meclofenamic acid (BioDeep_00000408890)

Main id: BioDeep_00000002023

 

Volatile Flavor Compounds


代谢物信息卡片


2-[(2,6-dichloro-3-methylphenyl)amino]-benzoic acid, monosodium salt

化学式: C14H11Cl2NO2 (295.01668060000003)
中文名称: 甲氯芬那酸
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC1=C(C(=C(C=C1)Cl)NC2=CC=CC=C2C(=O)O)Cl
InChI: InChI=1S/C14H11Cl2NO2/c1-8-6-7-10(15)13(12(8)16)17-11-5-3-2-4-9(11)14(18)19/h2-7,17H,1H3,(H,18,19)

描述信息

M - Musculo-skeletal system > M02 - Topical products for joint and muscular pain > M02A - Topical products for joint and muscular pain > M02AA - Antiinflammatory preparations, non-steroids for topical use
M - Musculo-skeletal system > M01 - Antiinflammatory and antirheumatic products > M01A - Antiinflammatory and antirheumatic products, non-steroids > M01AG - Fenamates
D018501 - Antirheumatic Agents > D000894 - Anti-Inflammatory Agents, Non-Steroidal > D016861 - Cyclooxygenase Inhibitors
C78272 - Agent Affecting Nervous System > C241 - Analgesic Agent > C2198 - Nonnarcotic Analgesic
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
D002491 - Central Nervous System Agents > D000700 - Analgesics
C471 - Enzyme Inhibitor > C1323 - Cyclooxygenase Inhibitor
D000893 - Anti-Inflammatory Agents
D004791 - Enzyme Inhibitors

同义名列表

4 个代谢物同义名

meclofenamic acid; 2-[(2,6-dichloro-3-methylphenyl)amino]-benzoic acid, monosodium salt; Meclofenamate (sodium salt); Meclofenamate



