Dorsomorphin (BioDeep_00000178523)
human metabolite blood metabolite
代谢物信息卡片
4-(6-{4-[2-(piperidin-1-yl)ethoxy]phenyl}pyrazolo[1,5-a]pyrimidin-3-yl)pyridine
化学式: C24H25N5O (399.2059)
中文名称: Dorsomorphin(化合物C)(DMSO溶液)
谱图信息:
最多检出来源 not specific(not specific) 0%
分子结构信息
SMILES: C(CN1CCCCC1)OC1=CC=C(C=C1)C1=CN2N=CC(=C2N=C1)C1=CC=NC=C1
InChI: InChI=1S/C24H25N5O/c1-2-12-28(13-3-1)14-15-30-22-6-4-19(5-7-22)21-16-26-24-23(17-27-29(24)18-21)20-8-10-25-11-9-20/h4-11,16-18H,1-3,12-15H2
描述信息
D004791 - Enzyme Inhibitors > D047428 - Protein Kinase Inhibitors
Dorsomorphin (Compound C) is a selective and ATP-competitive AMPK inhibitor (Ki=109 nM in the absence of AMP). Dorsomorphin (BML-275) selectively inhibits BMP type I receptors ALK2, ALK3, and ALK6. Dorsomorphin can reverse autophagy activation and anti-inflammatory effect of Urolithin A (HY-100599)[1][2].
同义名列表
9 个代谢物同义名
4-(6-{4-[2-(piperidin-1-yl)ethoxy]phenyl}pyrazolo[1,5-a]pyrimidin-3-yl)pyridine; 4-(6-(4-(2-(Piperidin-1-yl)ethoxy)phenyl)pyrazolo(1,5-a)pyrimidin-3-yl)pyridine; 6-(4-(2-(1-Piperidinyl)ethoxy)phenyl)-3-(4-pyridinyl)pyrazolo(1,5-a)pyrimidine; (6-(4-(2-Piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine; AMPK inhibitor, compound C; Compound C dorsomorphin; dorsomorphin; Compound C; BML-275
数据库引用编号
7 个数据库交叉引用编号
- ChEBI: CHEBI:78510
- PubChem: 11524144
- HMDB: HMDB0251590
- DrugBank: DB08597
- ChEMBL: CHEMBL478629
- CAS: 866405-64-3
- medchemexpress: HY-13418A
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
2 个相关的物种来源信息
- 9606 - Homo sapiens: -
- 78534 - Trigonella foenum-graecum: 10.1016/J.JPBA.2012.11.005
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
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BMC complementary medicine and therapies.
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2023 Jun; ?(?):116773. doi:
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2023 May; 313(?):116581. doi:
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European review for medical and pharmacological sciences.
2022 04; 26(7):2489-2500. doi:
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10.1016/j.bbamem.2013.05.026. [PMID: 23747367] - K Karthikeyan, Mahamad Yunnus A Mahat, S Chandrasekaran, K Gopal, P X Franklin, Balasubramanian Jaganatha Sivakumar, Gajendra Singh, Shridhar Narayanan, B Gopalan, Ansar A Khan. Bioanalytical method development, validation and quantification of dorsomorphin in rat plasma by LC-MS/MS.
Biomedical chromatography : BMC.
2013 Aug; 27(8):1018-26. doi:
10.1002/bmc.2899. [PMID: 23526253] - Yong Pil Hwang, Hyung Gyun Kim, Jae Ho Choi, Minh Truong Do, Young Chul Chung, Tae Cheon Jeong, Hye Gwang Jeong. S-allyl cysteine attenuates free fatty acid-induced lipogenesis in human HepG2 cells through activation of the AMP-activated protein kinase-dependent pathway.
The Journal of nutritional biochemistry.
2013 Aug; 24(8):1469-78. doi:
10.1016/j.jnutbio.2012.12.006. [PMID: 23465592] - Fei Fang, George C Liu, Crystal Kim, Rana Yassa, Joyce Zhou, James W Scholey. Adiponectin attenuates angiotensin II-induced oxidative stress in renal tubular cells through AMPK and cAMP-Epac signal transduction pathways.
