D-Leucine (BioDeep_00001868196)

Main id: BioDeep_00000014649

 

PANOMIX_OTCML-2023


代谢物信息卡片


H-D-Leu-OH

化学式: C6H13NO2 (131.0946238)
中文名称: D-亮氨酸
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC(C)CC(C(=O)O)N
InChI: InChI=1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t5-/m1/s1

描述信息

The D-enantiomer of leucine.
D-Leucine is a more potent anti-seizure agent than L-leucine. D-leucine potently terminates seizures even after the onset of seizure activity. D-leucine, but not L-leucine, reduces long-term potentiation but had no effect on basal synaptic transmission in vitro[1].
D-Leucine is a more potent anti-seizure agent than L-leucine. D-leucine potently terminates seizures even after the onset of seizure activity. D-leucine, but not L-leucine, reduces long-term potentiation but had no effect on basal synaptic transmission in vitro[1].

同义名列表

3 个代谢物同义名

H-D-Leu-OH; D-Leucine; (R)-Leucine



数据库引用编号

13 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Nobuhiro Mori, Megumi Yamamoto, Eri Tsukada, Tomoharu Yokooji, Naoko Matsumura, Masanori Sasaki, Teruo Murakami. Comparison of in vivo with in vitro pharmacokinetics of mercury between methylmercury chloride and methylmercury cysteine using rats and Caco2 cells. Archives of environmental contamination and toxicology. 2012 Nov; 63(4):628-36. doi: 10.1007/s00244-012-9800-5. [PMID: 22932937]
  • Anne Freudenberg, Klaus J Petzke, Susanne Klaus. Comparison of high-protein diets and leucine supplementation in the prevention of metabolic syndrome and related disorders in mice. The Journal of nutritional biochemistry. 2012 Nov; 23(11):1524-30. doi: 10.1016/j.jnutbio.2011.10.005. [PMID: 22405695]
  • Héctor García-Villalobos, Adriana Morales-Trejo, Benedicto A Araiza-Piña, John K Htoo, Miguel Cervantes-Ramírez. Effects of dietary protein and amino acid levels on the expression of selected cationic amino acid transporters and serum amino acid concentration in growing pigs. Archives of animal nutrition. 2012 Aug; 66(4):257-70. doi: 10.1080/1745039x.2012.697351. [PMID: 22924173]
  • Lukasz Samluk, Magdalena Czeredys, Krzysztof Skowronek, Katarzyna A Nałęcz. Protein kinase C regulates amino acid transporter ATB(0,+). Biochemical and biophysical research communications. 2012 May; 422(1):64-9. doi: 10.1016/j.bbrc.2012.04.106. [PMID: 22561015]
  • Raluca-Ioana Stefan-van Staden, R'afat Mahmoud Nejem, Jacobus Frederick van Staden, Hassan Y Aboul-Enein. Amperometric biosensor based on diamond paste for the enantioanalysis of L-lysine. Biosensors & bioelectronics. 2012 May; 35(1):439-442. doi: 10.1016/j.bios.2012.02.036. [PMID: 22417875]
  • Andrew L Neal, Shakoor Ahmad, Ruth Gordon-Weeks, Jurriaan Ton. Benzoxazinoids in root exudates of maize attract Pseudomonas putida to the rhizosphere. PloS one. 2012; 7(4):e35498. doi: 10.1371/journal.pone.0035498. [PMID: 22545111]
  • Saskia B Wortmann, Leo A Kluijtmans, Udo F H Engelke, Ron A Wevers, Eva Morava. The 3-methylglutaconic acidurias: what's new?. Journal of inherited metabolic disease. 2012 Jan; 35(1):13-22. doi: 10.1007/s10545-010-9210-7. [PMID: 20882351]
  • Erik M Mueller, Elisabeth A Evers, Jan Wacker, Freddy van der Veen. Acute tryptophan depletion attenuates brain-heart coupling following external feedback. Frontiers in human neuroscience. 2012; 6(?):77. doi: 10.3389/fnhum.2012.00077. [PMID: 22509162]
  • Zulfitri A Mat Daud, Boniface Tubie, Judy Adams, Tracey Quainton, Robert Osia, Sharon Tubie, Deepinder Kaur, Pramod Khosla, Marina Sheyman. Effects of protein and omega-3 supplementation, provided during regular dialysis sessions, on nutritional and inflammatory indices in hemodialysis patients. Vascular health and risk management. 2012; 8(?):187-95. doi: 10.2147/vhrm.s28739. [PMID: 22536073]
