UNII:S7S079H2C2 (BioDeep_00000410639)

Main id: BioDeep_00000026928

 

PANOMIX_OTCML-2023


代谢物信息卡片


2-Phenylbutyric acid

化学式: C10H12O2 (164.0837252)
中文名称: 2-苯基丁酸
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CCC(C(O)=O)C1=CC=CC=C1
InChI: InChI=1S/C10H12O2/c1-2-9(10(11)12)8-6-4-3-5-7-8/h3-7,9H,2H2,1H3,(H,11,12)

描述信息

A monocarboxylic acid that is butyric acid substituted by a phenyl group at position 2.
C471 - Enzyme Inhibitor > C1946 - Histone Deacetylase Inhibitor
C274 - Antineoplastic Agent > C163758 - Targeted Therapy Agent
2-Phenylbutanoic acid is an endogenous metabolite.

同义名列表

4 个代谢物同义名

2-Phenylbutyric acid; UNII:S7S079H2C2; 2-Phenylbutanoic acid; 2-Phenylbutyric acid



数据库引用编号

9 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

7 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Nishikant Wase, Boqiang Tu, James W Allen, Paul N Black, Concetta C DiRusso. Identification and Metabolite Profiling of Chemical Activators of Lipid Accumulation in Green Algae. Plant physiology. 2017 Aug; 174(4):2146-2165. doi: 10.1104/pp.17.00433. [PMID: 28652262]
  • M Mokhtarani, G A Diaz, W Rhead, U Lichter-Konecki, J Bartley, A Feigenbaum, N Longo, W Berquist, S A Berry, R Gallagher, D Bartholomew, C O Harding, M S Korson, S E McCandless, W Smith, J Vockley, S Bart, D Kronn, R Zori, S Cederbaum, N Dorrani, J L Merritt, Sandesh Sreenath-Nagamani, M Summar, C Lemons, K Dickinson, D F Coakley, T L Moors, B Lee, B F Scharschmidt. Urinary phenylacetylglutamine as dosing biomarker for patients with urea cycle disorders. Molecular genetics and metabolism. 2012 Nov; 107(3):308-14. doi: 10.1016/j.ymgme.2012.08.006. [PMID: 22958974]
  • Thomas Asklund, Samuel Kvarnbrink, Camilla Holmlund, Carl Wibom, Tommy Bergenheim, Roger Henriksson, Håkan Hedman. Synergistic killing of glioblastoma stem-like cells by bortezomib and HDAC inhibitors. Anticancer research. 2012 Jul; 32(7):2407-13. doi: NULL. [PMID: 22753697]
  • Avik Roy, Anamitra Ghosh, Arundhati Jana, Xiaojuan Liu, Saurav Brahmachari, Howard E Gendelman, Kalipada Pahan. Sodium phenylbutyrate controls neuroinflammatory and antioxidant activities and protects dopaminergic neurons in mouse models of Parkinson's disease. PloS one. 2012; 7(6):e38113. doi: 10.1371/journal.pone.0038113. [PMID: 22723850]
  • Richard S Finkel, Thomas O Crawford, Kathryn J Swoboda, Petra Kaufmann, Peter Juhasz, Xiaohong Li, Yu Guo, Rebecca H Li, Felicia Trachtenberg, Suzanne J Forrest, Dione T Kobayashi, Karen S Chen, Cynthia L Joyce, Thomas Plasterer. Candidate proteins, metabolites and transcripts in the Biomarkers for Spinal Muscular Atrophy (BforSMA) clinical study. PloS one. 2012; 7(4):e35462. doi: 10.1371/journal.pone.0035462. [PMID: 22558154]
  • Uta Lichter-Konecki, G A Diaz, J L Merritt, A Feigenbaum, C Jomphe, J F Marier, M Beliveau, J Mauney, K Dickinson, A Martinez, M Mokhtarani, B Scharschmidt, W Rhead. Ammonia control in children with urea cycle disorders (UCDs); phase 2 comparison of sodium phenylbutyrate and glycerol phenylbutyrate. Molecular genetics and metabolism. 2011 Aug; 103(4):323-9. doi: 10.1016/j.ymgme.2011.04.013. [PMID: 21612962]
  • Shabana I Khan, Jianping Zhao, Ikhlas A Khan, Larry A Walker, Asok K Dasmahapatra. Potential utility of natural products as regulators of breast cancer-associated aromatase promoters. Reproductive biology and endocrinology : RB&E. 2011 Jun; 9(?):91. doi: 10.1186/1477-7827-9-91. [PMID: 21693041]
