Cobinamide (BioDeep_00000014597)

Main id: BioDeep_00000898450

 

human metabolite Endogenous


代谢物信息卡片


[(1R,2R,3S,4S,6Z,8S,9S,11Z,14S,18R,19R)-4,9,14-tris(2-carbamoylethyl)-3,8,19-tris(carbamoylmethyl)-18-(2-{[(2R)-2-hydroxypropyl]carbamoyl}ethyl)-2,3,6,8,13,13,16,18-octamethyl-20,21,22,23-tetraazapentacyclo[15.2.1.1^{2,5}.1^{7,10}.1^{12,15}]tricosa-5(23),6,10(22),11,15(21),16-hexaen-20-yl]cobaltbis(ylium)

化学式: C48H72CoN11O8- (989.4897032)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC1=C2C(C(C([N-]2)(C3C(C(C(=N3)C(=C4C(C(C(=N4)C=C5C(C(C1=N5)(C)CC(=O)N)CCC(=O)N)(C)C)CCC(=O)N)C)(C)CCC(=O)NCC(C)O)CC(=O)N)C)(C)CC(=O)N)CCC(=O)N.[Co]
InChI: InChI=1S/C48H73N11O8.Co/c1-23(60)22-55-38(67)16-17-45(6)29(18-35(52)64)43-48(9)47(8,21-37(54)66)28(12-15-34(51)63)40(59-48)25(3)42-46(7,20-36(53)65)26(10-13-32(49)61)30(56-42)19-31-44(4,5)27(11-14-33(50)62)39(57-31)24(2)41(45)58-43

描述信息

Cobinamide is an intermediate in porphyrin and chlorophyll metabolism. It is converted to adenosyl cobinamide via the enzyme cob(I)alamin adenosyltransferase [EC:2.5.1.17]. Adenosyl cobinamide is the third to last step in the synthesis of vitamin B12 coenzyme. [HMDB]
Cobinamide is an intermediate in porphyrin and chlorophyll metabolism. It is converted to adenosyl cobinamide via the enzyme cob(I)alamin adenosyltransferase [EC:2.5.1.17]. Adenosyl cobinamide is the third to last step in the synthesis of vitamin B12 coenzyme.

同义名列表

8 个代谢物同义名

[(1R,2R,3S,4S,6Z,8S,9S,11Z,14S,18R,19R)-4,9,14-tris(2-carbamoylethyl)-3,8,19-tris(carbamoylmethyl)-18-(2-{[(2R)-2-hydroxypropyl]carbamoyl}ethyl)-2,3,6,8,13,13,16,18-octamethyl-20,21,22,23-tetraazapentacyclo[15.2.1.1^{2,5}.1^{7,10}.1^{12,15}]tricosa-5(23),6,10(22),11,15(21),16-hexaen-20-yl]cobaltbis(ylium); cobalt;3-[(1R,2S,3S,4Z,7S,8S,9Z,13S,14Z,17R,18R)-2,7,18-tris(2-amino-2-oxoethyl)-3,13-bis(3-amino-3-oxopropyl)-17-[3-[[(2R)-2-hydroxypropyl]amino]-3-oxopropyl]-1,2,5,7,12,12,15,17-octamethyl-8,13,18,19-tetrahydro-3H-corrin-21-id-8-yl]propanamide; Cobinamide dihydrate; Diaquocobinamide; Cob(I)inamide; Cobinamide; Cobinamid; Cbi



