Exact Mass: 430.2288

Exact Mass Matches: 430.2288

Found 459 metabolites which its exact mass value is equals to given mass value 430.2288, within given mass tolerance error 0.01 dalton. Try search metabolite list with more accurate mass tolerance error 0.001 dalton.

11-hydroxy-8-(2-hydroxyacetyl)-9,13-dimethyl-6-propyl-5,7-dioxapentacyclo[10.8.0.0^{2,9}.0^{4,8}.0^{13,18}]icosa-14,17-dien-16-one

C25H34O6 (430.2355)

Ingenol mebutate

5,6-dihydroxy-7-(hydroxymethyl)-3,11,11,14-tetramethyl-15-oxotetracyclo[7.5.1.0¹,⁵.0¹⁰,¹²]pentadeca-2,7-dien-4-yl 2-methylbut-2-enoate

C25H34O6 (430.2355)

Ingenol_mebutate

2-Butenoic acid, 2-methyl-, (1aR,2S,5R,5aS,6S,8aS,9R,10aR)-1a,2,5,5a,6,9,10,10a-octahydro-5,5a-dihydroxy-4-(hydroxymethyl)-1,1,7,9-tetramethyl-11-oxo-1H-2,8a-methanocyclopenta(a)cyclopropa(e)cyclodecen-6-yl ester, (2Z)-

C25H34O6 (430.2355)

Ingenol mebutate is a tetracyclic diterpenoid ester obtained by formal condensation of the carboxy group of (2Z)-2-methylbut-2-enoic (angelic) acid with the 3-hydroxy group of ingenol. Used for the topical treatment of actinic keratosis. It has a role as an antineoplastic agent. It is a tetracyclic diterpenoid, a carboxylic ester and a cyclic terpene ketone. It is functionally related to an angelic acid and an ingenol. Ingenol mebutate was approved by the FDA in January 2012, and it is marketed under the name Picato®. Picato gel is indicated for the topical treatment of actinic keratosis. Before approval, ingenol mebutate was called PEP005 as an investigational drug. PEP005 is a selective small molecule activator of protein kinase C (PKC) extracted from the plant Euphorbia peplus, whose sap has been used as a traditional medicine for the treatment of skin conditions including warts and cancer. PEP005 also has potent anti-leukemic effects, inducing apoptosis in myeloid leukemia cell lines and primary AML cells at nanomolar concentrations. Ingenol mebutate is a Cell Death Inducer. The physiologic effect of ingenol mebutate is by means of Increased Cellular Death. Ingenol mebutate is a natural product found in Euphorbia peplus with data available. Ingenol Mebutate is a selective small-molecule activator of protein kinase C (PKC) isolated from the plant Euphorbia peplus with potential antineoplastic activity. Ingenol mebutate activates various protein kinase C (PKC) isoforms, thereby inducing apoptosis in some tumor cells, including myeloid leukemia cells, melanoma cells, and basal cell carcinoma cells. The PKC family consists of signaling isoenzymes that regulate many cell processes including proliferation, differentiation, and apoptosis. D - Dermatologicals > D06 - Antibiotics and chemotherapeutics for dermatological use > D06B - Chemotherapeutics for topical use C274 - Antineoplastic Agent > C129839 - Apoptotic Pathway-targeting Antineoplastic Agent Ingenol Mebutate is an active ingredient in Euphorbia peplus, acts as a potent PKC modulator, with Kis of 0.3, 0.105, 0.162, 0.376, and 0.171 nM for PKC-α, PKC-β, PKC-γ, PKC-δ, and PKC-ε, respectively, and has antiinflammatory and antitumor activity.

Sonchuside I

[3S-(3alpha,3aalpha,5abeta,6beta,9alpha,9aalpha,9bbeta)]-9-[(beta-D-Glucopyranosyloxy)methyl]decahydro-6-hydroxy-3,5a-dimethylnaphtho[1,2-b]furan-2(3H)-one

integric acid

51333-22-3

C25H34O6 (430.2355)

MLS001077323-01!51333-22-3

C25H34O6 (430.2355)

C21H34O9_2(1H)-Azulenone, 6-(beta-D-glucopyranosyloxy)-4,5,6,7,8,8a-hexahydro-5-hydroxy-5-(1-hydroxy-1-methylethyl)-3,8-dimethyl

NCGC00384740-01_C21H34O9_2(1H)-Azulenone, 6-(beta-D-glucopyranosyloxy)-4,5,6,7,8,8a-hexahydro-5-hydroxy-5-(1-hydroxy-1-methylethyl)-3,8-dimethyl-

C21H34O9 (430.2203)

C25H34O6_(1S,3R,3aS,4S,8aR)-1-Acetoxy-3-hydroxy-3-isopropyl-6,8a-dimethyl-1,2,3,3a,4,5,8,8a-octahydro-4-azulenyl 4-methoxybenzoate

NCGC00385575-01_C25H34O6_(1S,3R,3aS,4S,8aR)-1-Acetoxy-3-hydroxy-3-isopropyl-6,8a-dimethyl-1,2,3,3a,4,5,8,8a-octahydro-4-azulenyl 4-methoxybenzoate

C25H34O6 (430.2355)

(2S)-2-{[(2S)-1-[(2S)-2-[(2S)-2-amino-4-(methylsulfanyl)butanamido]propanoyl]pyrrolidin-2-yl]formamido}-4-methylpentanoic acid

C19H34N4O5S (430.225)

Met Ile Ala Pro

(2S)-1-[(2S)-2-[(2S,3S)-2-[(2S)-2-amino-4-(methylsulfanyl)butanamido]-3-methylpentanamido]propanoyl]pyrrolidine-2-carboxylic acid

