sulfamic acid [4-[4-(2,3-dihydro-1H-inden-1-ylamino)-7-pyrrolo[2,3-d]pyrimidinyl]-2-hydroxycyclopentyl]methyl ester (BioDeep_00001881702)
代谢物信息卡片
sulfamic acid [4-[4-(2,3-dihydro-1H-inden-1-ylamino)-7-pyrrolo[2,3-d]pyrimidinyl]-2-hydroxycyclopentyl]methyl ester
化学式: C21H25N5O4S (443.16271700000004)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1CC2=CC=CC=C2C1NC3=C4C=CN(C4=NC=N3)C5CC(C(C5)O)COS(=O)(=O)N
InChI: InChI=1S/C21H25N5O4S/c22-31(28,29)30-11-14-9-15(10-19(14)27)26-8-7-17-20(23-12-24-21(17)26)25-18-6-5-13-3-1-2-4-16(13)18/h1-4,7-8,12,14-15,18-19,27H,5-6,9-11H2,(H2,22,28,29)(H,23,24,25)
相关代谢途径
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代谢反应
0 个相关的代谢反应过程信息。
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0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Jayaprakasam Bolleddula, Hao Chen, Lawrence Cohen, Xiaofei Zhou, Sandeepraj Pusalkar, Allison Berger, Farhad Sedarati, Karthik Venkatakrishnan, Swapan K Chowdhury. Metabolism and Disposition of [14C]Pevonedistat, a First-in-Class NEDD8-Activating Enzyme Inhibitor, after Intravenous Infusion to Patients with Advanced Solid Tumors.
Drug metabolism and disposition: the biological fate of chemicals.
2022 Jul; 50(7):989-997. doi:
10.1124/dmd.122.000842. [PMID: 35504658] - Philip Sandoval, Bei-Ching Chuang, Lawrence Cohen, Tomoki Yoneyama, Sandeepraj Pusalkar, Robert W Yucha, Swapan K Chowdhury, Paresh P Chothe. Sinusoidal Uptake Determines the Hepatic Clearance of Pevonedistat (TAK-924) as Explained by Extended Clearance Model.
Drug metabolism and disposition: the biological fate of chemicals.
2022 Jul; 50(7):980-988. doi:
10.1124/dmd.122.000836. [PMID: 35545257] - Sathish K Murali, Robert Little, Søren B Poulsen, Mohammed Z Ferdaus, David H Ellison, James A McCormick, Robert A Fenton. Potassium Effects on NCC Are Attenuated during Inhibition of Cullin E3-Ubiquitin Ligases.
Cells.
2021 12; 11(1):. doi:
10.3390/cells11010095. [PMID: 35011657] - Yousra M El-Far, Mohamed El-Mesery. Pevonedistat attenuates cisplatin-induced nephrotoxicity in mice by downregulating the release of inflammatory mediators.
Journal of biochemical and molecular toxicology.
2021 Nov; 35(11):e22908. doi:
10.1002/jbt.22908. [PMID: 34476871] - Ji Zhang, Jing Cui, Fei Zhao, Longhua Yang, Xueli Xu, Yangyang Shi, Bo Wei. Cardioprotective effect of MLN4924 on ameliorating autophagic flux impairment in myocardial ischemia-reperfusion injury by Sirt1.
Redox biology.
2021 10; 46(?):102114. doi:
10.1016/j.redox.2021.102114. [PMID: 34454165] - Sara Petillo, Cristina Capuano, Rosa Molfetta, Cinzia Fionda, Abdelilah Mekhloufi, Chiara Pighi, Fabrizio Antonangeli, Alessandra Zingoni, Alessandra Soriani, Maria Teresa Petrucci, Ricciarda Galandrini, Rossella Paolini, Angela Santoni, Marco Cippitelli. Immunomodulatory effect of NEDD8-activating enzyme inhibition in Multiple Myeloma: upregulation of NKG2D ligands and sensitization to Natural Killer cell recognition.
Cell death & disease.
2021 09; 12(9):836. doi:
10.1038/s41419-021-04104-w. [PMID: 34482362] - Xiaofei Zhou, Farhad Sedarati, Douglas V Faller, Dan Zhao, Hélène M Faessel, Swapan Chowdhury, Jayaprakasam Bolleddula, Yuexian Li, Karthik Venkatakrishnan, Zsuzsanna Papai. Phase I study assessing the mass balance, pharmacokinetics, and excretion of [14C]-pevonedistat, a NEDD8-activating enzyme inhibitor in patients with advanced solid tumors.
