Mazindol (BioDeep_00000018254)

   

human metabolite blood metabolite Chemicals and Drugs


代谢物信息卡片


5-(4-chlorophenyl)-2H,3H,5H-imidazo[2,1-a]isoindol-5-ol

化学式: C16H13ClN2O (284.0716358)
中文名称: 马吲哚
谱图信息: 最多检出来源 Homo sapiens(blood) 16.11%

分子结构信息

SMILES: c1ccc2c(c1)C1=NCCN1C2(c1ccc(cc1)Cl)O
InChI: InChI=1S/C16H13ClN2O/c17-12-7-5-11(6-8-12)16(20)14-4-2-1-3-13(14)15-18-9-10-19(15)16/h1-8,20H,9-10H2

描述信息

Mazindol is only found in individuals that have used or taken this drug. It is a tricyclic anorexigenic agent unrelated to and less toxic than amphetamine, but with some similar side effects. It inhibits uptake of catecholamines and blocks the binding of cocaine to the dopamine uptake transporter. [PubChem]Although the mechanism of action of the sympathomimetics in the treatment of obesity is not fully known, these medications have pharmacological effects similar to those of amphetamines. Unlike other sympathomimetic appetite suppressants such as phentermine, mazindol is thought to inhibit the reuptake of norepinephrine rather than to cause its release.
A - Alimentary tract and metabolism > A08 - Antiobesity preparations, excl. diet products > A08A - Antiobesity preparations, excl. diet products > A08AA - Centrally acting antiobesity products
D018377 - Neurotransmitter Agents > D014179 - Neurotransmitter Uptake Inhibitors > D018759 - Adrenergic Uptake Inhibitors
D018377 - Neurotransmitter Agents > D014179 - Neurotransmitter Uptake Inhibitors > D018765 - Dopamine Uptake Inhibitors
D002491 - Central Nervous System Agents > D000697 - Central Nervous System Stimulants
C78272 - Agent Affecting Nervous System > C47795 - CNS Stimulant
D018377 - Neurotransmitter Agents > D018663 - Adrenergic Agents
D018377 - Neurotransmitter Agents > D015259 - Dopamine Agents
D049990 - Membrane Transport Modulators

同义名列表

18 个代谢物同义名

5-(4-chlorophenyl)-2H,3H,5H-imidazo[2,1-a]isoindol-5-ol; Novartis brand OF mazindol; Searle brand OF mazindol; Medix brand OF mazindol; Wyeth brand OF mazindol; Mazindol novartis brand; Mazindol searle brand; Mazindol wyeth brand; Mazindol medix brand; Mazindole; Solucaps; Sanjorex; mazindol; Teronak; Teronac; Sanorex; Diestet; Mazanor



数据库引用编号

11 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Dilip K Tosh, Aaron Janowsky, Amy J Eshleman, Eugene Warnick, Zhan-Guo Gao, Zhoumou Chen, Elizabeth Gizewski, John A Auchampach, Daniela Salvemini, Kenneth A Jacobson. Scaffold Repurposing of Nucleosides (Adenosine Receptor Agonists): Enhanced Activity at the Human Dopamine and Norepinephrine Sodium Symporters. Journal of medicinal chemistry. 2017 04; 60(7):3109-3123. doi: 10.1021/acs.jmedchem.7b00141. [PMID: 28319392]
  • Megan L Fitzgerald, Suham A Kassir, Mark D Underwood, Mihran J Bakalian, J John Mann, Victoria Arango. Dysregulation of Striatal Dopamine Receptor Binding in Suicide. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2017 Mar; 42(4):974-982. doi: 10.1038/npp.2016.124. [PMID: 27402414]
  • Y Kimura, J Maeda, M Yamada, K Takahata, K Yokokawa, Y Ikoma, C Seki, H Ito, M Higuchi, T Suhara. Measurement of psychological state changes at low dopamine transporter occupancy following a clinical dose of mazindol. Psychopharmacology. 2017 Feb; 234(3):323-328. doi: 10.1007/s00213-016-4464-x. [PMID: 27766370]
  • Daisuke Aotani, Cheol Son, Yoshiyuki Shimizu, Hidenari Nomura, Takatoshi Hikida, Toru Kusakabe, Tomohiro Tanaka, Takashi Miyazawa, Kiminori Hosoda, Kazuwa Nakao. Reevaluation of anti-obesity action of mazindol and elucidation of its effect on the reward system. Neuroscience letters. 2016 10; 633(?):141-145. doi: 10.1016/j.neulet.2016.09.014. [PMID: 27658895]
  • Marcella Herbstrith de Oliveira, Pâmela Cristina Lukasewicz Ferreira, Graciela Carlos, Fernanda Rodrigues Salazar, Ana Maria Bergold, Flavio Pechansky, Renata Pereira Limberger, Pedro Eduardo Fröehlich. Pharmacokinetics study of mazindol in plasma, oral fluid, and urine of volunteers. European journal of clinical pharmacology. 2016 Aug; 72(8):945-51. doi: 10.1007/s00228-016-2055-8. [PMID: 27066959]
