Classification Term: 2799
Purine nucleotide sugars (ontology term: CHEMONTID:0001293)
Purine nucleotides bound to a saccharide derivative through the terminal phosphate group." []
found 23 associated metabolites at sub_class metabolite taxonomy ontology rank level.
Ancestor: Purine nucleotides
Child Taxonomies: There is no child term of current ontology term.
Guanosine diphosphate mannose
Guanosine diphosphate mannose, also known as gdp-D-mannose or guanosine pyrophosphoric acid mannose, is a member of the class of compounds known as purine nucleotide sugars. Purine nucleotide sugars are purine nucleotides bound to a saccharide derivative through the terminal phosphate group. Guanosine diphosphate mannose is slightly soluble (in water) and a moderately acidic compound (based on its pKa). Guanosine diphosphate mannose can be found in a number of food items such as sorrel, common persimmon, citrus, and butternut, which makes guanosine diphosphate mannose a potential biomarker for the consumption of these food products. Guanosine diphosphate mannose exists in all living species, ranging from bacteria to humans. In humans, guanosine diphosphate mannose is involved in a couple of metabolic pathways, which include fructose and mannose degradation and fructose intolerance, hereditary. Guanosine diphosphate mannose is also involved in fructosuria, which is a metabolic disorder. Guanosine diphosphate mannose or GDP-mannose is a nucleotide sugar that is a substrate for glycosyltransferase reactions in metabolism. This compound is a substrate for enzymes called mannosyltransferases . GDP-mannose is a nucleoside diphosphate sugar that is important in the production of fucosylated oligosaccharides. In particular, GDP-mannose is converted to GDP-fucose, which is the fucose donor in the construction of all mammalian fucosylated glycans. GDP-mannose is transformed to GDP-fucose via three enzymatic reactions carried out by two proteins, GDP-mannose 4,6-dehydratase (GMD) and a second enzyme, GDP-keto-6-deoxymannose 3,5-epimerase, 4-reductase. GDP-mannose 4,6-dehydratase (EC 4.2.1.47) catalyzes the chemical reaction: GDP-mannose <--> GDP-4-dehydro-6-deoxy-D-mannose + H2O. The epimerase converts the GDP-4-dehydro-6-deoxy-D-mannose to GDP-fucose (PMID: 12651883). GDP-mannose is also synthesized from mannose 1-phosphate via the enzyme ATP-mannose-1-phosphate-guanyltransferase and GTP. Acquisition and generation of the data is financially supported in part by CREST/JST.
ADP-glucose
ADP-glucose serves as the glycosyl donor for formation of bacterial glycogen, amylose in green algae, and amylopectin in higher plants. ADP-glucose has been found to be a metabolite of Escherichia (PMID: 25102309). Acquisition and generation of the data is financially supported in part by CREST/JST.
GDP-L-fucose
GDP-L-fucose is a sugar nucleotide and a readily available source of fucose. Fucose is a deoxyhexose that is found in nearly all plant and animal species. The monosaccharide plays several important metabolic roles in complex carbohydrates and in glycoproteins. Fucosylated oligosaccharides are involved in cell-cell recognition, selectin-mediated leukocyte-endothelial adhesion, and mouse embryogenesis. They form the basis of the Lewis-type blood group antigens, are involved in the formation of atherosclerosis, and mediate host-bacterial interactions. A decrease in the availability of fucose is associated with leukocyte adhesion deficiency type-II disorder, and fucosylated glycoproteins have been implicated in memory processes. Fucose is made available during the synthesis of fucosylated glycolipids, oligosaccharides, and glycoproteins via a sugar nucleotide intermediate, specifically GDP-L-fucose. GTP-L-fucose pyrophosphorylase (GFPP, E. C. 2.7.7.30) catalyzes the reversible condensation of guanosine triphosphate and beta-L-fucose-1-phosphate to form the nucleotide-sugar GDP-L-fucose. The enzyme functions primarily in the mammalian liver and kidney to salvage free L-fucose during the breakdown of glycolipids and glycoproteins. (PMID: 16086588). Gdp-l-fucose, also known as gdp fucose or guanosine diphosphate fucose, is a member of the class of compounds known as purine nucleotide sugars. Purine nucleotide sugars are purine nucleotides bound to a saccharide derivative through the terminal phosphate group. Gdp-l-fucose is slightly soluble (in water) and a moderately acidic compound (based on its pKa). Gdp-l-fucose can be found in a number of food items such as breadnut tree seed, okra, pineapple, and pitanga, which makes gdp-l-fucose a potential biomarker for the consumption of these food products. Gdp-l-fucose can be found primarily throughout most human tissues. Gdp-l-fucose exists in all living organisms, ranging from bacteria to humans. In humans, gdp-l-fucose is involved in a couple of metabolic pathways, which include fructose and mannose degradation and fructose intolerance, hereditary. Gdp-l-fucose is also involved in fructosuria, which is a metabolic disorder. Acquisition and generation of the data is financially supported in part by CREST/JST.
