Linoleoyl-CoA (BioDeep_00000873071)
Main id: BioDeep_00000630247
代谢物信息卡片
化学式: C39H66N7O17P3S (1029.3448576)
中文名称: 亚麻酰基辅酵素 a
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCCCC/C=C\C/C=C\CCCCCCCC(=O)SCCNC(=O)CCNC(=O)[C@@H](C(C)(C)COP(=O)(O)OP(=O)(O)OC[C@@H]1[C@H]([C@H]([C@H](n2cnc3c(N)ncnc23)O1)O)OP(=O)(O)O)O
InChI: InChI=1S/C39H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,26-28,32-34,38,49-50H,4-7,10,13-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b9-8+,12-11+
描述信息
An octadecadienoyl-CoA that results from the formal condensation of the thiol group of coenzyme A with the carboxy group of linoleic acid.
Linoleoyl-CoA is the acyl-CoA of linoleic acid found in the human body. It binds to and results in decreased activity of Glutathione S-transferase1. It has been proposed that inhibition of mitochondrial adenine nucleotide translocator by long chain acyl-CoA underlies the mechanism associating obesity and type 2 diabetes. Unsaturated fatty acids play an important role in the prevention of human diseases such as diabetes, obesity, cancer, and neurodegeneration. Their oxidation in vivo by acyl-CoA dehydrogenases (ACADs) catalyze the first step of each cycle of mitochondrial fatty acid {beta}-oxidation; ACAD-9 had maximal activity with long-chain unsaturated acyl-CoAs as substrates. (PMID: 17184976, 16020546) [HMDB]
同义名列表
数据库引用编号
11 个数据库交叉引用编号
- ChEBI: CHEBI:15530
- KEGG: C02050
- PubChem: 5497112
- foodb: FDB022403
- CAS: 6709-57-5
- MetaboLights: MTBLC15530
- PubChem: 5139
- LipidMAPS: LMFA07050343
- 3DMET: B04835
- NIKKAJI: J2.735.439D
- RefMet: Linoleoyl-CoA
分类词条
相关代谢途径
Reactome(6)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
- 9606 - Homo sapiens: 10.1007/S11306-016-1051-4
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
文献列表
- Kenshi Watanabe, Makoto Ohno, Masahiro Taguchi, Seiji Kawamoto, Kazuhisa Ono, Tsunehiro Aki. Identification of amino acid residues that determine the substrate specificity of mammalian membrane-bound front-end fatty acid desaturases.
Journal of lipid research.
2016 Jan; 57(1):89-99. doi:
10.1194/jlr.m064121
. [PMID: 26590171] - Mauricio A Retamal, Flavio Evangelista-Martínez, Carmen G León-Paravic, Guillermo A Altenberg, Luis Reuss. Biphasic effect of linoleic acid on connexin 46 hemichannels.
Pflugers Archiv : European journal of physiology.
2011 Jun; 461(6):635-43. doi:
10.1007/s00424-011-0936-3
. [PMID: 21360038] - Wei Gao, Hong-Ye Li, Shi Xiao, Mee-Len Chye. Protein interactors of acyl-CoA-binding protein ACBP2 mediate cadmium tolerance in Arabidopsis.
Plant signaling & behavior.
2010 Aug; 5(8):1025-7. doi:
10.4161/psb.5.8.12294
. [PMID: 20657176] - A L Thompson, G J Cooney. Acyl-CoA inhibition of hexokinase in rat and human skeletal muscle is a potential mechanism of lipid-induced insulin resistance.
Diabetes.
2000 Nov; 49(11):1761-5. doi:
10.2337/diabetes.49.11.1761
. [PMID: 11078441] - G Griffiths, A K Stobart, S Stymne. Delta 6- and delta 12-desaturase activities and phosphatidic acid formation in microsomal preparations from the developing cotyledons of common borage (Borago officinalis).
The Biochemical journal.
1988 Jun; 252(3):641-7. doi:
10.1042/bj2520641
. [PMID: 3421914] - T Kawasaki, F Snyder. Synthesis of a novel acetylated neutral lipid related to platelet-activating factor by acyl-CoA:1-O-alkyl-2-acetyl-sn-glycerol acyltransferase in HL-60 cells.
The Journal of biological chemistry.
1988 Feb; 263(6):2593-6. doi:
. [PMID: 3422635]
- S Stymne, A K Stobart. Biosynthesis of gamma-linolenic acid in cotyledons and microsomal preparations of the developing seeds of common borage (Borago officinalis).
The Biochemical journal.
1986 Dec; 240(2):385-93. doi:
10.1042/bj2400385
. [PMID: 3028375] - O Colard, M Breton, R Infante, G Bereziat, J Polonovski. 1-Acyl-lysolecithin acyltransferase and synthesis of biliary lecithins in rat liver.
Biochimie.
1984 Mar; 66(3):215-21. doi:
10.1016/0300-9084(84)90065-8
. [PMID: 6743697] - P B Smith, R C Reitz, D Kelley. Acyl-CoA synthase and acyltransferase activity in developing skeletal muscle membranes.
Biochimica et biophysica acta.
1982 Oct; 713(1):128-35. doi:
10.1016/0005-2760(82)90175-8
. [PMID: 7138893] - M Mahfouz, S Johnson, R T Holman. Inhibition of desaturation of palmitic, linoleic and eicosa-8,11,14-trienoic acids in vitro by isomeric cis-octadecenoic acids.
Biochimica et biophysica acta.
1981 Jan; 663(1):58-68. doi:
10.1016/0005-2760(81)90194-6
. [PMID: 7213772] - T Okayasu. [Purification and characterization of Linoleoyl-CoA desaturase from rat liver microsomes (author's transl)].
[Hokkaido igaku zasshi] The Hokkaido journal of medical science.
1981 Jan; 56(1):43-54. doi:
. [PMID: 7262818]
- . .
.
. doi:
. [PMID: 18781350]