American journal of physiology. Renal physiology.
2013 Jun; 304(11):F1366-74. doi:
10.1152/ajprenal.00137.2012. [PMID: 23535586] - Craig Beall, Kenneth R Watterson, Rory J McCrimmon, Michael L J Ashford. AMPK modulates glucose-sensing in insulin-secreting cells by altered phosphotransfer to KATP channels.
Journal of bioenergetics and biomembranes.
2013 Jun; 45(3):229-41. doi:
10.1007/s10863-013-9509-9. [PMID: 23575945] - Hyun Jin Kwon, Go-Eun Kim, Yun Taek Lee, Meong-Sook Jeong, Insug Kang, Dongki Yang, Eui-Ju Yeo. Inhibition of platelet-derived growth factor receptor tyrosine kinase and downstream signaling pathways by Compound C.
Cellular signalling.
2013 Apr; 25(4):883-97. doi:
10.1016/j.cellsig.2012.12.016. [PMID: 23277201] - Hai Yan Quan, Do Yeon Kim, Sung Hyun Chung. Caffeine attenuates lipid accumulation via activation of AMP-activated protein kinase signaling pathway in HepG2 cells.
BMB reports.
2013 Apr; 46(4):207-12. doi:
10.5483/bmbrep.2013.46.4.153. [PMID: 23615262] - Yong Pil Hwang, Jae Ho Choi, Hyung Gyun Kim, Tilak Khanal, Gye Young Song, Myoung Soo Nam, Hyun-Sun Lee, Young Chul Chung, Young Chun Lee, Hye Gwang Jeong. Saponins, especially platycodin D, from Platycodon grandiflorum modulate hepatic lipogenesis in high-fat diet-fed rats and high glucose-exposed HepG2 cells.
Toxicology and applied pharmacology.
2013 Mar; 267(2):174-83. doi:
10.1016/j.taap.2013.01.001. [PMID: 23319015] - Jing Xiao, Bing Sun, Ming Li, Ying Wu, Xiao-Bo Sun. A novel adipocytokine visfatin protects against H(2)O(2) -induced myocardial apoptosis: a missing link between obesity and cardiovascular disease.
Journal of cellular physiology.
2013 Mar; 228(3):495-501. doi:
10.1002/jcp.24257. [PMID: 23065734] - Blanca Herrera, María García-Álvaro, Silvia Cruz, Peter Walsh, Margarita Fernández, Cesáreo Roncero, Isabel Fabregat, Aránzazu Sánchez, Gareth J Inman. BMP9 is a proliferative and survival factor for human hepatocellular carcinoma cells.
PloS one.
2013; 8(7):e69535. doi:
10.1371/journal.pone.0069535. [PMID: 23936038] - Lin Li, Yongqiang Chen, Spencer B Gibson. Starvation-induced autophagy is regulated by mitochondrial reactive oxygen species leading to AMPK activation.
Cellular signalling.
2013 Jan; 25(1):50-65. doi:
10.1016/j.cellsig.2012.09.020. [PMID: 23000343] - Yan Geng, Lian Li, Yingying Dong, Xue Liu, Xiao-He Li, Wen Ning. Impaired elastin deposition in Fstl1-/- lung allograft under the renal capsule.
PloS one.
2013; 8(11):e81368. doi:
10.1371/journal.pone.0081368. [PMID: 24282586] - Evelien Gebruers, María Lorena Cordero-Maldonado, Alexander I Gray, Carol Clements, Alan L Harvey, Ruangelie Edrada-Ebel, Peter A M de Witte, Alexander D Crawford, Camila V Esguerra. A phenotypic screen in zebrafish identifies a novel small-molecule inducer of ectopic tail formation suggestive of alterations in non-canonical Wnt/PCP signaling.
PloS one.
2013; 8(12):e83293. doi:
10.1371/journal.pone.0083293. [PMID: 24349481] - P Skrobuk, S von Kraemer, M M Semenova, A Zitting, H A Koistinen. Acute exposure to resveratrol inhibits AMPK activity in human skeletal muscle cells.
Diabetologia.
