Picibanil (BioDeep_00000840363)
Secondary id: BioDeep_00001871935
代谢物信息卡片
Picibanil
化学式: C16H17N2O4S- (333.0908982)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1(C(N2C(S1)C(C2=O)NC(=O)CC3=CC=CC=C3)C(=O)[O-])C
InChI: InChI=1S/C16H18N2O4S/c1-16(2)12(15(21)22)18-13(20)11(14(18)23-16)17-10(19)8-9-6-4-3-5-7-9/h3-7,11-12,14H,8H2,1-2H3,(H,17,19)(H,21,22)/p-1/t11-,12+,14-/m1/s1
描述信息
C308 - Immunotherapeutic Agent > C210 - Immunoadjuvant > C2141 - Chemo Immunostimulant Adjuvant
D000970 - Antineoplastic Agents
C2140 - Adjuvant
同义名列表
1 个代谢物同义名
相关代谢途径
Reactome(0)
BioCyc(3)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Masahiro Ogasawara, Mamiko Miyashita, Shuichi Ota. Vaccination of Urological Cancer Patients With WT1 Peptide-Pulsed Dendritic Cells in Combination With Molecular Targeted Therapy or Conventional Chemotherapy Induces Immunological and Clinical Responses.
Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy.
2018 Jun; 22(3):266-277. doi:
10.1111/1744-9987.12694. [PMID: 29851270] - Shinji Miwa, Hideji Nishida, Yoshikazu Tanzawa, Akihiko Takeuchi, Katsuhiro Hayashi, Norio Yamamoto, Eishiro Mizukoshi, Yasunari Nakamoto, Shuichi Kaneko, Hiroyuki Tsuchiya. Phase 1/2 study of immunotherapy with dendritic cells pulsed with autologous tumor lysate in patients with refractory bone and soft tissue sarcoma.
Cancer.
2017 05; 123(9):1576-1584. doi:
10.1002/cncr.30606. [PMID: 28241093] - A Domènech, A Serrano, I Forner-Cordero, F Gómez, D Maldonado, C Domínguez. [Urological pathology of lymphatic origin].
Cirugia pediatrica : organo oficial de la Sociedad Espanola de Cirugia Pediatrica.
2016 Jan; 29(1):35-40. doi:
NULL. [PMID: 27911069] - Yujin Kudo, Hiroyuki Miura, Eiji Nakajima, Hidenobu Takahashi, Akiko Aoki, Norihiko Ikeda. Chylothorax in POEMS syndrome.
The Tohoku journal of experimental medicine.
2014 01; 232(1):43-6. doi:
10.1620/tjem.232.43. [PMID: 24477187] - Bing-ling Xu, Jin-quan Yu, Ke-jing Tang, Da-yue Liu, Yu-kun Kuang. Elevation of serum procalcitonin in patients after chemical pleurodesis with intrapleural injection of OK-432.
The clinical respiratory journal.
2014 Jan; 8(1):41-4. doi:
10.1111/crj.12032. [PMID: 23711195] - Go Ohe, Akiko Sasai, Daisuke Uchida, Tetsuya Tamatani, Hirokazu Nagai, Youji Miyamoto. Effect of soluble factors derived from oral cancer cells on the production of interferon-γ from peripheral blood mononuclear cells following stimulation with OK-432.
Oncology reports.
2013 Aug; 30(2):945-51. doi:
10.3892/or.2013.2480. [PMID: 23685791] - Takashi Ogasawara, Hiroki Umezawa, Shinpei Kato, Toshiaki Yano, Norio Kasamatsu, Ikko Hashizume. Intrathoracic administration of OK-432 elevates the serum procalcitonin levels.
Internal medicine (Tokyo, Japan).
2012; 51(19):2727-31. doi:
10.2169/internalmedicine.51.8315. [PMID: 23037463] - Shinji Miwa, Hideji Nishida, Yoshikazu Tanzawa, Munetomo Takata, Akihiko Takeuchi, Norio Yamamoto, Toshiharu Shirai, Katsuhiro Hayashi, Hiroaki Kimura, Kentaro Igarashi, Eishiro Mizukoshi, Yasunari Nakamoto, Shuichi Kaneko, Hiroyuki Tsuchiya. TNF-α and tumor lysate promote the maturation of dendritic cells for immunotherapy for advanced malignant bone and soft tissue tumors.
PloS one.
2012; 7(12):e52926. doi:
10.1371/journal.pone.0052926. [PMID: 23300824] - Y Nakamoto, E Mizukoshi, M Kitahara, F Arihara, Y Sakai, K Kakinoki, Y Fujita, Y Marukawa, K Arai, T Yamashita, N Mukaida, K Matsushima, O Matsui, S Kaneko. Prolonged recurrence-free survival following OK432-stimulated dendritic cell transfer into hepatocellular carcinoma during transarterial embolization.
