Exact Mass: 436.2274

Exact Mass Matches: 436.2274

Found 500 metabolites which its exact mass value is equals to given mass value 436.2274, within given mass tolerance error 0.05 dalton. Try search metabolite list with more accurate mass tolerance error 0.01 dalton.

Polhovolide

C23H32O8 (436.2097)

MLS002638824

11beta,16alpha,17alpha,21-Tetrahydroxy-9alpha-fluoropregn-4-ene-3,20-dione 16,17-acetonide

C24H33FO6 (436.2261)

9-Fluoro-2alpha-methylcortisol 21-acetate

9-Fluoro-11beta,17,21-trihydroxy-2alpha-methylpregn-4-ene-3,20-dione 21-acetate; 9-Fluoro-2alpha-methylcortisol 21-acetate

C24H33FO6 (436.2261)

HC Toxin

(6R,9S,14aR)-3,6R-dimethyl-9S-(7-((S)-oxiran-2-yl)-7-oxoheptyl)decahydropyrrolo[1,2-a][1,4,7,10]tetraazacyclododecine-1,4,7,10-tetranone

C21H32N4O6 (436.2322)

A homodetic cyclic tetrapeptide made up from L-alanyl, D-alanyl, L-prolyl and 2-amino-8-oxo-9,10-epoxydecanoyl residues.

Flurandrenolide

(1S,2S,4R,8S,9S,11S,12S,13R,19S)-19-fluoro-11-hydroxy-8-(2-hydroxyacetyl)-6,6,9,13-tetramethyl-5,7-dioxapentacyclo[10.8.0.0²,⁹.0⁴,⁸.0¹³,¹⁸]icos-17-en-16-one

C24H33FO6 (436.2261)

Flurandrenolide is only found in individuals that have used or taken this drug. It is a corticosteroid used topically in the treatment of various skin disorders. It is usually employed as a cream or an ointment, and is also used as a polyethylene tape with an adhesive. (From Martindale, The Extra Pharmacopoeia, 30th ed, p733)Flurandrenolide is a topical corticosteroid. It is normally applied to a plastic tape called Cordran. Cordran is primarily effective because of its anti-inflammatory, antipruritic, and vasoconstrictive actions. Flurandrenolide, which is slowly released from the Cordran tape, binds to the cytosolic glucocorticoid receptor. After binding the receptor the newly formed receptor-ligand complex translocates itself into the cell nucleus, where it binds to many glucocorticoid response elements (GRE) in the promoter region of the target genes. The DNA bound receptor then interacts with basic transcription factors, causing the increase in expression of specific target genes. The anti-inflammatory actions of corticosteroids are thought to involve lipocortins, phospholipase A2 inhibitory proteins which, through inhibition arachidonic acid, control the biosynthesis of prostaglandins and leukotrienes. Specifically glucocorticoids induce lipocortin-1 (annexin-1) synthesis, which then binds to cell membranes preventing the phospholipase A2 from coming into contact with its substrate arachidonic acid. This leads to diminished eicosanoid production. Cyclooxygenase (both COX-1 and COX-2) expression is also suppressed, potentiating the effect. In another words, the two main products in inflammation Prostaglandins and Leukotrienes are inhibited by the action of Glucocorticoids. Glucocorticoids also stimulate the lipocortin-1 escaping to the extracellular space, where it binds to the leukocyte membrane receptors and inhibits various inflammatory events: epithelial adhesion, emigration, chemotaxis, phagocytosis, respiratory burst and the release of various inflammatory mediators (lysosomal enzymes, cytokines, tissue plasminogen activator, chemokines etc.) from neutrophils, macrophages and mastocytes. Additionally the immune system is suppressed by corticosteroids due to a decrease in the function of the lymphatic system, a reduction in immunoglobulin and complement concentrations, the precipitation of lymphocytopenia, and interference with antigen-antibody binding. Like other glucocorticoid agents Fluocinolone acetonide acts as a physiological antagonist to insulin by decreasing glycogenesis (formation of glycogen). It also promotes the breakdown of lipids (lipolysis), and proteins, leading to the mobilization of extrahepatic amino acids and ketone bodies. This leads to increased circulating glucose concentrations (in the blood). There is also decreased glycogen formation in the liver. D - Dermatologicals > D07 - Corticosteroids, dermatological preparations > D07A - Corticosteroids, plain > D07AC - Corticosteroids, potent (group iii) D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones > D005938 - Glucocorticoids C147908 - Hormone Therapy Agent > C548 - Therapeutic Hormone > C1636 - Therapeutic Steroid Hormone C308 - Immunotherapeutic Agent > C574 - Immunosuppressant > C211 - Therapeutic Corticosteroid D000893 - Anti-Inflammatory Agents

Kanzonol I

8-[5,7-dimethoxy-6-(3-methylbut-2-en-1-yl)-3,4-dihydro-2H-1-benzopyran-3-yl]-2,2-dimethyl-2H-chromen-5-ol

C27H32O5 (436.225)

Kanzonol I is found in herbs and spices. Kanzonol I is a constituent of Glycyrrhiza uralensis (Chinese licorice). Constituent of Glycyrrhiza uralensis (Chinese licorice). Kanzonol I is found in herbs and spices.

