Exact Mass: 148.06365979999998
Exact Mass Matches: 148.06365979999998
Found 317 metabolites which its exact mass value is equals to given mass value 148.06365979999998,
within given mass tolerance error 0.01 dalton. Try search metabolite list with more accurate mass tolerance error
0.001 dalton.
Mevalonic acid
Mevalonic acid, also known as MVA, mevalonate, or hiochic acid, belongs to the class of organic compounds known as hydroxy fatty acids. These are fatty acids in which the chain bears a hydroxyl group. Mevalonic acid is a key organic compound in biochemistry. It is found in most higher organisms ranging from plants to animals. Mevalonic acid is a precursor in the biosynthetic pathway known as the mevalonate pathway that produces terpenes (in plants) and steroids (in animals). Mevalonic acid is the primary precursor of isopentenyl pyrophosphate (IPP), that is in turn the basis for all terpenoids. The production of mevalonic acid by the enzyme 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase, is the rate-limiting step in the biosynthesis of cholesterol (PMID: 12872277). The cholesterol biosynthetic pathway has three major steps: (1) acetate to mevalonate, (2) mevalonate to squalene, and (3) squalene to cholesterol. In the first step, which catalyzed by thiolase, two acetyl-CoA molecules form acetoacetyl-CoA and one CoA molecule is released, then the acetoacetyl-CoA reacts with another molecule of acetyl-CoA and generates 3-hydroxy-3-methylglutaryl-CoA (HMGCoA). The enzyme responsible for this reaction is 3-hydroxy-3-methylglutaryl-CoA synthase (HMG-CoA synthase): In the pathway to synthesize cholesterol, one of the HMG-CoA carboxyl groups undergoes reduction to an alcohol, releasing CoA, leading to the formation of mevalonate, a six carbon compound. This reaction is catalyzed by hydroxy-methylglutaryl-CoA reductase, In the second step (mevalonate to squalene) mevalonate receives a phosphoryl group from ATP to form 5-phosphomevalonate. This compound accepts another phosphate to generate mevalonate-5-pyrophosphate. After a third phosphorylation, the compound is decarboxylated, loses water, and generates isopentenyl pyrophosphate (IPP). Then through successive condensations, IPP forms squalene, a terpene hydrocarbon that contains 30 carbon atoms. By cyclization and other changes, this compound will finally result in cholesterol. Mevalonic acid is found, on average, in the highest concentration within a few different foods, such as apples, corns, and wild carrots and in a lower concentration in garden tomato (var.), pepper (C. frutescens), and cucumbers. Mevalonic acid has also been detected, but not quantified in, several different foods, such as sweet oranges, potato, milk (cow), cabbages, and white cabbages. This could make mevalonic acid a potential biomarker for the consumption of these foods. Plasma concentrations and urinary excretion of MVA are decreased by HMG-CoA reductase inhibitor drugs such as pravastatin, simvastatin, and atorvastatin (PMID: 8808497). Mevalonic acid (MVA) is a key organic compound in biochemistry. The anion of mevalonic acid, the predominant form in biological media, is known as mevalonate. This compound is of major pharmaceutical importance. Drugs, such as the statins, stop the production of mevalonate by inhibiting HMG-CoA reductase. [Wikipedia]. Mevalonic acid is found in many foods, some of which are pepper (c. frutescens), cabbage, wild carrot, and white cabbage.
Pantoate
Pantoic acid (along with beta-alanine) is used to synthesize pantothenic acid (vitamin B5) in most microorganisms and plants. Pantothenic acid is a structural component of coenzyme A (CoA) which is involved in essential biological processes such as the citric acid cycle (TCA cycle) and the synthesis of carbohydrates, proteins, and fat. Pantothenic acid is found widespread in foods but especially in egg yolk, offal, fish, whole-grains, legumes, mushrooms, avocados, broccoli, and royal jelly (from bees).
2,3-dihydroxy-3-methylvalerate
2,3-dihydroxy-3-methylvalerate is a member of the class of compounds known as hydroxy fatty acids. Hydroxy fatty acids are fatty acids in which the chain bears a hydroxyl group. Thus, 2,3-dihydroxy-3-methylvalerate is considered to be a fatty acid lipid molecule. 2,3-dihydroxy-3-methylvalerate is soluble (in water) and a weakly acidic compound (based on its pKa). 2,3-dihydroxy-3-methylvalerate can be found in a number of food items such as jostaberry, spelt, roman camomile, and common pea, which makes 2,3-dihydroxy-3-methylvalerate a potential biomarker for the consumption of these food products.