数据库引用编号

19 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Amalia Barmpa, George D Geromichalos, Antonios G Hatzidimitriou, George Psomas. Nickel(II)-meclofenamate complexes: Structure, in vitro and in silico DNA- and albumin-binding studies, antioxidant and anticholinergic activity. Journal of inorganic biochemistry. 2021 09; 222(?):111507. doi: 10.1016/j.jinorgbio.2021.111507. [PMID: 34139455]
  • Amalia Barmpa, Antonios G Hatzidimitriou, George Psomas. Copper(II) complexes with meclofenamate ligands: Structure, interaction with DNA and albumins, antioxidant and anticholinergic activity. Journal of inorganic biochemistry. 2021 04; 217(?):111357. doi: 10.1016/j.jinorgbio.2021.111357. [PMID: 33556771]
  • Emmanuelle Soleilhac, Marjorie Comte, Anaelle da Costa, Caroline Barette, Christèle Picoli, Magda Mortier, Laurence Aubry, Franck Mouthon, Marie-Odile Fauvarque, Mathieu Charvériat. Quantitative Automated Assays in Living Cells to Screen for Inhibitors of Hemichannel Function. SLAS discovery : advancing life sciences R & D. 2021 03; 26(3):420-427. doi: 10.1177/2472555220954388. [PMID: 32914684]
  • Peihui Zhou, Ming Wu, Chaoyang Ye, Qingqing Xu, Li Wang. Meclofenamic acid promotes cisplatin-induced acute kidney injury by inhibiting fat mass and obesity-associated protein-mediated m6A abrogation in RNA. The Journal of biological chemistry. 2019 11; 294(45):16908-16917. doi: 10.1074/jbc.ra119.011009. [PMID: 31578283]
  • Hongyan Dong, Michael G Wade. Application of a nonradioactive assay for high throughput screening for inhibition of thyroid hormone uptake via the transmembrane transporter MCT8. Toxicology in vitro : an international journal published in association with BIBRA. 2017 Apr; 40(?):234-242. doi: 10.1016/j.tiv.2017.01.014. [PMID: 28119167]
  • Hussin A Rothan, Hirbod Bahrani, Ammar Y Abdulrahman, Zulqarnain Mohamed, Teow Chong Teoh, Shatrah Othman, Nurshamimi Nor Rashid, Noorsaadah A Rahman, Rohana Yusof. Mefenamic acid in combination with ribavirin shows significant effects in reducing chikungunya virus infection in vitro and in vivo. Antiviral research. 2016 Mar; 127(?):50-6. doi: 10.1016/j.antiviral.2016.01.006. [PMID: 26794398]
  • Irina Iakovleva, Kristoffer Brännström, Lina Nilsson, Anna L Gharibyan, Afshan Begum, Intissar Anan, Malin Walfridsson, A Elisabeth Sauer-Eriksson, Anders Olofsson. Enthalpic Forces Correlate with the Selectivity of Transthyretin-Stabilizing Ligands in Human Plasma. Journal of medicinal chemistry. 2015 Aug; 58(16):6507-15. doi: 10.1021/acs.jmedchem.5b00544. [PMID: 26214366]
  • Yuji Narukawa, Akiko Niimura, Hitomi Noguchi, Hiroomi Tamura, Fumiyuki Kiuchi. New diterpenoids with estrogen sulfotransferase inhibitory activity from Leonurus sibiricus L. Journal of natural medicines. 2014 Jan; 68(1):125-31. doi: 10.1007/s11418-013-0781-0. [PMID: 23736977]
  • Chika Saigo, Yui Nomura, Yuko Yamamoto, Masataka Sagata, Rika Matsunaga, Hirofumi Jono, Kazuhiko Nishi, Hideyuki Saito. Meclofenamate elicits a nephropreventing effect in a rat model of ischemic acute kidney injury by suppressing indoxyl sulfate production and restoring renal organic anion transporters. Drug design, development and therapy. 2014; 8(?):1073-82. doi: 10.2147/dddt.s67456. [PMID: 25143712]
  • Daniel J Warner, Hongming Chen, Louis-David Cantin, J Gerry Kenna, Simone Stahl, Clare L Walker, Tobias Noeske. Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification. Drug metabolism and disposition: the biological fate of chemicals. 2012 Dec; 40(12):2332-41. doi: 10.1124/dmd.112.047068. [PMID: 22961681]
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  • Barbara Bobrowska, Andrzej Tokarz, Sławomir Białek, Małgorzata Seweryn. Effect of dietary supplementation on the prognostic value of urinary and serum 8-isoprostaglandin F2α in chemically-induced mammary carcinogenesis in the rat. Lipids in health and disease. 2011 Mar; 10(?):40. doi: 10.1186/1476-511x-10-40. [PMID: 21371291]
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  • Sarah Thomas, Amanda Sutton, Uttam Garg. Quantitation of indomethacin in serum and plasma using gas chromatography-mass spectrometry (GC-MS). Methods in molecular biology (Clifton, N.J.). 2010; 603(?):297-305. doi: 10.1007/978-1-60761-459-3_28. [PMID: 20077081]