Clinical and experimental immunology.
2011 Feb; 163(2):165-77. doi:
10.1111/j.1365-2249.2010.04246.x. [PMID: 21087443] - Mervi Närkiö-Mäkelä, Teppo Mäkelä, Pia Saarinen, Päivi Salminen, Ilkka Julkunen, Anne Pitkäranta. Treatment of lymphatic malformations of head and neck with OK-432 sclerotherapy induce systemic inflammatory response.
European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery.
2011 Jan; 268(1):123-9. doi:
10.1007/s00405-010-1332-x. [PMID: 20635092] - L Bennet, R V Cowie, P R Stone, R Barrett, A S Naylor, A B Blood, A J Gunn. The neural and vascular effects of killed Su-Streptococcus pyogenes (OK-432) in preterm fetal sheep.
American journal of physiology. Regulatory, integrative and comparative physiology.
2010 Aug; 299(2):R664-72. doi:
10.1152/ajpregu.00116.2010. [PMID: 20484698] - Wei-liang Chen, Zhi-quan Huang, Jin-song Li, Qiang Chai, Da-ming Zhang. Percutaneous sclerotherapy of juvenile nasopharyngeal angiofibroma using fibrin glue combined with OK-432 and bleomycin.
International journal of pediatric otorhinolaryngology.
2010 Apr; 74(4):422-5. doi:
10.1016/j.ijporl.2010.02.002. [PMID: 20189660] - Wei-liang Chen, Zhi-quan Huang, Da-ming Zhang, Qiang Chai. Percutaneous sclerotherapy of massive venous malformations of the face and neck using fibrin glue combined with OK-432 and pingyangmycin.
Head & neck.
2010 Apr; 32(4):467-72. doi:
10.1002/hed.21206. [PMID: 19672870] - Andreas Kremser, Julia Dressig, Christine Grabrucker, Anja Liepert, Tanja Kroell, Nina Scholl, Christoph Schmid, Johanna Tischer, Stefanie Kufner, Helmut Salih, Hans Jochem Kolb, Helga Schmetzer. Dendritic cells (DCs) can be successfully generated from leukemic blasts in individual patients with AML or MDS: an evaluation of different methods.
Journal of immunotherapy (Hagerstown, Md. : 1997).
2010 Feb; 33(2):185-99. doi:
10.1097/cji.0b013e3181b8f4ce. [PMID: 20139775] - Dagmar Bund, Raymund Buhmann, Füsun Gökmen, Andreas Kremser, Julia Dreyssig, Hans Jochem Kolb, Helga Maria Schmetzer. Canine-DCs using different serum-free methods as an approach to provide an animal-model for immunotherapeutic strategies.
Cellular immunology.
2010; 263(1):88-98. doi:
10.1016/j.cellimm.2010.03.003. [PMID: 20347071] - Young Deuk Choi, Won Sik Ham, Won Tae Kim, Kang Su Cho, Joo Hyoung Lee, Soung Yong Cho, Ju Wan Seo, Ok Hyun Jin. Clinical experience of single-session percutaneous aspiration and OK-432 sclerotherapy for treatment of simple renal cysts: 1-year follow-up.
Journal of endourology.
2009 Jun; 23(6):1001-6. doi:
10.1089/end.2008.0137. [PMID: 19459755] - Zenei Taira, Hiroshi Monmasu, Yukari Ueda. Innate host-defensive function of a hepatic lipid fraction produced in low-dose carbon tetrachloride-pretreated mice.
Anticancer research.
2009 Mar; 29(3):837-41. doi:
". [PMID: 19414317] - Kazuya Higashihara, Yoshiyuki Kimbara, Yohei Suzuki, Eriko Kawate, Hideki Takahashi. Severe hyponatremia due to inappropriate secretion of antidiuretic hormone following pleurodesis.
Internal medicine (Tokyo, Japan).
2009; 48(12):1069-71. doi:
10.2169/internalmedicine.48.2021. [PMID: 19525601] - Won Sik Ham, Joo Hyoung Lee, Won Tae Kim, Ho Song Yu, Young Deuk Choi. Comparison of multiple session 99\% ethanol and single session OK-432 sclerotherapy for the treatment of simple renal cysts.
The Journal of urology.
2008 Dec; 180(6):2552-6. doi:
10.1016/j.juro.2008.08.026. [PMID: 18930501] - Wei-Liang Chen, Zhao-Hui Yang, Zhi-Bao Bai, Yong-Yuan Wang, Zhi-Quan Huang, Yong-Jie Wang. A pilot study on combination compartmentalisation and sclerotherapy for the treatment of massive venous malformations of the face and neck.
Journal of plastic, reconstructive & aesthetic surgery : JPRAS.