Adenosine diphosphate ribose
Adenosine diphosphate ribose is a molecule formed into poly(ADP-ribose) or PAR chains by the enzyme poly ADP ribose polymerase or PARP. PARP is found in every cell nucleus. Its main role is to detect and signal single-strand DNA breaks (SSB) to the enzymatic machinery involved in the SSB repair. PARP activation is an immediate cellular response to metabolic, chemical, or radiation-induced DNA SSB damage. Once PARP detects a SSB, it binds to the DNA, and, after a structural change, begins the synthesis of a poly (ADP-ribose) chain (PAR) as a signal for the other DNA-repairing enzymes such as DNA ligase III (LigIII), DNA polymerase beta, and scaffolding proteins such as X-ray cross-complementing gene 1 (XRCC1). After repairing, the PAR chains are degraded via PAR glycohydrolase (PARG). ADP-ribose binds to and activates the TRPM2 ion channel. Adenosine diphosphate ribose is an intermediate in NAD metabolism. The enzyme NAD(P)+ nucleosidase [EC:3.2.2.6] catalyzes the production of this metabolite from nicotinamide adenine dinucleotide phosphate. This reaction is irreversible and occurs in the cytosol. Adenosine diphosphate ribose is a molecule formed into chains by the enzyme poly ADP ribose polymerase. COVID info from PDB, Protein Data Bank Corona-virus Coronavirus SARS-CoV-2 COVID-19 SARS-CoV COVID19 SARS2 SARS
ADP-Ribosyl-L-arginine
ADP-Ribosyl-L-arginine is the substrate of the protein ADP-ribosylarginine hydrolase (EC-Number 3.2.2.19 ), removing ADP-ribose from arginine residues in ADP ribosylated proteins. Arginine residues in proteins act as acceptors, catalyzing the NAD (+)-dependent activation of the enzyme adenylate cyclase (EC 4.6.1.1). (MetaCyc) [HMDB] ADP-Ribosyl-L-arginine is the substrate of the protein ADP-ribosylarginine hydrolase (EC-Number 3.2.2.19 ), removing ADP-ribose from arginine residues in ADP ribosylated proteins. Arginine residues in proteins act as acceptors, catalyzing the NAD (+)-dependent activation of the enzyme adenylate cyclase (EC 4.6.1.1). (MetaCyc).
GDP-4-Dehydro-6-deoxy-D-mannose
GDP-4-Dehydro-6-deoxy-D-mannose is an intermediate in the fucosylation of mammalian cells. The functional significance of these fucosylated glycans is unclear, although there is evidence that the sialyl Lex determinant participaates in leukocyte adhesion and trafficking processes. GDP-4-Dehydro-6-deoxy-D-mannose is generated by GDP-D-mannose-4,6-dehydratase (GMD). This compound is then converted by the FX protein (GDP-4-keto-6-D-deoxymannose epimerase/GDP-4-keto-6-L-galactose reductase) to GDP-L-fucose. (PMID: 11698403) [HMDB]. GDP-4-Dehydro-6-deoxy-D-mannose is found in many foods, some of which are bayberry, cherimoya, greenthread tea, and pulses. GDP-4-Dehydro-6-deoxy-D-mannose is an intermediate in the fucosylation of mammalian cells. The functional significance of these fucosylated glycans is unclear, although there is evidence that the sialyl Lex determinant participaates in leukocyte adhesion and trafficking processes. GDP-4-Dehydro-6-deoxy-D-mannose is generated by GDP-D-mannose-4,6-dehydratase (GMD). This compound is then converted by the FX protein (GDP-4-keto-6-D-deoxymannose epimerase/GDP-4-keto-6-L-galactose reductase) to GDP-L-fucose. (PMID: 11698403). COVID info from COVID-19 Disease Map Corona-virus Coronavirus SARS-CoV-2 COVID-19 SARS-CoV COVID19 SARS2 SARS
ADP-ribose 2'-phosphate
ADP-ribose 2-phosphate is an intermediate metabolite in vitamin and cofactor metabolism, more specifically NAD metabolism. In the cytosol, ADP-ribose 2-phosphate is irreversibly produced from NADP via the enzyme NAD(P)+ nucleosidase [EC:3.2.2.6]. (BiGG Database). COVID info from PDB, Protein Data Bank Corona-virus Coronavirus SARS-CoV-2 COVID-19 SARS-CoV COVID19 SARS2 SARS
NADHX
