Exact Mass: 358.9763
Exact Mass Matches: 358.9763
Found 35 metabolites which its exact mass value is equals to given mass value 358.9763,
within given mass tolerance error 0.05 dalton. Try search metabolite list with more accurate mass tolerance error
0.01 dalton.
Methyclothiazide
Methyclothiazide is only found in individuals that have used or taken this drug. It is a thiazide diuretic with properties similar to those of hydrochlorothiazide. (From Martindale, The Extra Pharmacopoeia, 30th ed, p825)Methyclothiazide appears to block the active reabsorption of chloride and possibly sodium in the ascending loop of Henle, altering electrolyte transfer in the proximal tubule. This results in excretion of sodium, chloride, and water and, hence, diuresis. As a diuretic, methyclothiazide inhibits active chloride reabsorption at the early distal tubule via the Na-Cl cotransporter, resulting in an increase in the excretion of sodium, chloride, and water. Thiazides like methyclothiazide also inhibit sodium ion transport across the renal tubular epithelium through binding to the thiazide sensitive sodium-chloride transporter. This results in an increase in potassium excretion via the sodium-potassium exchange mechanism. The antihypertensive mechanism of methyclothiazide is less well understood although it may be mediated through its action on carbonic anhydrases in the smooth muscle or through its action on the large-conductance calcium-activated potassium (KCa) channel, also found in the smooth muscle. C - Cardiovascular system > C03 - Diuretics > C03A - Low-ceiling diuretics, thiazides > C03AA - Thiazides, plain D045283 - Natriuretic Agents > D004232 - Diuretics > D049993 - Sodium Chloride Symporter Inhibitors C78275 - Agent Affecting Blood or Body Fluid > C448 - Diuretic > C49185 - Thiazide Diuretic D002317 - Cardiovascular Agents > D045283 - Natriuretic Agents D049990 - Membrane Transport Modulators
p-Chloromercuribenzoate; p-Chloromercuribenzoic acid; PCMB
methyclothiazide
C - Cardiovascular system > C03 - Diuretics > C03A - Low-ceiling diuretics, thiazides > C03AA - Thiazides, plain D045283 - Natriuretic Agents > D004232 - Diuretics > D049993 - Sodium Chloride Symporter Inhibitors C78275 - Agent Affecting Blood or Body Fluid > C448 - Diuretic > C49185 - Thiazide Diuretic D002317 - Cardiovascular Agents > D045283 - Natriuretic Agents D049990 - Membrane Transport Modulators
2-(4-Iodophenyl)-6-methyl-1,3,6,2-dioxazaborocane-4,8-dione
2-(4-bromophenyl)-6-fluoro-3-methylquinoline-4-carboxylic acid
tert-Butyl 3-iodo-1H-pyrrolo[2,3-b]pyridin-5-ylcarbamate
2-(3-iodophenyl)-6-methyl-1,3,6,2-dioxazaborocane-4,8-dione
7-AMINO-1,3-NAPHTHALENEDISULFONIC ACID, MONOPOTASSIUM SALT, HYDRATE
2-BROMO-1-(5-FLUORO-6-METHYLPYRIDIN-2-YL)-2-(QUINOXALIN-6-YL)ETHANONE
3-Bromo-8-(phenylsulfonyl)-1-oxa-8-azaspiro[4.5]decane
methyl (2Z,4Z)-2-(bromomethyl)-5-chloro-5-(4-nitrophenyl)penta-2,4-dienoate
8-Amino-1-naphthol-3,6-disulfonic acid monosodium salt monohydrate
2-(3-bromophenyl)-6-methyl-1,3,6,2-dioxazaborocane-4,8-dione
3-Bromo-N,N-diethyl-5-(trifluoromethyl)benzenesulfonamide
3-Bromo-N-butyl-5-(trifluoromethyl)benzenesulfonamide
4-Bromo-N-butyl-3-(trifluoromethyl)benzenesulfonamide
4-Bromo-N-(tert-butyl)-3-(trifluoromethyl)benzenesulfonamide
2-bromo-N-cyclopropyl-4-(trifluoromethoxy)benzenesulfonamide
4-Bromo-N,N-diethyl-3-(trifluoromethyl)benzenesulfonamide
Para-mercury-benzenesulfonic acid
D010575 - Pesticides > D005659 - Fungicides, Industrial > D010663 - Phenylmercury Compounds
N-(6-fluoro-1,3-benzothiazol-2-yl)-6,7-dihydro-[1,4]dioxino[2,3-f][1,3]benzothiazol-2-amine
N-(3-bicyclo[2.2.1]heptanyl)-3-bromo-4-methoxybenzenesulfonamide
Methyl 5-(2,4-dichloro-6-fluorophenoxy)-2-nitrobenzoate
Lipofermata
Lipofermata is a fatty acid transport protein 2 (FATP2) inhibitor. Lipofermata shows fatty acid transport inhibition with an IC50 of 4.84 μM in Caco-2 cells. Lipofermata, an analog of spiro-indoline-thadiazole, shows zinc-specific suppression of antibacterial activity. Lipofermata perturbs zinc homeostasis in E. coli K-12 with a MIC of 16 μM[1][2][3].
VU0422288
VU0422288 (ML396) is a positive allosteric modulator of group III mGluRs. VU0422288 inhibits mGluRs with EC50s of 125 nM, 146 nM, and 108 nM for mGluR4, mGluR7, and mGluR8, respectively in calcium mobilization assays. VU0422288 reverses deficits in contextual fear memory, social recognition, and apneas in Rett syndrome (RTT) model mice[1][2].