  • Marcella Herbstrith de Oliveira, Pâmela Cristina Lukasewicz Ferreira, Graciela Carlos, Fernanda Rodrigues Salazar, Ana Maria Bergold, Flavio Pechansky, Renata Pereira Limberger, Pedro Eduardo Fröehlich. Validation and application of a liquid chromatography-electrospray ionization mass spectrometric method for determination of mazindol in human plasma and urine. Journal of pharmacological and toxicological methods. 2016 May; 79(?):1-6. doi: 10.1016/j.vascn.2015.12.003. [PMID: 26718151]
  • Jason R Richardson, Michele M Taylor, Stuart L Shalat, Thomas S Guillot, W Michael Caudle, Muhammad M Hossain, Tiffany A Mathews, Sara R Jones, Deborah A Cory-Slechta, Gary W Miller. Developmental pesticide exposure reproduces features of attention deficit hyperactivity disorder. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2015 May; 29(5):1960-72. doi: 10.1096/fj.14-260901. [PMID: 25630971]
  • Marcella Herbstrith de Oliveira, Graciela Carlos, Ana Maria Bergold, Flavio Pechansky, Renata Pereira Limberger, Pedro Eduardo Fröehlich. Determination of mazindol in human oral fluid by high performance liquid chromatography-electrospray ionization mass spectrometry. Biomedical chromatography : BMC. 2014 Aug; 28(8):1064-9. doi: 10.1002/bmc.3120. [PMID: 24458547]
  • Takeshi Sakayori, Amane Tateno, Ryosuke Arakawa, Yumiko Ikeda, Hidenori Suzuki, Yoshiro Okubo. Effect of mazindol on extracellular dopamine concentration in human brain measured by PET. Psychopharmacology. 2014 Jun; 231(11):2321-5. doi: 10.1007/s00213-013-3392-2. [PMID: 24398821]
  • Kasper Severinsen, Heidi Koldsø, Katrine Almind Vinberg Thorup, Christina Schjøth-Eskesen, Pernille Thornild Møller, Ove Wiborg, Henrik Helligsø Jensen, Steffen Sinning, Birgit Schiøtt. Binding of mazindol and analogs to the human serotonin and dopamine transporters. Molecular pharmacology. 2014 Feb; 85(2):208-17. doi: 10.1124/mol.113.088922. [PMID: 24214825]
  • Hui Wang, April Goehring, Kevin H Wang, Aravind Penmatsa, Ryan Ressler, Eric Gouaux. Structural basis for action by diverse antidepressants on biogenic amine transporters. Nature. 2013 Nov; 503(7474):141-5. doi: 10.1038/nature12648. [PMID: 24121440]
  • Simon Bulling, Klaus Schicker, Yuan-Wei Zhang, Thomas Steinkellner, Thomas Stockner, Christian W Gruber, Stefan Boehm, Michael Freissmuth, Gary Rudnick, Harald H Sitte, Walter Sandtner. The mechanistic basis for noncompetitive ibogaine inhibition of serotonin and dopamine transporters. The Journal of biological chemistry. 2012 May; 287(22):18524-34. doi: 10.1074/jbc.m112.343681. [PMID: 22451652]
  • Cédric M Hysek, Linda D Simmler, Valentina G Nicola, Nerina Vischer, Massimiliano Donzelli, Stephan Krähenbühl, Eric Grouzmann, Jörg Huwyler, Marius C Hoener, Matthias E Liechti. Duloxetine inhibits effects of MDMA ('ecstasy') in vitro and in humans in a randomized placebo-controlled laboratory study. PloS one. 2012; 7(5):e36476. doi: 10.1371/journal.pone.0036476. [PMID: 22574166]
  • Mari Gabrielsen, Rafał Kurczab, Aina W Ravna, Irina Kufareva, Ruben Abagyan, Zdzisław Chilmonczyk, Andrzej J Bojarski, Ingebrigt Sylte. Molecular mechanism of serotonin transporter inhibition elucidated by a new flexible docking protocol. European journal of medicinal chemistry. 2012 Jan; 47(1):24-37. doi: 10.1016/j.ejmech.2011.09.056. [PMID: 22071255]
  • David J O'Neill, Adedayo Adedoyin, Jenifer A Bray, Darlene C Deecher, Andrew Fensome, Joel A Goldberg, Jim Harrison, Liza Leventhal, Charles Mann, Lilly Mark, Lisa Nogle, Nicole R Sullivan, Taylor B Spangler, Eugene A Terefenko, Eugene J Trybulski, Albert J Uveges, An Vu, Garth T Whiteside, Puwen Zhang. Discovery of novel selective norepinephrine inhibitors: 1-(2-morpholin-2-ylethyl)-3-aryl-1,3-dihydro-2,1,3-benzothiadiazole 2,2-dioxides (WYE-114152). Journal of medicinal chemistry. 2011 Oct; 54(19):6824-31. doi: 10.1021/jm200733r. [PMID: 21916421]
  • Sonja Sucic, Ali El-Kasaby, Oliver Kudlacek, Subhodeep Sarker, Harald H Sitte, Philippe Marin, Michael Freissmuth. The serotonin transporter is an exclusive client of the coat protein complex II (COPII) component SEC24C. The Journal of biological chemistry. 2011 May; 286(18):16482-90. doi: 10.1074/jbc.m111.230037. [PMID: 21454670]
  • Vaneeta Jindal, Dinesh Dhingra, Sunil Sharma, Milind Parle, Rajinder Kumar Harna. Hypolipidemic and weight reducing activity of the ethanolic extract of Tamarindus indica fruit pulp in cafeteria diet- and sulpiride-induced obese rats. Journal of pharmacology & pharmacotherapeutics. 2011 Apr; 2(2):80-4. doi: 10.4103/0976-500x.81896. [PMID: 21772765]
