Zonisamide (BioDeep_00000002510)

human metabolite blood metabolite

代谢物信息卡片

Benzo[D]isoxazol-3-yl-methanesulphonamide

化学式: C8H8N2O3S (212.0255618)
中文名称: 唑尼沙胺
谱图信息: 最多检出来源 Homo sapiens(blood) 41.44%

Reviewed

Last reviewed on 2024-09-14.

Cite this Page

Zonisamide. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China. https://query.biodeep.cn/s/zonisamide (retrieved 2024-11-25) (BioDeep RN: BioDeep_00000002510). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

分子结构信息

SMILES: C1=CC=C2C(=C1)C(=NO2)CS(=O)(=O)N
InChI: InChI=1S/C8H8N2O3S/c9-14(11,12)5-7-6-3-1-2-4-8(6)13-10-7/h1-4H,5H2,(H2,9,11,12)

描述信息

Zonisamide is a sulfonamide anticonvulsant approved for use as an adjunctive therapy in adults with partial-onset seizures. Zonisamide may be a carbonic anhydrase inhibitor although this is not one of the primary mechanisms of action. Zonisamide may act by blocking repetitive firing of voltage-gated sodium channels leading to a reduction of T-type calcium channel currents, or by binding allosterically to GABA receptors. This latter action may inhibit the uptake of the inhibitory neurotransmitter GABA while enhancing the uptake of the excitatory neurotransmitter glutamate.
C78272 - Agent Affecting Nervous System > C264 - Anticonvulsant Agent
D002317 - Cardiovascular Agents > D002121 - Calcium Channel Blockers
D002491 - Central Nervous System Agents > D000927 - Anticonvulsants
N - Nervous system > N03 - Antiepileptics > N03A - Antiepileptics
D000077264 - Calcium-Regulating Hormones and Agents
CONFIDENCE standard compound; EAWAG_UCHEM_ID 3132
D049990 - Membrane Transport Modulators

同义名列表

17 个代谢物同义名

Benzo[D]isoxazol-3-yl-methanesulphonamide; Benzo[D]isoxazol-3-yl-methanesulfonamide; 1,2-Benzisoxazole-3-methanesulphonamide; 1,2-Benzisoxazole-3-methanesulfonamide; 3-(Sulphamoylmethyl)-1,2-benzisoxazole; 3-(Sulfamoylmethyl)-1,2-benzisoxazole; 1,2-benzoxazol-3-ylmethanesulfonamide; 3 Sulfamoylmethyl 1,2 benzisoxazole; 3-Sulfamoylmethyl-1,2-benzisoxazole; Elan brand OF zonisamide; Zonisamide monosodium; Zonisamidum; zonisamide; Zonisamida; Zonegran; Excegran; Zonisamide

数据库引用编号

31 个数据库交叉引用编号

ChEBI: CHEBI:10127
KEGG: C07504
KEGG: C76163
KEGGdrug: D00538
PubChem: 5734
HMDB: HMDB0015045
Metlin: METLIN66666
DrugBank: DB00909
ChEMBL: CHEMBL750
Wikipedia: Zonisamide
MeSH: Zonisamide
chemspider: 5532
CAS: 68291-97-4
MoNA: EQ313251
MoNA: EQ313254
MoNA: EQ313201
MoNA: EQ313256
MoNA: EQ313204
MoNA: EQ313206
MoNA: EQ313253
MoNA: EQ313202
MoNA: EQ313205
MoNA: EQ313252
MoNA: EQ313255
MoNA: EQ313203
PMhub: MS000002883
PubChem: 9707
PDB-CCD: ZON
NIKKAJI: J20.559A
RefMet: Zonisamide
KNApSAcK: 10127

