Amifloxacin (BioDeep_00000036528)

   

human metabolite


代谢物信息卡片


6-fluoro-1-(methylamino)-7-(4-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

化学式: C16H19FN4O3 (334.1441116)
中文名称: 氨氟沙星
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CNN1C=C(C(=O)C2=CC(=C(C=C21)N3CCN(CC3)C)F)C(=O)O
InChI: InChI=1S/C16H19FN4O3/c1-18-21-9-11(16(23)24)15(22)10-7-12(17)14(8-13(10)21)20-5-3-19(2)4-6-20/h7-9,18H,3-6H2,1-2H3,(H,23,24)

描述信息

Amifloxacin belongs to the family of Phenylpiperazines. These are compounds containing a phenylpiperazine skeleton, which consists of a piperazine bound to a phenyl group.
D000970 - Antineoplastic Agents > D059003 - Topoisomerase Inhibitors > D059005 - Topoisomerase II Inhibitors
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D024841 - Fluoroquinolones
C254 - Anti-Infective Agent > C258 - Antibiotic > C795 - Quinolone Antibiotic
D004791 - Enzyme Inhibitors

同义名列表

5 个代谢物同义名

6-fluoro-1-(methylamino)-7-(4-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid; 6-Fluoro-1-methylamino-7-(4-methylpiperazin-1-yl)-1,4-dihydroquinolin-4-one-3-carboxylic acid; 6-Fluoro-1-(methylamino)-7-(4-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylate; amifloxacin; WIN 49



数据库引用编号

7 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

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PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • A Nangia, F Lam, C T Hung. Reversed-phase ion-pair high-performance liquid chromatographic determination of fluoroquinolones in human plasma. Journal of pharmaceutical sciences. 1990 Nov; 79(11):988-91. doi: 10.1002/jps.2600791109. [PMID: 2292775]
  • B P Crawmer, J A Cook, R R Brown. Determination of amifloxacin and two of its principal metabolites in plasma and urine by high-performance liquid chromatography using automated column switching. Journal of chromatography. 1990 Sep; 530(2):407-17. doi: 10.1016/s0378-4347(00)82343-9. [PMID: 2127781]
  • J A Cook, M H Silverman, D J Schelling, D E Nix, J J Schentag, R R Brown, R M Stroshane. Multiple-dose pharmacokinetics and safety of oral amifloxacin in healthy volunteers. Antimicrobial agents and chemotherapy. 1990 Jun; 34(6):974-9. doi: 10.1128/aac.34.6.974. [PMID: 2393295]
  • R M Stroshane, M H Silverman, R Sauerschell, R R Brown, A W Boddy, J A Cook. Preliminary study of the pharmacokinetics of oral amifloxacin in elderly subjects. Antimicrobial agents and chemotherapy. 1990 May; 34(5):751-4. doi: 10.1128/aac.34.5.751. [PMID: 2360815]
  • J R Lentino, R Strodthman. Comparison of in vitro activity of daptomycin, vancomycin and fluoroquinolones in broth and serum against Staphylococcus epidermidis as determined by time-kill kinetics. Chemotherapy. 1989; 35(3):168-73. doi: 10.1159/000238666. [PMID: 2548817]
  • C H Collins, A H Uttley. In-vitro activity of seventeen antimicrobial compounds against seven species of mycobacteria. The Journal of antimicrobial chemotherapy. 1988 Dec; 22(6):857-61. doi: 10.1093/jac/22.6.857. [PMID: 3243734]
  • A A Divo, A C Sartorelli, C L Patton, F J Bia. Activity of fluoroquinolone antibiotics against Plasmodium falciparum in vitro. Antimicrobial agents and chemotherapy. 1988 Aug; 32(8):1182-6. doi: 10.1128/aac.32.8.1182. [PMID: 2847647]
  • T C Gasser, P H Graversen, E H Larsen, T Dørflinger. Quinolone penetration into canine vaginal and urethral secretions. Scandinavian journal of urology and nephrology. Supplementum. 1987; 104(?):101-5. doi: NULL. [PMID: 3481457]
  • H C Neu, P Labthavikul. Antibacterial activity of amifloxacin (WIN 49, 375), a new quinolone agent. Diagnostic microbiology and infectious disease. 1985 Nov; 3(6):469-78. doi: 10.1016/s0732-8893(85)80003-1. [PMID: 4064609]
  • L F McCoy, B P Crawmer, D P Benziger. Analysis of amifloxacin in plasma and urine by high-pressure liquid chromatography and intravenous pharmacokinetics in rhesus monkeys. Antimicrobial agents and chemotherapy. 1985 May; 27(5):769-73. doi: 10.1128/aac.27.5.769. [PMID: 4015070]
  • J A Johnson, D P Benziger. Metabolism and disposition of amifloxacin in laboratory animals. Antimicrobial agents and chemotherapy. 1985 May; 27(5):774-81. doi: 10.1128/aac.27.5.774. [PMID: 4015071]
  • A Iravani, G S Welty, B R Newton, G A Richard. Effects of changes in pH, medium, and inoculum size on the in vitro activity of amifloxacin against urinary isolates of Staphylococcus saprophyticus and Escherichia coli. Antimicrobial agents and chemotherapy. 1985 Apr; 27(4):449-51. doi: 10.1128/aac.27.4.449. [PMID: 3890724]
  • P C Frimodt-Møller, T Dørflinger, P O Madsen. Amifloxacin distribution in the dog prostate. The Prostate. 1985; 6(2):163-8. doi: 10.1002/pros.2990060206. [PMID: 3975177]
  • J B Cornett, R B Wagner, R A Dobson, M P Wentland, D M Bailey. In vitro and in vivo antibacterial activities of the fluoroquinolone WIN 49375 (amifloxacin). Antimicrobial agents and chemotherapy. 1985 Jan; 27(1):4-10. doi: 10.1128/aac.27.1.4. [PMID: 3885845]