  • Gbolagade Sunmaila Akintomide, Hugh Rickards. Narcolepsy: a review. Neuropsychiatric disease and treatment. 2011; 7(?):507-18. doi: 10.2147/ndt.s23624. [PMID: 21931493]
  • Pierre-Olivier Fernagut, Qin Li, Sandra Dovero, Piu Chan, Tao Wu, Paula Ravenscroft, Michael Hill, Zhenwen Chen, Erwan Bezard. Dopamine transporter binding is unaffected by L-DOPA administration in normal and MPTP-treated monkeys. PloS one. 2010 Nov; 5(11):e14053. doi: 10.1371/journal.pone.0014053. [PMID: 21124922]
  • Stefan Schildknecht, Dominik Pöltl, Daniel M Nagel, Florian Matt, Diana Scholz, Julie Lotharius, Nathalie Schmieg, Alberto Salvo-Vargas, Marcel Leist. Requirement of a dopaminergic neuronal phenotype for toxicity of low concentrations of 1-methyl-4-phenylpyridinium to human cells. Toxicology and applied pharmacology. 2009 Nov; 241(1):23-35. doi: 10.1016/j.taap.2009.07.027. [PMID: 19647008]
  • John A Gruner, Val R Marcy, Yin-Guo Lin, Donna Bozyczko-Coyne, Michael J Marino, Maciej Gasior. The roles of dopamine transport inhibition and dopamine release facilitation in wake enhancement and rebound hypersomnolence induced by dopaminergic agents. Sleep. 2009 Nov; 32(11):1425-38. doi: 10.1093/sleep/32.11.1425. [PMID: 19928382]
  • Erik R Hill, Jinbin Tian, Michael R Tilley, Michael X Zhu, Howard H Gu. Potencies of cocaine methiodide on major cocaine targets in mice. PloS one. 2009 Oct; 4(10):e7578. doi: 10.1371/journal.pone.0007578. [PMID: 19855831]
  • Puwen Zhang, Eugene A Terefenko, Jenifer Bray, Darlene Deecher, Andrew Fensome, Jim Harrison, Callain Kim, Elizabeth Koury, Lilly Mark, Casey C McComas, Cheryl A Mugford, Eugene J Trybulski, An T Vu, Garth T Whiteside, Paige E Mahaney. 1- or 3-(3-Amino-2-hydroxy-1-phenyl propyl)-1,3-dihydro-2H-benzimidazol-2-ones: potent, selective, and orally efficacious norepinephrine reuptake inhibitors. Journal of medicinal chemistry. 2009 Sep; 52(18):5703-11. doi: 10.1021/jm900888c. [PMID: 19722525]
  • Callain Y Kim, Paige E Mahaney, Oliver McConnell, Yingru Zhang, Eric Manas, Douglas M Ho, Darlene C Deecher, Eugene J Trybulski. Discovery of a new series of monoamine reuptake inhibitors, the 1-amino-3-(1H-indol-1-yl)-3-phenylpropan-2-ols. Bioorganic & medicinal chemistry letters. 2009 Sep; 19(17):5029-32. doi: 10.1016/j.bmcl.2009.07.053. [PMID: 19632110]
  • David J Lapinsky, Shaili Aggarwal, Yurong Huang, Christopher K Surratt, John R Lever, James D Foster, Roxanne A Vaughan. A novel photoaffinity ligand for the dopamine transporter based on pyrovalerone. Bioorganic & medicinal chemistry. 2009 Jun; 17(11):3770-4. doi: 10.1016/j.bmc.2009.04.057. [PMID: 19442525]
  • An T Vu, Stephen T Cohn, Eugene A Terefenko, William J Moore, Puwen Zhang, Paige E Mahaney, Eugene J Trybulski, Igor Goljer, Rebecca Dooley, Jenifer A Bray, Grace H Johnston, Jennifer Leiter, Darlene C Deecher. 3-(Arylamino)-3-phenylpropan-2-olamines as a new series of dual norepinephrine and serotonin reuptake inhibitors. Bioorganic & medicinal chemistry letters. 2009 May; 19(9):2464-7. doi: 10.1016/j.bmcl.2009.03.054. [PMID: 19329313]
  • Sung-Su Kim, Heon-Woo Lee, Kyung-Tae Lee. Validated method for determination of mazindol in human plasma by liquid chromatography/tandem mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2009 Apr; 877(10):1011-6. doi: 10.1016/j.jchromb.2009.02.049. [PMID: 19272843]
  • Shinobu Mori, Mayumi Satou, Satoshi Kanazawa, Naonobu Yoshizuka, Tadashi Hase, Ichiro Tokimitsu, Yoshinori Takema, Yoshinori Nishizawa, Toshihiko Yada. Body fat mass reduction and up-regulation of uncoupling protein by novel lipolysis-promoting plant extract. International journal of biological sciences. 2009; 5(4):311-8. doi: 10.7150/ijbs.5.311. [PMID: 19421341]
  • A Bailey, A Metaxas, J H Yoo, T McGee, I Kitchen. Decrease of D2 receptor binding but increase in D2-stimulated G-protein activation, dopamine transporter binding and behavioural sensitization in brains of mice treated with a chronic escalating dose 'binge' cocaine administration paradigm. The European journal of neuroscience. 2008 Aug; 28(4):759-70. doi: 10.1111/j.1460-9568.2008.06369.x. [PMID: 18671743]
