Classification Term: 401

Pyrazolo[1,5-a]pyrimidines (ontology term: CHEMONTID:0004390)

Aromatic heterocyclic compounds containing a pyrazolo[3,4-d]pyrimidine ring system, which consists of a pyrazole ring fused to and sharing exactly one nitrogen atom with a pyrimidine ring." [PMID:17997320]

found 3 associated metabolites at sub_class metabolite taxonomy ontology rank level.

Ancestor: Pyrazolopyrimidines

Child Taxonomies: 3-arylsulfonyl-pyrazolo[1,5-a]pyrimidines

   

Dorsomorphin

4-(6-{4-[2-(piperidin-1-yl)ethoxy]phenyl}pyrazolo[1,5-a]pyrimidin-3-yl)pyridine

C24H25N5O (399.2059)


D004791 - Enzyme Inhibitors > D047428 - Protein Kinase Inhibitors Dorsomorphin (Compound C) is a selective and ATP-competitive AMPK inhibitor (Ki=109 nM in the absence of AMP). Dorsomorphin (BML-275) selectively inhibits BMP type I receptors ALK2, ALK3, and ALK6. Dorsomorphin can reverse autophagy activation and anti-inflammatory effect of Urolithin A (HY-100599)[1][2].