2012 Nov; 55(11):3051-60. doi:
10.1007/s00125-012-2691-1. [PMID: 22898769] - R Narcisi, L Signorile, J A N Verhaar, P Giannoni, G J V M van Osch. TGFβ inhibition during expansion phase increases the chondrogenic re-differentiation capacity of human articular chondrocytes.
Osteoarthritis and cartilage.
2012 Oct; 20(10):1152-60. doi:
10.1016/j.joca.2012.06.010. [PMID: 22772045] - Christina A Shugrue, Martine Alexandre, Alexander Diaz de Villalvilla, Thomas R Kolodecik, Lawrence H Young, Fred S Gorelick, Edwin C Thrower. Cerulein hyperstimulation decreases AMP-activated protein kinase levels at the site of maximal zymogen activation.
American journal of physiology. Gastrointestinal and liver physiology.
2012 Sep; 303(6):G723-32. doi:
10.1152/ajpgi.00082.2012. [PMID: 22821946] - Hisanori Kurooka, Takeshi Nakahiro, Kentaro Mori, Kazuo Sano, Yoshifumi Yokota. BMP signaling is responsible for serum-induced Id2 expression.
Biochemical and biophysical research communications.
2012 Apr; 420(2):281-7. doi:
10.1016/j.bbrc.2012.02.150. [PMID: 22421219] - Soon Shik Shin, Dongmin Park, Hee Young Lee, Yeonhee Hong, Jeonghyun Choi, Jaeho Oh, Hyunghee Lee, Hye Rim Lee, Mi Ryeo Kim, Zhi Bin Shen, Hong Hua Cui, Michung Yoon. The herbal composition GGEx18 from Laminaria japonica, Rheum palmatum, and Ephedra sinica reduces obesity via skeletal muscle AMPK and PPARα.
Pharmaceutical biology.
2012 Apr; 50(4):506-15. doi:
10.3109/13880209.2011.618502. [PMID: 22129093] - Peng Guo, Ze-qin Lian, Ling-hui Sheng, Chong-ming Wu, Jian Gao, Jin Li, Yao Wang, Yan-shen Guo, Hai-bo Zhu. The adenosine derivative 2',3',5'-tri-O-acetyl-N6-(3-hydroxylaniline) adenosine activates AMPK and regulates lipid metabolism in vitro and in vivo.
Life sciences.
2012 Jan; 90(1-2):1-7. doi:
10.1016/j.lfs.2011.09.001. [PMID: 21939670] - Andrea Hirsch, Dagmar Hahn, Petra Kempná, Gaby Hofer, Primus E Mullis, Jean-Marc Nuoffer, Christa E Flück. Role of AMP-activated protein kinase on steroid hormone biosynthesis in adrenal NCI-H295R cells.
PloS one.
2012; 7(1):e30956. doi:
10.1371/journal.pone.0030956. [PMID: 22295121] - Yucun Niu, Songtao Li, Lixin Na, Rennan Feng, Liyan Liu, Ying Li, Changhao Sun. Mangiferin decreases plasma free fatty acids through promoting its catabolism in liver by activation of AMPK.
PloS one.
2012; 7(1):e30782. doi:
10.1371/journal.pone.0030782. [PMID: 22292039] - Khang Wei Ong, Annie Hsu, Benny Kwong Huat Tan. Chlorogenic acid stimulates glucose transport in skeletal muscle via AMPK activation: a contributor to the beneficial effects of coffee on diabetes.
PloS one.
2012; 7(3):e32718. doi:
10.1371/journal.pone.0032718. [PMID: 22412912] - Eva B Nygaard, Sara G Vienberg, Cathrine Ørskov, Harald S Hansen, Birgitte Andersen. Metformin stimulates FGF21 expression in primary hepatocytes.
Experimental diabetes research.
2012; 2012(?):465282. doi:
10.1155/2012/465282. [PMID: 23118742] - Keanae Jo, Seung-Eun Lee, Sang-Won Lee, Jae-Kwan Hwang. Prunus yedoensis Matsum. stimulates glucose uptake in L6 rat skeletal muscle cells by activating AMP-activated protein kinase and phosphatidylinositol 3-kinase/Akt pathways.
