Exact Mass: 118.027

Exact Mass Matches: 118.027

Found 84 metabolites which its exact mass value is equals to given mass value 118.027, within given mass tolerance error 0.01 dalton. Try search metabolite list with more accurate mass tolerance error 0.001 dalton.

Succinic acid

butanedioic acid

C4H6O4 (118.0266)


Succinic acid appears as white crystals or shiny white odorless crystalline powder. pH of 0.1 molar solution: 2.7. Very acid taste. (NTP, 1992) Succinic acid is an alpha,omega-dicarboxylic acid resulting from the formal oxidation of each of the terminal methyl groups of butane to the corresponding carboxy group. It is an intermediate metabolite in the citric acid cycle. It has a role as a nutraceutical, a radiation protective agent, an anti-ulcer drug, a micronutrient and a fundamental metabolite. It is an alpha,omega-dicarboxylic acid and a C4-dicarboxylic acid. It is a conjugate acid of a succinate(1-). A water-soluble, colorless crystal with an acid taste that is used as a chemical intermediate, in medicine, the manufacture of lacquers, and to make perfume esters. It is also used in foods as a sequestrant, buffer, and a neutralizing agent. (Hawleys Condensed Chemical Dictionary, 12th ed, p1099; McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed, p1851) Succinic acid is a metabolite found in or produced by Escherichia coli (strain K12, MG1655). Succinic acid is a dicarboxylic acid. The anion, succinate, is a component of the citric acid cycle capable of donating electrons to the electron transfer chain. Succinic acid is created as a byproduct of the fermentation of sugar. It lends to fermented beverages such as wine and beer a common taste that is a combination of saltiness, bitterness and acidity. Succinate is commonly used as a chemical intermediate, in medicine, the manufacture of lacquers, and to make perfume esters. It is also used in foods as a sequestrant, buffer, and a neutralizing agent. Succinate plays a role in the citric acid cycle, an energy-yielding process and is metabolized by succinate dehydrogenase to fumarate. Succinate dehydrogenase (SDH) plays an important role in the mitochondria, being both part of the respiratory chain and the Krebs cycle. SDH with a covalently attached FAD prosthetic group, binds enzyme substrates (succinate and fumarate) and physiological regulators (oxaloacetate and ATP). Oxidizing succinate links SDH to the fast-cycling Krebs cycle portion where it participates in the breakdown of acetyl-CoA throughout the whole Krebs cycle. Succinate can readily be imported into the mitochondrial matrix by the n-butylmalonate- (or phenylsuccinate-) sensitive dicarboxylate carrier in exchange with inorganic phosphate or another organic acid, e.g. malate. (A3509) Mutations in the four genes encoding the subunits of succinate dehydrogenase are associated with a wide spectrum of clinical presentations (i.e.: Huntingtons disease. (A3510). Succinate also acts as an oncometabolite. Succinate inhibits 2-oxoglutarate-dependent histone and DNA demethylase enzymes, resulting in epigenetic silencing that affects neuroendocrine differentiation. A water-soluble, colorless crystal with an acid taste that is used as a chemical intermediate, in medicine, the manufacture of lacquers, and to make perfume esters. It is also used in foods as a sequestrant, buffer, and a neutralizing agent. (Hawleys Condensed Chemical Dictionary, 12th ed, p1099; McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed, p1851) Succinic acid (succinate) is a dicarboxylic acid. It is an important component of the citric acid or TCA cycle and is capable of donating electrons to the electron transfer chain. Succinate is found in all living organisms ranging from bacteria to plants to mammals. In eukaryotes, succinate is