Depropionylbezitramide

4-[4-(2-oxo-2,3-dihydro-1H-1,3-benzodiazol-1-yl)piperidin-1-yl]-2,2-diphenylbutanenitrile

C28H28N4O (436.2263)

DN-isobutylamide

N-[1-(2-carbamoylpyrrolidin-1-yl)-3-(3H-imidazol-4-yl)-1-oxopropan-2-yl]-2-hydroxy-N-(2-methylpropyl)pentanediamide

C20H32N6O5 (436.2434)

D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones

APD 791

3-Methoxy-N-[3-(1-methyl-1H-pyrazol-5-yl)-4-[2-(morpholin-4-yl)ethoxy]phenyl]benzene-1-carboximidate

C24H28N4O4 (436.211)

Lespedezaflavanone F

Neocaesalpin Q

C27H32O5 (436.225)

15beta-Methoxyfaciculatin

(6aR,11aR)-3,9-dihydroxy-2,10-di(3,3-dimethylally)-8-methyl-1-methoxypterocarpan|bicolosin A

C27H32O5 (436.225)

athrolide A

C23H32O8 (436.2097)

A natural product found in Athroisma proteiforme.

klymollin D

C24H36O7 (436.2461)

(2S)-2-{[(2S)-1-[(2S)-2-[(2S)-2-amino-4-methylpentanamido]-3-(1H-imidazol-4-yl)propanoyl]pyrrolidin-2-yl]formamido}propanoic acid

C20H32N6O5 (436.2434)

Tyr Val Arg

C20H32N6O5 (436.2434)

C27H32O5 (436.225)

4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1-trityl-1H-pyrazole

C28H29BN2O2 (436.2322)

Isoaminilecitrate

Isoaminile citrate

C16H24N2.C6H8O7 (436.2209)

D019141 - Respiratory System Agents > D000996 - Antitussive Agents D002491 - Central Nervous System Agents

1H-Pyrazole-1-propanenitrile, β-cyclopentyl-4-[7-[[2-(triMethylsilyl)ethoxy]Methyl]-7H-pyrrolo[2,3-d]pyriMidin-4-yl]-, (βR)-

C23H32N6OSi (436.2407)

Propargyl-PEG8-acid

C20H36O10 (436.2308)

(S)-N-Fmoc-2-(6-azido)alanine

C24H28N4O4 (436.211)

Tris(4-methoxy-3,5-dimethylphenyl)phosphine

C27H33O3P (436.2167)

4-[4-[5-[(Acetylamino)methyl]-2-oxo-3-oxazolidinyl]-2-fluorophenyl]-1-piperazinecarboxylic acid tert-butyl ester

C21H29FN4O5 (436.2122)

TEMANOGREL

C24H28N4O4 (436.211)

D018377 - Neurotransmitter Agents > D018490 - Serotonin Agents > D012702 - Serotonin Antagonists C78272 - Agent Affecting Nervous System > C66885 - Serotonin Antagonist Temanogrel is a highly selective 5-HT2A receptor antagonist with a Ki of 4.9 nM.

4-(2,3-Dihydro-2-oxo-1H-benzimidazol-1-yl)-alpha,alpha-diphenylpiperidine-1-butyronitrile

C28H28N4O (436.2263)

9-Fluoro-17-hydroxy-2alpha-methylcorticosterone 21-acetate

C24H33FO6 (436.2261)

Arg-Val-Tyr

C20H32N6O5 (436.2434)

Brevione F

C27H32O5 (436.225)

9-Fluoro-16a,17-(isopropylidenedioxy)corticosterone

11beta,16alpha,17alpha,21-Tetrahydroxy-9alpha-fluoropregn-4-ene-3,20-dione 16,17-acetonide

C24H33FO6 (436.2261)

isoadenolin H

A natural product found in Dodonaea polyandra.

15,16-Epoxy-2alpha-benzoyloxycleroda-3,13(16),14-trien-18-oic acid, (rel)-

{"Ingredient_id": "HBIN000739","Ingredient_name": "12-benzoyloxycrotohalimaneicacid","Alias": "NA","Ingredient_formula": "C27H32O5","Ingredient_Smile": "Not Available","Ingredient_weight": "NA","OB_score": "NA","CAS_id": "NA","SymMap_id": "NA","TCMID_id": "2251","TCMSP_id": "NA","TCM_ID_id": "NA","PubChem_id": "NA","DrugBank_id": "NA"}

15α-methoxyfaciculatin b

C23H32O8 (436.2097)

{"Ingredient_id": "HBIN001621","Ingredient_name": "15\u03b1-methoxyfaciculatin b","Alias": "NA","Ingredient_formula": "C23H32O8","Ingredient_Smile": "CC(=O)OC1CC2(CO2)C3(CCC4(O3)CC(OC4)OC)C56C1C(CCC5)(C(=O)OC6)C","Ingredient_weight": "NA","OB_score": "NA","CAS_id": "NA","SymMap_id": "NA","TCMID_id": "13920","TCMSP_id": "NA","TCM_ID_id": "NA","PubChem_id": "NA","DrugBank_id": "NA"}

3-O-Benzoyl-20-deoxyingenol

C27H32O5 (436.225)

{"Ingredient_id": "HBIN009125","Ingredient_name": "3-O-Benzoyl-20-deoxyingenol","Alias": "NA","Ingredient_formula": "C27H32O5","Ingredient_Smile": "CC1CC2C(C2(C)C)C3C=C(C(C4(C1(C3=O)C=C(C4OC(=O)C5=CC=CC=C5)C)O)O)C","Ingredient_weight": "436.5 g/mol","OB_score": "12.27269666","CAS_id": "NA","SymMap_id": "SMIT04796","TCMID_id": "NA","TCMSP_id": "MOL002583","TCM_ID_id": "NA","PubChem_id": "121231388","DrugBank_id": "NA"}

5-O-Benzoyl-20-deoxyingenol