Classification Term: 674
Metallotetrapyrroles (ontology term: CHEMONTID:0001926)
Polycyclic compounds containing a tetrapyrrole skeleton combined with a metal atom." []
found 11 associated metabolites at sub_class metabolite taxonomy ontology rank level.
Ancestor: Tetrapyrroles and derivatives
Child Taxonomies: Metalloporphyrins
Heme O
C49H58FeN4O5 (838.3756367999999)
Heme O differs from the closely related heme A by having a methyl group at ring position 8 instead of the formyl group, the isoprenoid chain at position 2 is the same (Wikipedia). Heme O differs from the closely related heme A by having a methyl group at ring position 8 instead of the formyl group, the isoprenoid chain at position 2 is the same . [HMDB]
Cobinamide
Cobinamide is an intermediate in porphyrin and chlorophyll metabolism. It is converted to adenosyl cobinamide via the enzyme cob(I)alamin adenosyltransferase [EC:2.5.1.17]. Adenosyl cobinamide is the third to last step in the synthesis of vitamin B12 coenzyme. [HMDB] Cobinamide is an intermediate in porphyrin and chlorophyll metabolism. It is converted to adenosyl cobinamide via the enzyme cob(I)alamin adenosyltransferase [EC:2.5.1.17]. Adenosyl cobinamide is the third to last step in the synthesis of vitamin B12 coenzyme.
Ferrocytochrome
C33H32FeN4O4 (604.1772821999999)
Ferricytochrome is a cytochrome containing reduced (ferrous) iron. Cytochrome c is an electron-carrying protein found in mitochondria of all aerobic organisms. It is part of the terminal oxidation chain, which completes the breakdown of foods to COZ and HzO, storing the liberated chemical energy in molecules of ATP. Like myoglobin, it is an iron porphyrin protein, made up of one heme group and one polypeptide chain. The iron atomalternates between the +2 and +3 oxidation state as the molecule interacts in turn with cytochrome reductase and cytochrome oxidase, each a large multimolecular complex (l-3). One of the goals of the present x-ray analysis is to understand how electron. transfer occurs into and out of cytochrome c, which will ultimately require a knowledge of the molecular structure in both the ferric and ferrous states. Ferricytochrome is a cytochrome containing reduced (ferrous) iron.
Adenosyl cobinamide phosphate
C58H85CoN16O14P (1319.5500459999998)
Adenosyl cobinamide phosphate, a known intermediate of the de novo biosynthetic pathway, is involved in Porphyrin and chlorophyll metabolism.In Salmonella typhimurium LT2, under anaerobic conditions, CobU (EC 2.7.7.62 and EC 2.7.1.156), CobT (EC 2.4.2.21), CobC (EC 3.1.3.73) and CobS (EC 2.7.8.26) catalyse reactions in the nucleotide loop. assembly pathway, which convert adenosylcobinamide (AdoCbi) into. adenosylcobalamin (AdoCbl). CobT and CobC are involved in 5,6-dimethylbenzimidazole activation whereby. 5,6-dimethylbenzimidazole is converted to its riboside,. alpha-ribazole. The second branch of the nuclotide loop assembly. pathway is the cobinamide (Cbi) activation branch where AdoCbi or. adenosylcobinamide-phosphate is converted to the activated. intermediate AdoCbi-GDP by the bifunctional enzyme Cob U. The final. step in adenosylcobalamin biosynthesis is the condensation of. AdoCbi-GDP with alpha-ribazole, which is catalysed by EC 2.7.8.26,. cobalamin synthase (CobS), to yield adenosylcobalamin.
