8-Hydroxyadenine (BioDeep_00000603879)

Main id: BioDeep_00000025560

 

natural product


代谢物信息卡片


8H-Purin-8-one,6-amino-7,9-dihydro-

化学式: C5H5N5O (151.049408)
中文名称: 8-羟基腺嘌呤
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1=NC(=C2C(=N1)NC(=O)N2)N
InChI: InChI=1S/C5H5N5O/c6-3-2-4(8-1-7-3)10-5(11)9-2/h1H,(H4,6,7,8,9,10,11)

描述信息

A nucleobase analogue that is adenine bearing a single hydroxy substituent at position 8.

同义名列表

2 个代谢物同义名

8H-Purin-8-one,6-amino-7,9-dihydro-; 8-Hydroxyadenine



数据库引用编号

10 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

14 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Dong Gao, Juan Zeng, Xiaodong Wang, Yu Liu, Wang Li, Yunlong Hu, Ningning Gao, Yuwen Diao, Zhulin Wang, Wenqi Jiang, Jinhua Chen, Guangyi Jin. Conjugation of weak ligands with weak antigens to activate TLR-7: A step toward better vaccine adjuvants. European journal of medicinal chemistry. 2016 Sep; 120(?):111-20. doi: 10.1016/j.ejmech.2016.04.070. [PMID: 27187863]
  • M Biffen, H Matsui, S Edwards, A J Leishman, K Eiho, E Holness, G Satterthwaite, I Doyle, H Wada, N J Fraser, S L Hawkins, M Aoki, H Tomizawa, A D Benjamin, H Takaku, T McInally, C M Murray. Biological characterization of a novel class of toll-like receptor 7 agonists designed to have reduced systemic activity. British journal of pharmacology. 2012 May; 166(2):573-86. doi: 10.1111/j.1476-5381.2011.01790.x. [PMID: 22122192]
  • Toshifumi Tsujiuchi, Kyoko Okabe, Nobuyuki Fukushima. Genetic and epigenetic alterations of lysophosphatidic Acid receptor genes in rodent tumors by experimental models. Journal of toxicologic pathology. 2011 Sep; 24(3):143-8. doi: 10.1293/tox.24.143. [PMID: 22272054]
  • Ayumu Kurimoto, Kazuki Hashimoto, Tomoaki Nakamura, Kei Norimura, Haruhisa Ogita, Haruo Takaku, Roger Bonnert, Tom McInally, Hiroki Wada, Yoshiaki Isobe. Synthesis and biological evaluation of 8-oxoadenine derivatives as toll-like receptor 7 agonists introducing the antedrug concept. Journal of medicinal chemistry. 2010 Apr; 53(7):2964-72. doi: 10.1021/jm100070n. [PMID: 20232824]
  • Marcus S Cooke, Paul T Henderson, Mark D Evans. Sources of extracellular, oxidatively-modified DNA lesions: implications for their measurement in urine. Journal of clinical biochemistry and nutrition. 2009 Nov; 45(3):255-70. doi: 10.3164/jcbn.sr09-41. [PMID: 19902015]
  • Thomas Borrmann, Aliaa Abdelrahman, Rosaria Volpini, Catia Lambertucci, Edgars Alksnis, Simone Gorzalka, Melanie Knospe, Anke C Schiedel, Gloria Cristalli, Christa E Müller. Structure-activity relationships of adenine and deazaadenine derivatives as ligands for adenine receptors, a new purinergic receptor family. Journal of medicinal chemistry. 2009 Oct; 52(19):5974-89. doi: 10.1021/jm9006356. [PMID: 19731917]
  • Goksel Gokce, Gonen Ozsarlak-Sozer, Gulgun Oktay, Güldal Kirkali, Pawel Jaruga, Miral Dizdaroglu, Zeliha Kerry. Glutathione depletion by buthionine sulfoximine induces oxidative damage to DNA in organs of rabbits in vivo. Biochemistry. 2009 Jun; 48(22):4980-7. doi: 10.1021/bi900030z. [PMID: 19374446]
  • Eric van der Walt, Darren P Martin, Arvind Varsani, Jane E Polston, Edward P Rybicki. Experimental observations of rapid Maize streak virus evolution reveal a strand-specific nucleotide substitution bias. Virology journal. 2008 Sep; 5(?):104. doi: 10.1186/1743-422x-5-104. [PMID: 18816368]
  • Hubert Allgayer, Maximilian Kolb, Volker Stuber, Wolfgang Kruis. Effects of bile acids on base hydroxylation in a model of human colonic mucosal DNA. Cancer detection and prevention. 2002; 26(1):85-9. doi: 10.1016/s0361-090x(02)00008-9. [PMID: 12088208]
  • W G Stillwell, H X Xu, J A Adkins, J S Wishnok, S R Tannenbaum. Analysis of methylated and oxidized purines in urine by capillary gas chromatography-mass spectrometry. Chemical research in toxicology. 1989 Mar; 2(2):94-9. doi: 10.1021/tx00008a004. [PMID: 2519715]
  • H A Simmonds, K J Van Acker, J S Cameron, A McBurney. Purine excretion in complete adenine phosphoribosyltransferase deficiency: effect of diet and allopurinol therapy. Advances in experimental medicine and biology. 1977; 76B(?):304-11. doi: 10.1007/978-1-4684-3285-5_46. [PMID: 857624]