(R)-2,3-Dihydroxy-3-methylvalerate
(R) 2,3-Dihydroxy-methylvalerate is an intermediate in valine, leucine and isoleucine biosynthesis. The pathway of valine biosynthesis is a four-step pathway that shares all of its steps with the parallel pathway of isoleucine biosynthesis. These entwined pathways are part of the superpathway of leucine, valine, and isoleucine biosynthesis, that generates not only isoleucine and valine, but also leucine. (R) 2,3-Dihydroxy-methylvalerate is generated from 3-Hydroxy-3-methyl-2-oxopentanoic acid via the enzyme ketol-acid reductoisomerase (EC 1.1.1.86) then it is converted to (S)-3-methyl-2-oxopentanoic via the dihydroxy-acid dehydratase (EC:4.2.1.9). [HMDB] (R)-2,3-Dihydroxy-methylvalerate is an intermediate in valine, leucine, and isoleucine biosynthesis. The pathway of valine biosynthesis is a four-step pathway that shares all of its steps with the parallel pathway of isoleucine biosynthesis. These entwined pathways are part of the superpathway of leucine, valine, and isoleucine biosynthesis, which generates not only isoleucine and valine but also leucine. (R)-2,3-Dihydroxy-methylvalerate is generated from 3-hydroxy-3-methyl-2-oxopentanoic acid via the enzyme ketol-acid reductoisomerase (EC 1.1.1.86). It is converted into (S)-3-methyl-2-oxopentanoic via the dihydroxy-acid dehydratase (EC 4.2.1.9).
Mevalonic acid
A dihydroxy monocarboxylic acid comprising valeric acid having two hydroxy groups at the 3- and 5-positions together with a methyl group at the 3-position.
3-(2-Methoxyethoxy)propanoic acid
A monocarboxylic acid that is propanoic acid substituted at C-3 by a 2-methoxyethoxy group.
3-(Methylthio)propyl acetate
3-(Methylthio)propyl acetate is found in alcoholic beverages. 3-(Methylthio)propyl acetate is found in apple, melon, pineapple, beer, whisky and wine. 3-(Methylthio)propyl acetate is a flavouring agent Found in apple, melon, pineapple, beer, whisky and wine. Flavouring agent
Ethyl 3-(methylthio)propanoate
Isolated from pineapple (Ananas comosus), melon, passion fruit and other fruitsand is) also present in alcoholic beverages and Parmesan cheese. Flavouring ingredient. Ethyl 3-(methylthio)propanoate is found in many foods, some of which are milk and milk products, pineapple, fruits, and alcoholic beverages. Ethyl 3-(methylthio)propanoate is found in alcoholic beverages. Ethyl 3-(methylthio)propanoate is isolated from pineapple (Ananas comosus), melon, passion fruit and other fruits. Also present in alcoholic beverages and Parmesan cheese. Ethyl 3-(methylthio)propanoate is a flavouring ingredient.
Glycerol 1-propanoate
Glycerol 1-propanoate is classified as a Natural Food Constituent (code WA) in the DF
Ethyl 3-mercaptobutyrate
Ethyl 3-mercaptobutyrate is used as a food additive [EAFUS] ("EAFUS: Everything Added to Food in the United States. [http://www.eafus.com/]") It is used as a food additive .
Methyl 3-(methylthio)butanoate
Methyl 3-(methylthio)butanoate is used as a food additive [EAFUS] ("EAFUS: Everything Added to Food in the United States. [http://www.eafus.com/]") It is used as a food additive .
Propyl 2-mercaptopropionate
Propyl 2-mercaptopropionate is used as a food additive [EAFUS] ("EAFUS: Everything Added to Food in the United States. [http://www.eafus.com/]")
3-Mercapto-3-methylbutyl formate
3-Mercapto-3-methylbutyl formate is found in coffee and coffee products. 3-Mercapto-3-methylbutyl formate is present in coffee volatiles. 3-Mercapto-3-methylbutyl formate is a flavouring agent Present in coffee volatiles. Flavouring agent. 3-Mercapto-3-methylbutyl formate is found in coffee and coffee products.