分类词条

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

9606 - Homo sapiens: -

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

文献列表

Zhengguang Wang, Yongfang Tan, Fei Xu. Zonisamide improves Fas/FasL-mediated apoptosis and inflammation in a degenerative cervical myelopathy rat model. Tissue & cell. 2023 Jan; 81(?):102024. doi: 10.1016/j.tice.2023.102024. [PMID: 36669388]
Page B Pennell, Ashwin Karanam, Kimford J Meador, Elizabeth Gerard, Laura Kalayjian, Patricia Penovich, Abigail Matthews, Thomas M McElrath, Angela K Birnbaum. Antiseizure Medication Concentrations During Pregnancy: Results From the Maternal Outcomes and Neurodevelopmental Effects of Antiepileptic Drugs (MONEAD) Study. JAMA neurology. 2022 04; 79(4):370-379. doi: 10.1001/jamaneurol.2021.5487. [PMID: 35157004]
Tess K Smith, Starr Cameron, Lauren A Trepanier. Incidence of hepatopathies in dogs administered zonisamide orally: A retrospective study of 384 cases. Journal of veterinary internal medicine. 2022 Mar; 36(2):576-579. doi: 10.1111/jvim.16398. [PMID: 35238072]
Linghui Kong, Jiaqiu Xi, Zhenyuan Jiang, Xiaowen Yu, Hailiang Liu, Zhonglin Wang. Zonisamide's Efficacy and Safety on Parkinson's Disease and Dementia with Lewy Bodies: A Meta-Analysis and Systematic Review. BioMed research international. 2022; 2022(?):4817488. doi: 10.1155/2022/4817488. [PMID: 36132085]
Katsuyuki Tanabe, Natsumi Matsuoka-Uchiyama, Tomoyo Mifune, Chieko Kawakita, Hitoshi Sugiyama, Jun Wada. Management of corticosteroid-dependent eosinophilic interstitial nephritis: A case report. Medicine. 2021 Dec; 100(50):e28252. doi: 10.1097/md.0000000000028252. [PMID: 34918693]
Ricardo de Matos, Brendan P Noonan, Deanna M W Schaefer, James Morrisey, Curtis Dewey, Elizabeth L Buckles, Dawn Boothe. Pharmacokinetics of zonisamide after oral single dosing and multiple-dose escalation administration in domestic chickens (Gallus gallus). Veterinary medicine and science. 2021 09; 7(5):1928-1937. doi: 10.1002/vms3.512. [PMID: 34004072]
Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
Reem Odi, Valentina Franco, Emilio Perucca, Meir Bialer. Bioequivalence and switchability of generic antiseizure medications (ASMs): A re-appraisal based on analysis of generic ASM products approved in Europe. Epilepsia. 2021 02; 62(2):285-302. doi: 10.1111/epi.16802. [PMID: 33426641]
Ryuki Matsuura, Shin-Ichiro Hamano, Erika Hiwatari, Satoru Ikemoto, Yuko Hirata, Reiko Koichihara, Kenjiro Kikuchi. Zonisamide Therapy for Patients With Paroxysmal Kinesigenic Dyskinesia. Pediatric neurology. 2020 10; 111(?):23-26. doi: 10.1016/j.pediatrneurol.2020.06.017. [PMID: 32951651]
Shunsuke Kanbara, Bisei Ohkawara, Hiroaki Nakashima, Kyotaro Ohta, Hiroyuki Koshimizu, Taro Inoue, Hiroyuki Tomita, Mikako Ito, Akio Masuda, Naoki Ishiguro, Shiro Imagama, Kinji Ohno. Zonisamide ameliorates progression of cervical spondylotic myelopathy in a rat model. Scientific reports. 2020 08; 10(1):13138. doi: 10.1038/s41598-020-70068-0. [PMID: 32753675]
