Hydroxyisovaleroylcarnitine (BioDeep_00001884112)
Main id: BioDeep_00000606020
blood metabolite human metabolite Endogenous
代谢物信息卡片
3-(3-hydroxy-3-methylbutanoyl)oxy-4-(trimethylazaniumyl)butanoate
化学式: C12H23NO5 (261.1576148)
中文名称: 3-羟基异戊酰肉碱
谱图信息:
最多检出来源 () 0%
Reviewed
Last reviewed on 2024-10-17.
Cite this Page
Hydroxyisovaleroylcarnitine. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China.
https://query.biodeep.cn/s/hydroxyisovaleroylcarnitine (retrieved
2024-11-25) (BioDeep RN: BioDeep_00001884112). Licensed
under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).
分子结构信息
SMILES: CC(C)(CC(=O)OC(CC(=O)[O-])C[N+](C)(C)C)O
InChI: InChI=1S/C12H23NO5/c1-12(2,17)7-11(16)18-9(6-10(14)15)8-13(3,4)5/h9,17H,6-8H2,1-5H3
描述信息
An O-acylcarnitine having 3-hydroxyisovaleryl as the acyl substituent.
同义名列表
1 个代谢物同义名
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Adrian Post, M Yusof Said, Antonio W Gomes-Neto, Isidor Minović, Dion Groothof, J Casper Swarte, Theo Boer, Ido P Kema, M Rebecca Heiner-Fokkema, Casper F M Franssen, Stephan J L Bakker. Urinary 3-hydroxyisovaleryl carnitine excretion, protein energy malnutrition and risk of all-cause mortality in kidney transplant recipients: Results from the TransplantLines cohort studies.
Clinical nutrition (Edinburgh, Scotland).
2021 04; 40(4):2109-2120. doi:
10.1016/j.clnu.2020.09.035. [PMID: 33071013] - Hanghang Wang, Kevin Anstrom, Olga Ilkayeva, Michael J Muehlbauer, James R Bain, Steven McNulty, Christopher B Newgard, William E Kraus, Adrian Hernandez, G Michael Felker, Margaret Redfield, Svati H Shah. Sildenafil Treatment in Heart Failure With Preserved Ejection Fraction: Targeted Metabolomic Profiling in the RELAX Trial.
JAMA cardiology.
2017 08; 2(8):896-901. doi:
10.1001/jamacardio.2017.1239. [PMID: 28492915] - Shin-Ichiro Hagiwara, Mitsuru Kubota, Ryusuke Nambu, Seiichi Kagimoto. Screening of carnitine and biotin deficiencies on tandem mass spectrometry.
Pediatrics international : official journal of the Japan Pediatric Society.
2017 Apr; 59(4):458-461. doi:
10.1111/ped.13167. [PMID: 27634667] - Roy W A Peake. A Case of Increased C5-OH Acylcarnitine.
Clinical chemistry.
2016 09; 62(9):1278-9. doi:
10.1373/clinchem.2016.257600. [PMID: 27573455] - Jiuling Wei, Sai Fan, Liping Li, Xuesong Xiang, Rong Zhao, Zhu Wang. [Determination of 3-hydroxyisovaleryl carnitine in plasma and urinary excretion by ultra-performance liquid chromatography-tandem mass spectrometry].
Wei sheng yan jiu = Journal of hygiene research.
2016 May; 45(3):470-4. doi:
NULL. [PMID: 27459814] - Jaana Nevalainen, Mikko Sairanen, Heidi Appelblom, Mika Gissler, Susanna Timonen, Markku Ryynänen. First-Trimester Maternal Serum Amino Acids and Acylcarnitines Are Significant Predictors of Gestational Diabetes.
The review of diabetic studies : RDS.
2016; 13(4):236-245. doi:
10.1900/rds.2016.13.236. [PMID: 28278310] - Anna Bogusiewicz, Gunnar Boysen, Donald M Mock. In HepG2 cells, coexisting carnitine deficiency masks important indicators of marginal biotin deficiency.
The Journal of nutrition.
2015 Jan; 145(1):32-40. doi:
10.3945/jn.114.201343. [PMID: 25527659] - Cydne A Perry, Allyson A West, Antoinette Gayle, Lauren K Lucas, Jian Yan, Xinyin Jiang, Olga Malysheva, Marie A Caudill. Pregnancy and lactation alter biomarkers of biotin metabolism in women consuming a controlled diet.
The Journal of nutrition.
2014 Dec; 144(12):1977-84. doi:
10.3945/jn.114.194472. [PMID: 25122647] - Li-fei Gong, Jun Ye, Lian-shu Han, Wen-juan Qiu, Hui-wen Zhang, Xiao-lan Gao, Jing Jin, Hao Xu, Xue-fan Gu. [Clinical and mutational features of maternal 3-methylcrotonyl coenzyme deficiency].
Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics.