  • Changting Xiao, Adria Giacca, Gary F Lewis. Sodium phenylbutyrate, a drug with known capacity to reduce endoplasmic reticulum stress, partially alleviates lipid-induced insulin resistance and beta-cell dysfunction in humans. Diabetes. 2011 Mar; 60(3):918-24. doi: 10.2337/db10-1433. [PMID: 21270237]
  • Nicola Brunetti-Pierri, Brendan Lanpher, Ayelet Erez, Elitsa A Ananieva, Mohammad Islam, Juan C Marini, Qin Sun, Chunli Yu, Madhuri Hegde, Jun Li, R Max Wynn, David T Chuang, Susan Hutson, Brendan Lee. Phenylbutyrate therapy for maple syrup urine disease. Human molecular genetics. 2011 Feb; 20(4):631-40. doi: 10.1093/hmg/ddq507. [PMID: 21098507]
  • Marta Daniotti, Giancarlo la Marca, Patrizio Fiorini, Luca Filippi. New developments in the treatment of hyperammonemia: emerging use of carglumic acid. International journal of general medicine. 2011 Jan; 4(?):21-8. doi: 10.2147/ijgm.s10490. [PMID: 21403788]
  • G Wright, A Chattree, R Jalan. Management of hepatic encephalopathy. International journal of hepatology. 2011; 2011(?):841407. doi: 10.4061/2011/841407. [PMID: 21994873]
  • Brendan Lee, William Rhead, George A Diaz, Bruce F Scharschmidt, Asad Mian, Oleg Shchelochkov, J F Marier, Martin Beliveau, Joseph Mauney, Klara Dickinson, Antonia Martinez, Sharron Gargosky, Masoud Mokhtarani, Susan A Berry. Phase 2 comparison of a novel ammonia scavenging agent with sodium phenylbutyrate in patients with urea cycle disorders: safety, pharmacokinetics and ammonia control. Molecular genetics and metabolism. 2010 Jul; 100(3):221-8. doi: 10.1016/j.ymgme.2010.03.014. [PMID: 20382058]
  • Brendan M McGuire, Igor A Zupanets, Mark E Lowe, Xunjun Xiao, Vasyliy A Syplyviy, Jon Monteleone, Sharron Gargosky, Klara Dickinson, Antonia Martinez, Masoud Mokhtarani, Bruce F Scharschmidt. Pharmacology and safety of glycerol phenylbutyrate in healthy adults and adults with cirrhosis. Hepatology (Baltimore, Md.). 2010 Jun; 51(6):2077-85. doi: 10.1002/hep.23589. [PMID: 20512995]
  • Erika N Ebbel, Nancy Leymarie, Susan Schiavo, Swati Sharma, Sona Gevorkian, Steven Hersch, Wayne R Matson, Catherine E Costello. Identification of phenylbutyrate-generated metabolites in Huntington disease patients using parallel liquid chromatography/electrochemical array/mass spectrometry and off-line tandem mass spectrometry. Analytical biochemistry. 2010 Apr; 399(2):152-61. doi: 10.1016/j.ab.2010.01.010. [PMID: 20074541]
  • Fernando Scaglia. New insights in nutritional management and amino acid supplementation in urea cycle disorders. Molecular genetics and metabolism. 2010; 100 Suppl 1(?):S72-6. doi: 10.1016/j.ymgme.2010.02.019. [PMID: 20299258]
  • Laurence Colin, Carine Van Lint. Molecular control of HIV-1 postintegration latency: implications for the development of new therapeutic strategies. Retrovirology. 2009 Dec; 6(?):111. doi: 10.1186/1742-4690-6-111. [PMID: 19961595]
  • V Walker. Ammonia toxicity and its prevention in inherited defects of the urea cycle. Diabetes, obesity & metabolism. 2009 Sep; 11(9):823-35. doi: 10.1111/j.1463-1326.2009.01054.x. [PMID: 19531057]
  • S Jones, C A B Reed, S Vijay, J H Walter, A A M Morris. N-carbamylglutamate for neonatal hyperammonaemia in propionic acidaemia. Journal of inherited metabolic disease. 2008 Dec; 31 Suppl 2(?):S219-22. doi: 10.1007/s10545-008-0777-1. [PMID: 18338235]