Yuki Takami, Takeshi Izawa, Miyuu Tanaka, Shingo Hatoya, Tomoyo Nabetani, Jyoji Yamate, Mitsuru Kuwamura. Hepatocellular necrosis with prominent regenerative reactions in a zonisamide administrated dog. The Journal of veterinary medical science. 2020 Jun; 82(6):704-706. doi: 10.1292/jvms.20-0045. [PMID: 32249255]
Joana Gonçalves, Gilberto Alves, Andreia Carona, Joana Bicker, Carla Vitorino, Amílcar Falcão, Ana Fortuna. Pre-Clinical Assessment of the Nose-to-Brain Delivery of Zonisamide After Intranasal Administration. Pharmaceutical research. 2020 Mar; 37(4):74. doi: 10.1007/s11095-020-02786-z. [PMID: 32215749]
Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
Daiki Eto, Ryota Tanaka, Yosuke Suzuki, Yuhki Sato, Hiroki Itoh. Comparison of performance characteristics between high-performance liquid chromatography and latex agglutination turbidimetric immunoassay for therapeutic drug monitoring of zonisamide. Journal of clinical laboratory analysis. 2019 Sep; 33(7):e22940. doi: 10.1002/jcla.22940. [PMID: 31218755]
Allison L Limmer, Levi C Holland, Brian D Loftus. Zonisamide for Cluster Headache Prophylaxis: A Case Series. Headache. 2019 06; 59(6):924-929. doi: 10.1111/head.13546. [PMID: 31038740]
Harini Bejjanki, Vincent Bird, Rupam Ruchi. Letter to the editor regarding the manuscript 'Efficacy, tolerability, and blood concentration of zonisamide in daily clinical practice'. Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia. 2019 05; 63(?):283. doi: 10.1016/j.jocn.2019.01.035. [PMID: 30773475]
Krista A Keller, David Sanchez-Migallon Guzman, Dawn M Boothe, Marike Visser, Ricardo E de Matos, Olivia A Petritz, Philip H Kass, Joanne R Paul-Murphy. Pharmacokinetics and safety of zonisamide after oral administration of single and multiple doses to Hispaniolan Amazon parrots (Amazona ventralis). American journal of veterinary research. 2019 Feb; 80(2):195-200. doi: 10.2460/ajvr.80.2.195. [PMID: 30681361]
Shin-Ichi Ueno, Shinji Saiki, Motoki Fujimaki, Haruka Takeshige-Amano, Taku Hatano, Genko Oyama, Kei-Ichi Ishikawa, Akihiro Yamaguchi, Shuko Nojiri, Wado Akamatsu, Nobutaka Hattori. Zonisamide Administration Improves Fatty Acid β-Oxidation in Parkinson's Disease. Cells. 2018 12; 8(1):. doi: 10.3390/cells8010014. [PMID: 30597973]
Joesph R Wiencek, Dennis J Dietzen, Teresa Murray, Sheila Dawling, Jennifer M Colby, James H Nichols. Persistently Increased Alloisoleucine in a Patient with Seizures. Clinical chemistry. 2018 10; 64(10):1433-1437. doi: 10.1373/clinchem.2017.278804. [PMID: 30266717]
Masayasu Ukai, Yuji Hamamoto, Yoshihiko Yu, Aki Fujiwara-Igarashi, Michio Fujita, Daisuke Hasegawa. Efficacy of zonisamide on interictal electroencephalography in familial spontaneous epileptic cats. Journal of feline medicine and surgery. 2018 10; 20(10):962-967. doi: 10.1177/1098612x17740247. [PMID: 29110561]
Karen R Muñana, Arturo J Otamendi, Julie A Nettifee, Mark G Papich. Population pharmacokinetics of extended-release levetiracetam in epileptic dogs when administered alone, with phenobarbital or zonisamide. Journal of veterinary internal medicine. 2018 Sep; 32(5):1677-1683. doi: 10.1111/jvim.15298. [PMID: 30238679]