2008 Dec; 61(12):1486-92. doi:
10.1016/j.bjps.2007.10.002. [PMID: 17993298] - Young Deuk Choi, Soung Yong Cho, Kang Su Cho, Dong Hoon Lee, Seung Hwan Lee. Percutaneous treatment of renal cysts with OK-432 sclerosis.
Yonsei medical journal.
2007 Apr; 48(2):270-3. doi:
10.3349/ymj.2007.48.2.270. [PMID: 17461526] - Shu-Mei Li, Xiao-Ting Luo, Jin-Hua Ye, Yue-Ling Xiong, Lei Yu, Fu-You Zhong, Qin Huang. [Inhibitory effect of combined bacterin on growth of sarcoma 180 in mice].
Ai zheng = Aizheng = Chinese journal of cancer.
2007 Apr; 26(4):382-5. doi:
NULL. [PMID: 17430656] - Keiko Ogita, Tomoaki Taguchi, Sachiyo Suita. Experimental study concerning safety dosage of OK-432 for intrauterine treatment.
Asian journal of surgery.
2006 Jul; 29(3):202-6. doi:
10.1016/s1015-9584(09)60088-9. [PMID: 16877226] - Kazue Nakata, Hiroyuki Inagawa, Takashi Nishizawa, Teruko Honda, Chie Kohchi, Yasuhito Tonomoto, Hiroshi Yoshimura, Naofumi Nagasue, Shynji Natori, Hiroshi Terada, Gen-Ichiro Soma. Inherent potential for production of tumor necrosis factor-alpha by human intestinal macrophages.
International journal of colorectal disease.
2006 May; 21(4):339-47. doi:
10.1007/s00384-005-0021-5. [PMID: 16091914] - Juan Alonso, Luis Barbier, Julio Alvarez, Laura Romo, Jesús C Martín, Iciar Arteagoitia, Joseba Santamaría. OK432 (picibanil) efficacy in an adult with cystic cervical lymphangioma. A case report.
Medicina oral, patologia oral y cirugia bucal.
2005 Aug; 10(4):362-6. doi:
NULL. [PMID: 16056191] - Masatoshi Shiratori, Ikuo Nagashima, Tadahiro Takada, Shinichiro Morofuji, Hiroshi Motomiya, Keiji Matsuda, Tsuyoshi Inaba, Junichi Fukushima, Kota Okinaga. Successful treatment of ruptured hepatocellular carcinoma with intraperitoneal injection of OK-432.
Journal of hepato-biliary-pancreatic surgery.
2004; 11(6):426-9. doi:
10.1007/s00534-004-0921-8. [PMID: 15619020] - Masato Okamoto, Mitsunobu Sato. Toll-like receptor signaling in anti-cancer immunity.
The journal of medical investigation : JMI.
2003 Feb; 50(1-2):9-24. doi:
". [PMID: 12630564] - Kouki Kuwabara, Hideyuki Ishida, Tomonori Ohsawa, Hiroshi Nakata, Nobuo Murata, Daijo Hashimoto, Akiko Adachi, Shinji Itoyama. [Short-term intraperitoneal infusion of cisplatin and OK-432 for a case of malignant mesothelioma of the peritoneum].
Gan to kagaku ryoho. Cancer & chemotherapy.
2002 Nov; 29(12):2333-5. doi:
NULL. [PMID: 12484067] - Masato Watanabe, Kazuo Chijiiwa, Nobuhisa Kameoka, Kenji Nakano, Hirokazu Noshiro, Masao Tanaka. Effects of streptococcal preparation OK-432 on liver regeneration and energy status after partial hepatectomy under ischemia/reperfusion in rats.
Hepato-gastroenterology.
2002 Jan; 49(43):218-21. doi:
NULL. [PMID: 11941959] - Yukio Kageyama, Yasuyuki Sakai, Gaku Arai, Nobuhiko Hyochi, Masahito Suzuki, Hitoshi Masuda, Satoru Kawakami, Tetsuo Hayashi, Tetsuo Okuno, Tsuyoshi Kobayashi, Kazunori Kihara. Intracavitary administration of OK-432 with subcutaneous priming for malignant ascites in a case of advanced renal cell carcinoma.
International journal of urology : official journal of the Japanese Urological Association.
2002 Jan; 9(1):57-9. doi:
10.1046/j.1442-2042.2002.00411.x. [PMID: 11972652] - M Nishikido, T Kiyohara, S Koga, K Shindo, F Matsuya, Y Saito, H Kanetake. OK432-induced killer cell activity: potential method for monitoring immunological complications after renal transplantation.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.
2001 Oct; 16(10):2067-71. doi:
10.1093/ndt/16.10.2067. [PMID: 11572898] - T Uehara, T Yano, S Kuninaka, I Yoshino, H Asoh, Y Ichinose. The influence of enhanced postoperative inflammation by the intrapleural administration of streptococcal preparation (OK-432) on the prognosis of completely resected non-small-cell lung cancer.