  • Yoko Hirata, Hiromi Suzuno, Tadamiki Tsuruta, Kentaro Oh-hashi, Kazutoshi Kiuchi. The role of dopamine transporter in selective toxicity of manganese and rotenone. Toxicology. 2008 Feb; 244(2-3):249-56. doi: 10.1016/j.tox.2007.11.018. [PMID: 18206288]
  • Xavier Castells, Miguel Casas, Xavier Vidal, Rosa Bosch, Carlos Roncero, Josep Antoni Ramos-Quiroga, Dolors Capellà. Efficacy of central nervous system stimulant treatment for cocaine dependence: a systematic review and meta-analysis of randomized controlled clinical trials. Addiction (Abingdon, England). 2007 Dec; 102(12):1871-87. doi: 10.1111/j.1360-0443.2007.01943.x. [PMID: 18031423]
  • John N Mason, Darlene C Deecher, Rhonda L Richmond, Gary Stack, Paige E Mahaney, Eugene Trybulski, Richard C Winneker, Randy D Blakely. Desvenlafaxine succinate identifies novel antagonist binding determinants in the human norepinephrine transporter. The Journal of pharmacology and experimental therapeutics. 2007 Nov; 323(2):720-9. doi: 10.1124/jpet.107.125716. [PMID: 17673606]
  • Nianhang Chen, Maarten E A Reith. Substrates and inhibitors display different sensitivity to expression level of the dopamine transporter in heterologously expressing cells. Journal of neurochemistry. 2007 Apr; 101(2):377-88. doi: 10.1111/j.1471-4159.2006.04384.x. [PMID: 17250655]
  • Roxanne A Vaughan, Dhananjay S Sakrikar, M Laura Parnas, Steven Adkins, James D Foster, Romain A Duval, John R Lever, Santosh S Kulkarni, Amy Hauck-Newman. Localization of cocaine analog [125I]RTI 82 irreversible binding to transmembrane domain 6 of the dopamine transporter. The Journal of biological chemistry. 2007 Mar; 282(12):8915-25. doi: 10.1074/jbc.m610633200. [PMID: 17255098]
  • Okechukwu T Ukairo, Suneetha Ramanujapuram, Christopher K Surratt. Fluctuation of the dopamine uptake inhibition potency of cocaine, but not amphetamine, at mammalian cells expressing the dopamine transporter. Brain research. 2007 Feb; 1131(1):68-76. doi: 10.1016/j.brainres.2006.11.018. [PMID: 17169338]
  • Lily Y Moy, Sheng-Ping Wang, Patricia K Sonsalla. Mitochondrial stress-induced dopamine efflux and neuronal damage by malonate involves the dopamine transporter. The Journal of pharmacology and experimental therapeutics. 2007 Feb; 320(2):747-56. doi: 10.1124/jpet.106.110791. [PMID: 17090704]
  • J L Short, C Ledent, E Borrelli, J Drago, A J Lawrence. Genetic interdependence of adenosine and dopamine receptors: evidence from receptor knockout mice. Neuroscience. 2006 May; 139(2):661-70. doi: 10.1016/j.neuroscience.2005.12.052. [PMID: 16476524]
  • José Manuel Trigo, Fany Panayi, Guadalupe Soria, Rafael Maldonado, Patricia Robledo. A reliable model of intravenous MDMA self-administration in naïve mice. Psychopharmacology. 2006 Jan; 184(2):212-20. doi: 10.1007/s00213-005-0229-7. [PMID: 16362403]
  • Balachandra K Gorentla, Roxanne A Vaughan. Differential effects of dopamine and psychoactive drugs on dopamine transporter phosphorylation and regulation. Neuropharmacology. 2005 Nov; 49(6):759-68. doi: 10.1016/j.neuropharm.2005.08.011. [PMID: 16181646]
  • Stephanie Padilla, Renée S Marshall, Deborah L Hunter, Sharon Oxendine, Virginia C Moser, Stanley B Southerland, Richard B Mailman. Neurochemical effects of chronic dietary and repeated high-level acute exposure to chlorpyrifos in rats. Toxicological sciences : an official journal of the Society of Toxicology. 2005 Nov; 88(1):161-71. doi: 10.1093/toxsci/kfi274. [PMID: 16081522]
  • Benjamin J Copeland, Norton H Neff, Maria Hadjiconstantinou. Enhanced dopamine uptake in the striatum following repeated restraint stress. Synapse (New York, N.Y.). 2005 Sep; 57(3):167-74. doi: 10.1002/syn.20169. [PMID: 15945060]
  • W Michael Caudle, Jason R Richardson, Minzheng Wang, Gary W Miller. Perinatal heptachlor exposure increases expression of presynaptic dopaminergic markers in mouse striatum. Neurotoxicology. 2005 Aug; 26(4):721-728. doi: 10.1016/j.neuro.2004.09.003. [PMID: 16112329]
  • Dalit E Dar, Cheryl Mayo, George R Uhl. The interaction of methylphenidate and benztropine with the dopamine transporter is different than other substrates and ligands. Biochemical pharmacology. 2005 Aug; 70(3):461-9. doi: 10.1016/j.bcp.2005.04.032. [PMID: 15950948]
