Exact Mass: 226.1106
Exact Mass Matches: 226.1106
Found 66 metabolites which its exact mass value is equals to given mass value 226.1106,
within given mass tolerance error 8.0E-6 dalton. Try search metabolite list with more accurate mass tolerance error
1.6E-6 dalton.
Metyrapone
Metyrapone is only found in individuals that have used or taken this drug. It is an inhibitor of the enzyme steroid 11-beta-monooxygenase. It is used as a test of the feedback hypothalamic-pituitary mechanism in the diagnosis of cushing syndrome. [PubChem]The pharmacological effect of Metopirone is to reduce cortisol and corticosterone production by inhibiting the 11-ß-hydroxylation reaction in the adrenal cortex. Removal of the strong inhibitory feedback mechanism exerted by cortisol results in an increase in adrenocorticotropic hormone (ACTH) production by the pituitary. With continued blockade of the enzymatic steps leading to production of cortisol and corticosterone, there is a marked increase in adrenocortical secretion of their immediate precursors, 11-desoxycortisol and desoxycorticosterone, which are weak suppressors of ACTH release, and a corresponding elevation of these steroids in the plasma and of their metabolites in the urine. These metabolites are readily determined by measuring urinary 17-hydroxycorticosteroids (17-OHCS) or 17-ketogenic steroids (17-KGS). Because of these actions, metopirone is used as a diagnostic test, with urinary 17-OHCS measured as an index of pituitary ACTH responsiveness. Metopirone may also suppress biosynthesis of aldosterone, resulting in a mild natriuresis. V - Various > V04 - Diagnostic agents > V04C - Other diagnostic agents > V04CD - Tests for pituitary function D009676 - Noxae > D000963 - Antimetabolites KEIO_ID M111; [MS2] KO009044 D004791 - Enzyme Inhibitors C471 - Enzyme Inhibitor KEIO_ID M111
5-[[Methyl(prop-2-ynyl)amino]methyl]quinolin-8-ol
6-Isoquinolinol,1,2,3,4-tetrahydro-1-(4-pyridinyl)-(9CI)
3-METHYL-1-PHENYL-6,7-DIHYDRO-1H-INDAZOL-4(5H)-ONE
8-phenyl-1,2,3,4-tetrahydropyrido[1,2-a]pyrimidin-6-one
(1R,2R,4R)-BICYCLO[2.2.1]HEPT-5-ENE-2-CARBOXYLIC ACID
4-BENZYL-3,4-DIHYDROPYRROLO[1,2-A]PYRAZIN-1(2H)-ONE
4-PHENYL-5,6,7,8-TETRAHYDRO-1,6-NAPHTHYRIDIN-2(1H)-ONE
2-ethyl-2,3-dihydro-2-(1H-imidazol-5-yl)-1H-Inden-1-one
1H-Indole,2,3-dihydro-5-methoxy-2-(4-pyridinyl)-(9CI)
N(2)-methylharmine
A member of the class of beta-carbolines that is 9H-beta-carboline substituted by a methoxy group at position 7 and methyl groups at positions 1 and 2. It is semisynthetic derivative of harmine and has been shown to exhibit significant anti-HIV activity.
3-(1,5-dimethyl-1H-pyrazol-4-yl)-1-phenyl-2-propen-1-one
metyrapone
V - Various > V04 - Diagnostic agents > V04C - Other diagnostic agents > V04CD - Tests for pituitary function D009676 - Noxae > D000963 - Antimetabolites D004791 - Enzyme Inhibitors C471 - Enzyme Inhibitor