Ken Ikeda, Masaru Yanagihashi, Ken Miura, Yuichi Ishikawa, Takehisa Hirayama, Takanori Takazawa, Osamu Kano, Kiyokazu Kawabe, Nao Mizumura, Yasuo Iwasaki. Zonisamide cotreatment delays striatal dopamine transporter reduction in Parkinson disease: A retrospective, observational cohort study. Journal of the neurological sciences. 2018 08; 391(?):5-9. doi: 10.1016/j.jns.2018.05.013. [PMID: 30103971]
Michael J Palte, Sankha S Basu, Jameson L Dahlin, Ralitsa Gencheva, Donald Mason, Petr Jarolim, Athena K Petrides. Development and Validation of an Ultra-Performance Liquid Chromatography-Tandem Mass Spectrometry Method for the Concurrent Measurement of Gabapentin, Lamotrigine, Levetiracetam, Monohydroxy Derivative of Oxcarbazepine, and Zonisamide Concentrations in Serum in a Clinical Setting. Therapeutic drug monitoring. 2018 08; 40(4):469-476. doi: 10.1097/ftd.0000000000000516. [PMID: 29994986]
Arne Reimers, Grethe Helde, Noémi Becser Andersen, Dag Aurlien, Elisabeth Surlien Navjord, Kathrine Haggag, Jakob Christensen, Kari Mette Lillestølen, Karl Otto Nakken, Eylert Brodtkorb. Zonisamide serum concentrations during pregnancy. Epilepsy research. 2018 08; 144(?):25-29. doi: 10.1016/j.eplepsyres.2018.05.002. [PMID: 29751353]
Joana Gonçalves, Gilberto Alves, Joana Bicker, Amílcar Falcão, Ana Fortuna. Development and full validation of an innovative HPLC-diode array detection technique to simultaneously quantify lacosamide, levetiracetam and zonisamide in human plasma. Bioanalysis. 2018 Apr; 10(8):541-557. doi: 10.4155/bio-2017-0199. [PMID: 29561632]
Audrey Collinet, Veronique Sammut. Suspected zonisamide-related anticonvulsant hypersensitivity syndrome in a cat. Journal of the American Veterinary Medical Association. 2017 Dec; 251(12):1457-1461. doi: 10.2460/javma.251.12.1457. [PMID: 29190192]
Aneta Stefanidis, Matthew J Watt, Michael A Cowley, Brian J Oldfield. Prevention of the adverse effects of olanzapine on lipid metabolism with the antiepileptic zonisamide. Neuropharmacology. 2017 Sep; 123(?):55-66. doi: 10.1016/j.neuropharm.2017.04.010. [PMID: 28400260]
D A Garcia-Estevez, M Pardo-Parrado, S Silvarrey-Rodriguez. [Frequent episodic migraine and calcitonin gene-related peptide. Influence of treatment with topiramate and zonisamide on levels of the peptide]. Revista de neurologia. 2017 Aug; 65(4):153-156. doi: NULL. [PMID: 28726232]
Fawzia A Ibrahim, Amira F El-Yazbi, Mira M Wagih, Magda A Barary. Chromatographic determination of zonisamide, topiramate and sulpiride in plasma by a fluorescent 'turn-on' chemosensor. Bioanalysis. 2017 Jul; 9(14):1049-1064. doi: 10.4155/bio-2017-0090. [PMID: 28737428]
Jennifer R Michaels, Amy J Hodshon, William B Thomas, Dawn M Boothe, Lindsay Williams. Pharmacokinetics of zonisamide following rectal administration to healthy dogs. American journal of veterinary research. 2016 Dec; 77(12):1374-1380. doi: 10.2460/ajvr.77.12.1374. [PMID: 27901384]
Keaton S Smetana, Aaron M Cook, Melissa L Thompson Bastin, Douglas R Oyler. Antiepileptic dosing for critically ill adult patients receiving renal replacement therapy. Journal of critical care. 2016 12; 36(?):116-124. doi: 10.1016/j.jcrc.2016.06.023. [PMID: 27546759]