generated in the mitochondria via the tricarboxylic acid cycle (TCA). Succinate can readily be imported into the mitochondrial matrix by the n-butylmalonate- (or phenylsuccinate-) sensitive dicarboxylate carrier in exchange with inorganic phosphate or another organic acid, e. g. malate (PMID 16143825). Succinate can exit the mitochondrial matrix and function in the cytoplasm as well as the extracellular space. Succinate has multiple biological roles including roles as a metabolic intermediate and roles as a cell signalling molecule. Succinate can alter gene expression patterns, thereby modulating the epigenetic landscape or it can exhibit hormone-like signaling functions (PMID: 26971832). As such, succinate links cellular metabolism, especially ATP formation, to the regulation of cellular function. Succinate can be broken down or metabolized into fumarate by the enzyme succinate dehydrogenase (SDH), which is part of the electron transport chain involved in making ATP. Dysregulation of succinate synthesis, and therefore ATP synthesis, can happen in a number of genetic mitochondrial diseases, such as Leigh syndrome, and Melas syndrome. Succinate has been found to be associated with D-2-hydroxyglutaric aciduria, which is an inborn error of metabolism. Succinic acid has recently been identified as an oncometabolite or an endogenous, cancer causing metabolite. High levels of this organic acid can be found in tumors or biofluids surrounding tumors. Its oncogenic action appears to due to its ability to inhibit prolyl hydroxylase-containing enzymes. In many tumours, oxygen availability becomes limited (hypoxia) very quickly due to rapid cell proliferation and limited blood vessel growth. The major regulator of the response to hypoxia is the HIF transcription factor (HIF-alpha). Under normal oxygen levels, protein levels of HIF-alpha are very low due to constant degradation, mediated by a series of post-translational modification events catalyzed by the prolyl hydroxylase domain-containing enzymes PHD1, 2 and 3, (also known as EglN2, 1 and 3) that hydroxylate HIF-alpha and lead to its degradation. All three of the PHD enzymes are inhibited by succinate. In humans, urinary succinic acid is produced by Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumonia, Enterobacter, Acinetobacter, Proteus mirabilis, Citrobacter frundii, Enterococcus faecalis (PMID: 22292465). Succinic acid is also found in Actinobacillus, Anaerobiospirillum, Mannheimia, Corynebacterium and Basfia (PMID: 22292465; PMID: 18191255; PMID: 26360870). Succinic acid is widely distributed in higher plants and produced by microorganisms. It is found in cheeses and fresh meats. Succinic acid is a flavouring enhancer, pH control agent [DFC]. Succinic acid is also found in yellow wax bean, swamp cabbage, peanut, and abalone. An alpha,omega-dicarboxylic acid resulting from the formal oxidation of each of the terminal methyl groups of butane to the corresponding carboxy group. It is an intermediate metabolite in the citric acid cycle. COVID info from PDB, Protein Data Bank Corona-virus Coronavirus SARS-CoV-2 COVID-19 SARS-CoV COVID19 SARS2 SARS Acquisition and generation of the data is financially supported in part by CREST/JST. KEIO_ID S004 Succinic acid is a potent and orally active anxiolytic agent. Succinic acid is an intermediate product of the tricarboxylic acid cycle. Succinic acid can be used as a precursor of many industrially important chemicals in food, chemical and pharmaceutical industries[1][2]. Succinic acid is a potent and orally active anxiolytic agent. Succinic acid is an intermediate product of the tricarboxylic acid cycle. Succinic acid can be used as a precursor of many industrially important chemicals in food, chemical and pharmaceutical industries[1][2].

