Meclofenamic acid (BioDeep_00000002023)

 

Secondary id: BioDeep_00000408890

human metabolite blood metabolite Chemicals and Drugs


代谢物信息卡片


Benzoic acid, 2-((2,6-dichloro-3-methylphenyl)amino)-, monosodium salt, monohydrate

化学式: C14H11Cl2NO2 (295.01668060000003)
中文名称: 甲氯芬那酸
谱图信息: 最多检出来源 Homo sapiens(blood) 16.67%

分子结构信息

SMILES: CC1=C(C(=C(C=C1)Cl)NC2=CC=CC=C2C(=O)O)Cl
InChI: InChI=1S/C14H11Cl2NO2/c1-8-6-7-10(15)13(12(8)16)17-11-5-3-2-4-9(11)14(18)19/h2-7,17H,1H3,(H,18,19)

描述信息

Meclofenamic acid is only found in individuals that have used or taken this drug. It is a non-steroidal anti-inflammatory agent with antipyretic and antigranulation activities. It also inhibits prostaglandin biosynthesis. [PubChem]The mode of action, like that of other nonsteroidal anti-inflammatory agents, is not known. Therapeutic action does not result from pituitary-adrenal stimulation. In animal studies, meclofenamic acid was found to inhibit prostaglandin synthesis and to compete for binding at the prostaglandin receptor site. In vitro meclofenamic acid was found to be an inhibitor of human leukocyte 5-lipoxygenase activity. These properties may be responsible for the anti-inflammatory action of meclofenamic acid. There is no evidence that meclofenamic acid alters the course of the underlying disease.
M - Musculo-skeletal system > M02 - Topical products for joint and muscular pain > M02A - Topical products for joint and muscular pain > M02AA - Antiinflammatory preparations, non-steroids for topical use
M - Musculo-skeletal system > M01 - Antiinflammatory and antirheumatic products > M01A - Antiinflammatory and antirheumatic products, non-steroids > M01AG - Fenamates
D018501 - Antirheumatic Agents > D000894 - Anti-Inflammatory Agents, Non-Steroidal > D016861 - Cyclooxygenase Inhibitors
C78272 - Agent Affecting Nervous System > C241 - Analgesic Agent > C2198 - Nonnarcotic Analgesic
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
D002491 - Central Nervous System Agents > D000700 - Analgesics
C471 - Enzyme Inhibitor > C1323 - Cyclooxygenase Inhibitor
CONFIDENCE standard compound; EAWAG_UCHEM_ID 3690
D000893 - Anti-Inflammatory Agents
D004791 - Enzyme Inhibitors

同义名列表

27 个代谢物同义名

Benzoic acid, 2-((2,6-dichloro-3-methylphenyl)amino)-, monosodium salt, monohydrate; 2-[(2,6-dichloro-3-methylphenyl)amino]benzoic acid; N-(3-Methyl-2,6-dichlorophenyl)anthranilic acid; N-(2,6-Dichloro-3-methylphenyl)anthranilic acid; N-(2,6-Dichloro-3-methylphenyl)anthranilate; N-(3-Methyl-2,6-dichlorophenyl)anthranilate; Parke davis brand OF sodium meclofenamate; N-(2,6-Dichloro-m-tolyl)anthranilic acid; N-(2,6-Dichloro-m-tolyl)anthranilate; Meclofenamate sodium monohydrate; Anhydrous, meclofenamate sodium; Meclofenamate sodium anhydrous; Meclofenamate, sodium; Sodium, meclofenamate; Acidum meclofenamicum; Acide meclofenamique; Sodium meclofenamate; Meclofenamate sodium; Meclomen (free acid); Acido meclofenamico; Acid, meclofenamic; Meclophenamic acid; meclofenamic acid; Meclofenamate; Meclomen; INF 4668; CI-583



数据库引用编号

31 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Amalia Barmpa, George D Geromichalos, Antonios G Hatzidimitriou, George Psomas. Nickel(II)-meclofenamate complexes: Structure, in vitro and in silico DNA- and albumin-binding studies, antioxidant and anticholinergic activity. Journal of inorganic biochemistry. 2021 09; 222(?):111507. doi: 10.1016/j.jinorgbio.2021.111507. [PMID: 34139455]
  • Amalia Barmpa, Antonios G Hatzidimitriou, George Psomas. Copper(II) complexes with meclofenamate ligands: Structure, interaction with DNA and albumins, antioxidant and anticholinergic activity. Journal of inorganic biochemistry. 2021 04; 217(?):111357. doi: 10.1016/j.jinorgbio.2021.111357. [PMID: 33556771]
  • Emmanuelle Soleilhac, Marjorie Comte, Anaelle da Costa, Caroline Barette, Christèle Picoli, Magda Mortier, Laurence Aubry, Franck Mouthon, Marie-Odile Fauvarque, Mathieu Charvériat. Quantitative Automated Assays in Living Cells to Screen for Inhibitors of Hemichannel Function. SLAS discovery : advancing life sciences R & D. 2021 03; 26(3):420-427. doi: 10.1177/2472555220954388. [PMID: 32914684]
  • Peihui Zhou, Ming Wu, Chaoyang Ye, Qingqing Xu, Li Wang. Meclofenamic acid promotes cisplatin-induced acute kidney injury by inhibiting fat mass and obesity-associated protein-mediated m6A abrogation in RNA. The Journal of biological chemistry. 2019 11; 294(45):16908-16917. doi: 10.1074/jbc.ra119.011009. [PMID: 31578283]
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  • Chika Saigo, Yui Nomura, Yuko Yamamoto, Masataka Sagata, Rika Matsunaga, Hirofumi Jono, Kazuhiko Nishi, Hideyuki Saito. Meclofenamate elicits a nephropreventing effect in a rat model of ischemic acute kidney injury by suppressing indoxyl sulfate production and restoring renal organic anion transporters. Drug design, development and therapy. 2014; 8(?):1073-82. doi: 10.2147/dddt.s67456. [PMID: 25143712]
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  • Floriana Vinci, Serena Fabbrocino, Maurizio Fiori, Luigi Serpe, Pasquale Gallo. Determination of fourteen non-steroidal anti-inflammatory drugs in animal serum and plasma by liquid chromatography/mass spectrometry. Rapid communications in mass spectrometry : RCM. 2006; 20(22):3412-20. doi: 10.1002/rcm.2748. [PMID: 17066368]
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