Journal of surgical oncology.
2000 Sep; 75(1):51-4. doi:
10.1002/1096-9098(200009)75:1<51::aid-jso9>3.0.co;2-f. [PMID: 11025462] - M Okamoto, G Ohe, T Oshikawa, H Nishikawa, S Furuichi, T Bando, H Yoshida, T Sakai, K Himeno, M Sato, S Ohkubo. Purification and characterization of cytokine-inducing protein of seed extract from Aeginetia indica L., a parasitic plant.
Immunopharmacology.
2000 Sep; 49(3):377-89. doi:
10.1016/s0162-3109(00)00253-8. [PMID: 10996035] - K Aoyagi, K Koufuji, S Yano, N Murakami, Y Terasaki, Y Yamasaki, J Takeda, K Shirouzu. Unresectable advanced gastric cancer effectively treated by combined chemo-immunotherapy: a report of two cases.
The Kurume medical journal.
2000; 47(2):177-82. doi:
10.2739/kurumemedj.47.177. [PMID: 10948658] - S Ikeda, Y Takabayashi, Y Maejima, N Tachibana, T Ehara, A Nezu, Y Hoshii. Nodular lung disease with five year survival and unilateral pleural effusion in AL amyloidosis.
Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis.
1999 Dec; 6(4):292-6. doi:
10.3109/13506129909007343. [PMID: 10611952] - T Ueno, K Sujaku, S Tamaki, R Ogata, M Kin, T Nakamura, M Sakamoto, T Torimura, K Mitsuyama, S Sakisaka, M Sata, K Tanikawa. OK-432 treatment increases matrix metalloproteinase-9 production and improves dimethylnitrosamine-induced liver cirrhosis in rats.
International journal of molecular medicine.
1999 May; 3(5):497-503. doi:
10.3892/ijmm.3.5.497. [PMID: 10202181] - M Nose, A Uzawa, M Nomura, Y Ikarashi, Y Nakata, M Akashi, G Suzuki. Control of endotoxin shock by the dried preparation of low virulent Streptococcus pyogenes OK-432.
Cellular immunology.
1998 Sep; 188(2):97-104. doi:
10.1006/cimm.1998.1357. [PMID: 9756639] - T Kanda, S Kogure, M Nara, S Tsukui, T Utsugi, S Tomono, S Kawazu, R Nagai, I Kobayashi. Combination of OK432 and human interferon-alpha for treating viral-induced diabetes mellitus in mice.
European journal of pharmacology.
1998 Jan; 342(2-3):297-302. doi:
10.1016/s0014-2999(97)01476-3. [PMID: 9548400] - T Hanagiri, H Muranaka, M Hashimoto, A Nagashima. A syndrome of inappropriate secretion of antidiuretic hormone associated with pleuritis caused by OK-432.
Respiration; international review of thoracic diseases.
1998; 65(4):310-2. doi:
10.1159/000029283. [PMID: 9730800] - Y Higuchi. Antitumor effect of Streptococcus pyogenes by inducing hydrogen peroxide production.
Japanese journal of cancer research : Gann.
1996 Dec; 87(12):1271-9. doi:
10.1111/j.1349-7006.1996.tb03143.x. [PMID: 9045963] - J Nakajima, M Mogi, T Chino. Inhibition by streptococcal immunopotentiator OK432 of lymph-node metastasis in hamster cheek-pouch carcinoma with enhancement of tumour necrosis factor-alpha and interleukin-6 in serum.
Archives of oral biology.
1996 May; 41(5):513-6. doi:
10.1016/0003-9969(95)00151-4. [PMID: 8809316] - T Misaki, S Miyamoto, M S Alam, K Kasagi, J Konishi. Tumoricidal cytokines enhance radioiodine uptake in cultured thyroid cancer cells.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine.
1996 Apr; 37(4):646-8. doi:
NULL. [PMID: 8691260] - H Matsuoka, K Yano, H Wasasugi, Y Seo, T Saito, H Tomoda. Potential advantages in therapeutic index of OK-432 ointment to abdominal skin over systemic applied in a mouse model.
Cancer letters.
1996 Mar; 101(1):15-20. doi:
10.1016/0304-3835(95)04103-6. [PMID: 8625276] - T Himoto, S Watanabe, M Nishioka, T Maeba, S Tanaka, M Saito. Combination immunotherapy with OK-432, recombinant granulocyte-colony-stimulating factor and recombinant interleukin-2 for human hepatocellular carcinoma.
Cancer immunology, immunotherapy : CII.
1996 Feb; 42(2):127-31. doi:
10.1007/s002620050262. [PMID: 8620522] - S Fujita, S Arii, K Monden, S Ishiguro, T Nakamura, M Mizumoto, M Imamura. The preventive effects of OK432 on endotoxin-induced liver injury: liver protection by the modulation of hepatic macrophage function.
