Exact Mass: 1101.3448576

(5S,6Z,8E,12R,14Z)-5,12-Dihydroxy-3-oxoicosatrienoyl-CoA

C41H66N7O20P3S (1101.3296026000003)

(5S,6Z,8E,12R,14Z)-5,12-Dihydroxy-3-oxoicosatrienoyl-CoA, also known as 3-oxo-5(S),12(R)-dihydroxy-eicosa-8-trans-6,14-cis-trienoyl-CoA, belongs to the class of organic compounds known as long-chain 3-oxoacyl CoAs. These are organic compounds containing a coenzyme A derivative which has a 3-oxo acylated long aliphatic chain of 13 to 21 carbon atoms. (5S,6Z,8E,12R,14Z)-5,12-Dihydroxy-3-oxoicosatrienoyl-CoA is considered to be a practically insoluble (in water) and relatively neutral molecule.

(5Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(1E,3S,5Z)-3-hydroxyocta-1,5-dien-1-yl]cyclopentyl]hept-5-enoyl-CoA

C41H66N7O20P3S (1101.3296026000003)

(5z)-7-[(1r,2r,3r,5s)-3,5-dihydroxy-2-[(1e,3s,5z)-3-hydroxyocta-1,5-dien-1-yl]cyclopentyl]hept-5-enoyl-coa is an acyl-CoA or acyl-coenzyme A. More specifically, it is a (5Z)-7-[(1R_2R_3R_5S)-3_5-dihydroxy-2-[(1E_3S_5Z)-3-hydroxyocta-1_5-dien-1-yl]cyclopentyl]hept-5-enoic acid thioester of coenzyme A. (5z)-7-[(1r,2r,3r,5s)-3,5-dihydroxy-2-[(1e,3s,5z)-3-hydroxyocta-1,5-dien-1-yl]cyclopentyl]hept-5-enoyl-coa is an acyl-CoA with 20 fatty acid group as the acyl moiety attached to coenzyme A. Coenzyme A was discovered in 1946 by Fritz Lipmann (Journal of Biological Chemistry (1946) 162 (3): 743–744) and its structure was determined in the early 1950s at the Lister Institute in London. Coenzyme A is a complex, thiol-containing molecule that is naturally synthesized from pantothenate (vitamin B5), which is found in various foods such as meat, vegetables, cereal grains, legumes, eggs, and milk. More specifically, coenzyme A (CoASH or CoA) consists of a beta-mercaptoethylamine group linked to the vitamin pantothenic acid (B5) through an amide linkage and 3-phosphorylated ADP. Coenzyme A is synthesized in a five-step process that requires four molecules of ATP, pantothenate and cysteine. It is believed that there are more than 1100 types of acyl-CoA’s in the human body, which also corresponds to the number of acylcarnitines in the human body. Acyl-CoAs exists in all living species, ranging from bacteria to plants to humans. The general role of acyl-CoA’s is to assist in transferring fatty acids from the cytoplasm to mitochondria. This process facilitates the production of fatty acids in cells, which are essential in cell membrane structure. Acyl-CoAs are also susceptible to beta oxidation, forming, ultimately, acetyl-CoA. Acetyl-CoA can enter the citric acid cycle, eventually forming several equivalents of ATP. In this way, fats are converted to ATP -- or biochemical energy. Acyl-CoAs can be classified into 9 different categories depending on the size of their acyl-group: 1) short-chain acyl-CoAs; 2) medium-chain acyl-CoAs; 3) long-chain acyl-CoAs; and 4) very long-chain acyl-CoAs; 5) hydroxy acyl-CoAs; 6) branched chain acyl-CoAs; 7) unsaturated acyl-CoAs; 8) dicarboxylic acyl-CoAs and 9) miscellaneous acyl-CoAs. Short-chain acyl-CoAs have acyl-groups with two to four carbons (C2-C4), medium-chain acyl-CoAs have acyl-groups with five to eleven carbons (C5-C11), long-chain acyl-CoAs have acyl-groups with twelve to twenty carbons (C12-C20) while very long-chain acyl-CoAs have acyl groups with more than 20 carbons. (5z)-7-[(1r,2r,3r,5s)-3,5-dihydroxy-2-[(1e,3s,5z)-3-hydroxyocta-1,5-dien-1-yl]cyclopentyl]hept-5-enoyl-coa is therefore classified as a long chain acyl-CoA. The oxidative degradation of fatty acids is a two-step process, catalyzed by acyl-CoA synthetase/synthase. Fatty acids are first converted to their acyl phosphate, the precursor to acyl-CoA. The latter conversion is mediated by acyl-CoA synthase. Three types of acyl-CoA synthases are employed, depending on the chain length of the fatty acid. (5z)-7-[(1r,2r,3r,5s)-3,5-dihydroxy-2-[(1e,3s,5z)-3-hydroxyocta-1,5-dien-1-yl]cyclopentyl]hept-5-enoyl-coa, being a long chain acyl-CoA is a substrate for long chain acyl-CoA synthase. The second step of fatty acid degradation is beta oxidation. Beta oxidation occurs in mitochondria and, in the case of very long chain acyl-CoAs, the peroxisome. After its formation in the cytosol, (5Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(1E,3S,5Z)-3-hydroxyocta-1,5-dien-1-yl]cyclopentyl]hept-5-enoyl-CoA is transported into the mitochondria, the locus of beta oxidation. Transport of (5Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(1E,3S,5Z)-3-hydroxyocta-1,5-dien-1-yl]cyclopentyl]hept-5-enoyl-CoA into the mitochondria requires carnitine palmitoyltransferase 1 (CPT1), which converts (5Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(1E,3S,5Z)-3-hydroxyocta-1,5-dien-1-yl]cyclopentyl]hept-5-enoyl-CoA into (5Z)-7-[(1R_2R_3R_5S)-3_5-dihydroxy-2-[(1E_3S_5Z)-3-hydroxyocta-1_5-dien-1-...