Tomoya Takeuchi, Jun Natsume, Hiroyuki Kidokoro, Naoko Ishihara, Hiroyuki Yamamoto, Yoshiteru Azuma, Yuji Ito, Naoko Kurahashi, Takeshi Tsuji, Motomasa Suzuki, Kazuya Itomi, Keitaro Yamada, Hirokazu Kurahashi, Shinpei Abe, Akihisa Okumura, Koichi Maruyama, Tamiko Negoro, Kazuyoshi Watanabe, Seiji Kojima. The effects of co-medications on lamotrigine clearance in Japanese children with epilepsy. Brain & development. 2016 Sep; 38(8):723-30. doi: 10.1016/j.braindev.2016.03.004. [PMID: 27033151]
Júlia Miro, Sònia Jaraba, Roser Juvany, Milagrosa Santurino, Sara Cobo, Mercè Falip. Could Adult European Pharmacoresistant Epilepsy Patients Be Treated With Higher Doses of Zonisamide?. Clinical neuropharmacology. 2016 May; 39(3):121-4. doi: 10.1097/wnf.0000000000000138. [PMID: 26818046]
Scott Mintzer, Rachael Miller, Krunal Shah, Inna Chervoneva, Maromi Nei, Christopher Skidmore, Michael R Sperling. Long-term effect of antiepileptic drug switch on serum lipids and C-reactive protein. Epilepsy & behavior : E&B. 2016 05; 58(?):127-32. doi: 10.1016/j.yebeh.2016.02.023. [PMID: 27074299]
Vera Russmann, Josephine D Salvamoser, Maruja L Rettenbeck, Takafumi Komori, Heidrun Potschka. Synergism of perampanel and zonisamide in the rat amygdala kindling model of temporal lobe epilepsy. Epilepsia. 2016 Apr; 57(4):638-47. doi: 10.1111/epi.13328. [PMID: 26854031]
Dean C Carlow, Heng Shi, Ryan C Schofield. Simultaneous Quantitation of Lamotrigine, Levetiracetam, 10-Hydroxycarbazepine, Topiramate, and Zonisamide in Serum Using HPLC-MS/MS. Methods in molecular biology (Clifton, N.J.). 2016; 1383(?):29-37. doi: 10.1007/978-1-4939-3252-8_4. [PMID: 26660171]
Amy C Jongeling, Rachel J Richins, Carl W Bazil. Safety and tolerability of an oral zonisamide loading dose. Seizure. 2015 Nov; 32(?):69-71. doi: 10.1016/j.seizure.2015.09.012. [PMID: 26552566]
Paul P Lerner, Chanoch Miodownik, Vladimir Lerner. Tardive dyskinesia (syndrome): Current concept and modern approaches to its management. Psychiatry and clinical neurosciences. 2015 Jun; 69(6):321-34. doi: 10.1111/pcn.12270. [PMID: 25556809]
D M Brewer, S Cerda-Gonzalez, C W Dewey, D Boothe, K Van Horne. Pharmacokinetics of single-dose rectal zonisamide administration in normal dogs. Journal of veterinary internal medicine. 2015 Mar; 29(2):603-6. doi: 10.1111/jvim.12540. [PMID: 25818215]
Yasmin Idu Jion, Amanda Raff, Brian M Grosberg, Randolph W Evans. The risk and management of kidney stones from the use of topiramate and zonisamide in migraine and idiopathic intracranial hypertension. Headache. 2015 Jan; 55(1):161-6. doi: 10.1111/head.12480. [PMID: 25486999]
Karin M Wallander, Inger Ohman, Maria Dahlin. Zonisamide: pharmacokinetics, efficacy, and adverse events in children with epilepsy. Neuropediatrics. 2014 Dec; 45(6):362-70. doi: 10.1055/s-0034-1387815. [PMID: 25133701]
Kamal M Matar. A simple and accurate liquid chromatography-tandem mass spectrometry method for quantification of zonisamide in plasma and its application to a pharmacokinetic study. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2014 Jun; 961(?):103-9. doi: 10.1016/j.jchromb.2014.05.017. [PMID: 24874192]