数据库引用编号

9 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

2 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(2)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Tara B Hendry-Hofer, Patrick C Ng, Alison M McGrath, Kirsten Soules, David S Mukai, Adriano Chan, Joseph K Maddry, Carl W White, Jangwoen Lee, Sari B Mahon, Matthew Brenner, Gerry R Boss, Vikhyat S Bebarta. Intramuscular cobinamide as an antidote to methyl mercaptan poisoning. Inhalation toxicology. 2021 01; 33(1):25-32. doi: 10.1080/08958378.2020.1866123. [PMID: 33356664]
  • Tara B Hendry-Hofer, Patrick C Ng, Alison M McGrath, David Mukai, Matthew Brenner, Sari Mahon, Joseph K Maddry, Gerry R Boss, Vikhyat S Bebarta. Intramuscular aminotetrazole cobinamide as a treatment for inhaled hydrogen sulfide poisoning in a large swine model. Annals of the New York Academy of Sciences. 2020 11; 1479(1):159-167. doi: 10.1111/nyas.14339. [PMID: 32233102]
  • Joseph K Dzisam, Matthew Brenner, Sari B Mahon, Gary A Rockwood, Brian A Logue. Determination of free cyano-cobinamide in swine and rabbit plasma by liquid chromatography tandem mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2019 Aug; 1124(?):100-108. doi: 10.1016/j.jchromb.2019.05.020. [PMID: 31185415]
  • Hema Kalyanaraman, Ghania Ramdani, Jisha Joshua, Nadine Schall, Gerry R Boss, Esther Cory, Robert L Sah, Darren E Casteel, Renate B Pilz. A Novel, Direct NO Donor Regulates Osteoblast and Osteoclast Functions and Increases Bone Mass in Ovariectomized Mice. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 2017 01; 32(1):46-59. doi: 10.1002/jbmr.2909. [PMID: 27391172]
  • Jangwoen Lee, Sari B Mahon, David Mukai, Tanya Burney, Behdod S Katebian, Adriano Chan, Vikhyat S Bebarta, David Yoon, Gerry R Boss, Matthew Brenner. The Vitamin B12 Analog Cobinamide Is an Effective Antidote for Oral Cyanide Poisoning. Journal of medical toxicology : official journal of the American College of Medical Toxicology. 2016 12; 12(4):370-379. doi: 10.1007/s13181-016-0566-4. [PMID: 27631586]
  • Michael W Stutelberg, Joseph K Dzisam, Alexandre R Monteil, Ilona Petrikovics, Gerry R Boss, Steven E Patterson, Gary A Rockwood, Brian A Logue. Simultaneous determination of 3-mercaptopyruvate and cobinamide in plasma by liquid chromatography-tandem mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2016 Jan; 1008(?):181-188. doi: 10.1016/j.jchromb.2015.11.027. [PMID: 26655110]
  • Brent A McCracken, Matthew K Brittain. High performance liquid chromatography tandem mass spectrometry assay for the determination of cobinamide in pig plasma. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2015 Dec; 1006(?):104-111. doi: 10.1016/j.jchromb.2015.10.008. [PMID: 26540437]
  • Vikhyat S Bebarta, David A Tanen, Susan Boudreau, Maria Castaneda, Lee A Zarzabal, Toni Vargas, Gerry R Boss. Intravenous cobinamide versus hydroxocobalamin for acute treatment of severe cyanide poisoning in a swine (Sus scrofa) model. Annals of emergency medicine. 2014 Dec; 64(6):612-9. doi: 10.1016/j.annemergmed.2014.02.009. [PMID: 24746273]
  • Dorte L Lildballe, Elena Mutti, Henrik Birn, Ebba Nexo. Maximal load of the vitamin B12 transport system: a study on mice treated for four weeks with high-dose vitamin B12 or cobinamide. PloS one. 2012; 7(10):e46657. doi: 10.1371/journal.pone.0046657. [PMID: 23049711]
  • Evelyne Furger, Sergey N Fedosov, Dorte Launholt Lildballe, Robert Waibel, Roger Schibli, Ebba Nexo, Eliane Fischer. Comparison of recombinant human haptocorrin expressed in human embryonic kidney cells and native haptocorrin. PloS one. 2012; 7(5):e37421. doi: 10.1371/journal.pone.0037421. [PMID: 22662153]
  • Kate E Broderick, Maheswari Balasubramanian, Adriano Chan, Prasanth Potluri, Jake Feala, Darrell D Belke, Andrew McCulloch, Vijay S Sharma, Renate B Pilz, Timothy D Bigby, Gerry R Boss. The cobalamin precursor cobinamide detoxifies nitroprusside-generated cyanide. Experimental biology and medicine (Maywood, N.J.). 2007 Jun; 232(6):789-98. doi: NULL. [PMID: 17526771]
  • S N Fedosov, T E Petersen, E Nexø. Binding of cobalamin and cobinamide to transcobalamin from bovine milk. Biochemistry. 1995 Dec; 34(49):16082-7. doi: 10.1021/bi00049a023. [PMID: 8519765]
  • H Kondo, T Iseki, S Iwasa, K Okuda, S Kanazawa, M Ohto, K Okuda. Cobalamin-dependent replication of L1210 leukemia cells and effects of cobalamin analogues. Acta haematologica. 1989; 81(2):61-9. doi: 10.1159/000205528. [PMID: 2496552]
  • M Hansen, E Nexø. The interaction of human transcobalamin isopeptides in cerebrospinal fluid and plasma with cobalamin and the cellular acceptor. Biochimica et biophysica acta. 1987 Dec; 926(3):359-64. doi: 10.1016/0304-4165(87)90222-4. [PMID: 2825803]
  • V Herbert, N Colman, D Palat, C Manusselis, G Drivas, E Block, A Akerkar, D Weaver, E Frenkel. Is there a 'gold standard' for human serum vitamin B12 assay?. The Journal of laboratory and clinical medicine. 1984 Nov; 104(5):829-41. doi: NULL. [PMID: 6387014]
  • C G Halpin, D J Harris, I W Caple, D S Petterson. Contribution of cobalamin analogues to plasma vitamin B12 concentrations in cattle. Research in veterinary science. 1984 Sep; 37(2):249-51. doi: 10.1016/s0034-5288(18)31915-5. [PMID: 6438747]
  • J Lindemans, H J Neijens, K F Kerrebijn, J Abels. Vitamin B12 absorption in cystic fibrosis. Acta paediatrica Scandinavica. 1984 Jul; 73(4):537-40. doi: 10.1111/j.1651-2227.1984.tb09967.x. [PMID: 6464742]
  • S P Rothenberg, G P Marcoullis, S Schwarz, E Lader. Measurement of cyanocobalamin in serum by a specific radioimmunoassay. The Journal of laboratory and clinical medicine. 1984 Jun; 103(6):959-72. doi: . [PMID: 6726060]
  • T R Rickard, J M Elliot. Effect of factor B on vitamin B12 status and propionate metabolism in sheep. Journal of animal science. 1982 Jul; 55(1):168-73. doi: 10.2527/jas1982.551168x. [PMID: 7118741]
  • N P Kubasik, M Ricotta, H E Sine. Commercially-supplied binders for plasma cobalamin (vitamin B12), analysis--'purified' intrinsic factor, 'cobinamide'-blocked R-protein binder, and non-purified intrinsic factor-R-protein binder--compared to microbiological assay. Clinical chemistry. 1980 Apr; 26(5):598-600. doi: NULL. [PMID: 7261303]