  • Okechukwu T Ukairo, Corry D Bondi, Amy Hauck Newman, Santosh S Kulkarni, Alan P Kozikowski, Stephen Pan, Christopher K Surratt. Recognition of benztropine by the dopamine transporter (DAT) differs from that of the classical dopamine uptake inhibitors cocaine, methylphenidate, and mazindol as a function of a DAT transmembrane 1 aspartic acid residue. The Journal of pharmacology and experimental therapeutics. 2005 Aug; 314(2):575-83. doi: 10.1124/jpet.105.085829. [PMID: 15879005]
  • Johannes Backs, Elke Bresch, Matthias Lutz, Arnt V Kristen, Markus Haass. Endothelin-1 inhibits the neuronal norepinephrine transporter in hearts of male rats. Cardiovascular research. 2005 Aug; 67(2):283-90. doi: 10.1016/j.cardiores.2005.03.018. [PMID: 16005303]
  • Christian Pifl, Gabor Nagy, Sándor Berényi, Alexandra Kattinger, Harald Reither, Sándor Antus. Pharmacological characterization of ecstasy synthesis byproducts with recombinant human monoamine transporters. The Journal of pharmacology and experimental therapeutics. 2005 Jul; 314(1):346-54. doi: 10.1124/jpet.105.084426. [PMID: 15831439]
  • Michelle Porritt, Davor Stanic, David Finkelstein, Peter Batchelor, Sharon Lockhart, Andrew Hughes, Renate Kalnins, David Howells. Dopaminergic innervation of the human striatum in Parkinson's disease. Movement disorders : official journal of the Movement Disorder Society. 2005 Jul; 20(7):810-8. doi: 10.1002/mds.20399. [PMID: 15726582]
  • Jeffrey N Joyce, Cheryl Woolsey, Han Ryoo, Sabine Borwege, Diane Hagner. Low dose pramipexole is neuroprotective in the MPTP mouse model of Parkinson's disease, and downregulates the dopamine transporter via the D3 receptor. BMC biology. 2004 Oct; 2(?):22. doi: 10.1186/1741-7007-2-22. [PMID: 15473914]
  • David M Raffel, Wei Chen. Binding of [3H]mazindol to cardiac norepinephrine transporters: kinetic and equilibrium studies. Naunyn-Schmiedeberg's archives of pharmacology. 2004 Jul; 370(1):9-16. doi: 10.1007/s00210-004-0949-y. [PMID: 15300361]
  • Jon D Gaffaney, Roxanne A Vaughan. Uptake inhibitors but not substrates induce protease resistance in extracellular loop two of the dopamine transporter. Molecular pharmacology. 2004 Mar; 65(3):692-701. doi: 10.1124/mol.65.3.692. [PMID: 14978248]
  • Eun-Sook Y Lee, Hongtao Chen, Kennie R Shepherd, Nazarius S Lamango, Karam F A Soliman, Clivel G Charlton. The inhibitory role of methylation on the binding characteristics of dopamine receptors and transporter. Neuroscience research. 2004 Mar; 48(3):335-44. doi: 10.1016/j.neures.2003.11.010. [PMID: 15154679]
  • Aurelio Orjales, Ramón Mosquera, Antonio Toledo, M Carmen Pumar, Neftalí García, Lourdes Cortizo, Luis Labeaga, Ana Innerárity. Syntheses and binding studies of new [(aryl)(aryloxy)methyl]piperidine derivatives and related compounds as potential antidepressant drugs with high affinity for serotonin (5-HT) and norepinephrine (NE) transporters. Journal of medicinal chemistry. 2003 Dec; 46(25):5512-32. doi: 10.1021/jm0309349. [PMID: 14640559]
  • Hanne Hastrup, Namita Sen, Jonathan A Javitch. The human dopamine transporter forms a tetramer in the plasma membrane: cross-linking of a cysteine in the fourth transmembrane segment is sensitive to cocaine analogs. The Journal of biological chemistry. 2003 Nov; 278(46):45045-8. doi: 10.1074/jbc.c300349200. [PMID: 14519759]
  • Aloke K Dutta, Shijun Zhang, Rohit Kolhatkar, Maarten E A Reith. Dopamine transporter as target for drug development of cocaine dependence medications. European journal of pharmacology. 2003 Oct; 479(1-3):93-106. doi: 10.1016/j.ejphar.2003.08.060. [PMID: 14612141]
  • Iain A Sharpe, Elka Palant, Christina I Schroeder, David M Kaye, David J Adams, Paul F Alewood, Richard J Lewis. Inhibition of the norepinephrine transporter by the venom peptide chi-MrIA. Site of action, Na+ dependence, and structure-activity relationship. The Journal of biological chemistry. 2003 Oct; 278(41):40317-23. doi: 10.1074/jbc.m213030200. [PMID: 12885787]
  • R G Wiley, M B Harrison, A I Levey, D A Lappi. Destruction of midbrain dopaminergic neurons by using immunotoxin to dopamine transporter. Cellular and molecular neurobiology. 2003 Oct; 23(4-5):839-50. doi: 10.1023/a:1025065306264. [PMID: 14514035]