Surgery today.
1996; 26(1):29-35. doi:
10.1007/bf00311988. [PMID: 8680117] - K Kishi, T Kanai, M Sakon, Y Fujiwara, Y Takeda, N Higaki, T Yamada, K Taniguchi, Y Hasuike, M Gotoh. [The efficacy of transarterial immuno-embolization therapy in patients with unresectable hepatocellular carcinoma].
Gan to kagaku ryoho. Cancer & chemotherapy.
1995 Sep; 22(11):1590-3. doi:
NULL. [PMID: 7574767] - T Kanda, T Yokoyama, S Imai, T Suzuki, K Murata, I Kobayashi. Effect of combination therapy with OK432 and recombinant human interferon-alpha A/D on atrial natriuretic peptide gene expression in mice with viral myocarditis.
The Journal of pharmacology and experimental therapeutics.
1995 Jul; 274(1):494-8. doi:
NULL. [PMID: 7616436] - T Yoshikawa, H Takano, N Yoshida, M Kondo. Simultaneous intraperitoneal administration of OK-432 and serum enhances superoxide generation from migrated polymorphonuclear leukocytes, with special emphasis on the role of complements.
Immunopharmacology and immunotoxicology.
1995 May; 17(2):265-82. doi:
10.3109/08923979509019750. [PMID: 7650290] - K Okamoto, K Hamazaki, H Iwagaki, K Orita, A Mori. Effect of Picibanil (OK-432) on the scavenging effect of free radicals produced during liver regeneration in the rat.
Acta medica Okayama.
1995 Apr; 49(2):75-9. doi:
10.18926/amo/30392. [PMID: 7618491] - Y Akiyama, H Kondo, S Kimura, Y Fujii. [A case of chest wall tumor associated with production of CA125 treated effectively by chemotherapy].
Gan to kagaku ryoho. Cancer & chemotherapy.
1995 Apr; 22(5):687-90. doi:
NULL. [PMID: 7717723] - K Haranaka, A Sakurai, N Satomi, T Ono, R Haranaka. Combination therapy with traditional Chinese medicines and Streptococcus pyogenes products (OK 432) for endogenous tumor necrosis factor therapy. A preliminary report.
Cancer biotherapy.
1995; 10(2):131-8. doi:
10.1089/cbr.1995.10.131. [PMID: 7663572] - Y C Lee, S P Luh, R M Wu, C J Lee. Adjuvant immunotherapy with intrapleural Streptococcus pyogenes (OK-432) in lung cancer patients after resection.
Cancer immunology, immunotherapy : CII.
1994 Oct; 39(4):269-74. doi:
10.1007/bf01525991. [PMID: 7954529] - T Yoshida, T Kanai, M Monden, Y Kita, M Sakon, M Gotoh, K Umeshita, Y Hanike, T Monden, H Nakamura. [Immunological and histological analyses of transarterial immuno-embolization therapy (TIE) in operable patients with hepatocellular carcinoma].
Gan to kagaku ryoho. Cancer & chemotherapy.
1994 Sep; 21(13):2111-4. doi:
NULL. [PMID: 7944415] - Y Tsuji, T Suematsu, S Kawabata, I Kodama, K Koufuji, K Aoyagi, T Tanaka, M Maruiwa, J Ohta, H Kumegawa. [Complete response in a case of unresectable gastric cancer treated by combined chemoimmunotherapy of MMC, 5-FU and OK-432].
Gan to kagaku ryoho. Cancer & chemotherapy.
1994 Sep; 21(12):2045-8. doi:
NULL. [PMID: 8085856] - M Nose, Y Aoki, Y Kawase, G Suzuki, M Akashi, A Akanuma. In vitro effects of OK-432 on irradiated mouse bone marrow cells.
International journal of radiation oncology, biology, physics.
1994 Jun; 29(3):631-4. doi:
10.1016/0360-3016(94)90471-5. [PMID: 8005828] - M Oka, S Hazama, S Yoshino, K Shimoda, M Suzuki, R Shimizu, K Yano, M Nishida, T Suzuki. Intraarterial combined immunochemotherapy for unresectable hepatocellular carcinoma: preliminary results.
Cancer immunology, immunotherapy : CII.
1994 Mar; 38(3):194-200. doi:
10.1007/bf01525641. [PMID: 8124688] - Y Abe, K Kimura, A Horiuchi, Y Watanabe, S Kimura. The elevation of plasma soluble tumor necrosis factor receptor levels by TNF induction therapy for patients with malignancy.
Surgery today.