   

Methylmalonic acid

1,1-Ethanedicarboxylic acid

C4H6O4 (118.0266)


Methylmalonic acid is a malonic acid derivative, which is a vital intermediate in the metabolism of fat and protein. In particular, the coenzyme A-linked form of methylmalonic acid, methylmalonyl-CoA, is converted into succinyl-CoA by methylmalonyl-CoA mutase in a reaction that requires vitamin B12 as a cofactor. In this way, methylmalonic acid enters the Krebs cycle and is thus part of one of the anaplerotic reactions. Abnormalities in methylmalonic acid metabolism lead to methylmalonic aciduria. This inborn error of metabolism is attributed to a block in the enzymatic conversion of methylmalonyl CoA to succinyl CoA. Methylmalonic acid is also found to be associated with other inborn errors of metabolism, including cobalamin deficiency, cobalamin malabsorption, malonyl-CoA decarboxylase deficiency, and transcobalamin II deficiency. When present in sufficiently high levels, methylmalonic acid can act as an acidogen and a metabotoxin. An acidogen is an acidic compound that induces acidosis, which has multiple adverse effects on many organ systems. A metabotoxin is an endogenously produced metabolite that causes adverse health effects at chronically high levels. Chronically high levels of methylmalonic acid are associated with at least 5 inborn errors of metabolism, including Malonyl CoA decarboxylase deficiency, Malonic Aciduria, Methylmalonate Semialdehyde Dehydrogenase Deficiency, Methylmalonic Aciduria and Methylmalonic Aciduria Due to Cobalamin-Related Disorders. Methylmalonic acid is an organic acid and abnormally high levels of organic acids in the blood (organic acidemia), urine (organic aciduria), the brain, and other tissues lead to general metabolic acidosis. Acidosis typically occurs when arterial pH falls below 7.35. In infants with acidosis, the initial symptoms include poor feeding, vomiting, loss of appetite, weak muscle tone (hypotonia), and lack of energy (lethargy). These can progress to heart abnormalities, kidney abnormalities, liver damage, seizures, coma, and possibly death. These are also the characteristic symptoms of the untreated IEMs mentioned above. Many affected children with organic acidemias experience intellectual disability or delayed development. In adults, acidosis or acidemia is characterized by headaches, confusion, feeling tired, tremors, sleepiness, and seizures. A malonic acid derivative which is a vital intermediate in the metabolism of fat and protein. Abnormalities in methylmalonic acid metabolism lead to methylmalonic aciduria. This metabolic disease is attributed to a block in the enzymatic conversion of methylmalonyl CoA to succinyl CoA. [HMDB] KEIO_ID M014 Methylmalonic acid (Methylmalonate) is an indicator of Vitamin B-12 deficiency in cancer. Methylmalonic acid (Methylmalonate) is an indicator of Vitamin B-12 deficiency in cancer.

   

Methyl oxalate

Dimethyl oxalate

C4H6O4 (118.0266)


   

N-Nitrosothiazolidine

N-Nitroso-1,3-thiazolidine

C3H6N2OS (118.0201)


   

L-malic semialdehyde

3-hydroxy-4-oxobutanoic acid

C4H6O4 (118.0266)


   

Erythrono-1,4-lactone

(3R,4R)-Dihydro-3,4-dihydroxy-threono-1,4-lactone 2(3H)-furanone

C4H6O4 (118.0266)


Erythrono-1,4-lactone has been identified as a lactone of tetronic acid in the urine from normal adults and neonates. The formation of this compound may be a consequence of lactonization of erythronic acid during the extraction/isolation process. Lactonization is a potential problem when measuring acids that contain a hydroxyl group at the number 4 carbon, as lactones are formed under acidic conditions. Evidence indicates that most 4-hydroxy acids do not normally exist to any appreciable extent as lactones in urine. (PMID 1192581). [HMDB] Erythrono-1,4-lactone has been identified as a lactone of tetronic acid in the urine from normal adults and neonates. The formation of this compound may be a consequence of lactonization of erythronic acid during the extraction/isolation process. Lactonization is a potential problem when measuring acids that contain a hydroxyl group at the number 4 carbon, as lactones are formed under acidic conditions. Evidence indicates that most 4-hydroxy acids do not normally exist to any appreciable extent as lactones in urine. (PMID 1192581).

   

xi-3-Hydroxy-2-oxobutanoic acid

beta-Hydroxy-alpha-ketobutyric acid

C4H6O4 (118.0266)


xi-3-Hydroxy-2-oxobutanoic acid is found in fruits. xi-3-Hydroxy-2-oxobutanoic acid is isolated from fruits of cowberry (Vaccinium vitis-idaea). xi-3-Hydroxy-2-oxobutanoic acid is a component of cheese aroma. Isolated from fruits of cowberry (Vaccinium vitis-idaea). Component of cheese aroma. xi-3-Hydroxy-2-oxobutanoic acid is found in milk and milk products and fruits.

