Classification Term: 1894
Macrolides and analogues (ontology term: CHEMONTID:0000147)
Organic compounds containing a lactone ring of at least twelve members." []
found 49 associated metabolites at class metabolite taxonomy ontology rank level.
Ancestor: Phenylpropanoids and polyketides
Child Taxonomies: Epothilones and analogues, Zearalenones, Pectenotoxins and derivatives, Milbemycins
Zeranol
Zeranol is isolated from Fusarium species. It is an anabolic agent and estrogenic agent (mainly veterinary use). Zeranol is used as a growth promoter for food animals. It was banned by the EU in 1989, but is still permitted in the USA and some other countries. It may also arise in livestock by ingestion of Fusarium contaminated pasture or feeds D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones > D004967 - Estrogens Same as: D06362
alpha-Zearalenol
Alpha-zearlenol is a nonsteroidal estrogen or mycoestrogen found in fungi belonging to the Fusarium genus including F. graminearum, F. culmorum, F. crookwellense, etc (PMID: 22095651), As a mycotoxin, alpha-zearalenol is a widely distributed compound that contaminates many crops, grains, and other commodities (PMID: 30830360). Alpha-zearalenol, is also a major hepatic metabolite of zearalenone (another mycotoxin). Zearalenone has two metabolites, alpha and beta zearalenol which are produced in the liver by 3α-hydroxisteroid dehydrogenase and 3β-hydroxisteroid dehydrogenase (PMID: 30830360). Like Alpha-zearlenol, zearalenone or F-2 mycotoxin is produced by certain Fusarium species. It causes infertility, abortion and other breeding problems in swine. Alpha-zearlenol is also produced synthetically and sold as Zeranol, which is used as an anabolic agent for cattle. Alpha-zearlenol exhibits strong growth-promoting properties, but its sale is restricted in Europe (PMID: 22095651). Alpha-zearalenol has three to four times the biological activity of zearalenone. Alpha-zearlenol contains a lactone ring in its structure and is structurally analogous to estrogen, thus it can bind to estrogen receptors, and causes hepatotoxic, hematotoxic, immunotoxic, genotoxic, teratogenic and carcinogenic effects on different animal species (PMID: 17045381).
Carpaine
Pseudocarpaine is found in fruits. Minor alkaloid from leaves of Carica papaya (papaya Alkaloid from leaves of Carica papaya (papaya)
Fluvalinate
D010575 - Pesticides > D007306 - Insecticides > D011722 - Pyrethrins D016573 - Agrochemicals
beta-Zearalenol
Beta-zearalenol is a nonsteroidal estrogen or mycoestrogen found in fungi belonging to the Fusarium genus including F. graminearum, F. culmorum, F. crookwellense, etc (PMID: 22095651), As a mycotoxin, beta-zearalenol is a widely distributed compound that contaminates many crops, grains, and other commodities (PMID: 30830360). Beta-zearalenol is the beta epimer of alpha-zearalenol. It is also a major hepatic metabolite of zearalenone (another mycotoxin). Zearalenone has two major metabolites, alpha and beta zearalenol which are produced in the liver by 3α-hydroxisteroid dehydrogenase and 3β-hydroxisteroid dehydrogenase (PMID: 30830360). Beta-zearalenol is formed mainly in the liver but also to a lesser extent in the intestines during first-pass metabolism. It contains a lactone ring in its structure and is structurally analogous to estrogen, thus it can bind to estrogen receptors, and causes hepatotoxic, hematotoxic, immunotoxic, genotoxic, teratogenic and carcinogenic effects on different animal species (PMID: 17045381). However, beta-zearalenol is somewhat less active estrogenically than alpha-zearalenol. β-Zearalenol is a non-steroidal estrogenic mycotoxin synthesized by Fusarium species. β-Zearalenol potentially influences transcription and effects gene expression on translational level[1].
Exaltolide
Cyclopentadecanolide is a macrolide. Oxacyclohexadecan-2-one is a natural product found in Lonicera japonica and Angelica archangelica with data available. Constituent of angelica root oil (Angelica archangelica). Flavouring agent. Exaltolide is found in fats and oils, herbs and spices, and green vegetables. Exaltolide is found in fats and oils. Exaltolide is a constituent of angelica root oil (Angelica archangelica). Exaltolide is a flavouring agent ω-Pentadecalactone is a fragrance ingredient. ω-Pentadecalactone is a member of the fragrance structural group macrocyclic lactone and lactide derivative[1]. ω-Pentadecalactone is a fragrance ingredient. ω-Pentadecalactone is a member of the fragrance structural group macrocyclic lactone and lactide derivative[1].
(Z)-7-Hexadecen-1,16-olide
Once used in fruit flavouring; its use has been discontinued due to its toxic natur
Oxacyclotetradecan-2-one
Constituent of blackberries (Rubus species) and Angelica archangelica (angelica). Oxacyclotetradecan-2-one is found in fats and oils, fruits, and green vegetables. Oxacyclotetradecan-2-one is found in fats and oils. Oxacyclotetradecan-2-one is a constituent of blackberries (Rubus sp.) and Angelica archangelica (angelica).