  • Ignacio Cota, Anne Béatrice Blanc-Potard, Josep Casadesús. STM2209-STM2208 (opvAB): a phase variation locus of Salmonella enterica involved in control of O-antigen chain length. PloS one. 2012; 7(5):e36863. doi: 10.1371/journal.pone.0036863. [PMID: 22606300]
  • Antje Bruckbauer, Michael B Zemel. Effects of dairy consumption on SIRT1 and mitochondrial biogenesis in adipocytes and muscle cells. Nutrition & metabolism. 2011 Dec; 8(?):91. doi: 10.1186/1743-7075-8-91. [PMID: 22185590]
  • Bilal Ahmad Zafar Amin, Johnny Beaugrand, Philippe Debeire, Brigitte Chabbert, Isabelle Bertrand. Impact of epiphytic and endogenous enzyme activities of senescent maize leaves and roots on the soil biodegradation process. Comptes rendus biologies. 2011 Nov; 334(11):824-36. doi: 10.1016/j.crvi.2011.07.004. [PMID: 22078739]
  • F Marzo, F I Milagro, E Urdaneta, J Barrenetxe, F C Ibañez. Extrusion decreases the negative effects of kidney bean on enzyme and transport activities of the rat small intestine. Journal of animal physiology and animal nutrition. 2011 Oct; 95(5):591-8. doi: 10.1111/j.1439-0396.2010.01088.x. [PMID: 21114542]
  • Francisco L Torres-Leal, Miriam H Fonseca-Alaniz, Gabriela Fr Teodoro, Mariana D de Capitani, Daiana Vianna, Lucas C Pantaleão, Emidio M Matos-Neto, Marcelo M Rogero, Jose Donato, Julio Tirapegui. Leucine supplementation improves adiponectin and total cholesterol concentrations despite the lack of changes in adiposity or glucose homeostasis in rats previously exposed to a high-fat diet. Nutrition & metabolism. 2011 Sep; 8(1):62. doi: 10.1186/1743-7075-8-62. [PMID: 21899736]
  • Anne Noatsch, Klaus J Petzke, Marion K Millrose, Susanne Klaus. Body weight and energy homeostasis was not affected in C57BL/6 mice fed high whey protein or leucine-supplemented low-fat diets. European journal of nutrition. 2011 Sep; 50(6):479-88. doi: 10.1007/s00394-010-0155-2. [PMID: 21170537]
  • Animesh Sahana, Sudipta Das, Raja Saha, Moumita Gupta, Subrata Laskar, Debasis Das. Identification and interaction of amino acids with leucine-anthracene reagent by TLC and spectrophotometry: experimental and theoretical studies. Journal of chromatographic science. 2011 Sep; 49(8):652-6. doi: 10.1093/chrsci/49.8.652. [PMID: 21859542]
  • Nahid Akhtar, Mark Js Miller, Tariq M Haqqi. Effect of a Herbal-Leucine mix on the IL-1β-induced cartilage degradation and inflammatory gene expression in human chondrocytes. BMC complementary and alternative medicine. 2011 Aug; 11(?):66. doi: 10.1186/1472-6882-11-66. [PMID: 21854562]
  • Wei Liu, Kai Huang, Xiaoyong Rao, Xiaoyan Liu, Shasha Sun, Xiaojian Luo. [A new water-soluble lubricant of tablets-L-leucine combined with PEG6000]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2011 Aug; 36(15):2061-5. doi: 10.4268/cjcmm20111511. [PMID: 22066440]
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  • Martine Avella, Franck Borgese, Jordi Ehrenfeld. Characterization of the L683P mutation of SLC26A9 in Xenopus oocytes. Biochimica et biophysica acta. 2011 Jun; 1810(6):577-83. doi: 10.1016/j.bbagen.2011.03.012. [PMID: 21439353]
  • M Cristina L Martins, Vanessa Ochoa-Mendes, Gisela Ferreira, Judite N Barbosa, Scott A Curtin, Buddy D Ratner, Mário A Barbosa. Interactions of leukocytes and platelets with poly(lysine/leucine) immobilized on tetraethylene glycol-terminated self-assembled monolayers. Acta biomaterialia. 2011 May; 7(5):1949-55. doi: 10.1016/j.actbio.2011.01.013. [PMID: 21237292]
  • Lars Steinstraesser, Jennifer Hauk, Cornelius Schubert, Sammy Al-Benna, Ingo Stricker, Hanns Hatt, Yechiel Shai, Hans-Ulrich Steinau, Frank Jacobsen. Suppression of soft tissue sarcoma growth by a host defense-like lytic peptide. PloS one. 2011 Mar; 6(3):e18321. doi: 10.1371/journal.pone.0018321. [PMID: 21483840]