   

4-Hydroxy-2-oxobutanoic acid

4-Hydroxy-2-oxo-butanoic acid

C4H6O4 (118.0266)


4-Hydroxy-2-oxobutanoic acid is found in fruits. 4-Hydroxy-2-oxobutanoic acid is isolated from fruits of Vaccinium vitis-idaea (cowberry) and from Vaccinium oxycoccus (small cranberry

   

Threonolactone

cis-Dihydro-3,4-bis[(trimethylsilyl)oxy]-2(3H)-furanone

C4H6O4 (118.0266)


Threonolactone is an oxidation product of the autoxidation reaction of L-ascorbic acid. [HMDB] Threonolactone is an oxidation product of the autoxidation reaction of L-ascorbic acid.

   

Threonic acid 1-4-lactone

Threonic acid 1-4-lactone

C4H6O4 (118.0266)


   

Methylmalonic acid

Methylmalonic acid

C4H6O4 (118.0266)


A dicarboxylic acid that is malonic acid in which one of the methylene hydrogens is substituted by a methyl group. Methylmalonic acid (Methylmalonate) is an indicator of Vitamin B-12 deficiency in cancer. Methylmalonic acid (Methylmalonate) is an indicator of Vitamin B-12 deficiency in cancer.

   

GUANYLTHIOUREA

GUANYLTHIOUREA

C2H6N4S (118.0313)


   

Acetoxyacetic acid

Acetoxyacetic acid

C4H6O4 (118.0266)


   

N-Acetylthiourea

N-Acetylthiourea

C3H6N2OS (118.0201)


   

DIACETYL PEROXIDE

DIACETYL PEROXIDE

C4H6O4 (118.0266)


   

3,3-Dimethylacryloyl chloride

3,3-Dimethylacryloyl chloride

C5H7ClO (118.0185)


   

Succinate

Succinic acid

C4H6O4 (118.0266)


Succinic acid is a potent and orally active anxiolytic agent. Succinic acid is an intermediate product of the tricarboxylic acid cycle. Succinic acid can be used as a precursor of many industrially important chemicals in food, chemical and pharmaceutical industries[1][2]. Succinic acid is a potent and orally active anxiolytic agent. Succinic acid is an intermediate product of the tricarboxylic acid cycle. Succinic acid can be used as a precursor of many industrially important chemicals in food, chemical and pharmaceutical industries[1][2].

   

Succinic acid

Succinic acid

C4H6O4 (118.0266)


Succinic acid is a potent and orally active anxiolytic agent. Succinic acid is an intermediate product of the tricarboxylic acid cycle. Succinic acid can be used as a precursor of many industrially important chemicals in food, chemical and pharmaceutical industries[1][2]. Succinic acid is a potent and orally active anxiolytic agent. Succinic acid is an intermediate product of the tricarboxylic acid cycle. Succinic acid can be used as a precursor of many industrially important chemicals in food, chemical and pharmaceutical industries[1][2].

   

Succinis acid

Succinis acid

C4H6O4 (118.0266)


Succinic acid is a potent and orally active anxiolytic agent. Succinic acid is an intermediate product of the tricarboxylic acid cycle. Succinic acid can be used as a precursor of many industrially important chemicals in food, chemical and pharmaceutical industries[1][2]. Succinic acid is a potent and orally active anxiolytic agent. Succinic acid is an intermediate product of the tricarboxylic acid cycle. Succinic acid can be used as a precursor of many industrially important chemicals in food, chemical and pharmaceutical industries[1][2].

   

Erythronolactone

Erythronolactone

C4H6O4 (118.0266)


   

Succinic acid (not validated)

Succinic acid (not validated)

C4H6O4 (118.0266)


Annotation level-3

   

Asuccin

Asuccin

C4H6O4 (118.0266)


   

Isosuccinic acid

Isosuccinic acid

C4H6O4 (118.0266)


   

Methylmalonate

Methylmalonic acid

C4H6O4 (118.0266)


Methylmalonic acid (Methylmalonate) is an indicator of Vitamin B-12 deficiency in cancer. Methylmalonic acid (Methylmalonate) is an indicator of Vitamin B-12 deficiency in cancer.