  • V M Goettl, H Zhang, A C Burrows, T A Wemlinger, N H Neff, M Hadjiconstantinou. GM1 enhances dopaminergic markers in the brain of aged rats. Experimental neurology. 2003 Oct; 183(2):665-72. doi: 10.1016/s0014-4886(03)00223-1. [PMID: 14552908]
  • Violetta Klimek, Gary Roberson, Craig A Stockmeier, Gregory A Ordway. Serotonin transporter and MAO-B levels in monoamine nuclei of the human brainstem are normal in major depression. Journal of psychiatric research. 2003 Sep; 37(5):387-97. doi: 10.1016/s0022-3956(03)00045-1. [PMID: 12849931]
  • Xilu Jiao, William P Paré, Shanaz Tejani-Butt. Strain differences in the distribution of dopamine transporter sites in rat brain. Progress in neuro-psychopharmacology & biological psychiatry. 2003 Sep; 27(6):913-9. doi: 10.1016/s0278-5846(03)00150-7. [PMID: 14499307]
  • D Stanic, C L Parish, W M Zhu, E V Krstew, A J Lawrence, J Drago, D I Finkelstein, M K Horne. Changes in function and ultrastructure of striatal dopaminergic terminals that regenerate following partial lesions of the SNpc. Journal of neurochemistry. 2003 Jul; 86(2):329-43. doi: 10.1046/j.1471-4159.2003.01843.x. [PMID: 12871574]
  • Sukumar Sakamuri, Istvan J Enyedy, Wahiduz A Zaman, Srihari R Tella, Alan P Kozikowski, Judith L Flippen-Anderson, Tivadar Farkas, Kenneth M Johnson, Shaomeng Wang. 2,3-Disubstituted quinuclidines as a novel class of dopamine transporter inhibitors. Bioorganic & medicinal chemistry. 2003 Mar; 11(6):1123-36. doi: 10.1016/s0968-0896(02)00450-9. [PMID: 12614900]
  • Tianhong Pan, Jian Fei, Xiaoda Zhou, Joseph Jankovic, Weidong Le. Effects of green tea polyphenols on dopamine uptake and on MPP+ -induced dopamine neuron injury. Life sciences. 2003 Jan; 72(9):1073-83. doi: 10.1016/s0024-3205(02)02347-0. [PMID: 12495785]
  • Jie Wu, Piu Chan, Katherine M Schroeder, Kevin Ellsworth, L Donald L Partridge. 1-Methyl-4-phenylpridinium (MPP+)-induced functional run-down of GABA(A) receptor-mediated currents in acutely dissociated dopaminergic neurons. Journal of neurochemistry. 2002 Oct; 83(1):87-99. doi: 10.1046/j.1471-4159.2002.01099.x. [PMID: 12358732]
  • William J Houlihan, Lawrence Kelly, Jessica Pankuch, Judith Koletar, Leonard Brand, Aaron Janowsky, Theresa A Kopajtic. Mazindol analogues as potential inhibitors of the cocaine binding site at the dopamine transporter. Journal of medicinal chemistry. 2002 Sep; 45(19):4097-109. doi: 10.1021/jm010302r. [PMID: 12213053]
  • William J Houlihan, Umer F Ahmad, Judith Koletar, Lawrence Kelly, Leonard Brand, Theresa A Kopajtic. Benzo- and cyclohexanomazindol analogues as potential inhibitors of the cocaine binding site at the dopamine transporter. Journal of medicinal chemistry. 2002 Sep; 45(19):4110-8. doi: 10.1021/jm010301z. [PMID: 12213054]
  • Santosh S Kulkarni, Amy Hauck Newman, William J Houlihan. Three-dimensional quantitative structure-activity relationships of mazindol analogues at the dopamine transporter. Journal of medicinal chemistry. 2002 Sep; 45(19):4119-27. doi: 10.1021/jm0102093. [PMID: 12213055]
  • Maurício Silva de Lima, Bernardo Garcia de Oliveira Soares, Anelise Alves Pereira Reisser, Michael Farrell. Pharmacological treatment of cocaine dependence: a systematic review. Addiction (Abingdon, England). 2002 Aug; 97(8):931-49. doi: 10.1046/j.1360-0443.2002.00209.x. [PMID: 12144591]
  • Istvan J Enyedy, Jiansuo Wang, Wahiduz A Zaman, Kenneth M Johnson, Shaomeng Wang. Discovery of substituted 3,4-diphenyl-thiazoles as a novel class of monoamine transporter inhibitors through 3-D pharmacophore search using a new pharmacophore model derived from mazindol. Bioorganic & medicinal chemistry letters. 2002 Jul; 12(13):1775-8. doi: 10.1016/s0960-894x(02)00243-3. [PMID: 12067559]
  • Geoffrey M Pavey, David L Copolov, Brian Dean. High-resolution phosphor imaging: validation for use with human brain tissue sections to determine the affinity and density of radioligand binding. Journal of neuroscience methods. 2002 May; 116(2):157-63. doi: 10.1016/s0165-0270(02)00036-5. [PMID: 12044665]
  • Zhicheng Lin, George R Uhl. Dopamine transporter mutants with cocaine resistance and normal dopamine uptake provide targets for cocaine antagonism. Molecular pharmacology. 2002 Apr; 61(4):885-91. doi: 10.1124/mol.61.4.885. [PMID: 11901228]