(6s)-6-beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide, also known as (S)-nadh-hydrate or (S)-nadhx, is a member of the class of compounds known as purine nucleotide sugars. Purine nucleotide sugars are purine nucleotides bound to a saccharide derivative through the terminal phosphate group (6s)-6-beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide is slightly soluble (in water) and a moderately acidic compound (based on its pKa). (6s)-6-beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide can be found in a number of food items such as angelica, pomegranate, purple laver, and catjang pea, which makes (6s)-6-beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide a potential biomarker for the consumption of these food products (6s)-6-beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide exists in all living organisms, ranging from bacteria to humans. NADHX, also known as monohydroxytetrahydronicotinamide adenine dinucleotide, belongs to the class of organic compounds known as purine nucleotide sugars. These are purine nucleotides bound to a saccharide derivative through the terminal phosphate group. NADHX is a very strong basic compound (based on its pKa). NADHX exists in all living organisms, ranging from bacteria to humans. Outside of the human body, NADHX has been detected, but not quantified in, several different foods, such as pineapples, fireweeds, silver lindens, mentha (mint), and broad beans. This could make NADHX a potential biomarker for the consumption of these foods. NADHX is a substrate for ATP-dependent NAD(P)H-hydrate dehydratase.
O-acetyl-ADP-ribose
O-acetyl-adp-ribose is part of the Amphetamine addiction pathway. It is a substrate for: NAD-dependent protein deacetylase sirtuin-1, NAD-dependent protein deacetylase sirtuin-2, NAD-dependent protein deacetylase sirtuin-3, mitochondrial, NAD-dependent protein deacetylase sirtuin-4, NAD-dependent protein deacetylase sirtuin-6, and NAD-dependent protein deacetylase sirtuin-7. COVID info from COVID-19 Disease Map Corona-virus Coronavirus SARS-CoV-2 COVID-19 SARS-CoV COVID19 SARS2 SARS
GDP-4-Dehydro-6-L-deoxygalactose
A human metabolite taken as a putative food compound of mammalian origin [HMDB] A human metabolite taken as a putative food compound of mammalian origin.
GDP-D-Rhamnose
GDP-D-rhamnose is produced in virus-infected cells. Rhamnose is components of the glycans attached to capsid protein, the pathway could circumvent a limited supply of GDP sugars by the algal host.(http://www.jbc.org/cgi/content/abstract/278/24/21559) [HMDB] GDP-D-rhamnose is produced in virus-infected cells. Rhamnose is components of the glycans attached to capsid protein, the pathway could circumvent a limited supply of GDP sugars by the algal host.(http://www.jbc.org/cgi/content/abstract/278/24/21559).
GDP-glucose
Acquisition and generation of the data is financially supported in part by CREST/JST. GDP-glucose is a substrate for Uridine diphosphate glucose pyrophosphatase. [HMDB] GDP-glucose is a substrate for Uridine diphosphate glucose pyrophosphatase.
ADP-Mannose
ADP-mannose is one of the major substrates of human hydrolases. Nudix hydrolases catalyze the hydrolysis of a variety of nucleoside diphosphate derivatives, and ADP-sugar pyrophosphatase are non-specific nucleoside diphosphosugar or diphosphoalcohol (NDP-X) pyrophosphatases, which hydrolyse some nonreducing NDP-X substrates. It has been found in erythrocytes, placenta and liver. (PMID: 1128712, 10722730, 9693963) [HMDB] ADP-mannose is one of the major substrates of human hydrolases. Nudix hydrolases catalyze the hydrolysis of a variety of nucleoside diphosphate derivatives, and ADP-sugar pyrophosphatase are non-specific nucleoside diphosphosugar or diphosphoalcohol (NDP-X) pyrophosphatases, which hydrolyse some nonreducing NDP-X substrates. It has been found in erythrocytes, placenta and liver. (PMID: 1128712, 10722730, 9693963).