   

Succinic acid; LC-tDDA; CE10

Succinic acid; LC-tDDA; CE10

C4H6O4 (118.0266)


   

Succinic acid; LC-tDDA; CE20

Succinic acid; LC-tDDA; CE20

C4H6O4 (118.0266)


   

Succinic acid; LC-tDDA; CE30

Succinic acid; LC-tDDA; CE30

C4H6O4 (118.0266)


   

Succinic acid; LC-tDDA; CE40

Succinic acid; LC-tDDA; CE40

C4H6O4 (118.0266)


   

Methylmalonic acid; LC-tDDA; CE10

Methylmalonic acid; LC-tDDA; CE10

C4H6O4 (118.0266)


   

Methylmalonic acid; LC-tDDA; CE20

Methylmalonic acid; LC-tDDA; CE20

C4H6O4 (118.0266)


   

Methylmalonic acid; LC-tDDA; CE30

Methylmalonic acid; LC-tDDA; CE30

C4H6O4 (118.0266)


   

D-Erythronolactone

(3R,4R)-3,4-dihydroxyoxolan-2-one

C4H6O4 (118.0266)


   

Erythrono-1,4-lactone

Erythrono-1,4-lactone

C4H6O4 (118.0266)


   

Threonolactone

Threonolactone

C4H6O4 (118.0266)


   

2(3H)-Furanone, dihydro-3,4-dihydroxy

2(3H)-Furanone, dihydro-3,4-dihydroxy

C4H6O4 (118.0266)


   

4-Hydroxy-2-oxobutanoic acid

4-Hydroxy-2-oxo-butanoic acid

C4H6O4 (118.0266)


   

3-hydroxy-2-oxobutanoic acid

xi-3-Hydroxy-2-oxobutanoic acid

C4H6O4 (118.0266)


   

FA 4:1;O2

xi-3-Hydroxy-2-oxobutanoic acid

C4H6O4 (118.0266)


Methylmalonic acid (Methylmalonate) is an indicator of Vitamin B-12 deficiency in cancer. Methylmalonic acid (Methylmalonate) is an indicator of Vitamin B-12 deficiency in cancer.

   

Amidinothiourea

Amidinothiourea

C2H6N4S (118.0313)


   

Ethoxy(oxo)acetic acid

Ethoxy(oxo)acetic acid

C4H6O4 (118.0266)


   

Succinic acid-1,2-13C2

Succinic acid-1,2-13C2

C4H6O4 (118.0266)


   

2-Chlorocyclopentanone

2-Chlorocyclopentanone

C5H7ClO (118.0185)


   

4,5-Dicyanoimidazole

4,5-Dicyanoimidazole

C5H2N4 (118.0279)


   

2-carbamothioylacetamide

2-carbamothioylacetamide

C3H6N2OS (118.0201)


   

1,2-Diformyloxyethane

1,2-Diformyloxyethane

C4H6O4 (118.0266)


   

cyclobutancarbonylchlorid

cyclobutancarbonylchlorid

C5H7ClO (118.0185)


   

3-Cyanoazetidine hydrochloride

3-Cyanoazetidine hydrochloride

C4H7ClN2 (118.0298)


   

2-(chloromethyl)-4,5-dihydro-1H-imidazole

2-(chloromethyl)-4,5-dihydro-1H-imidazole

C4H7ClN2 (118.0298)


   

4-Methylpyrazole hydrochloride

4-Methylpyrazole hydrochloride

C4H7ClN2 (118.0298)


   

(2E)-(2H2)-2-Butenedioic acid

(2E)-(2H2)-2-Butenedioic acid

C4H2D2O4 (118.0235)


   

(2Z)-(2H2)-2-Butenedioic acid

(2Z)-(2H2)-2-Butenedioic acid

C4H2D2O4 (118.0235)


   

sodium formate

sodium formate

C2HD3NaO4 (118.0196)


   

1-Methylimidazole hydrochloride

1-Methylimidazole hydrochloride

C4H7ClN2 (118.0298)


   

3-Methoxy-3-oxopropanoic acid

3-Methoxy-3-oxopropanoic acid

C4H6O4 (118.0266)


   