  • Kui Xu, Yue-Hang Xu, Jiang-Fan Chen, Michael A Schwarzschild. Caffeine's neuroprotection against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine toxicity shows no tolerance to chronic caffeine administration in mice. Neuroscience letters. 2002 Mar; 322(1):13-6. doi: 10.1016/s0304-3940(02)00069-1. [PMID: 11958832]
  • L Lyras, B-Y Zeng, G McKenzie, R K B Pearce, B Halliwell, P Jenner. Chronic high dose L-DOPA alone or in combination with the COMT inhibitor entacapone does not increase oxidative damage or impair the function of the nigro-striatal pathway in normal cynomologus monkeys. Journal of neural transmission (Vienna, Austria : 1996). 2002; 109(1):53-67. doi: 10.1007/s702-002-8236-2. [PMID: 11793162]
  • A Kanthasamy, J E Sprague, J R Shotwell, D E Nichols. Unilateral infusion of a dopamine transporter antisense into the substantia nigra protects against MDMA-induced serotonergic deficits in the ipsilateral striatum. Neuroscience. 2002; 114(4):917-24. doi: 10.1016/s0306-4522(02)00368-8. [PMID: 12379247]
  • S Purkerson-Parker, K L McDaniel, V C Moser. Dopamine transporter binding in the rat striatum is increased by gestational, perinatal, and adolescent exposure to heptachlor. Toxicological sciences : an official journal of the Society of Toxicology. 2001 Dec; 64(2):216-23. doi: 10.1093/toxsci/64.2.216. [PMID: 11719704]
  • A Kaddoumi, M Mori, K Nanashima, M Kono, K Nakashima. High performance liquid chromatographic determination of mazindol in human plasma. The Analyst. 2001 Nov; 126(11):1963-8. doi: 10.1039/b106008m. [PMID: 11763075]
  • M E Reith, J L Berfield, L C Wang, J V Ferrer, J A Javitch. The uptake inhibitors cocaine and benztropine differentially alter the conformation of the human dopamine transporter. The Journal of biological chemistry. 2001 Aug; 276(31):29012-8. doi: 10.1074/jbc.m011785200. [PMID: 11395483]
  • N Chen, R A Vaughan, M E Reith. The role of conserved tryptophan and acidic residues in the human dopamine transporter as characterized by site-directed mutagenesis. Journal of neurochemistry. 2001 May; 77(4):1116-27. doi: 10.1046/j.1471-4159.2001.00312.x. [PMID: 11359877]
  • E M Adkins, E L Barker, R D Blakely. Interactions of tryptamine derivatives with serotonin transporter species variants implicate transmembrane domain I in substrate recognition. Molecular pharmacology. 2001 Mar; 59(3):514-23. doi: 10.1124/mol.59.3.514. [PMID: 11179447]
  • A Tidjane Corera, J C Do-Régo, J Costentin, J J Bonnet. Differential sensitivity to NaCl for inhibitors and substrates that recognize mutually exclusive binding sites on the neuronal transporter of dopamine in rat striatal membranes. Neuroscience research. 2001 Mar; 39(3):319-25. doi: 10.1016/s0168-0102(00)00230-3. [PMID: 11248372]
  • A K Dutta, M E Reith, B K Madras. Synthesis and preliminary characterization of a high-affinity novel radioligand for the dopamine transporter. Synapse (New York, N.Y.). 2001 Feb; 39(2):175-81. doi: 10.1002/1098-2396(200102)39:2<175::aid-syn9>3.0.co;2-w. [PMID: 11180505]
  • L Naudon, I Leroux-Nicollet, D Boulay, J Costentin. Decreased densities of dopamine and serotonin transporters and of vesicular monoamine transporter 2 in severely kainic acid lesioned subregions of the striatum. Journal of neural transmission (Vienna, Austria : 1996). 2001; 108(4):431-44. doi: 10.1007/s007020170064. [PMID: 11475010]
  • K R Prakash, M Trzcinska, K M Johnson, A P Kozikowski. An enantioselective synthesis and biobehavioral evaluation of 7-fluoro-3-(p-fluorophenyl)-2-propyltropanes. Bioorganic & medicinal chemistry letters. 2000 Jul; 10(13):1443-6. doi: 10.1016/s0960-894x(00)00269-9. [PMID: 10888328]
  • C Saunders, J V Ferrer, L Shi, J Chen, G Merrill, M E Lamb, L M Leeb-Lundberg, L Carvelli, J A Javitch, A Galli. Amphetamine-induced loss of human dopamine transporter activity: an internalization-dependent and cocaine-sensitive mechanism. Proceedings of the National Academy of Sciences of the United States of America. 2000 Jun; 97(12):6850-5. doi: 10.1073/pnas.110035297. [PMID: 10823899]
  • J E Demaria, G M Nagy, A A Lerant, M I Fekete, C W Levenson, M E Freeman. Dopamine transporters participate in the physiological regulation of prolactin. Endocrinology. 2000 Jan; 141(1):366-74. doi: 10.1210/endo.141.1.7281. [PMID: 10614659]