Nahid Shahabadi, Aref Khorshidi, Mahnaz Mohammadpour. Investigation of the effects of Zn2+, Ca2+ and Na+ ions on the interaction between zonisamide and human serum albumin (HSA) by spectroscopic methods. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy. 2014 Mar; 122(?):48-54. doi: 10.1016/j.saa.2013.11.047. [PMID: 24291623]
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Vedat Ali Yürekli, Semih Gürler, Mustafa Nazıroğlu, Abdülhadi Cihangir Uğuz, Hasan Rifat Koyuncuoğlu. Zonisamide attenuates MPP+-induced oxidative toxicity through modulation of Ca2+ signaling and caspase-3 activity in neuronal PC12 cells. Cellular and molecular neurobiology. 2013 Mar; 33(2):205-12. doi: 10.1007/s10571-012-9886-3. [PMID: 23229024]
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Dong Wook Kim, Moon-Won Yoo, Kyoung Sik Park. Low serum leptin level is associated with zonisamide-induced weight loss in overweight female epilepsy patients. Epilepsy & behavior : E&B. 2012 Apr; 23(4):497-9. doi: 10.1016/j.yebeh.2011.11.024. [PMID: 22440324]
Shinichi Takahashi, Yoshikane Izawa, Norihiro Suzuki. Astroglial pentose phosphate pathway rates in response to high-glucose environments. ASN neuro. 2012 Mar; 4(2):. doi: 10.1042/an20120002. [PMID: 22300409]
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Eriko Eguchi, Keiji Shimazu, Kensuke Nishiguchi, Soushi Yorifuji, Atsuo Tanaka, Takashi Kuwahara. Granulomatous interstitial nephritis associated with atypical drug-induced hypersensitivity syndrome induced by carbamazepine. Clinical and experimental nephrology. 2012 Feb; 16(1):168-72. doi: 10.1007/s10157-011-0531-0. [PMID: 21947692]
Marica Carbone, Susan Duty, Marcus Rattray. Riluzole elevates GLT-1 activity and levels in striatal astrocytes. Neurochemistry international. 2012 Jan; 60(1):31-8. doi: 10.1016/j.neuint.2011.10.017. [PMID: 22080156]
Devrim Coskun, Dev T Britto, Yuel-Kai Jean, Lasse M Schulze, Alexander Becker, Herbert J Kronzucker. Silver ions disrupt K⁺ homeostasis and cellular integrity in intact barley (Hordeum vulgare L.) roots. Journal of experimental botany. 2012 Jan; 63(1):151-62. doi: 10.1093/jxb/err267. [PMID: 21948852]
Letizia Antonilli, Valentina Brusadin, Francesca Filipponi, Renzo Guglielmi, Paolo Nencini. Development and validation of an analytical method based on high performance thin layer chromatography for the simultaneous determination of lamotrigine, zonisamide and levetiracetam in human plasma. Journal of pharmaceutical and biomedical analysis. 2011 Dec; 56(4):763-70. doi: 10.1016/j.jpba.2011.07.018. [PMID: 21840147]
Kwon-Bok Kim, Kyung-Ah Seo, Sung-Eun Kim, Soo Kyung Bae, Dong-Hyun Kim, Jae-Gook Shin. Simple and accurate quantitative analysis of ten antiepileptic drugs in human plasma by liquid chromatography/tandem mass spectrometry. Journal of pharmaceutical and biomedical analysis. 2011 Dec; 56(4):771-7. doi: 10.1016/j.jpba.2011.07.019. [PMID: 21840666]
Malte Schwartz, Karen R Muñana, Natasha J Olby. Possible drug-induced hepatopathy in a dog receiving zonisamide monotherapy for treatment of cryptogenic epilepsy. The Journal of veterinary medical science. 2011 Nov; 73(11):1505-8. doi: 10.1292/jvms.11-0164. [PMID: 21720107]
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