Natural product research.
2012; 26(17):1610-5. doi:
10.1080/14786419.2011.574133. [PMID: 21809954] - Yong-Qiang Liu, Xin Cheng, Liang-Xia Guo, Chan Mao, Yi-Jie Chen, Hai-Xia Liu, Qi-Cai Xiao, Sheng Jiang, Zhu-Jun Yao, Guang-Biao Zhou. Identification of an annonaceous acetogenin mimetic, AA005, as an AMPK activator and autophagy inducer in colon cancer cells.
PloS one.
2012; 7(10):e47049. doi:
10.1371/journal.pone.0047049. [PMID: 23056575] - Wilfred Lieberthal, Leiqing Zhang, Vimal A Patel, Jerrold S Levine. AMPK protects proximal tubular cells from stress-induced apoptosis by an ATP-independent mechanism: potential role of Akt activation.
American journal of physiology. Renal physiology.
2011 Dec; 301(6):F1177-92. doi:
10.1152/ajprenal.00034.2011. [PMID: 21957177] - Qiu-Xia Zhang, Maryam Nakhaei-Nejad, George Haddad, Xuemei Wang, Rodger Loutzenhiser, Allan G Murray. Glomerular endothelial PI3 kinase-α couples to VEGFR2, but is not required for eNOS activation.
American journal of physiology. Renal physiology.
2011 Dec; 301(6):F1242-50. doi:
10.1152/ajprenal.00662.2010. [PMID: 21937609] - Jin-Taek Hwang, Ock Jin Park, Yun Kyung Lee, Mi Jeong Sung, Haeng Jeon Hur, Myung Sunny Kim, Joo Hun Ha, Dae Young Kwon. Anti-tumor effect of luteolin is accompanied by AMP-activated protein kinase and nuclear factor-κB modulation in HepG2 hepatocarcinoma cells.
International journal of molecular medicine.
2011 Jul; 28(1):25-31. doi:
10.3892/ijmm.2011.667. [PMID: 21468539] - Gau-Jun Tang, Hsin-Yi Wang, Jen-Ying Wang, Chih-Chieh Lee, Hsu-Wen Tseng, Yuh-Lin Wu, Song-Kun Shyue, Tzong-Shyuan Lee, Yu Ru Kou. Novel role of AMP-activated protein kinase signaling in cigarette smoke induction of IL-8 in human lung epithelial cells and lung inflammation in mice.
Free radical biology & medicine.
2011 Jun; 50(11):1492-502. doi:
10.1016/j.freeradbiomed.2011.02.030. [PMID: 21376115] - Bo Huang, Hai Dan Yuan, Do Yeon Kim, Hai Yan Quan, Sung Hyun Chung. Cinnamaldehyde prevents adipocyte differentiation and adipogenesis via regulation of peroxisome proliferator-activated receptor-γ (PPARγ) and AMP-activated protein kinase (AMPK) pathways.
Journal of agricultural and food chemistry.
2011 Apr; 59(8):3666-73. doi:
10.1021/jf104814t. [PMID: 21401097] - Atsuko Tomizawa, Yoshiyuki Hattori, Teruo Inoue, Sachiko Hattori, Kikuo Kasai. Fenofibrate suppresses microvascular inflammation and apoptosis through adenosine monophosphate-activated protein kinase activation.
Metabolism: clinical and experimental.
2011 Apr; 60(4):513-22. doi:
10.1016/j.metabol.2010.04.020. [PMID: 20580385] - Konstantin Tsoyi, Hwa Jin Jang, Irina Tsoy Nizamutdinova, Young Min Kim, Young Soo Lee, Hye Jung Kim, Han Geuk Seo, Jae Heun Lee, Ki Churl Chang. Metformin inhibits HMGB1 release in LPS-treated RAW 264.7 cells and increases survival rate of endotoxaemic mice.
British journal of pharmacology.