Protoisoeruboside B
Protoisoeruboside B is found in onion-family vegetables. Protoisoeruboside B is a constituent of fresh garlic bulbs (Allium sativum)
Yuzu lactone
Yuzu lactone is found in citrus. Yuzu lactone is a constituent of Citrus junos (yuzu). Constituent of Citrus junos (yuzu). Yuzu lactone is found in citrus.
(R)-14-Methyloxacyclotetradecan-2-one
(R)-14-Methyloxacyclotetradecan-2-one is found in herbs and spices. (R)-14-Methyloxacyclotetradecan-2-one is a constituent of Ferula galbaniflua (galbanum)
10-Oxo-11-octadecen-13-olide
10-Oxo-11-octadecen-13-olide is found in cereals and cereal products. 10-Oxo-11-octadecen-13-olide is isolated from cor
Lagerstroemine
Lagerstroemine is found in fruits. Lagerstroemine is an alkaloid from Plantago psyllium seeds (African plantain
12-Methyl-13-tridecanolide
12-Methyl-13-tridecanolide is found in fats and oils. 12-Methyl-13-tridecanolide is a constituent of root of Angelica archangelica (angelica)
Dehydrocarpaine I
Dehydrocarpaine I is found in fruits. Dehydrocarpaine I is an alkaloid from the leaves of Carica papaya (papaya Alkaloid from the leaves of Carica papaya (papaya). Dehydrocarpaine I is found in papaya and fruits.
15-Hexadecanolide
15-Hexadecanolide is found in herbs and spices. 15-Hexadecanolide is a constituent of Galbanum absolute (from Ferula galbaniflua and Ferula rubicaulis)
Isoambrettolide
Isoambrettolide is used as a food additive [EAFUS] ("EAFUS: Everything Added to Food in the United States. [http://www.eafus.com/]")
D6-Ambrettolide
D6-Ambrettolide is a flavouring ingredient. Flavouring ingredient
Ethylene brassylate
Ethylene brassylate is a component of fragrances for soaps, detergents, food etc. Component of fragrances for soaps, detergents, food etc.
Amifloxacin
Amifloxacin belongs to the family of Phenylpiperazines. These are compounds containing a phenylpiperazine skeleton, which consists of a piperazine bound to a phenyl group. D000970 - Antineoplastic Agents > D059003 - Topoisomerase Inhibitors > D059005 - Topoisomerase II Inhibitors D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D024841 - Fluoroquinolones C254 - Anti-Infective Agent > C258 - Antibiotic > C795 - Quinolone Antibiotic D004791 - Enzyme Inhibitors
(17E,19E,21E,23E,25E)-4,6,8,10,12,14,16,27-Octahydroxy-3-(1-hydroxyhexyl)-17,28-dimethyl-1-oxacyclooctacosa-17,19,21,23,25-pentaen-2-one
(1R,4E,5'R,6R,6'R,7S,8S,10S,11S,12R,14S,15R,16S,18E,20E,22S,25R,27S,29S)-22-Ethyl-7,11,14,15-tetrahydroxy-6'-(2-hydroxypropyl)-5',6,8,10,12,14,16,29-octamethylspiro[2,26-dioxabicyclo[23.3.1]nonacosa-4,18,20-triene-27,2'-oxane]-3,9,13-trione
(1R,4E,6S,7S,17R)-4-Ethylidene-7-hydroxy-7-(hydroxymethyl)-6-methyl-2,9-dioxa-14-azatricyclo[9.5.1.014,17]heptadec-11-ene-3,8-dione
(1R,7S,13S,15S)-2,15-Dihydroxy-7-methyl-6-oxabicyclo[11.3.0]hexadeca-3,11-dien-5-one
Avermectin A1a
Doramectin
Integerrimine
(4S,8R)-8,16,18-Trihydroxy-4-methyl-3-oxabicyclo[12.4.0]octadeca-1(14),12,15,17-tetraen-2-one
7-O-Succinyl macrolactin A
Bafilomycin A1(Baf-A1)
Aab(1) avermectin
Avermectin
Concanamycin
concanamycin a
Fidaxomicin
Filipin II
latrunculin a
C22H31NO5S (421.19228360000005)
latrunculin B
C20H29NO5S (395.17663440000007)
lipiarmycin a4
C51H72Cl2O18 (1042.4095472000001)
Avemectin B1
Nonactin
Oligomycin
Sagopilone
Ornithylamphotericin methyl ester
Tiacumicin C
PL
Pl, also known as ddaxhpp-ii, is a member of the class of compounds known as macrolides and analogues. Macrolides and analogues are organic compounds containing a lactone ring of at least twelve members. Pl is practically insoluble (in water) and a very weakly acidic compound (based on its pKa). Pl can be found in cucumber, which makes pl a potential biomarker for the consumption of this food product. PL, P.L., Pl, or .pl may refer to: .