Classification Term: 325
Pyrrolidine-2-ones (ontology term: CHEMONTID:0003031)
Pyrrolidines which bear a C=O group at position 2 of the pyrrolidine ring." []
found 19 associated metabolites at category metabolite taxonomy ontology rank level.
Ancestor: Pyrrolidones
Child Taxonomies: There is no child term of current ontology term.
N-VINYL-2-PYRROLIDONE
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Succinimide
Succinimide is an organic compound with the formula (CH2)2(CO)2NH. This white solid is used in a variety of organic syntheses, as well as in some industrial silver plating processes. The compound is classified as a cyclic imide. It may be prepared by thermal decomposition of ammonium succinate.[4] Succinimide, also known as butanimide, belongs to the class of organic compounds known as pyrrolidine-2-ones. These are pyrrolidines that bear a C=O group at position 2 of the pyrrolidine ring. Succinimide has been identified in urine (PMID: 22409530). Succinimides refers to compounds that contain the succinimide group. These compounds have some notable uses. Several succinimides are used as anticonvulsant drugs, including ethosuximide, phensuximide, and methsuximide.[5] Succinimides are also used to form covalent bonds between proteins or peptides and plastics, which is useful in a variety of assay techniques. Succinimide. CAS Common Chemistry. CAS, a division of the American Chemical Society, n.d. https://commonchemistry.cas.org/detail?cas_rn=123-56-8 (retrieved 2024-06-29) (CAS RN: 123-56-8). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).
Ethosuximide
Ethosuximide is only found in individuals that have used or taken this drug. It is an anticonvulsant especially useful in the treatment of absence seizures unaccompanied by other types of seizures. [PubChem]Binds to T-type voltage sensitive calcium channels. Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1G gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by mibefradil. A particularity of this type of channels is an opening at quite negative potentials and a voltage-dependent inactivation. T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle. They may also be involved in the modulation of firing patterns of neurons which is important for information processing as well as in cell growth processes. N - Nervous system > N03 - Antiepileptics > N03A - Antiepileptics > N03AD - Succinimide derivatives C78272 - Agent Affecting Nervous System > C264 - Anticonvulsant Agent D002491 - Central Nervous System Agents > D000927 - Anticonvulsants
2-Pyrrolidinone
2-Pyrrolidinone is a lactam cyclization product of gamma-aminobutyric acid (GABA) (PMID 10332870). Vigabatrin (VGB, an antiepileptic drug) increases human brain gamma-aminobutyric acid (GABA) and the related metabolites, including 2-pyrrolidinone. Patients taking VGB are expected to have an increase of these metabolites (PMID 10403220, 10840398). 2-Pyrrolidone is an organic compound consisting of a five-membered lactam. It is a colorless liquid which is used in industrial settings as a high-boiling non-corrosive polar solvent for a wide variety of applications. It is miscible with a wide variety of other solvents including water, ethanol, diethyl ether, chloroform, benzene, ethyl acetate and carbon disulfide. Pyrrolidin-2-one is the simplest member of the class of pyrrolidin-2-ones, consisting of pyrrolidine in which the hydrogens at position 2 are replaced by an oxo group. The lactam arising by the formal intramolecular condensation of the amino and carboxy groups of gamma-aminobutyric acid (GABA). It has a role as a polar solvent and a metabolite. 2-Pyrrolidinone is a natural product found in Ascochyta medicaginicola, Microtropis japonica, and other organisms with data available. The simplest member of the class of pyrrolidin-2-ones, consisting of pyrrolidine in which the hydrogens at position 2 are replaced by an oxo group. The lactam arising by the formal intramolecular condensation of the amino and carboxy groups of gamma-aminobutyric acid (GABA). Present in red ginseng 2-Pyrrolidone. CAS Common Chemistry. CAS, a division of the American Chemical Society, n.d. https://commonchemistry.cas.org/detail?cas_rn=616-45-5 (retrieved 2024-07-01) (CAS RN: 616-45-5). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).
Pterolactam
Constituent of Pteridium aquilinum (bracken fern). Pterolactam is found in green vegetables and root vegetables. Pterolactam is found in green vegetables. Pterolactam is a constituent of Pteridium aquilinum (bracken fern).
Eupolauridine
Eupolauridine is an alkaloid from the bark of Cananga odorata (ylang ylang
3-(Dichloromethylene)-2,5-pyrrolidinedione
Bacterial mutagen produced by chlorination of simulated poultry chiller water Bacterial mutagen produced by chlorination of simulated poultry chiller wate
3-Chloro-4-(dichloromethylene)-2,5-pyrrolidinedione
Bacterial mutagen produced by chlorination of simulated poultry chiller water Bacterial mutagen produced by chlorination of simulated poultry chiller wate
3,3-Dichloro-4-(dichloromethylene)-2,5-pyrrolidinedione
Bacterial mutagen produced by chlorination of simulated poultry chiller water Bacterial mutagen produced by chlorination of simulated poultry chiller wate