2011 Apr; 162(7):1498-508. doi:
10.1111/j.1476-5381.2010.01126.x. [PMID: 21091653] - George A Lemieux, Jason Liu, Nasima Mayer, Roland J Bainton, Kaveh Ashrafi, Zena Werb. A whole-organism screen identifies new regulators of fat storage.
Nature chemical biology.
2011 Apr; 7(4):206-13. doi:
10.1038/nchembio.534. [PMID: 21390037] - Ryota Narishima, Masahiro Yamasaki, Shinya Hasegawa, Saki Yoshida, Shinya Tanaka, Tetsuya Fukui. Leptin controls ketone body utilization in hypothalamic neuron.
Neuroscience letters.
2011 Mar; 490(3):185-90. doi:
10.1016/j.neulet.2010.11.081. [PMID: 21194556] - Ines Lohse, Patrick Reilly, Kathrin Zaugg. The CPT1C 5'UTR contains a repressing upstream open reading frame that is regulated by cellular energy availability and AMPK.
PloS one.
2011; 6(9):e21486. doi:
10.1371/journal.pone.0021486. [PMID: 21961029] - Myoung-Su Lee, Kyung Jin Kim, Daeyoung Kim, Kyung-Eun Lee, Jae-Kwan Hwang. meso-Dihydroguaiaretic acid inhibits hepatic lipid accumulation by activating AMP-activated protein kinase in human HepG2 cells.
Biological & pharmaceutical bulletin.
2011; 34(10):1628-30. doi:
10.1248/bpb.34.1628. [PMID: 21963507] - Sujit K Bhutia, Timothy P Kegelman, Swadesh K Das, Belal Azab, Zhao-Zhong Su, Seok-Geun Lee, Devanand Sarkar, Paul B Fisher. Astrocyte elevated gene-1 induces protective autophagy.
Proceedings of the National Academy of Sciences of the United States of America.
2010 Dec; 107(51):22243-8. doi:
10.1073/pnas.1009479107. [PMID: 21127263] - Daiane S Alves, Glen A Farr, Patricia Seo-Mayer, Michael J Caplan. AS160 associates with the Na+,K+-ATPase and mediates the adenosine monophosphate-stimulated protein kinase-dependent regulation of sodium pump surface expression.
Molecular biology of the cell.
2010 Dec; 21(24):4400-8. doi:
10.1091/mbc.e10-06-0507. [PMID: 20943949] - Suofu Qin, Gerard A Rodrigues. Differential roles of AMPKα1 and AMPKα2 in regulating 4-HNE-induced RPE cell death and permeability.
Experimental eye research.
2010 Dec; 91(6):818-24. doi:
10.1016/j.exer.2010.10.007. [PMID: 21029733] - Yung-Chieh Tsai, Yen-Mei Lee, Kwok-Keung Lam, Yu-Chuan Wu, Mao-Hsiung Yen, Pao-Yun Cheng. The role of hypothalamic AMP-activated protein kinase in ovariectomy-induced obesity in rats.
Menopause (New York, N.Y.).
2010 Nov; 17(6):1194-200. doi:
10.1097/gme.0b013e3181dfca27. [PMID: 20613671] - James Kain Ching, Pooja Rajguru, Nandhini Marupudi, Sankha Banerjee, Jonathan S Fisher. A role for AMPK in increased insulin action after serum starvation.
American journal of physiology. Cell physiology.
2010 Nov; 299(5):C1171-9. doi:
10.1152/ajpcell.00514.2009. [PMID: 20810907] - Myoung-Su Lee, Daeyoung Kim, Keunae Jo, Jae-Kwan Hwang. Nordihydroguaiaretic acid protects against high-fat diet-induced fatty liver by activating AMP-activated protein kinase in obese mice.
Biochemical and biophysical research communications.
2010 Oct; 401(1):92-7. doi:
10.1016/j.bbrc.2010.09.016. [PMID: 20836990] - Jaw-Shiun Tsai, Ching-Yu Chen, Yuh-Lien Chen, Lee-Ming Chuang. Rosiglitazone inhibits monocyte/macrophage adhesion through de novo adiponectin production in human monocytes.
Journal of cellular biochemistry.
2010 Aug; 110(6):1410-9. doi:
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