Exact Mass: 435.2409
Exact Mass Matches: 435.2409
Found 24 metabolites which its exact mass value is equals to given mass value 435.2409,
within given mass tolerance error 0.0002 dalton. Try search metabolite list with more accurate mass tolerance error
4.0E-5 dalton.
Paxilline
Paxilline is an indole diterpene alkaloid with formula C27H33NO4 isolated from Penicillium paxilli. It is a potent inhibitor of large conductance Ca2(+)- and voltage-activated K(+) (BK)-type channels. It has a role as a mycotoxin, a Penicillium metabolite, an anticonvulsant, an Aspergillus metabolite, a potassium channel blocker, a genotoxin, a geroprotector and an EC 3.6.3.8 (Ca(2+)-transporting ATPase) inhibitor. It is an organic heterohexacyclic compound, a tertiary alcohol, a terpenoid indole alkaloid, an enone and a diterpene alkaloid. Paxilline is a natural product found in Penicillium thiersii, Aspergillus foveolatus, and other organisms with data available. Tremorgenic agent from Penicillium paxilli, Acremonium lorii, Emericella foveolata, Emericella desertorum and Emericella striata Paxilline is a potassium channel blocker. Paxilline is a toxic, tremorgenic indole alkaloid produced by Penicillium paxilli An indole diterpene alkaloid with formula C27H33NO4 isolated from Penicillium paxilli. It is a potent inhibitor of large conductance Ca2(+)- and voltage-activated K(+) (BK)-type channels. Tremorgenic agent from Penicillium paxilli, Acremonium lorii, Emericella foveolata, Emericella desertorum and Emericella striata D002317 - Cardiovascular Agents > D026902 - Potassium Channel Blockers D049990 - Membrane Transport Modulators Paxilline is an indole alkaloid mycotoxin from Penicillium paxilli, acts as a potent BK channels inhibitor by an almost exclusively closed-channel block mechanism. Paxilline also inhibits the sarco/endoplasmic reticulum Ca2+ ATPase (SERCA) with IC50s between 5 μM and 50 μM for differing isoforms. Paxilline possesses significant anticonvulsant activity[1][2][3].
14alpha-Hydroxy-4beta-deoxypaxilline
14alpha-Hydroxy-4beta-deoxypaxilline is a metabolite of Penicillium paxilli and Acremonium lolii. Metabolite of Penicillium paxilli and Acremonium lolii
Paxilline
Paxilline is an indole alkaloid mycotoxin from Penicillium paxilli, acts as a potent BK channels inhibitor by an almost exclusively closed-channel block mechanism. Paxilline also inhibits the sarco/endoplasmic reticulum Ca2+ ATPase (SERCA) with IC50s between 5 μM and 50 μM for differing isoforms. Paxilline possesses significant anticonvulsant activity[1][2][3].
7-Hydroxy-13-deoxypaxilline
(3E,5S)-3-[(2E,4E,8S,10E,12Z)-1-hydroxy-4,8-dimethyltetradeca-2,4,10,12-tetraenylidene]-5-[(4-hydroxyphenyl)methyl]pyrrolidine-2,4-dione
n-[2-(4-{[(2e)-4-(acetyloxy)-3,7-dimethylocta-2,6-dien-1-yl]oxy}phenyl)ethyl]benzenecarboximidic acid
ancistrobertsoine B
{"Ingredient_id": "HBIN015983","Ingredient_name": "ancistrobertsoine B","Alias": "NA","Ingredient_formula": "C27H33NO4","Ingredient_Smile": "CC1CC2=C(C(=CC(=C2C(N1C)C)OC)OC)C3=C4C=CC=C(C4=C(C=C3C)OC)OC","Ingredient_weight": "NA","OB_score": "NA","CAS_id": "NA","SymMap_id": "NA","TCMID_id": "35975","TCMSP_id": "NA","TCM_ID_id": "NA","PubChem_id": "NA","DrugBank_id": "NA"}
ancistrobertsonine C
{"Ingredient_id": "HBIN015985","Ingredient_name": "ancistrobertsonine C","Alias": "NA","Ingredient_formula": "C27H33NO4","Ingredient_Smile": "CC1CC2=C(C(=CC(=C2C(N1C)C)OC)OC)C3=C4C=C(C=C(C4=C(C=C3)OC)OC)C","Ingredient_weight": "435.6 g/mol","OB_score": "NA","CAS_id": "NA","SymMap_id": "NA","TCMID_id": "32450","TCMSP_id": "NA","TCM_ID_id": "NA","PubChem_id": "10410728","DrugBank_id": "NA"}
ancistrobrevin
{"Ingredient_id": "HBIN015987","Ingredient_name": "ancistrobrevin","Alias": "NA","Ingredient_formula": "C27H33NO4","Ingredient_Smile": "CC1CC2=CC(=C(C(=C2C(N1C)C)OC)C3=C4C=C(C=C(C4=C(C=C3)OC)OC)C)OC","Ingredient_weight": "NA","OB_score": "NA","CAS_id": "NA","SymMap_id": "NA","TCMID_id": "33058","TCMSP_id": "NA","TCM_ID_id": "NA","PubChem_id": "NA","DrugBank_id": "NA"}