Chenodeoxyglycocholoyl-CoA
Chenodeoxyglycocholoyl-CoA is a coenzyme A derivative of chenodeoxyglycocholate. It is involved in bile acid synthesis and is the penultimate component in the synthesis of chenodeoxyglycocholate. Chenodeoxyglycocholoyl-CoA is synthesized from 3a,7a-dihydroxy-5b-24-oxocholestanoyl-CoA via acetyl-CoA acyltransferase, it is then transformed via glycine N-choloyltransferase to chenodeoxyglycocholate. Chenodeoxyglycocholate is a glycine conjugated bile acid. Bile acids are steroid acids found predominantly in the bile of mammals. The distinction between different bile acids is minute, depending only on the presence or absence of hydroxyl groups on positions 3, 7, and 12. Bile acids are physiological detergents that facilitate excretion, absorption, and transport of fats and sterols in the intestine and liver. Bile acids are also steroidal amphipathic molecules derived from the catabolism of cholesterol. They modulate bile flow and lipid secretion, are essential for the absorption of dietary fats and vitamins, and have been implicated in the regulation of all the key enzymes involved in cholesterol homeostasis. Bile acids recirculate through the liver, bile ducts, small intestine and portal vein to form an enterohepatic circuit. They exist as anions at physiological pH and, consequently, require a carrier for transport across the membranes of the enterohepatic tissues. The unique detergent properties of bile acids are essential for the digestion and intestinal absorption of hydrophobic nutrients. Bile acids have potent toxic properties (e.g. membrane disruption) and there are a plethora of mechanisms to limit their accumulation in blood and tissues (PMID: 11316487, 16037564, 12576301, 11907135).
Heme A
C49H56FeN4O6 (852.3549026000001)
Heme A differs from heme B in that a methyl side chain at ring position 8 is oxidized into a formyl group, and one of the vinyl side chains, at ring position 2, has been replaced by an isoprenoid chain. Like heme B, heme A is often attached to the apoprotein (cytochromes or globins) through a coordination bond between the heme iron and a conserved amino acid side-chain. An example of a metalloprotein that contains heme A is cytochrome c oxidase. Both the formyl group and the isoprenoid side chain are thought to play important roles in conservation of the energy of oxygen reduction by cytochrome c oxidase.(Wikipedia). Heme A differs from heme B in that a methyl side chain at ring position 8 is oxidized into a formyl group, and one of the vinyl side chains, at ring position 2, has been replaced by an isoprenoid chain. Like heme B, heme A is often attached to the apoprotein (cytochromes or globins) through a coordination bond between the heme iron and a conserved amino acid side-chain. An example of a metalloprotein that contains heme A is cytochrome c oxidase. Both the formyl group and the isoprenoid side chain are thought to play important roles in conservation of the energy of oxygen reduction by cytochrome c oxidase. [HMDB]
Nitrosylhaem
C34H32FeN5O5 (646.1752711999999)
Nitrosylhaem is found in animal foods. Nitrosylhaem is a pigment responsible for the pink colouration of cooked cured meat. Pigment responsible for the pink colouration of cooked cured meat. Nitrosylhaem is found in animal foods.
71-hydroxychlorophyll a
C55H71MgN4O6 (907.5223825999999)
71-hydroxychlorophyll a is practically insoluble (in water) and a weakly acidic compound (based on its pKa). 71-hydroxychlorophyll a can be found in a number of food items such as cloudberry, agave, sweet orange, and mandarin orange (clementine, tangerine), which makes 71-hydroxychlorophyll a a potential biomarker for the consumption of these food products.
chlorophyllide b
Chlorophyllide b is a member of the class of compounds known as metallotetrapyrroles. Metallotetrapyrroles are polycyclic compounds containing a tetrapyrrole skeleton combined with a metal atom. Chlorophyllide b is practically insoluble (in water) and an extremely strong acidic compound (based on its pKa). Chlorophyllide b can be found in a number of food items such as cardoon, peach (variety), lime, and loquat, which makes chlorophyllide b a potential biomarker for the consumption of these food products.
dihydrogeranylgeranyl-chlorophyll a
C55H67MgN4O5 (887.4961691999999)
Dihydrogeranylgeranyl-chlorophyll a is practically insoluble (in water) and a very weakly acidic compound (based on its pKa). Dihydrogeranylgeranyl-chlorophyll a can be found in a number of food items such as hard wheat, common mushroom, common sage, and canada blueberry, which makes dihydrogeranylgeranyl-chlorophyll a a potential biomarker for the consumption of these food products.
divinylchlorophyllide a
Divinylchlorophyllide a is practically insoluble (in water) and a weakly acidic compound (based on its pKa). Divinylchlorophyllide a can be found in a number of food items such as wild rice, pecan nut, vaccinium (blueberry, cranberry, huckleberry), and black-eyed pea, which makes divinylchlorophyllide a a potential biomarker for the consumption of these food products.