1994; 24(6):506-11. doi:
10.1007/bf01884569. [PMID: 7919732] - T Kanai, M Monden, M Sakon, M Gotoh, K Umeshita, Y Hasuike, H Nakano, T Monden, T Murakami, H Nakamura. New development of transarterial immunoembolization (TIE) for therapy of hepatocellular carcinoma with intrahepatic metastases.
Cancer chemotherapy and pharmacology.
1994; 33 Suppl(?):S48-54. doi:
10.1007/bf00686668. [PMID: 8137485] - H Tazaki. [Cytokine treatment of renal cell carcinoma].
Gan to kagaku ryoho. Cancer & chemotherapy.
1994 Jan; 21(1):29-36. doi:
NULL. [PMID: 8291913] - T Ebina, K Murata. [Differences in antitumor effect of various BRMs by intratumoral administration: induction of immunosuppressive acidic protein].
Gan to kagaku ryoho. Cancer & chemotherapy.
1993 Aug; 20(11):1453-6. doi:
. [PMID: 8373204] - N Hino, T Higashi, T Ueki, H Nakatsukasa, S Ooguchi, K Ashida, K Fujio, A Takaki, T Yonei, T Hasui. Disappearance of pulmonary metastases by OK-432 treatment in a case of hepatocellular carcinoma.
Acta medica Okayama.
1993 Aug; 47(4):289-92. doi:
10.18926/amo/31549. [PMID: 7692705] - T Ogawara, T Sekikawa, K Kouno, Y Matsumoto. [A case of metastatic splenic tumor treated with intra-arterial immunochemotherapy to induce endogenous LAK cell].
Gan to kagaku ryoho. Cancer & chemotherapy.
1993 Aug; 20(11):1446-9. doi:
NULL. [PMID: 7690534] - K Suzuki, S Itaya, I Tsuge, T Matsuda, H Motai, T Kobayashi, J Shimada, S Baba. [Tissue and serum levels of 5-FU in the patients with head and neck malignant tumors--influence of a streptococcal preparation OK-432].
Gan to kagaku ryoho. Cancer & chemotherapy.
1993 Aug; 20(10):1349-54. doi:
NULL. [PMID: 8346933] - I A Holder, R G Miller, A N Neely. Biologic response modifier OK-432 pretreatment reduces mortality in burned mice infected with gram-negative bacteria.
The Journal of burn care & rehabilitation.
1993 Jul; 14(4):401-5. doi:
10.1097/00004630-199307000-00001. [PMID: 8408163] - K Miyamoto, M Nomura, M Sasakura, E Matsui, R Koshiura, T Murayama, T Furukawa, T Hatano, T Yoshida, T Okuda. Antitumor activity of oenothein B, a unique macrocyclic ellagitannin.
Japanese journal of cancer research : Gann.
1993 Jan; 84(1):99-103. doi:
10.1111/j.1349-7006.1993.tb02790.x. [PMID: 8449833] - T Kanda, T Yokoyama, T Suzuki, K Murata. Role of interferon in the protective effect of an immunomodulator derived from the Su strain of Streptococcus pyogenes A3 against viral myocarditis in mice.
Arzneimittel-Forschung.
1993 Jan; 43(1):80-3. doi:
NULL. [PMID: 7680562] - M Shinoda, Y Naide. [Treatment of advanced renal cell carcinoma with interferon alpha and OK-432 (streptococcal preparation)].
Hinyokika kiyo. Acta urologica Japonica.
1992 Nov; 38(11):1299-304. doi:
NULL. [PMID: 1485585] - S Fujieda, H Saito, Y Isobe, G Nakagawara, O Nishi, K Nagahara, Y Watanabe, T Hoshino. Effect of OK-432 on cytotoxic activity in cancer patients without tumor burden.
Anticancer research.
1992 Nov; 12(6B):1941-5. doi:
NULL. [PMID: 1341892] - J Nakashima, M Tachibana, S Baba, N Deguchi, S Jitsukawa, M Hata, H Tazaki. [Studies on the production of endogenous cytokines in patients with renal cell carcinoma].
Nihon Hinyokika Gakkai zasshi. The japanese journal of urology.
1992 Jul; 83(7):1110-7. doi:
10.5980/jpnjurol1989.83.1110. [PMID: 1507728] - M Mihara, Y Ohsugi. Autoimmune kidney disease in MRL/lpr mice inhibited by OK-432; II. Effect of indomethacin.
Journal of pharmacobio-dynamics.
1992 May; 15(5):255-9. doi:
10.1248/bpb1978.15.255. [PMID: 1527701] - H Saito, D Fukumura, I Kurose, M Suematsu, S Tada, T Kagawa, S Miura, T Morizane, M Tsuchiya. Visualization of oxidative processes at the cellular level during neutrophil-mediated cytotoxicity against a human hepatoma cell line, HCC-M.
International journal of cancer.