  • Maria João Pinho, José Miguel Cabral, Elisabete Silva, Maria Paula Serrão, Patrício Soares-da-Silva. LAT1 overexpression and function compensates downregulation of ASCT2 in an in vitro model of renal proximal tubule cell ageing. Molecular and cellular biochemistry. 2011 Mar; 349(1-2):107-16. doi: 10.1007/s11010-010-0665-5. [PMID: 21125315]
  • Ik Jae Lee, Jinsil Seong, Jung Im Bae, Sei Hwan You, Yumie Rhee, Jong Ho Lee. Effect of Oral Supplementation with Branched-chain Amino Acid (BCAA) during Radiotherapy in Patients with Hepatocellular Carcinoma: A Double-Blind Randomized Study. Cancer research and treatment. 2011 Mar; 43(1):24-31. doi: 10.4143/crt.2011.43.1.24. [PMID: 21509160]
  • Nikolaos Psychogios, David D Hau, Jun Peng, An Chi Guo, Rupasri Mandal, Souhaila Bouatra, Igor Sinelnikov, Ramanarayan Krishnamurthy, Roman Eisner, Bijaya Gautam, Nelson Young, Jianguo Xia, Craig Knox, Edison Dong, Paul Huang, Zsuzsanna Hollander, Theresa L Pedersen, Steven R Smith, Fiona Bamforth, Russ Greiner, Bruce McManus, John W Newman, Theodore Goodfriend, David S Wishart. The human serum metabolome. PloS one. 2011 Feb; 6(2):e16957. doi: 10.1371/journal.pone.0016957. [PMID: 21359215]
  • Margarita D Marinova, Bozhidar P Tchorbanov. Preparation of antioxidant enzymatic hydrolysates from honeybee-collected pollen using plant enzymes. Enzyme research. 2011 Jan; 2010(?):415949. doi: 10.4061/2010/415949. [PMID: 21318132]
  • David Duguay, Erika Bélanger-Nelson, Valérie Mongrain, Anna Beben, Armen Khatchadourian, Nicolas Cermakian. Dynein light chain Tctex-type 1 modulates orexin signaling through its interaction with orexin 1 receptor. PloS one. 2011; 6(10):e26430. doi: 10.1371/journal.pone.0026430. [PMID: 22028875]
  • Norihiro Ryuman, Nobuo Watanabe, Takao Arai. S-nitrosation of cellular proteins by NO donors in rat embryonic fibroblast 3Y1 cells: factors affecting S-nitrosation. Oxidative medicine and cellular longevity. 2011; 2011(?):450317. doi: 10.1155/2011/450317. [PMID: 21904643]
  • Arjun Sengupta, Angika Basant, Soumita Ghosh, Shobhona Sharma, Haripalsingh M Sonawat. Liver Metabolic Alterations and Changes in Host Intercompartmental Metabolic Correlation during Progression of Malaria. Journal of parasitology research. 2011; 2011(?):901854. doi: 10.1155/2011/901854. [PMID: 21772982]
  • Seonghee Lee, Yulin Jia, Melissa Jia, David R Gealy, Kenneth M Olsen, Ana L Caicedo. Molecular evolution of the rice blast resistance gene Pi-ta in invasive weedy rice in the USA. PloS one. 2011; 6(10):e26260. doi: 10.1371/journal.pone.0026260. [PMID: 22043312]
  • Mathieu Schue, Agnes Fekete, Philippe Ortet, Catherine Brutesco, Thierry Heulin, Philippe Schmitt-Kopplin, Wafa Achouak, Catherine Santaella. Modulation of metabolism and switching to biofilm prevail over exopolysaccharide production in the response of Rhizobium alamii to cadmium. PloS one. 2011; 6(11):e26771. doi: 10.1371/journal.pone.0026771. [PMID: 22096497]
  • Morten Schiøtt, Adelina Rogowska-Wrzesinska, Peter Roepstorff, Jacobus J Boomsma. Leaf-cutting ant fungi produce cell wall degrading pectinase complexes reminiscent of phytopathogenic fungi. BMC biology. 2010 Dec; 8(?):156. doi: 10.1186/1741-7007-8-156. [PMID: 21194476]
  • Łukasz Samluk, Magdalena Czeredys, Katarzyna A Nałęcz. Regulation of amino acid/carnitine transporter B 0,+ (ATB 0,+) in astrocytes by protein kinase C: independent effects on raft and non-raft transporter subpopulations. Journal of neurochemistry. 2010 Dec; 115(6):1386-97. doi: 10.1111/j.1471-4159.2010.07040.x. [PMID: 20977479]
  • Pavan Muttil, Brian Pulliam, Lucila Garcia-Contreras, John Kevin Fallon, Chenchen Wang, Anthony James Hickey, David A Edwards. Pulmonary immunization of guinea pigs with diphtheria CRM-197 antigen as nanoparticle aggregate dry powders enhance local and systemic immune responses. The AAPS journal. 2010 Dec; 12(4):699-707. doi: 10.1208/s12248-010-9229-6. [PMID: 20878294]
