D-Thyroxine (BioDeep_00000614958)

Main id: BioDeep_00000001625

 

Chemicals and Drugs PANOMIX_OTCML-2023


代谢物信息卡片


(2R)-2-amino-3-[4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]propanoic acid

化学式: C15H11I4NO4 (776.6867)
中文名称: D-甲状腺素
谱图信息: 最多检出来源 () 0%

Reviewed

Last reviewed on 2024-07-09.

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D-Thyroxine. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China. https://query.biodeep.cn/s/d-thyroxine (retrieved 2024-12-22) (BioDeep RN: BioDeep_00000614958). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

分子结构信息

SMILES: C1=C(C=C(C(=C1I)OC2=CC(=C(C(=C2)I)O)I)I)CC(C(=O)O)N
InChI: InChI=1S/C15H11I4NO4/c16-8-4-7(5-9(17)13(8)21)24-14-10(18)1-6(2-11(14)19)3-12(20)15(22)23/h1-2,4-5,12,21H,3,20H2,(H,22,23)/t12-/m1/s1

描述信息

The D-enantiomer of thyroxine.

D-Thyroxine (D-T4) is a thyroid hormone that can inhibit TSH secretion. D-Thyroxine can be used for the research of hypercholesterolemia[1][2].

同义名列表

4 个代谢物同义名

D-Thyroxine; (2R)-2-amino-3-[4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]propanoic acid; Dextrothyroxine; D-T4



数据库引用编号

9 个数据库交叉引用编号

分类词条

相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

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COVID-19 Disease Map(0)

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0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Yanjun Wang, Ping Guo, Lu Liu, Yanan Zhang, Ping Zeng, Zhongshang Yuan. Mendelian Randomization Highlights the Causal Role of Normal Thyroid Function on Blood Lipid Profiles. Endocrinology. 2021 05; 162(5):. doi: 10.1210/endocr/bqab037. [PMID: 33587120]
  • Christopher Hine, Hyo-Jeong Kim, Yan Zhu, Eylul Harputlugil, Alban Longchamp, Marina Souza Matos, Preeti Ramadoss, Kevin Bauerle, Lear Brace, John M Asara, C Keith Ozaki, Sheue-Yann Cheng, Subhankar Singha, Kyo Han Ahn, Alec Kimmelman, Ffolliott M Fisher, Pavlos Pissios, Dominic J Withers, Colin Selman, Rui Wang, Kelvin Yen, Valter D Longo, Pinchas Cohen, Andrzej Bartke, John J Kopchick, Richard Miller, Anthony N Hollenberg, James R Mitchell. Hypothalamic-Pituitary Axis Regulates Hydrogen Sulfide Production. Cell metabolism. 2017 Jun; 25(6):1320-1333.e5. doi: 10.1016/j.cmet.2017.05.003. [PMID: 28591635]
  • Simon H S Pearce, Salman Razvi, Mohammad E Yadegarfar, Carmen Martin-Ruiz, Andrew Kingston, Joanna Collerton, Theo J Visser, Tom B Kirkwood, Carol Jagger. Serum Thyroid Function, Mortality and Disability in Advanced Old Age: The Newcastle 85+ Study. The Journal of clinical endocrinology and metabolism. 2016 11; 101(11):4385-4394. doi: 10.1210/jc.2016-1935. [PMID: 27552542]
  • Shuai Yang, Feng-Tao Shi, Peter C K Leung, He-Feng Huang, Jianxia Fan. Low Thyroid Hormone in Early Pregnancy Is Associated With an Increased Risk of Gestational Diabetes Mellitus. The Journal of clinical endocrinology and metabolism. 2016 11; 101(11):4237-4243. doi: 10.1210/jc.2016-1506. [PMID: 27583471]
  • Tolga Unüvar, Ahmet Anık, Gönül Catlı, Ihsan Esen, Ayhan Abacı, Atilla Büyükgebiz, Ece Böber. Isolated hyperthyrotropinemia in childhood obesity and its relation with metabolic parameters. Journal of endocrinological investigation. 2014 Sep; 37(9):799-804. doi: 10.1007/s40618-014-0100-y. [PMID: 24920280]
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  • Adie Viljoen, Anthony S Wierzbicki. Safety and efficacy of laropiprant and extended-release niacin combination in the management of mixed dyslipidemias and primary hypercholesterolemia. Drug, healthcare and patient safety. 2010; 2(?):61-71. doi: 10.2147/dhps.s7302. [PMID: 21701618]
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