Classification Term: 1481
25-azasteroids and derivatives (ontology term: CHEMONTID:0003053)
Azasteroids where the carbon atom at position 25 is replaced by a nitrogen atom." []
found 4 associated metabolites at category metabolite taxonomy ontology rank level.
Ancestor: Azasteroids and derivatives
Child Taxonomies: There is no child term of current ontology term.
25-Azacholesterol
25-Azacholesterol has potent hypocholesterolemic activity. (PMID 14287266) It specifically inhibits cholesterol side-chain cleavage resulting in a decrease in steroid hormone production (PMID 5165491). Azasteroids may be membrane effectors which, in the case of mitochondria, lead to changes in adenosine triphosphate levels and(or) dehydrogenase activity. Their effects on sterol metabolism, therefore, may be of secondary consideration. (PMID 994744). 25-azacholesterol can induce a myotonic state in muscles. (PMID 5009506). 25-Azacholesterol has potent hypocholesterolemic activity. (PMID 14287266) It specifically inhibits cholesterol side-chain cleavage resulting in a decrease in steroid hormone production (PMID 5165491). Azasteroids may be membrane effectors which, in the case of mitochondria, lead to changes in adenosine triphosphate levels and(or) dehydrogenase activity. Their effects on sterol metabolism, therefore, may be of secondary consideration. (PMID 994744)