Classification Term: 716

Isoindoles (ontology term: CHEMONTID:0000127)

Heteropolycyclic compounds with a structure containing isoindole, a benzo-fused pyrrole." []

found 6 associated metabolites at sub_class metabolite taxonomy ontology rank level.

Ancestor: Isoindoles and derivatives

Child Taxonomies: Isoindole organothiophosphates

Mazindol

5-(4-chlorophenyl)-2H,3H,5H-imidazo[2,1-a]isoindol-5-ol

C16H13ClN2O (284.0716358)


Mazindol is only found in individuals that have used or taken this drug. It is a tricyclic anorexigenic agent unrelated to and less toxic than amphetamine, but with some similar side effects. It inhibits uptake of catecholamines and blocks the binding of cocaine to the dopamine uptake transporter. [PubChem]Although the mechanism of action of the sympathomimetics in the treatment of obesity is not fully known, these medications have pharmacological effects similar to those of amphetamines. Unlike other sympathomimetic appetite suppressants such as phentermine, mazindol is thought to inhibit the reuptake of norepinephrine rather than to cause its release. A - Alimentary tract and metabolism > A08 - Antiobesity preparations, excl. diet products > A08A - Antiobesity preparations, excl. diet products > A08AA - Centrally acting antiobesity products D018377 - Neurotransmitter Agents > D014179 - Neurotransmitter Uptake Inhibitors > D018759 - Adrenergic Uptake Inhibitors D018377 - Neurotransmitter Agents > D014179 - Neurotransmitter Uptake Inhibitors > D018765 - Dopamine Uptake Inhibitors D002491 - Central Nervous System Agents > D000697 - Central Nervous System Stimulants C78272 - Agent Affecting Nervous System > C47795 - CNS Stimulant D018377 - Neurotransmitter Agents > D018663 - Adrenergic Agents D018377 - Neurotransmitter Agents > D015259 - Dopamine Agents D049990 - Membrane Transport Modulators

   

Isoindole

2H-isoindole

C8H7N (117.0578462)


   

2-((4,5-Dihydro-1H-imidazol-2-yl)methyl)-2,3-dihydro-1-methyl-1H-isoindole

2-[(4,5-dihydro-1H-imidazol-2-yl)methyl]-1-methyl-2,3-dihydro-1H-isoindole

C13H17N3 (215.1422402)


D018377 - Neurotransmitter Agents > D018663 - Adrenergic Agents > D018674 - Adrenergic Antagonists

   

Dehydrophthalocyanine

2,11,20,29,37,38,39,40-octaazanonacyclo[28.6.1.1^{3,10}.1^{12,19}.1^{21,28}.0^{4,9}.0^{13,18}.0^{22,27}.0^{31,36}]tetraconta-1,3,5,9,11,13,15,17,19(39),20,22,24,26,28,30(37),31,33,35-octadecaen-7-yne

C32H16N8 (512.1497856)


D011838 - Radiation-Sensitizing Agents

   

Isoindoline

2,3-dihydro-1H-isoindole

C8H9N (119.0734954)


   

Navoximod

4-(2-{6-fluoro-5H-imidazo[4,3-a]isoindol-5-yl}-1-hydroxyethyl)cyclohexan-1-ol

C18H21FN2O2 (316.15869779999997)