  • Hui Sun, Alla Lapidus, Matt Nolan, Susan Lucas, Tijana Glavina Del Rio, Hope Tice, Jan-Fang Cheng, Roxane Tapia, Cliff Han, Lynne Goodwin, Sam Pitluck, Ioanna Pagani, Natalia Ivanova, Konstantinos Mavromatis, Natalia Mikhailova, Amrita Pati, Amy Chen, Krishna Palaniappan, Miriam Land, Loren Hauser, Yun-Juan Chang, Cynthia D Jeffries, Olivier Duplex Ngatchou Djao, Manfred Rohde, Johannes Sikorski, Markus Göker, Tanja Woyke, James Bristow, Jonathan A Eisen, Victor Markowitz, Philip Hugenholtz, Nikos C Kyrpides, Hans-Peter Klenk. Complete genome sequence of Nocardiopsis dassonvillei type strain (IMRU 509). Standards in genomic sciences. 2010 Nov; 3(3):325-36. doi: 10.4056/sigs.1363462. [PMID: 21304737]
  • Yulong Yin, Kang Yao, Zhaojin Liu, Min Gong, Zheng Ruan, Dun Deng, Bie Tan, Zhiqiang Liu, Guoyao Wu. Supplementing L-leucine to a low-protein diet increases tissue protein synthesis in weanling pigs. Amino acids. 2010 Nov; 39(5):1477-86. doi: 10.1007/s00726-010-0612-5. [PMID: 20473536]
  • Ludmila V Roze, Anindya Chanda, Maris Laivenieks, Randolph M Beaudry, Katherine A Artymovich, Anna V Koptina, Deena W Awad, Dina Valeeva, Arthur D Jones, John E Linz. Volatile profiling reveals intracellular metabolic changes in Aspergillus parasiticus: veA regulates branched chain amino acid and ethanol metabolism. BMC biochemistry. 2010 Aug; 11(?):33. doi: 10.1186/1471-2091-11-33. [PMID: 20735852]
  • Guanghou Shui, Xue Li Guan, Pradeep Gopalakrishnan, Yangkui Xue, Joyce Sze Yuin Goh, Hongyuan Yang, Markus R Wenk. Characterization of substrate preference for Slc1p and Cst26p in Saccharomyces cerevisiae using lipidomic approaches and an LPAAT activity assay. PloS one. 2010 Aug; 5(8):e11956. doi: 10.1371/journal.pone.0011956. [PMID: 20694142]
  • Kaiying Guo, Yi-Hao Yu, Jue Hou, Yiying Zhang. Chronic leucine supplementation improves glycemic control in etiologically distinct mouse models of obesity and diabetes mellitus. Nutrition & metabolism. 2010 Jul; 7(?):57. doi: 10.1186/1743-7075-7-57. [PMID: 20624298]
  • N López, J Sánchez, C Picó, A Palou, F Serra. Dietary l-leucine supplementation of lactating rats results in a tendency to increase lean/fat ratio associated to lower orexigenic neuropeptide expression in hypothalamus. Peptides. 2010 Jul; 31(7):1361-7. doi: 10.1016/j.peptides.2010.03.028. [PMID: 20347902]
  • Thomas Datzmann, Otto von Helversen, Frieder Mayer. Evolution of nectarivory in phyllostomid bats (Phyllostomidae Gray, 1825, Chiroptera: Mammalia). BMC evolutionary biology. 2010 Jun; 10(?):165. doi: 10.1186/1471-2148-10-165. [PMID: 20525339]
  • Masahiko Kaji, Maryam Kabir-Salmani, Naohiko Anzai, Chun Ji Jin, Yoshihiro Akimoto, Ayako Horita, Atsuhiko Sakamoto, Yoshikatsu Kanai, Hiroyuki Sakurai, Mitsutoshi Iwashita. Properties of L-type amino acid transporter 1 in epidermal ovarian cancer. International journal of gynecological cancer : official journal of the International Gynecological Cancer Society. 2010 Apr; 20(3):329-36. doi: 10.1111/igc.0b013e3181d28e13. [PMID: 20375792]
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  • Maria Lúcia Bonfleur, Emerielle Cristine Vanzela, Rosane Aparecida Ribeiro, Gabriel de Gabriel Dorighello, Carolina Prado de França Carvalho, Carla Beatriz Collares-Buzato, Everardo Magalhães Carneiro, Antonio Carlos Boschero, Helena Coutinho Franco de Oliveira. Primary hypercholesterolaemia impairs glucose homeostasis and insulin secretion in low-density lipoprotein receptor knockout mice independently of high-fat diet and obesity. Biochimica et biophysica acta. 2010 Feb; 1801(2):183-90. doi: 10.1016/j.bbalip.2009.10.012. [PMID: 19913637]
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