  • W-L Hwu, Y-H Chien, N L S Tang, L-K Law, C-Y Lin, N-C Lee. Deficiency of the carnitine transporter (OCTN2) with partial N-acetylglutamate synthase (NAGS) deficiency. Journal of inherited metabolic disease. 2007 Oct; 30(5):816. doi: 10.1007/s10545-007-0594-y. [PMID: 17703373]
  • L M Tanner, K Näntö-Salonen, J Venetoklis, S Kotilainen, H Niinikoski, K Huoponen, O Simell. Nutrient intake in lysinuric protein intolerance. Journal of inherited metabolic disease. 2007 Oct; 30(5):716-21. doi: 10.1007/s10545-007-0558-2. [PMID: 17588131]
  • F Maillot, P Crenn. [Urea cycle disorders in adult patients]. Revue neurologique. 2007 Oct; 163(10):897-903. doi: 10.1016/s0035-3787(07)92632-6. [PMID: 18033025]
  • A Atmaca, S-E Al-Batran, A Maurer, A Neumann, T Heinzel, B Hentsch, S E Schwarz, S Hövelmann, M Göttlicher, A Knuth, E Jäger. Valproic acid (VPA) in patients with refractory advanced cancer: a dose escalating phase I clinical trial. British journal of cancer. 2007 Jul; 97(2):177-82. doi: 10.1038/sj.bjc.6603851. [PMID: 17579623]
  • S A Belinsky, M J Grimes, E Casas, C A Stidley, W A Franklin, T J Bocklage, D H Johnson, J H Schiller. Predicting gene promoter methylation in non-small-cell lung cancer by evaluating sputum and serum. British journal of cancer. 2007 Apr; 96(8):1278-83. doi: 10.1038/sj.bjc.6603721. [PMID: 17406356]
  • R M Kern, Z Yang, P S Kim, W W Grody, R K Iyer, S D Cederbaum. Arginase induction by sodium phenylbutyrate in mouse tissues and human cell lines. Molecular genetics and metabolism. 2007 Jan; 90(1):37-41. doi: 10.1016/j.ymgme.2006.07.002. [PMID: 16935537]
  • Steven D Gore, Stephen Baylin, Elizabeth Sugar, Hetty Carraway, Carole B Miller, Michael Carducci, Michael Grever, Oliver Galm, Tianna Dauses, Judith E Karp, Michelle A Rudek, Ming Zhao, B Douglas Smith, Jasper Manning, Anchalee Jiemjit, George Dover, Abbie Mays, James Zwiebel, Anthony Murgo, Li-Jun Weng, James G Herman. Combined DNA methyltransferase and histone deacetylase inhibition in the treatment of myeloid neoplasms. Cancer research. 2006 Jun; 66(12):6361-9. doi: 10.1158/0008-5472.can-06-0080. [PMID: 16778214]
  • Alfonso Dueñas-González, Marcela Lizano, Myrna Candelaria, Lucely Cetina, Claudia Arce, Eduardo Cervera. Epigenetics of cervical cancer. An overview and therapeutic perspectives. Molecular cancer. 2005 Oct; 4(?):38. doi: 10.1186/1476-4598-4-38. [PMID: 16248899]
  • Surasak Phuphanich, Sharyn D Baker, Stuart A Grossman, Kathryn A Carson, Mark R Gilbert, Joy D Fisher, Michael A Carducci. Oral sodium phenylbutyrate in patients with recurrent malignant gliomas: a dose escalation and pharmacologic study. Neuro-oncology. 2005 Apr; 7(2):177-82. doi: 10.1215/s1152851704000183. [PMID: 15831235]
  • Fernando Scaglia, Susan Carter, William E O'Brien, Brendan Lee. Effect of alternative pathway therapy on branched chain amino acid metabolism in urea cycle disorder patients. Molecular genetics and metabolism. 2004 Apr; 81 Suppl 1(?):S79-85. doi: 10.1016/j.ymgme.2003.11.017. [PMID: 15050979]
  • Godfried M Roomans. Pharmacological approaches to correcting the ion transport defect in cystic fibrosis. American journal of respiratory medicine : drugs, devices, and other interventions. 2003; 2(5):413-31. doi: 10.1007/bf03256668. [PMID: 14719993]