1992 Apr; 51(1):124-9. doi:
10.1002/ijc.2910510122. [PMID: 1314229] - M Watanabe, Y Shishido, N Hirasawa, S Mue, H Fujiki, K Ohuchi. Stimulation of arachidonic acid metabolism by a streptococcal preparation (OK-432) in rat peritoneal macrophages.
Biochimica et biophysica acta.
1992 Feb; 1138(2):157-61. doi:
10.1016/0925-4439(92)90056-s. [PMID: 1540662] - S Yamasaki, T Okino, N Kan, K Satoh, K Mise, Y Teramura, T Harada, H Kodama, T Hori, K Ohgaki. Factors influencing the response and survival of patients with liver metastases from breast cancer receiving OK-432-combined adoptive immunotherapy.
Journal of cancer research and clinical oncology.
1992; 118(2):157-62. doi:
10.1007/bf01187506. [PMID: 1735736] - E Kumazawa, A Tohgo, T Soga, T Kusama, Y Osada. Significant antitumor effect of a synthetic lipid A analogue, DT-5461, on murine syngeneic tumor models.
Cancer immunology, immunotherapy : CII.
1992; 35(5):307-14. doi:
10.1007/bf01741143. [PMID: 1394335] - H Seino, J Satoh, S Shintani, K Takahashi, X P Zhu, T Masuda, T Nobunaga, M Saito, Y Terano, T Toyota. Inhibition of autoimmune diabetes in NOD mice with serum from streptococcal preparation (OK-432)-injected mice.
Clinical and experimental immunology.
1991 Dec; 86(3):413-8. doi:
10.1111/j.1365-2249.1991.tb02946.x. [PMID: 1747949] - H Takekoshi. [Immunochemo-embolization therapy of hepatocellular carcinoma].
Gan to kagaku ryoho. Cancer & chemotherapy.
1991 Aug; 18(11):1916-9. doi:
NULL. [PMID: 1715155] - M Taradi, M Urano, S K Taradi, Y Maruyama. Augmentation of mouse natural killer cell activity by combined hyperthermia and streptococcal preparation, OK-432 (Picibanil) treatment.
International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group.
1991 Jul; 7(4):653-65. doi:
10.3109/02656739109034977. [PMID: 1919160] - Y Kanaoka, N Umesaki. [The effect of intraperitoneal administration of OK-432 with recombinant interleukin-2 to patients with peritonitis carcinomatosa of recurrent gynecological cancer and changes in ascitic lymphocyte subsets].
Nihon Sanka Fujinka Gakkai zasshi.
1991 May; 43(5):489-96. doi:
NULL. [PMID: 2056223] - S Tanji. [Effect of biological response modifiers on a spontaneous murine renal cell carcinoma regression of metastases caused by the streptococcal preparation OK-432].
Nihon Hinyokika Gakkai zasshi. The japanese journal of urology.
1991 May; 82(5):716-25. doi:
10.5980/jpnjurol1989.82.716. [PMID: 1875566] - T Okuda. Murine polymorphonuclear leukocytes synthesize and secrete the third component and factor B of complement.
International immunology.
1991 Apr; 3(4):293-6. doi:
10.1093/intimm/3.4.293. [PMID: 1878337] - K Fujisawa, T Kanno, K Yokoi, K Onouchi, T Kawase, M Abe. [Antitumor effect of direct intra-tumor administration of OK-432 on malignant glioma: basic and clinical observations].
No shinkei geka. Neurological surgery.
1991 Mar; 19(3):241-6. doi:
NULL. [PMID: 2038413] - T Yamaguchi, H Suzuki, N Ishii, T Nakada, Y Onmura, S Matsushita. [Retroperitoneal mixed type liposarcoma: a case report].
Hinyokika kiyo. Acta urologica Japonica.
1991 Feb; 37(2):141-5. doi:
NULL. [PMID: 2048492] - T Monden, H Morimoto, M Murotani, T Yagyu, H Nagaoka, T Shimano, T Mori. [Intratumoral injection of OK-432 in conjunction with fibrinogen greatly enhances antitumor effect on colorectal carcinomas].
Nihon Geka Gakkai zasshi.
1991 Jan; 92(1):31-6. doi:
NULL. [PMID: 1707498] - S Natsuume-Sakai, T Murayama, T Furukawa, S Koshimura. Antibody production useful for cytotoxicity against mouse MM2 tumor cells by peritoneal macrophages.
Microbiology and immunology.
1991; 35(9):755-65. doi:
10.1111/j.1348-0421.1991.tb01608.x. [PMID: 1808471] - M Akimoto, T Nishihira, H Hirakawa, M Abe, N Ohuchi, S Mori, K Kumagai. [Improved therapeutic effect of sequential immunotherapy with cyclophosphamide, large doses of OK-432 and recombinant interleukin-2 in breast cancer patients with disseminated metastatic liver tumors].