2013 Oct; 30(5):574-8. doi:
10.3760/cma.j.issn.1003-9406.2013.05.014. [PMID: 24078573] - Anna Bogusiewicz, Thomas D Horvath, Shawna L Stratton, Donald M Mock, Gunnar Boysen. Measurement of acylcarnitine substrate to product ratios specific to biotin-dependent carboxylases offers a combination of indicators of biotin status in humans.
The Journal of nutrition.
2012 Sep; 142(9):1621-5. doi:
10.3945/jn.112.164814. [PMID: 22833654] - Donald M Mock, Shawna L Stratton, Thomas D Horvath, Anna Bogusiewicz, Nell I Matthews, Cindy L Henrich, Amanda M Dawson, Horace J Spencer, Suzanne N Owen, Gunnar Boysen, Jeffery H Moran. Urinary excretion of 3-hydroxyisovaleric acid and 3-hydroxyisovaleryl carnitine increases in response to a leucine challenge in marginally biotin-deficient humans.
The Journal of nutrition.
2011 Nov; 141(11):1925-30. doi:
10.3945/jn.111.146126. [PMID: 21918059] - Yoko Nakajima, Tetsuya Ito, Yasuhiro Maeda, Sayaka Ichiki, Satoru Kobayashi, Naoki Ando, Mohamed Hamed Hussein, Yukihisa Kurono, Naruji Sugiyama, Hajime Togari. Evaluation of valproate effects on acylcarnitine in epileptic children by LC-MS/MS.
Brain & development.
2011 Nov; 33(10):816-23. doi:
10.1016/j.braindev.2010.12.003. [PMID: 21196091] - Shawna L Stratton, Thomas D Horvath, Anna Bogusiewicz, Nell I Matthews, Cindy L Henrich, Horace J Spencer, Jeffery H Moran, Donald M Mock. Urinary excretion of 3-hydroxyisovaleryl carnitine is an early and sensitive indicator of marginal biotin deficiency in humans.
The Journal of nutrition.
2011 Mar; 141(3):353-8. doi:
10.3945/jn.110.135772. [PMID: 21248194] - Thomas D Horvath, Shawna L Stratton, Anna Bogusiewicz, Suzanne N Owen, Donald M Mock, Jeffery H Moran. Quantitative measurement of urinary excretion of 3-hydroxyisovaleryl carnitine by LC-MS/MS as an indicator of biotin status in humans.
Analytical chemistry.
2010 Nov; 82(22):9543-8. doi:
10.1021/ac102330k. [PMID: 21028833] - Thomas D Horvath, Shawna L Stratton, Anna Bogusiewicz, Lindsay Pack, Jeffery Moran, Donald M Mock. Quantitative measurement of plasma 3-hydroxyisovaleryl carnitine by LC-MS/MS as a novel biomarker of biotin status in humans.
Analytical chemistry.
2010 May; 82(10):4140-4. doi:
10.1021/ac1003213. [PMID: 20397702] - W L Nyhan, M Willis, B A Barshop, J Gangoiti. Positive newborn screen in the biochemically normal infant of a mother with treated holocarboxylase synthetase deficiency.
Journal of inherited metabolic disease.
2009 Dec; 32 Suppl 1(?):S79-82. doi:
10.1007/s10545-009-1062-7. [PMID: 19357990] - Yasuhiro Maeda, Tetsuya Ito, Hironori Ohmi, Kyoko Yokoi, Yoko Nakajima, Akihito Ueta, Yukihisa Kurono, Hajime Togari, Naruji Sugiyama. Determination of 3-hydroxyisovalerylcarnitine and other acylcarnitine levels using liquid chromatography-tandem mass spectrometry in serum and urine of a patient with multiple carboxylase deficiency.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2008 Jul; 870(2):154-9. doi:
10.1016/j.jchromb.2007.11.037. [PMID: 18088573] - M F Silva, J Selhorst, H Overmars, A H van Gennip, M Maya, R J Wanders, I T de Almeida, M Duran. Characterization of plasma acylcarnitines in patients under valproate monotherapy using ESI-MS/MS.
Clinical biochemistry.
2001 Nov; 34(8):635-8. doi:
10.1016/s0009-9120(01)00272-7. [PMID: 11849623] - W Röschinger, D S Millington, D A Gage, Z H Huang, T Iwamoto, S Yano, S Packman, K Johnston, S A Berry, L Sweetman. 3-Hydroxyisovalerylcarnitine in patients with deficiency of 3-methylcrotonyl CoA carboxylase.
Clinica chimica acta; international journal of clinical chemistry.
1995 Aug; 240(1):35-51. doi:
10.1016/0009-8981(95)06126-2. [PMID: 8582058] - J L van Hove, S L Rutledge, M A Nada, S G Kahler, D S Millington. 3-Hydroxyisovalerylcarnitine in 3-methylcrotonyl-CoA carboxylase deficiency.
Journal of inherited metabolic disease.
1995; 18(5):592-601. doi:
10.1007/bf02436004. [PMID: 8598640]