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  • Allison L Opay, Cynthia R Mouton, John J Mullins, Kenneth D Mitchell. Cyclooxygenase-2 inhibition normalizes arterial blood pressure in CYP1A1-REN2 transgenic rats with inducible ANG II-dependent malignant hypertension. American journal of physiology. Renal physiology. 2006 Sep; 291(3):F612-8. doi: 10.1152/ajprenal.00032.2006. [PMID: 16622181]
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  • A Muñoz de la Peña, A Espinosa Mansilla, N Mora Díez, D Bohoyo Gil, A C Olivieri, G M Escandar. Second-order calibration of excitation-emission matrix fluorescence spectra for the determination of N-phenylanthranilic acid derivatives. Applied spectroscopy. 2006 Mar; 60(3):330-8. doi: 10.1366/000370206776342643. [PMID: 16608576]
  • Kiyoshi Shimizu, Kanji Matsukawa, Jun Murata, Hirotsugu Tsuchimochi, Ishio Ninomiya. Partial renal ischemia elicits heterogeneous control of renal sympathetic nerve activity to ischemic and nonischemic regions of the kidney. American journal of physiology. Regulatory, integrative and comparative physiology. 2006 Feb; 290(2):R322-30. doi: 10.1152/ajpregu.00493.2005. [PMID: 16166203]
  • Jason M Hoover, Alan D Kaye, Ikhlass N Ibrahim, Aaron M Fields, Todd A Richards. Analysis of responses to kava kava in the feline pulmonary vascular bed. Journal of medicinal food. 2006; 9(1):62-71. doi: 10.1089/jmf.2006.9.62. [PMID: 16579730]
  • Floriana Vinci, Serena Fabbrocino, Maurizio Fiori, Luigi Serpe, Pasquale Gallo. Determination of fourteen non-steroidal anti-inflammatory drugs in animal serum and plasma by liquid chromatography/mass spectrometry. Rapid communications in mass spectrometry : RCM. 2006; 20(22):3412-20. doi: 10.1002/rcm.2748. [PMID: 17066368]
  • M B Kadiiska, B C Gladen, D D Baird, L B Graham, C E Parker, B N Ames, S Basu, G A Fitzgerald, J A Lawson, L J Marnett, J D Morrow, D M Murray, J Plastaras, L J Roberts, J Rokach, M K Shigenaga, J Sun, P B Walter, K B Tomer, J C Barrett, R P Mason. Biomarkers of oxidative stress study III. Effects of the nonsteroidal anti-inflammatory agents indomethacin and meclofenamic acid on measurements of oxidative products of lipids in CCl4 poisoning. Free radical biology & medicine. 2005 Mar; 38(6):711-8. doi: 10.1016/j.freeradbiomed.2004.10.024. [PMID: 15721981]
  • Julian A Skidmore, M Billah. Embryo transfer in the dromedary camel (Camelus dromedarius) using asynchronous, meclofenamic acid-treated recipients. Reproduction, fertility, and development. 2005; 17(4):417-21. doi: 10.1071/rd04081. [PMID: 15899153]
  • Dilek Memiş, Beyhan Karamanlioğlu, Alparslan Turan, Onur Koyuncu, Zafer Pamukçu. Effects of lornoxicam on the physiology of severe sepsis. Critical care (London, England). 2004 Dec; 8(6):R474-82. doi: 10.1186/cc2969. [PMID: 15566594]
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  • Aaron M Fields, Todd A Richards, Jason A Felton, Shaili K Felton, Erin Z Bayer, Ikhlass N Ibrahim, Alan David Kaye. Analysis of responses to valerian root extract in the feline pulmonary vascular bed. Journal of alternative and complementary medicine (New York, N.Y.). 2003 Dec; 9(6):909-18. doi: 10.1089/107555303771952253. [PMID: 14736362]
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  • Jason L Eriksen, Sarah A Sagi, Tawnya E Smith, Sascha Weggen, Pritam Das, D C McLendon, Victor V Ozols, Kevin W Jessing, Kenton H Zavitz, Edward H Koo, Todd E Golde. NSAIDs and enantiomers of flurbiprofen target gamma-secretase and lower Abeta 42 in vivo. The Journal of clinical investigation. 2003 Aug; 112(3):440-9. doi: 10.1172/jci18162. [PMID: 12897211]
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  • Wolfgang Schober, Rainer Kehlbach, Regina Gebert, Jakub Wiskirchen, Enno Rodegerdts, Claus D Claussen, Stephan H Duda. Meclofenamic acid for inhibition of human vascular smooth muscle cell proliferation and migration: an in vitro study. Cardiovascular and interventional radiology. 2002 Jan; 25(1):57-63. doi: 10.1007/s00270-001-0077-8. [PMID: 11907776]
  • R C Fowkes, C Chandras, E C Chin, S Okolo, D R Abayasekara, A E Michael. Relationship between the production of prostaglandins and progesterone by luteinizing human granulosa cells. The Journal of endocrinology. 2001 Dec; 171(3):455-62. doi: 10.1677/joe.0.1710455. [PMID: 11739011]
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