Nihon Geka Gakkai zasshi.
1991 Jan; 92(1):64-74. doi:
NULL. [PMID: 2014029] - A Horii, M Kyo, M Asakawa, R Yasumoto, M Maekawa. Multidisciplinary treatment for bladder carcinoma--biological response modifiers and kampo medicines.
Urologia internationalis.
1991; 47 Suppl 1(?):108-12. doi:
10.1159/000282266. [PMID: 1949364] - M Ullberg, W Tewodros, G Kronvall. Receptors for human plasminogen on the biological response modifier OK-432.
Journal of biological response modifiers.
1990 Dec; 9(6):592-6. doi:
NULL. [PMID: 1963635] - H Sakagami, S Kohno, S Tanuma, Y Kawazoe. Induction of cytotoxic factor in mice by lignified materials combined with OK-432 (Picibanil).
In vivo (Athens, Greece).
1990 Nov; 4(6):371-5. doi:
NULL. [PMID: 2103376] - G T Huang, P M Yang, J C Sheu, H C Hsu, J L Sung, T H Wang, D S Chen. Intratumor injection of OK-432 for the treatment of small hepatocellular carcinoma.
Hepato-gastroenterology.
1990 Oct; 37(5):452-6. doi:
NULL. [PMID: 2174823] - H Minagawa, H Kobayashi, H Yoshida, M Teranishi, A Morikawa, S Abe, H Oshima, D I Mizuno. Intratumoral induction of tumour necrosis factor by systemic administration of Bordetella pertussis vaccine.
British journal of cancer.
1990 Sep; 62(3):372-5. doi:
10.1038/bjc.1990.300. [PMID: 2206945] - M Yagita, E Saksela. Reduction by OK-432 of the monolayer contact-mediated inhibition of human natural killer cell activity.
Immunology letters.
1990 Sep; 25(4):347-53. doi:
10.1016/0165-2478(90)90206-6. [PMID: 2249878] - H Takekoshi. [Chemoembolization combined with hepatic arterial induction of endogenous TNF and anticancer agents for hepatocellular carcinoma--a case report].
Gan to kagaku ryoho. Cancer & chemotherapy.
1990 Aug; 17(8 Pt 2):1744-7. doi:
NULL. [PMID: 2167647] - H Anai, Y Okada, K Okubo, D Korenaga, Y Maehara, K Sugimachi, Y Ohi. [A case report of hemolytic uremic syndrome (HUS) induced by antineoplastic agents].
Nihon Gan Chiryo Gakkai shi.
1990 Jul; 25(7):1487-91. doi:
NULL. [PMID: 2120375] - Y Kanaoka, N Umesaki, M Kawabata, H Tsuda, T Sugawa. [Intraperitoneal administration of OK-432 and rIL-2 in a case of peritonitis carcinomatosa with chronic renal failure].
Nihon Gan Chiryo Gakkai shi.
1990 May; 25(5):1027-31. doi:
NULL. [PMID: 2391442] - T Shiraishi, Y Nio, S Imai, M Tsubono, H Morimoto, C C Tseng, T Tobe, T Tanaka, O Kitamura, S Sakanashi. [A double blind study of the evaluation of the optimal dose and its frequency in oral administration of OK-432 (Picibanil) by immunological parameters (the 1st report)].
Nihon Gan Chiryo Gakkai shi.
1990 Apr; 25(4):799-811. doi:
NULL. [PMID: 2196311] - J Muraki. Combination therapy for renal cell carcinoma using IFN-gamma and OK-432: in vitro study.
The Keio journal of medicine.
1990 Mar; 39(1):21-5. doi:
10.2302/kjm.39.21. [PMID: 2113148] - J Sagawa, T Miyagi, S Tsuiki. Effects of OK-432 activation on the sialidase activities of rat peritoneal macrophages.
The Tohoku journal of experimental medicine.
1990 Feb; 160(2):149-56. doi:
10.1620/tjem.160.149. [PMID: 2353349] - T Okino, N Kan, M Nakanishi, K Satoh, K Mise, Y Teramura, S Yamasaki, T Hori, H Kodama, K Ohgaki. The therapeutic effect of OK-432-combined adoptive immunotherapy against liver metastases from breast cancer.
Journal of cancer research and clinical oncology.
1990; 116(2):197-202. doi:
10.1007/bf01612677. [PMID: 2324164] - S J Shin, H Taniguchi, Y Hara, K Ejiri, Y Morimoto, Y Yamashiro, Y Ishida, N Kuroda, K Ishihara, J H Tsai. Lack of favorable effect of immunomodulators on outbred syngeneic rodent islet transplantation.
Diabetes research and clinical practice.
1990 Jan; 8(2):79-83. doi:
10.1016/0168-8227(90)90016-m. [PMID: 2106425]