C19H34N4O5S (430.225)

Met Ile Pro Ala

(2S)-2-{[(2S)-1-[(2S,3S)-2-[(2S)-2-amino-4-(methylsulfanyl)butanamido]-3-methylpentanoyl]pyrrolidin-2-yl]formamido}propanoic acid

C19H34N4O5S (430.225)

C21H30N6O4 (430.2328)

Arg Ala Ala Asn

(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-amino-5-carbamimidamidopentanamido]propanamido]propanamido]-3-carbamoylpropanoic acid

C16H30N8O6 (430.2288)

Arg Ala Gly Gln

(2S)-2-{2-[(2S)-2-[(2S)-2-amino-5-carbamimidamidopentanamido]propanamido]acetamido}-4-carbamoylbutanoic acid

C16H30N8O6 (430.2288)

Arg Ala Asn Ala

(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-amino-5-carbamimidamidopentanamido]propanamido]-3-carbamoylpropanamido]propanoic acid

C16H30N8O6 (430.2288)

Arg Ala Gln Gly

2-[(2S)-2-[(2S)-2-[(2S)-2-amino-5-carbamimidamidopentanamido]propanamido]-4-carbamoylbutanamido]acetic acid

C16H30N8O6 (430.2288)

C25H34O6 (430.2355)

Ingenol Mebutate

(1aR,2S,5R,5aS,6S,8aS,9R,10aR)-5,5a-dihydroxy-4-(hydroxymethyl)-1,1,7,9-tetramethyl-11-oxo-1a,2,5,5a,6,9,10,10a-octahydro-1H-2,8a-methanocyclopenta[a]cyclopropa[E][10]annulen-6-yl (2Z)-2-methylbut-2-enoate

C25H34O6 (430.2355)

D - Dermatologicals > D06 - Antibiotics and chemotherapeutics for dermatological use > D06B - Chemotherapeutics for topical use C274 - Antineoplastic Agent > C129839 - Apoptotic Pathway-targeting Antineoplastic Agent Ingenol Mebutate is an active ingredient in Euphorbia peplus, acts as a potent PKC modulator, with Kis of 0.3, 0.105, 0.162, 0.376, and 0.171 nM for PKC-α, PKC-β, PKC-γ, PKC-δ, and PKC-ε, respectively, and has antiinflammatory and antitumor activity.

Antibiotic 1142

C18H26N10O3 (430.2189)

(+/-)-4-O-benzyl-1,2:5,6-di-O-cyclohexylidene-myo-inositol

C25H34O6 (430.2355)

3-O-BENZYL-1,2,5,6-DI-O-CYCLOHEXYLIDENE-α-D-GLUCOFURANOSE

C25H34O6 (430.2355)

11-deoxycorticosterone-21-hemisuccinate

21-Hydroxypregn-4-ene-3,20-dione 21-(hydrogen succinate)

Progesterone 6-hemisuccinate

C25H34O6 (430.2355)

5-[10-(5-Methoxy-1,5-dioxopentyl)-1,7-dioxa-4,10-diazacyclododec-4-yl]-5-oxopentanoic acid methyl ester

C20H34N2O8 (430.2315)

Stachybotrysin B

C25H34O6 (430.2355)

[5,6-dihydroxy-7-(hydroxymethyl)-3,11,11,14-tetramethyl-15-oxo-4-tetracyclo[7.5.1.01,5.010,12]pentadeca-2,7-dienyl] (E)-2-methylbut-2-enoate

Antibiotic CJ 15544

C25H34O6 (430.2355)

11-Deoxycorticosterone hydrogen succinate

21-Hydroxypregn-4-ene-3,20-dione 21-(hydrogen succinate)

C25H34O6 (430.2355)

asnovolin I

C25H34O6 (430.2355)

A meroterpenoid with formula C25H34O6 isolated from the fungus Aspergillus novofumigatus. It is an intermediate produced in the biosynthetic pathway leading to the synthesis of novofumigatonin.

MGMG 12:3

C21H34O9 (430.2203)

ST 19:4;O;Hex

C25H34O6 (430.2355)

ST 25:5;O6

C25H34O6 (430.2355)

Opiranserin (hydrochloride)

(1e)-2-[(1s,3s,4r,5r,8s)-8-(2-methoxypropan-2-yl)-5,5'-dimethyl-2,2'-dioxospiro[bicyclo[3.3.1]nonane-3,3'-furan]-4-yl]ethenyl 3-methylbut-2-enoate

C25H34O6 (430.2355)

2-[(1s,2r,3r,6r)-2-[(3r,4r)-3-hydroxy-4-methyl-5-oxohept-1-en-2-yl]-1,3,5-trimethyl-7-oxabicyclo[4.1.0]hept-4-en-3-yl]-6-methoxy-3,5-dimethylpyran-4-one

C25H34O6 (430.2355)

(2s)-2-[(1r,3ar,4s,5ar,9as,11ar)-4-hydroxy-3a,6,6,9a,11a-pentamethyl-3,7,10-trioxo-1h,2h,4h,5h,5ah,8h,9h,11h-cyclopenta[a]phenanthren-1-yl]propanoic acid

C25H34O6 (430.2355)

(5r,5as,9as,9bs)-9b-hydroxy-6,6,9a-trimethyl-1-oxo-3h,5h,5ah,7h,8h,9h-naphtho[1,2-c]furan-5-yl (2e,4e,6e)-9-hydroxydeca-2,4,6-trienoate

C25H34O6 (430.2355)

2,4,6-trihydroxy-3,5-bis[(3-methylbutanoyl)oxy]cyclohexyl 3-methylbut-2-enoate

C21H34O9 (430.2203)