(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA(4-)

C45H66N7O17P3S-4 (1101.3448576)

(2E,6Z,9Z,12Z,15Z,18Z)-tetracosahexaenoyl-CoA(4-)

C45H66N7O17P3S-4 (1101.3448576)

(2E,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA

C45H66N7O17P3S-4 (1101.3448576)

(5Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(1E,3S,5Z)-3-hydroxyocta-1,5-dien-1-yl]cyclopentyl]hept-5-enoyl-CoA

C41H66N7O20P3S (1101.3296026000003)

Epoprostenol-CoA; (Acyl-CoA); [M+H]+

C41H66N7O20P3S (1101.3296026000003)

Dinoprostone-CoA; (Acyl-CoA); [M+H]+

C41H66N7O20P3S (1101.3296026000003)

DrugBank-DB02056-CoA; (Acyl-CoA); [M+H]+

C41H66N7O20P3S (1101.3296026000003)

(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA(4-)

C45H66N7O17P3S (1101.3448576)

An acyl-CoA(4-) obtained by deprotonation of the phosphate and diphosphate OH groups of (6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA; major species at pH 7.3.

(2E,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA(4-)

C45H66N7O17P3S (1101.3448576)

A 2,3-trans-enoyl CoA(4-) obtained by deprotonation of the phosphate and diphosphate OH groups of (2E,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA; major species at pH 7.3.

(2E,6Z,9Z,12Z,15Z,18Z)-tetracosahexaenoyl-CoA(4-)

C45H66N7O17P3S (1101.3448576)

A 2,3-trans-enoyl CoA(4-) arising from deprotonation of the phosphate and diphosphate functions of (2E,6Z,9Z,12Z,15Z,18Z)-tetracosahexaenoyl-CoA; major species at pH 7.3.