Fenugreekine
Isolated from the seeds of Trigonella foenum-graecum (fenugreek). Fenugreekine is found in herbs and spices and fenugreek. Fenugreekine is found in fenugreek. Fenugreekine is isolated from the seeds of Trigonella foenum-graecum (fenugreek).
Pictilisib
C274 - Antineoplastic Agent > C163758 - Targeted Therapy Agent > C2152 - Phosphatidylinositide 3-Kinase Inhibitor C274 - Antineoplastic Agent > C2189 - Signal Transduction Inhibitor > C129824 - Antineoplastic Protein Inhibitor C471 - Enzyme Inhibitor > C129825 - Antineoplastic Enzyme Inhibitor C274 - Antineoplastic Agent > C1742 - Angiogenesis Inhibitor C471 - Enzyme Inhibitor > C1404 - Protein Kinase Inhibitor
GDP-fucose
GDP-L-fucose is a sugar nucleotide and a readily available source of fucose. Fucose is a deoxyhexose that is found in nearly all plant and animal species. The monosaccharide plays several important metabolic roles in complex carbohydrates and in glycoproteins. Fucosylated oligosaccharides are involved in cell-cell recognition, selectin-mediated leukocyte-endothelial adhesion, and mouse embryogenesis. They form the basis of the Lewis-type blood group antigens, are involved in the formation of atherosclerosis, and mediate host-bacterial interactions. A decrease in the availability of fucose is associated with leukocyte adhesion deficiency type-II disorder, and fucosylated glycoproteins have been implicated in memory processes. Fucose is made available during the synthesis of fucosylated glycolipids, oligosaccharides, and glycoproteins via a sugar nucleotide intermediate, specifically GDP-L-fucose. GTP-L-fucose pyrophosphorylase (GFPP, E. C. 2.7.7.30) catalyzes the reversible condensation of guanosine triphosphate and beta-L-fucose-1-phosphate to form the nucleotide-sugar GDP-L-fucose. The enzyme functions primarily in the mammalian liver and kidney to salvage free L-fucose during the breakdown of glycolipids and glycoproteins. (PMID: 16086588) [HMDB]
NADH pyruvate
Tiazofurin adenine dinucleotide
Adenosine diphosphate-D-ribose
Adenosine diphosphate-d-ribose is slightly soluble (in water) and a moderately acidic compound (based on its pKa). Adenosine diphosphate-d-ribose can be found in mung bean, which makes adenosine diphosphate-d-ribose a potential biomarker for the consumption of this food product.
ADP ribose 1',2'-cyclic phosphate
Adp ribose 1,2-cyclic phosphate is slightly soluble (in water) and a moderately acidic compound (based on its pKa). Adp ribose 1,2-cyclic phosphate can be found in a number of food items such as sparkleberry, oval-leaf huckleberry, hedge mustard, and barley, which makes adp ribose 1,2-cyclic phosphate a potential biomarker for the consumption of these food products.
ADP-alpha-D-glucose
Adp-alpha-d-glucose is slightly soluble (in water) and a moderately acidic compound (based on its pKa). Adp-alpha-d-glucose can be found in a number of food items such as garden onion, european cranberry, carob, and teff, which makes adp-alpha-d-glucose a potential biomarker for the consumption of these food products.
GDP-mannuronate
Gdp-mannuronate, also known as gdp-mannuronic acid or gdp-α-D-mannuronate, is a member of the class of compounds known as purine nucleotide sugars. Purine nucleotide sugars are purine nucleotides bound to a saccharide derivative through the terminal phosphate group. Gdp-mannuronate is soluble (in water) and a moderately acidic compound (based on its pKa). Gdp-mannuronate can be found in a number of food items such as pineappple sage, red bell pepper, cherimoya, and potato, which makes gdp-mannuronate a potential biomarker for the consumption of these food products.
GDP-alpha-D-glucose
Gdp-alpha-d-glucose is soluble (in water) and a moderately acidic compound (based on its pKa). Gdp-alpha-d-glucose can be found in a number of food items such as watercress, french plantain, tartary buckwheat, and cherimoya, which makes gdp-alpha-d-glucose a potential biomarker for the consumption of these food products.