Methyl 4-(methylthio)butyrate
Methyl 4-(methylthio)butyrate is a flavouring ingredient. Flavouring ingredient
Methylthiomethyl butyrate
Methylthiomethyl butyrate is a flavouring agent especially for seasonings. Flavouring agent especies for seasonings
2,4,6-Trimethyl-1,3,5-dioxathiane
2,4,6-Trimethyl-1,3,5-dioxathiane is a component of an onion-like flavouring. Component of an onion-like flavouring
Methyl 2-(methylthio)butyrate
Methyl 2-(methylthio)butyrate is found in milk and milk products. Methyl 2-(methylthio)butyrate is a flavouring ingredient. Methyl 2-(methylthio)butyrate is present in cheese. Methyl 2-(methylthio)butyrate is a flavouring ingredient. It is found in milk and milk products.
(2-Methoxyethoxy)propanoic acid
(2-Methoxyethoxy)propanoic acid is a monocarboxylic acid that is propanoic acid substituted at C-2 by a 2-methoxyethoxy group.
4,5-dihydroxyhexanoic acid
4,5-dihydroxyhexanoic acid or DHHA is a water-soluble organic acid. It probably arises from the reaction of succinic semialdehyde with an intermediate in the pyruvate dehydrogenase pathway. DHHA is found in the urine and appears to be a marker for Succinic semialdehyde dehydrogenase (SSADH) deficiency (PMID: 3126356 ). SSADH is a disorder that arises from a defect in gamma-aminobutyric acid catabolism, resulting in the accumulation of gamma-hydroxybutyric acid (GHB), 2,4-dihydroxybutyric acid, adipic acid as well as elevated levels of 4,5-dihydroxyhexanoic acid, and 4,5-dihydroxyhexanoic acid lactone. SSADH causes neurological and cognitive disorders of varying severity (PMID: 3126356 ). Children with SSADH deficiency usually manifest with developmental delay, behavioral symptoms, language dysfunction, seizures, hypotonia, extrapyramidal symptoms, and ataxia (PMID: 32055132).
(2R,3R,4R,5S)-2-Methyl-tetrahydro-pyran-3,4,5-triol
(+/-)-3-Mercapto-1-butyl acetate
It is used as a food additive .
Deoxy-erythro-pentose,9CI,8CI-beta-D-Pyranose-form-Me glycoside
4-Pyridinecarbonitrile, 2-(hydroxymethyl)-6-methyl- (9CI)
Kethoxal
D000890 - Anti-Infective Agents > D000998 - Antiviral Agents C784 - Protein Synthesis Inhibitor
1,6-dihydro-6-methyl-7H-Pyrrolo[2,3-c]pyridin-7-one
2,4-Dimethyl-6-oxo-1,6-dihydro-3-pyridinecarbonitrile
6-METHYL-6,7-DIHYDRO-5H-PYRROLO[3,4-B]PYRIDIN-5-ONE
Pyrrole-3-carbonitrile, 5-formyl-2,4-dimethyl- (8CI)
3-Pyridinecarbonitrile, 1,2-dihydro-1,4-dimethyl-2-oxo-
Pyrrolo[1,2-c]pyrimidin-1(2H)-one, 2-methyl- (9CI)
N2-[(Isoquinolin-1-yl)methylene]-1-pyrrolidinecarbothiohydrazide
C5H12O3Si (148.05556819999998)
(2-Ethoxyethoxy)acetic acid
A monocarboxylic acid that is acetic acid in which one of the methyl hydrogens has been replaced by a 2-ethoxyethoxy group.
N,N-dihydroxy-L-valinate
An N,N-dihydroxy-alpha-amino-acid anion resulting from removal of a proton from the carboxylic acid group of N,N-dihydroxy-L-valine.
Glycolic acid, trimethylsilyl ester
C5H12O3Si (148.05556819999998)
Ethyl 3-methylthiopropionate
A carboxylic ester obtained by the formal condensation of the carboxy group of 3-(methylthio)propionic acid with ethanol.
3-methylthiopropyl acetate
An acetate ester obtained by the formal condensation of the hydroxy group of 3-(methylsulfanyl)propan-1-ol with acetic acid.
2-(2-methoxyethoxy)propanoic acid
A monocarboxylic acid that is propanoic acid substituted at C-2 by a 2-methoxyethoxy group.