  • Y Itzhak, J L Martin, S F Ali. Methamphetamine- and 1-methyl-4-phenyl- 1,2,3, 6-tetrahydropyridine-induced dopaminergic neurotoxicity in inducible nitric oxide synthase-deficient mice. Synapse (New York, N.Y.). 1999 Dec; 34(4):305-12. doi: 10.1002/(sici)1098-2396(19991215)34:4<305::aid-syn6>3.0.co;2-#. [PMID: 10529724]
  • F L Greenway, D H Ryan, G A Bray, J C Rood, E W Tucker, S R Smith. Pharmaceutical cost savings of treating obesity with weight loss medications. Obesity research. 1999 Nov; 7(6):523-31. doi: 10.1002/j.1550-8528.1999.tb00709.x. [PMID: 10574509]
  • J C Régo, M Syringas, B Leblond, J Costentin, J J Bonnet. Recovery of dopamine neuronal transporter but lack of change of its mRNA in substantia nigra after inactivation by a new irreversible inhibitor characterized in vitro and ex vivo in the rat. British journal of pharmacology. 1999 Sep; 128(1):51-60. doi: 10.1038/sj.bjp.0702784. [PMID: 10498834]
  • A P Kozikowski, D Simoni, M Roberti, R Rondanin, S Wang, P Du, K M Johnson. Synthesis of 8-Oxa analogues of norcocaine endowed with interesting cocaine-like activity. Bioorganic & medicinal chemistry letters. 1999 Jul; 9(13):1831-6. doi: 10.1016/s0960-894x(99)00273-5. [PMID: 10406650]
  • S Han, P P Rowell, L A Carr. D2 autoreceptors are not involved in the down-regulation of the striatal dopamine transporter caused by alpha-methyl-p-tyrosine. Research communications in molecular pathology and pharmacology. 1999; 104(3):331-8. doi: . [PMID: 10741383]
  • W S Thomas, B S Neal-Beliveau, J N Joyce. There is a limited critical period for dopamine's effects on D1 receptor expression in the developing rat neostriatum. Brain research. Developmental brain research. 1998 Nov; 111(1):99-106. doi: 10.1016/s0165-3806(98)00126-6. [PMID: 9804909]
  • E L Barker, M A Perlman, E M Adkins, W J Houlihan, Z B Pristupa, H B Niznik, R D Blakely. High affinity recognition of serotonin transporter antagonists defined by species-scanning mutagenesis. An aromatic residue in transmembrane domain I dictates species-selective recognition of citalopram and mazindol. The Journal of biological chemistry. 1998 Jul; 273(31):19459-68. doi: 10.1074/jbc.273.31.19459. [PMID: 9677366]
  • T A Patterson, M D Brot, A Zavosh, J O Schenk, P Szot, D P Figlewicz. Food deprivation decreases mRNA and activity of the rat dopamine transporter. Neuroendocrinology. 1998 Jul; 68(1):11-20. doi: 10.1159/000054345. [PMID: 9695934]
  • R T Malison, E McCance, L L Carpenter, R M Baldwin, J P Seibyl, L H Price, T R Kosten, R B Innis. [123I]beta-CIT SPECT imaging of dopamine transporter availability after mazindol administration in human cocaine addicts. Psychopharmacology. 1998 Jun; 137(4):321-5. doi: 10.1007/s002130050625. [PMID: 9676890]
  • H Wayment, S M Meiergerd, J O Schenk. Relationships between the catechol substrate binding site and amphetamine, cocaine, and mazindol binding sites in a kinetic model of the striatal transporter of dopamine in vitro. Journal of neurochemistry. 1998 May; 70(5):1941-9. doi: 10.1046/j.1471-4159.1998.70051941.x. [PMID: 9572278]
  • V Villemagne, J Yuan, D F Wong, R F Dannals, G Hatzidimitriou, W B Mathews, H T Ravert, J Musachio, U D McCann, G A Ricaurte. Brain dopamine neurotoxicity in baboons treated with doses of methamphetamine comparable to those recreationally abused by humans: evidence from [11C]WIN-35,428 positron emission tomography studies and direct in vitro determinations. The Journal of neuroscience : the official journal of the Society for Neuroscience. 1998 Jan; 18(1):419-27. doi: NULL. [PMID: 9412518]
  • T Hashitani, K Mizukawa, M Kumazaki, H Nishino. Dopamine metabolism in the striatum of hemiparkinsonian model rats with dopaminergic grafts. Neuroscience research. 1998 Jan; 30(1):43-52. doi: 10.1016/s0168-0102(97)00109-0. [PMID: 9572579]
  • Y Itzhak, J L Martin, S F Ali, M D Norenberg. Depletion of striatal dopamine transporter does not affect psychostimulant-induced locomotor activity. Neuroreport. 1997 Oct; 8(15):3245-9. doi: 10.1097/00001756-199710200-00012. [PMID: 9351651]
  • Q Wu, L L Coffey, M E Reith. Cations affect [3H]mazindol and [3H]WIN 35,428 binding to the human dopamine transporter in a similar fashion. Journal of neurochemistry. 1997 Sep; 69(3):1106-18. doi: 10.1046/j.1471-4159.1997.69031106.x. [PMID: 9282933]