acid

3-[(1,3-dihydroxy-2-{[1-hydroxy-2-(methylamino)ethylidene]amino}propylidene)amino]-4,5-dihydroxy-6-(2-hydroxy-4-iminopyrimidin-1-yl)oxane-2-carboximidic acid

C16H25N7O8 (443.1765)


   

(2s,3s,4s,5r,6r)-3-{[(2r)-1,3-dihydroxy-2-{[1-hydroxy-2-(methylamino)ethylidene]amino}propylidene]amino}-4,5-dihydroxy-6-(2-hydroxy-4-iminopyrimidin-1-yl)oxane-2-carboximidic acid

(2s,3s,4s,5r,6r)-3-{[(2r)-1,3-dihydroxy-2-{[1-hydroxy-2-(methylamino)ethylidene]amino}propylidene]amino}-4,5-dihydroxy-6-(2-hydroxy-4-iminopyrimidin-1-yl)oxane-2-carboximidic acid

C16H25N7O8 (443.1765)


   

7-hydroxy-3-(7-hydroxy-2,2-dimethylchromen-8-yl)-6-methoxy-5-methyl-2-phenyl-3h-isoindol-1-one

7-hydroxy-3-(7-hydroxy-2,2-dimethylchromen-8-yl)-6-methoxy-5-methyl-2-phenyl-3h-isoindol-1-one

C27H25NO5 (443.1733)


   

(9s,12s,15s)-9-amino-4,10,13-trihydroxy-12-[(1s)-1-hydroxyethyl]-2-oxa-11,14-diazatricyclo[15.2.2.1³,⁷]docosa-1(19),3(22),4,6,10,13,17,20-octaene-15-carboxylic acid

(9s,12s,15s)-9-amino-4,10,13-trihydroxy-12-[(1s)-1-hydroxyethyl]-2-oxa-11,14-diazatricyclo[15.2.2.1³,⁷]docosa-1(19),3(22),4,6,10,13,17,20-octaene-15-carboxylic acid

C22H25N3O7 (443.1692)


   

(2s,3'r,4's,6's,9'r)-3',4',9'-trihydroxy-6-methoxy-6'-(2-methylprop-1-en-1-yl)-1h-1',7'-diazaspiro[indole-2,5'-tricyclo[7.3.0.0³,⁷]dodecane]-2',3,8'-trione

(2s,3'r,4's,6's,9'r)-3',4',9'-trihydroxy-6-methoxy-6'-(2-methylprop-1-en-1-yl)-1h-1',7'-diazaspiro[indole-2,5'-tricyclo[7.3.0.0³,⁷]dodecane]-2',3,8'-trione

C22H25N3O7 (443.1692)


   

(2r,3r,4s,5s,6r)-2-{[(2s,3s,4s,5r)-3,4-dihydroxy-2,5-bis(hydroxymethyl)oxolan-2-yl]oxy}-4,5-dihydroxy-6-(hydroxymethyl)oxan-3-yl (2s,3r)-2-amino-3-hydroxybutanoate

(2r,3r,4s,5s,6r)-2-{[(2s,3s,4s,5r)-3,4-dihydroxy-2,5-bis(hydroxymethyl)oxolan-2-yl]oxy}-4,5-dihydroxy-6-(hydroxymethyl)oxan-3-yl (2s,3r)-2-amino-3-hydroxybutanoate

C16H29NO13 (443.1639)


   

2-{[3,4-dihydroxy-2,5-bis(hydroxymethyl)oxolan-2-yl]oxy}-4,5-dihydroxy-6-(hydroxymethyl)oxan-3-yl 2-amino-3-hydroxybutanoate

2-{[3,4-dihydroxy-2,5-bis(hydroxymethyl)oxolan-2-yl]oxy}-4,5-dihydroxy-6-(hydroxymethyl)oxan-3-yl 2-amino-3-hydroxybutanoate

C16H29NO13 (443.1639)


   

(2r,3s,4s,5s,6s)-2-(1,2-dihydroxyethyl)-6-{[(1r,2s)-1-hydroxy-1-(4-hydroxy-2-imino-1h-pteridin-6-yl)propan-2-yl]oxy}-4-methoxyoxane-3,5-diol

(2r,3s,4s,5s,6s)-2-(1,2-dihydroxyethyl)-6-{[(1r,2s)-1-hydroxy-1-(4-hydroxy-2-imino-1h-pteridin-6-yl)propan-2-yl]oxy}-4-methoxyoxane-3,5-diol

C17H25N5O9 (443.1652)


   

(9s,12s,15s)-9-amino-4,10,13-trihydroxy-12-[(1r)-1-hydroxyethyl]-2-oxa-11,14-diazatricyclo[15.2.2.1³,⁷]docosa-1(19),3(22),4,6,10,13,17,20-octaene-15-carboxylic acid

(9s,12s,15s)-9-amino-4,10,13-trihydroxy-12-[(1r)-1-hydroxyethyl]-2-oxa-11,14-diazatricyclo[15.2.2.1³,⁷]docosa-1(19),3(22),4,6,10,13,17,20-octaene-15-carboxylic acid

C22H25N3O7 (443.1692)


   

2-(1,2-dihydroxyethyl)-6-{[1-hydroxy-1-(4-hydroxy-2-imino-1h-pteridin-6-yl)propan-2-yl]oxy}-4-methoxyoxane-3,5-diol

2-(1,2-dihydroxyethyl)-6-{[1-hydroxy-1-(4-hydroxy-2-imino-1h-pteridin-6-yl)propan-2-yl]oxy}-4-methoxyoxane-3,5-diol

C17H25N5O9 (443.1652)