Succinic acid-2,3-13C2

Succinic acid-2,3-13C2

C4H6O4 (118.0266)


   

(E)-4-chloro-2-methyl-but-2-enal

(E)-4-chloro-2-methyl-but-2-enal

C5H7ClO (118.0185)


   

3-methylcrotonoyl chloride

3-methylcrotonoyl chloride

C5H7ClO (118.0185)


   

2-methylcyclopropane-1-carbonyl chloride

2-methylcyclopropane-1-carbonyl chloride

C5H7ClO (118.0185)


   

4-(Hydroxymethyl)-1,3-dioxolan-2-one

4-(Hydroxymethyl)-1,3-dioxolan-2-one

C4H6O4 (118.0266)


   

Peroxide, diacetyl

Peroxide, diacetyl

C4H6O4 (118.0266)


   

1,2-dichloropropane (d6)

1,2-dichloropropane (d6)

C3Cl2D6 (118.0223)


   

1-(difluoromethyl)pyrazole

1-(difluoromethyl)pyrazole

C4H4F2N2 (118.0343)


   

(2,3-14C2)Butanedioic acid

(2,3-14C2)Butanedioic acid

C4H6O4 (118.0266)


   

trans-2-Methyl-2-butenoyl chloride

trans-2-Methyl-2-butenoyl chloride

C5H7ClO (118.0185)


   

Cyclopropylacetyl chloride

Cyclopropylacetyl chloride

C5H7ClO (118.0185)


   

2-methylidenebutanoyl chloride

2-methylidenebutanoyl chloride

C5H7ClO (118.0185)


   

Guanidine thiocyanate

Guanidine thiocyanate

C2H6N4S (118.0313)


   

<1,4-13C2>-succinic acid

<1,4-13C2>-succinic acid

C4H6O4 (118.0266)


   

4-Pentenoyl chloride

4-Pentenoyl chloride

C5H7ClO (118.0185)


   

1-Amino-1-cyclopropanecarbonitrile hydrochloride

1-Amino-1-cyclopropanecarbonitrile hydrochloride

C4H7ClN2 (118.0298)


   

4-(difluoromethyl)-1H-pyrazole

4-(difluoromethyl)-1H-pyrazole

C4H4F2N2 (118.0343)


   

VINYLMETHYLSILOXANE HOMOPOLYMER

VINYLMETHYLSILOXANE HOMOPOLYMER

C3H10OSi2 (118.027)


   

Succinic acid-13C4

Succinic acid-13C4

C4H6O4 (118.0266)


   

1-Methylcyclopropanecarbonyl chloride

1-Methylcyclopropanecarbonyl chloride

C5H7ClO (118.0185)


   

2-Hydroxy-4-oxobutanoic acid

2-Hydroxy-4-oxobutanoic acid

C4H6O4 (118.0266)


   

Erythro-tetrodialdose

Erythro-tetrodialdose

C4H6O4 (118.0266)


   

3-Hydroxy3-formyl propanoic acid

3-Hydroxy3-formyl propanoic acid

C4H6O4 (118.0266)


   

L-Homocysteine thiolactone

L-Homocysteine thiolactone

C4H8NOS+ (118.0327)


   

Succinic acid-2,2,3,3-d4

Succinic acid-2,2,3,3-d4

C4H6O4 (118.0266)


COVID info from COVID-19 Disease Map Corona-virus Coronavirus SARS-CoV-2 COVID-19 SARS-CoV COVID19 SARS2 SARS

   

D-threonolactone

D-threonolactone

C4H6O4 (118.0266)


   

L-threosone

L-threosone

C4H6O4 (118.0266)


   

4-Amino-3-isothiazolidinone

4-Amino-3-isothiazolidinone

C3H6N2OS (118.0201)


   

(3R,4S)-3,4-dihydroxyoxolan-2-one

(3R,4S)-3,4-dihydroxyoxolan-2-one

C4H6O4 (118.0266)


   

L-threonolactone

L-threonolactone

C4H6O4 (118.0266)


A butan-4-olide that is dihydrofuran-2-one substituted at C-3 and C-4 by hydroxy groups (the 3R,4S-diastereomer).