Investigational new drugs.
2021 04; 39(2):488-498. doi:
10.1007/s10637-020-01017-x. [PMID: 33089874] - Hongmei Mao, Zaiming Tang, Hua Li, Bo Sun, Mingjia Tan, Shaohua Fan, Yuan Zhu, Yi Sun. Neddylation inhibitor MLN4924 suppresses cilia formation by modulating AKT1.
Protein & cell.
2019 10; 10(10):726-744. doi:
10.1007/s13238-019-0614-3. [PMID: 30850948] - Bo Xu, Yuyou Deng, Ran Bi, Haoran Guo, Chang Shu, Neelam Kumari Shah, Junliang Chang, Guanchen Liu, Yujun Du, Wei Wei, Chunxi Wang. A first-in-class inhibitor, MLN4924 (pevonedistat), induces cell-cycle arrest, senescence, and apoptosis in human renal cell carcinoma by suppressing UBE2M-dependent neddylation modification.
Cancer chemotherapy and pharmacology.
2018 06; 81(6):1083-1093. doi:
10.1007/s00280-018-3582-z. [PMID: 29667067] - Jiyou Wang, Shiwen Wang, Wenjuan Zhang, Xiaofang Wang, Xiaojun Liu, Liang Liu, Lihui Li, Yupei Liang, Jinha Yu, Lak Shin Jeong, Lijun Jia, Hu Zhao, Yanmei Zhang. Targeting neddylation pathway with MLN4924 (Pevonedistat) induces NOXA-dependent apoptosis in renal cell carcinoma.
Biochemical and biophysical research communications.
2017 09; 490(4):1183-1188. doi:
10.1016/j.bbrc.2017.06.179. [PMID: 28669728] - Shuai Tong, Yang Si, Hefen Yu, Lingqiang Zhang, Ping Xie, Wenguo Jiang. MLN4924 (Pevonedistat), a protein neddylation inhibitor, suppresses proliferation and migration of human clear cell renal cell carcinoma.
Scientific reports.
2017 07; 7(1):5599. doi:
10.1038/s41598-017-06098-y. [PMID: 28717191] - Jatin J Shah, Andrzej J Jakubowiak, Owen A O'Connor, Robert Z Orlowski, R Donald Harvey, Mitchell R Smith, Daniel Lebovic, Catherine Diefenbach, Kevin Kelly, Zhaowei Hua, Allison J Berger, George Mulligan, Hélène M Faessel, Stephen Tirrell, Bruce J Dezube, Sagar Lonial. Phase I Study of the Novel Investigational NEDD8-Activating Enzyme Inhibitor Pevonedistat (MLN4924) in Patients with Relapsed/Refractory Multiple Myeloma or Lymphoma.
Clinical cancer research : an official journal of the American Association for Cancer Research.
2016 Jan; 22(1):34-43. doi:
10.1158/1078-0432.ccr-15-1237. [PMID: 26561559] - Junwei Huang, Yi Zhou, Gregory S Thomas, Zhimin Gu, Ye Yang, Hongwei Xu, Guido Tricot, Fenghuang Zhan. NEDD8 Inhibition Overcomes CKS1B-Induced Drug Resistance by Upregulation of p21 in Multiple Myeloma.
Clinical cancer research : an official journal of the American Association for Cancer Research.
2015 Dec; 21(24):5532-42. doi:
10.1158/1078-0432.ccr-15-0254. [PMID: 26156395] - Ronan T Swords, Harry P Erba, Daniel J DeAngelo, Dale L Bixby, Jessica K Altman, Michael Maris, Zhaowei Hua, Stephen J Blakemore, Hélène Faessel, Farhad Sedarati, Bruce J Dezube, Francis J Giles, Bruno C Medeiros. Pevonedistat (MLN4924), a First-in-Class NEDD8-activating enzyme inhibitor, in patients with acute myeloid leukaemia and myelodysplastic syndromes: a phase 1 study.
British journal of haematology.
2015 May; 169(4):534-43. doi:
10.1111/bjh.13323. [PMID: 25733005] - Yanyan Gu, Jonathan L Kaufman, Leon Bernal, Claire Torre, Shannon M Matulis, R Donald Harvey, Jing Chen, Shi-Yong Sun, Lawrence H Boise, Sagar Lonial. MLN4924, an NAE inhibitor, suppresses AKT and mTOR signaling via upregulation of REDD1 in human myeloma cells.
Blood.
2014 May; 123(21):3269-76. doi:
10.1182/blood-2013-08-521914. [PMID: 24713927]