  • Steven D Gore, Li-Jun Weng, William D Figg, Suoping Zhai, Ross C Donehower, George Dover, Michael R Grever, Constance Griffin, Louise B Grochow, Anita Hawkins, Kathleen Burks, Yelena Zabelena, Carole B Miller. Impact of prolonged infusions of the putative differentiating agent sodium phenylbutyrate on myelodysplastic syndromes and acute myeloid leukemia. Clinical cancer research : an official journal of the American Association for Cancer Research. 2002 Apr; 8(4):963-70. doi: NULL. [PMID: 11948101]
  • J V Leonard, A A M Morris. Urea cycle disorders. Seminars in neonatology : SN. 2002 Feb; 7(1):27-35. doi: 10.1053/siny.2001.0085. [PMID: 12069536]
  • M A Carducci, J Gilbert, M K Bowling, D Noe, M A Eisenberger, V Sinibaldi, Y Zabelina, T L Chen, L B Grochow, R C Donehower. A Phase I clinical and pharmacological evaluation of sodium phenylbutyrate on an 120-h infusion schedule. Clinical cancer research : an official journal of the American Association for Cancer Research. 2001 Oct; 7(10):3047-55. doi: NULL. [PMID: 11595694]
  • S D Gore, L J Weng, S Zhai, W D Figg, R C Donehower, G J Dover, M Grever, C A Griffin, L B Grochow, E K Rowinsky, Y Zabalena, A L Hawkins, K Burks, C B Miller. Impact of the putative differentiating agent sodium phenylbutyrate on myelodysplastic syndromes and acute myeloid leukemia. Clinical cancer research : an official journal of the American Association for Cancer Research. 2001 Aug; 7(8):2330-9. doi: NULL. [PMID: 11489809]
  • A B Burlina, H Ogier, H Korall, F K Trefz. Long-term treatment with sodium phenylbutyrate in ornithine transcarbamylase-deficient patients. Molecular genetics and metabolism. 2001 Apr; 72(4):351-5. doi: 10.1006/mgme.2001.3156. [PMID: 11286510]
  • J Haginaka, H Matsunaga. Separation of enantiomers on HPLC chiral stationary phases based on human plasma alpha1-acid glycoprotein: effect of sugar moiety on chiral recognition ability. Enantiomer. 2000; 5(1):37-45. doi: NULL. [PMID: 10763868]
  • H Bohner, P S Janiak, V Nitsche, A Eichinger, H Schütz. Relative bioavailability of different butamirate citrate preparations after single dose oral administration to 18 healthy volunteers. International journal of clinical pharmacology and therapeutics. 1997 Mar; 35(3):117-22. doi: NULL. [PMID: 9089001]
  • S C Jacobson, S Andersson, S G Allenmark, G Guiochon. Estimation of the number of enantioselective sites of bovine serum albumin using frontal chromatography. Chirality. 1993; 5(7):513-5. doi: 10.1002/chir.530050707. [PMID: 8240928]
  • M T Tsamis, A M Mange, R Farinotti, G Mahuzier. [Assay of 2-phenylbutyric acid in plasma with gas and liquid chromatography]. Journal of chromatography. 1983 Oct; 277(?):61-9. doi: NULL. [PMID: 6643637]
  • M K Samson, R L Stephens, S Rivkin, M Opipari, T Maloney, C W Groppe, R Fisher. Vinblastine, bleomycin, and cis-dichlorodiammineplatinum(II) in disseminated testicular cancer: preliminary report of a Southwest Oncology Group Study. Cancer treatment reports. 1979 Sep; 63(9-10):1663-7. doi: . [PMID: 91435]
  • A MATHIVAT, J COTTET. [Clinical trials on the hypocholesteremia-producing effect of 2-phenylbutyric acid]. Bulletins et memoires de la Societe medicale des hopitaux de Paris. 1953 Nov; 69(30-31):1030-48. doi: ". [PMID: 13141149]