Ceragenin CSA-13 (BioDeep_00000177736)
human metabolite blood metabolite
代谢物信息卡片
化学式: C41H80N4O3 (676.623009)
中文名称:
谱图信息:
最多检出来源 Homo sapiens(blood) 50%
分子结构信息
SMILES: CCCCCCCCNCCCC(C)C1CCC2C1(C(CC3C2C(CC4C3(CCC(C4)OCCCN)C)OCCCN)OCCCN)C
InChI: InChI=1S/C41H80N4O3/c1-5-6-7-8-9-10-23-45-24-11-15-31(2)34-16-17-35-39-36(30-38(41(34,35)4)48-27-14-22-44)40(3)19-18-33(46-25-12-20-42)28-32(40)29-37(39)47-26-13-21-43/h31-39,45H,5-30,42-44H2,1-4H3
描述信息
同义名列表
3 个代谢物同义名
N-[4-[3,7,12-tris(3-aminopropoxy)-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentyl]octan-1-amine; 3-{[5,9-bis(3-aminopropoxy)-2,15-dimethyl-14-[5-(octylamino)pentan-2-yl]tetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadecan-16-yl]oxy}propan-1-amine; Ceragenin CSA-13
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Urszula Wnorowska, Ewelina Piktel, Piotr Deptuła, Tomasz Wollny, Grzegorz Król, Katarzyna Głuszek, Bonita Durnaś, Katarzyna Pogoda, Paul B Savage, Robert Bucki. Ceragenin CSA-13 displays high antibacterial efficiency in a mouse model of urinary tract infection.
Scientific reports.
2022 11; 12(1):19164. doi:
10.1038/s41598-022-23281-y. [PMID: 36357517] - Jiani Wang, Sally Ghali, Chunlan Xu, Caroline C Mussatto, Christina Ortiz, Elaine C Lee, Diana H Tran, Jonathan P Jacobs, Venu Lagishetty, Kym F Faull, Travis Moller, Maura Rossetti, Xinhua Chen, Hon Wai Koon. Ceragenin CSA13 Reduces Clostridium difficile Infection in Mice by Modulating the Intestinal Microbiome and Metabolites.
Gastroenterology.
2018 05; 154(6):1737-1750. doi:
10.1053/j.gastro.2018.01.026. [PMID: 29360463] - Marjan M Hashemi, John Rovig, Scott Weber, Brian Hilton, Mehdi M Forouzan, Paul B Savage. Susceptibility of Colistin-Resistant, Gram-Negative Bacteria to Antimicrobial Peptides and Ceragenins.
Antimicrobial agents and chemotherapy.
2017 08; 61(8):. doi:
10.1128/aac.00292-17. [PMID: 28584137] - Robert Bucki, Katarzyna Niemirowicz, Urszula Wnorowska, Fitzroy J Byfield, Ewelina Piktel, Marzena Wątek, Paul A Janmey, Paul B Savage. Bactericidal Activity of Ceragenin CSA-13 in Cell Culture and in an Animal Model of Peritoneal Infection.
Antimicrobial agents and chemotherapy.
2015 Oct; 59(10):6274-82. doi:
10.1128/aac.00653-15. [PMID: 26248361] - Urszula Wnorowska, Katarzyna Niemirowicz, Melissa Myint, Scott L Diamond, Marta Wróblewska, Paul B Savage, Paul A Janmey, Robert Bucki. Bactericidal activities of cathelicidin LL-37 and select cationic lipids against the hypervirulent Pseudomonas aeruginosa strain LESB58.
Antimicrobial agents and chemotherapy.
2015 Jul; 59(7):3808-15. doi:
10.1128/aac.00421-15. [PMID: 25870055] - Xiaobo Gu, Jacob D Jennings, Jason Snarr, Vinod Chaudhary, Jacob E Pollard, Paul B Savage. Optimization of ceragenins for prevention of bacterial colonization of hydrogel contact lenses.
Investigative ophthalmology & visual science.
2013 Sep; 54(9):6217-23. doi:
10.1167/iovs.13-12664. [PMID: 23970466] - Jake E Pollard, Jason Snarr, Vinod Chaudhary, Jacob D Jennings, Hannah Shaw, Bobbie Christiansen, Jonathan Wright, Wenyi Jia, Russell E Bishop, Paul B Savage. In vitro evaluation of the potential for resistance development to ceragenin CSA-13.
The Journal of antimicrobial chemotherapy.
2012 Nov; 67(11):2665-72. doi:
10.1093/jac/dks276. [PMID: 22899801] - C Nagant, P B Savage, J P Dehaye. Effect of pluronic acid F-127 on the toxicity towards eukaryotic cells of CSA-13, a cationic steroid analogue of antimicrobial peptides.
Journal of applied microbiology.
2012 Jun; 112(6):1173-83. doi:
10.1111/j.1365-2672.2012.05297.x. [PMID: 22469097] - K Leszczyńska, A Namiot, K Cruz, F J Byfield, E Won, G Mendez, W Sokołowski, P B Savage, R Bucki, P A Janmey. Potential of ceragenin CSA-13 and its mixture with pluronic F-127 as treatment of topical bacterial infections.
Journal of applied microbiology.
2011 Jan; 110(1):229-38. doi:
10.1111/j.1365-2672.2010.04874.x. [PMID: 20961363] - Raquel F Epand, Jake E Pollard, Jonathan O Wright, Paul B Savage, Richard M Epand. Depolarization, bacterial membrane composition, and the antimicrobial action of ceragenins.
Antimicrobial agents and chemotherapy.
2010 Sep; 54(9):3708-13. doi:
10.1128/aac.00380-10. [PMID: 20585129] - Michael D Howell, Joanne E Streib, Byung Eui Kim, Leighann J Lesley, Annegret P Dunlap, Dianliang Geng, Yanshu Feng, Paul B Savage, Donald Y M Leung. Ceragenins: a class of antiviral compounds to treat orthopox infections.
The Journal of investigative dermatology.
2009 Nov; 129(11):2668-75. doi:
10.1038/jid.2009.120. [PMID: 19516269] - Raquel F Epand, Paul B Savage, Richard M Epand. Bacterial lipid composition and the antimicrobial efficacy of cationic steroid compounds (Ceragenins).
Biochimica et biophysica acta.
2007 Oct; 1768(10):2500-9. doi:
10.1016/j.bbamem.2007.05.023. [PMID: 17599802]